| 11. |
|
|
| 12. |
|
|
| 13. |
- Ohlsson, Bodil, et al.
(författare)
-
Patients with irritable bowel syndrome and dysmotility express antibodies against gonadotropin-releasing hormone in serum.
- 2011
-
Ingår i: Neurogastroenterology and Motility. - : Wiley. - 1350-1925. ; 23, s. 459-1000
-
Tidskriftsartikel (refereegranskat)abstract
- Background The etiology of irritable bowel syndrome (IBS) and dysmotility is in most cases unknown. Organic, pathognomonic changes have not been described. We have previously demonstrated sporadic expressions of antibodies against gonadotropin-releasing hormone (GnRH) in serum from these patients. The aim of this study was to screen for the presence of GnRH antibodies in healthy subjects and patients with gastrointestinal (GI) diseases. Methods Consecutive patients suffering from either IBS, idiopathic dysmotility, GI complaints secondary to diabetes mellitus, celiac disease or inflammatory bowel disease (IBD) were included. Healthy blood donors served as controls. Blood samples were taken for analyzing IgM and IgG antibodies against GnRH using an ELISA method. Medical records were scrutinized with respect to duration of symptoms, co-existing diseases, drug treatments, hereditary factors, and laboratory analyses. Key Results Healthy controls expressed low levels of GnRH IgM antibodies in a prevalence of 23%. The prevalence of GnRH IgM antibodies in IBS and dysmotility patients was 42% (P = 0.008), and the levels were higher (P = 0.000). Patients with diabetes mellitus expressed GnRH IgM antibodies in the same prevalence as controls (25%), but in higher levels (P = 0.02). Patients with celiac disease or IBD had the same or lower levels of antibodies. There were no associations between antibodies, other co-existing diseases or laboratory analyses. Conclusions & Inferences Higher levels of GnRH IgM antibodies were detected in patients with IBS and dysmotility, but not organic GI diseases, compared with healthy controls. These findings suggest that IBS and dysmotility to some extent may be of an autoimmune origin.
|
|
| 14. |
- Roos, Susanne, et al.
(författare)
-
Bowel symptoms, self-image and comorbidity impact on well-being of women with coeliac disease
- 2011
-
Ingår i: Journal of Nursing and Healthcare of Chronic Illness. - Oxford : Wiley-Blackwell. - 1752-9816 .- 1752-9824. ; 3:3, s. 302-309
-
Tidskriftsartikel (refereegranskat)abstract
- Aim. To explore if gastrointestinal (GI) symptoms, self-image and comorbidity are related to well-being in women with coeliac disease (CD) and whether a history of CD in childhood impacts on well-being in adulthood. Background. Women in Sweden living with CD show a reduced level of well-being and report a high rate of GI complaints for unclear reasons. The self-image of these women is unknown. Design. A cross-sectional survey of 231 Swedish women with CD on long-term treatment (≥5 years) with a gluten-free diet (GFD) was conducted in 2010. Results. The study showed that well-being is related to a high rate GI symptoms (OR 16·9, 95% CI 5·6-50·7), a negative self-image (OR 8·9, 95% CI 3·5-22·9) and comorbidity (OR 3·3, 95% CI 1·7-6·4). There was no impact of childhood symptoms on well-being, GI symptoms, self-image or comorbidity in adulthood. Half of the study population showed reduced well-being compared with norms. Practically all women (97%) declared that they were always or usually following a GFD and 62% reported at least one disease besides CD. Conclusion. The study demonstrated that the well-being of women living with CD is affected by GI complaints, self-image and a high rate of comorbidity whereas a history of signs and symptoms of CD in childhood not seems to impact on the well-being in adulthood. Relevance to clinical practice. Gastrointestinal symptoms, self-image and comorbidity are factors contributing to a low level of well-being of CD women living on a GFD. Launching a multi-disciplinary team for follow-up would represent a novel approach to support these women and may prove valuable in improving their subjective health.
