| 11. |
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| 12. |
- Nilsson, Emma A, et al.
(författare)
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Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes
- 2014
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 63:9, s. 2962-2976
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Tidskriftsartikel (refereegranskat)abstract
- Genetics, epigenetics, and environment may together affect the susceptibility for type 2 diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using genome-wide expression and DNA methylation data in adipose tissue from monozygotic twin pairs discordant for T2D and independent case-control cohorts. In adipose tissue from diabetic twins, we found decreased expression of genes involved in oxidative phosphorylation; carbohydrate, amino acid, and lipid metabolism; and increased expression of genes involved in inflammation and glycan degradation. The most differentially expressed genes included ELOVL6, GYS2, FADS1, SPP1 (OPN), CCL18, and IL1RN. We replicated these results in adipose tissue from an independent case-control cohort. Several candidate genes for obesity and T2D (e.g., IRS1 and VEGFA) were differentially expressed in discordant twins. We found a heritable contribution to the genome-wide DNA methylation variability in twins. Differences in methylation between monozygotic twin pairs discordant for T2D were subsequently modest. However, 15,627 sites, representing 7,046 genes including PPARG, KCNQ1, TCF7L2, and IRS1, showed differential DNA methylation in adipose tissue from unrelated subjects with T2D compared with control subjects. A total of 1,410 of these sites also showed differential DNA methylation in the twins discordant for T2D. For the differentially methylated sites, the heritability estimate was 0.28. We also identified copy number variants (CNVs) in monozygotic twin pairs discordant for T2D. Taken together, subjects with T2D exhibit multiple transcriptional and epigenetic changes in adipose tissue relevant to the development of the disease.
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| 13. |
- Serenkov, I.T., et al.
(författare)
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Structural distortions induced during stress relaxation affecting electrical transport of nanometer-thick La0.67(Ba,Ca)0.33MnO3 films
- 2010
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Ingår i: Physica B: Condensed Matter. - : Elsevier BV. - 0921-4526. ; 404:23-24, s. 5234-5236
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Tidskriftsartikel (refereegranskat)abstract
- X-ray diffraction (XRD) and medium-energy ion scattering (MEIS) were used to clarify distortions induced during mechanical stress relaxation in nanometer-thick epitaxial La0.67Ba0.33MnO3 (LBMO) and La0.67Ca0.33MnO3 (LCMO) films fabricated by pulsed laser deposition. It follows from measured XRD and MEIS spectra that LBMO films grown on mismatched LaAlO3 were partly relaxed in the main part of the film, leaving about 4 nm heavily strained portion close to the interface. The critical thickness of LCMO films grown on LaAlO3 substrates was several times larger than that of LBMO due to a better match in lattice parameters. Electro- and magneto-transport parameters of nanometer-thick manganite films grown on mismatched substrates differed markedly from those of LBMO and LCMO layers nucleated and grown on well-matched ones because of non-stoichiometry, biaxial mechanical stresses, and phase separation. The resistivity ρ of manganite films grown coherently at a substrate with small mismatch obeyed the relation ρ=ρ1+ρ2(H)T4.5 at temperatures well below the Curie point. Parameter ρ1 was temperature T and magnetic field H independent while ρ2 was temperature independent but decreased linearly with increasing H.
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| 14. |
- Uberseder, E., et al.
(författare)
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First Experimental Constraint on the Fe-59(n, gamma)Fe-60 Reaction Cross Section at Astrophysical Energies via the Coulomb Dissociation of Fe-60
- 2014
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 112:21
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Tidskriftsartikel (refereegranskat)abstract
- The radionuclide Fe-60 has been of great interest to the nuclear astrophysics community for over a decade. An initial discrepancy between the observed and modeled Galactic Fe-60/Al-26 ratio motivated numerous studies focused on the nucleosynthesis of these two isotopes, though the cross section of the primary astrophysical production reaction, Fe-59(n,gamma)Fe-60, has remained purely theoretical. The present work offers a first experimental constraint on the Fe-59(n,gamma)Fe-60 cross section at astrophysical energies, obtained indirectly via Coulomb dissociation, and demonstrates that the theoretical reaction rates used in present stellar models are not highly erroneous.
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