|
|
| 15. |
- Sjöberg, Erik, 1978-
(författare)
-
Battlefields of memory : The Macedonian conflict and Greek historical culture
- 2011
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In 1991, a diplomatic controversy arose between Greece and the newly independent Republic of Macedonia, regarding naming, minority rights and the use of historical symbols. The claims of the new state to the name Macedonia and the historical heritage associated with it were perceived as a threat against Greek national identity and history itself. Within months, the so-called Macedonian question came to dominate the Greek domestic and foreign policy agenda. In Greek public debate, the conflict blended with concerns about the nation’s past, present and future, which played into the challenges brought about by the end of the Cold War. The Macedonian conflict can thus be understood as symptomatic of a crisis in Greek historical culture, as well as a catalyst for broader concerns about the role of history in contemporary society. This study explores the contexts in which the conflict evolved and how history was perceived, narrated and used by institutions, communities and individuals who sought to influence public opinion and policy-makers. The theoretical point of departure is the concept of historical culture, defined as the totality of discourses through which a society makes sense of itself, the present and the future through the interpretation of the past. In the study of historical culture, the notions of narratives and uses of history have been employed, with the notion of boundary-work as a supplementing analytical tool. The material of the study is primarily drawn from mainstream press, but also includes historiography. The study shows how the Macedonian controversy was intertwined with the identity- and memory-political demands of substate actors. Particular attention is paid to the emergence of a narrative on genocide among Greeks of Pontian origins. This happened in an age when traditional notions of national pride were being challenged by transnational history-cultural concerns about human rights and the notion of national guilt. The study also sheds light on how academic historians dealt with issues brought about by demands for politically committed scholarship, objectivity, legitimacy and the need to adjust in a transnational setting.
|
|
| 16. |
- Sjöberg, Klas, et al.
(författare)
-
Vitamin D levels in microscopic colitis.
- 2013
-
Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 1502-7708 .- 0036-5521. ; 48:8, s. 987-988
-
Tidskriftsartikel (refereegranskat)
|
|
| 17. |
- Svederberg, Eva, 1946-, et al.
(författare)
-
Bus drivers' and assistant nurses' conceptualizations of food and meals during working hours
- 2010
-
Ingår i: Forum qualitative Sozialforschung. - 1438-5627. ; 11:2, s. Art.15-
-
Tidskriftsartikel (refereegranskat)abstract
- In today's Europe, only 24 per cent of the labor force always works regular daytime hours. The aim of the current study was to explore conceptualizations of food and meals in relation to irregular working hours. The participants were eight bus drivers in city traffic and six assistant nurses in geriatric care. The data collection comprised participant observation and semi-structured interviews. The qualitative analysis of interview data showed that the main element in the participants' conceptualization was the importance of safety and confidence in their choices, which was managed partly within the content of food and meals: i.e. judgment of healthiness, food safety, freshness and taste, and partly within the structure of meals: i.e. management of conditions for meals and opportunities to make informed choices. Employees take past experiences as well as visualizations of the future into consideration as their basis for forming a judgment about choices of food and meals during working hours. The responsibility for food and meals during working hours is to a great extent the employee's alone, despite the fact that the irregularity of the working hours is set by the employer.
|
|
| 18. |
- Svederberg, Eva, et al.
(författare)
-
Bus drivers' and assistant nurses' conceptualizations of food and meals during working hours
- 2010
-
Ingår i: Forum Qualitative Sozialforschung. - : Institut fur Klinische Sychologie and Gemeindesychologie. - 1438-5627. ; 11:2
-
Tidskriftsartikel (refereegranskat)abstract
- In today's Europe, only 24 per cent of the labor force always works regular daytime hours. The aim of the current study was to explore conceptualizations of food and meals in relation to irregular working hours. The participants were eight bus drivers in city traffic and six assistant nurses in geriatric care. The data collection comprised participant observation and semi-structured interviews. The qualitative analysis of interview data showed that the main element in the participants' conceptualization was the importance of safety and confidence in their choices, which was managed partly within the content of food and meals: i.e. judgment of healthiness, food safety, freshness and taste, and partly within the structure of meals: i.e. management of conditions for meals and opportunities to make informed choices. Employees take past experiences as well as visualizations of the future into consideration as their basis for forming a judgment about choices of food and meals during working hours. The responsibility for food and meals during working hours is to a great extent the employee's alone, despite the fact that the irregularity of the working hours is set by the employer.
|
|
| 19. |
- Vigren, Lina, et al.
(författare)
-
An epidemiological study of collagenous colitis in southern Sweden from 2001-2010.
- 2012
-
Ingår i: World Journal of Gastroenterology. - : Baishideng Publishing Group Inc.. - 1007-9327. ; 18:22, s. 2821-2826
-
Tidskriftsartikel (refereegranskat)abstract
- AIM: To estimate the incidence of collagenous colitis (CC) in southern Sweden during 2001-2010. METHODS: Cases were identified by searching for CC in the diagnostic registers at the Pathology Departments in the county of Skåne. The catchment area comprised the south-west part of the county (394 307 inhabitants in 2010) and is a mixed urban and rural type with limited migration. CC patients that had undergone colonoscopy during the defined period and were living in this area were included in the study regardless of where in Skåne they had been diagnosed. Medical records were scrutinized and uncertain cases were reassessed to ensure that only newly diagnosed CC cases were included. The diagnosis of CC was based on both clinical and histopathological criteria. The clinical criterion was non-bloody watery diarrhoea. The histopathological criteria were a chronic inflammatory infiltrate in the lamina propria, a thickened subepithelial collagen layer ≥ 10 micrometers (μm) and epithelial damage such as flattening and detachment. RESULTS: During the ten year period from 2001-2010, 198 CC patients in the south-west part of the county of Skåne in southern Sweden were newly diagnosed. Of these, 146 were women and 52 were men, i.e., a female: male ratio of 2.8:1. The median age at diagnosis was 71 years (range 28-95/inter-quartile range 59-81); for women median age was 71 (range 28-95) years and was 73 (range 48-92) years for men. The mean annual incidence was 5.4/10(5) inhabitants. During the time periods 2001-2005 and 2006-2010, the mean annual incidence rates were 5.4/10(5) for both periods [95% confidence interval (CI): 4.3-6.5 in 2001-2005 and 4.4-6.4 in 2006-2010, respectively, and 4.7-6.2 for the whole period]. Although the incidence varied over the years (minimum 3.7 to maximum 6.7/10(5)) no increase or decrease in the incidence could be identified. The odds ratio (OR) for CC in women compared to men was estimated to be 2.8 (95% CI: 2.0-3.7). The OR for women 65 years of age or above compared to below 65 years of age was 6.9 (95% CI: 5.0-9.7), and for women 65 years of age or above compared to the whole group the OR was 4.7 (95% CI: 3.6-6.0). The OR for age in general, i.e., above or 65 years of age compared to those younger than 65 was 8.3 (95% CI: 6.2-11.1). During the last decade incidence figures for CC have also been reported from Calgary, Canada during 2002-2004 (4.6/10(5)) and from Terrassa, Spain during 2004-2008 (2.6/10(5)). Our incidence figures from southern Sweden during 2001-2010 (5.4/10(5)) as well as the incidence figures presented in the studies during the 1990s (Terrassa, Spain during 1993-1997 (2.3/10(5)), Olmsted, United States during 1985-2001 (3.1/10(5)), Örebro, Sweden during 1993-1998 (4.9/10(5)), and Iceland during 1995-1999 (5.2/10(5)) are all in line with a north-south gradient, something that has been suggested before both for CC and inflammatory bowel disease. CONCLUSION: The observed incidence of CC is comparable with previous reports from northern Europe and America. The incidence is stable but the female: male ratio seems to be decreasing.
|
|
| 20. |
- Vigren, Lina, et al.
(författare)
-
Are collagenous and lymphocytic colitis different aspects of the same disease?
- 2012
-
Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 1502-7708 .- 0036-5521. ; 47:12, s. 1448-1453
-
Tidskriftsartikel (refereegranskat)abstract
- Objective. Collagenous colitis (CC) and lymphocytic colitis (LC) are two subtypes of microscopic colitis (MC). Even though they most often are described as different entities they share many clinical and histological features. The aim of this study was to investigate the occurrence of conversion between CC and LC in a larger cohort of patients. Materials and methods. All 664 patients in our Pathology register with a diagnosis of CC and LC were scrutinized and those where additional endoscopies had been carried out were included, and their biopsies were re-examined. Results. Sixty-five patients (55 women, 10 men, median age 58 years; range 29-86) fulfilled our criteria for inclusion. The primary diagnosis was CC in 47 patients (39 women, 8 men, median age 58 years; range 29-86) and LC in 18 patients (16 women, 2 men, median age 58 years; range 33-74). Conversion occurred in nine of the 65 patients (14%, all women, median age 59 years; range 41-72), three from CC to LC and six from LC to CC. Conclusion. This study has found that patients can show histological features consistent with both CC and LC over time. These patients could represent a subgroup with a true conversion between two separate entities. Alternatively, MC could be a spectral disease where the varying histological features are manifestations of the natural fluctuation. A third possibility could be that the histological changes reflect different manifestations during the disease course and consequently, the diagnostic criteria could be too vague.
|
|
