| 221. |
- Aden, Hassan
(författare)
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Building futures through Refugee Education: Aspirations, Navigation, and (Non- )citizenship
- 2023
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This study explores how Somali secondary school and graduate-level youth in Kenya’s Dadaab camps attempt to build their futures through education, despite challenges posed by their non-citizen status. Using ethnographic data, the study specifically analyses the educational journeys, aspirations, and experiences of these refugee youth, shedding light on the everyday practices and dynamic strategies they employ to pursue their goals and manage obstacles. The study demonstrates how secondary school youth actively pursue educational aspirations, which they believe can enable them to exit the camps and potentially overcome their non-citizen status – through routes such as the resettlement-based scholarships for post-secondary education in Canada. Anchoring in their hopes in education, these students leverage various social resources, networks, and strategies to cope with challenges facing their education and aspirations, while simultaneously reflecting on various pathways to navigate post-graduation crossroads. Graduate-level youth, faced with limited opportunities, often adjust their aspirations to align with the available options to move forward, such as scholarships or incentive- (as opposed to wage-) paying jobs in the camps. More and more graduate youth opt to return to Somalia in seek of better employment opportunities, despite the potential security risks. The study also underscores the intergenerational solidarity and support system that emerge as academically successful refugee youth establish and manage nationally accredited schools, significantly contributing to students’ performance in national exams and the quality of education overall. By examining refugee youths’ enterprise of future-building through education within the context of long-term camps –characterised by perpetual precarity and uncertainty due to inhabitants’ exclusion from citizenship rights, freedoms, and advantages – this study provides theoretical insights into the complex and dynamic interplay among aspirations, navigational strategies, and non-citizenship status.
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| 222. |
- Aden, Hassan, et al.
(författare)
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From Refugees to Citizens? How Refugee Youth in the Dadaab Camps of Kenya Use Education to Challenge Their Status as Non-Citizens
- 2023
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Ingår i: Journal of Refugee Studies. - 0951-6328. ; 36:4, s. 736-755
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Tidskriftsartikel (refereegranskat)abstract
- The Dadaab camps of Kenya have 'warehoused' refugees from Somalia and elsewhere since 1991, providing their inhabitants with little hope to (re)gain the legal rights, participation, and membership that citizenship provides. Refugee youth in Dadaab hope that education can enable their access to citizenship rights-in particular, physical mobility and the right to work. Drawing on ethnographic research, semi-structured interviews, and life history interviews conducted in Dadaab and Mogadishu, this article discusses how refugee youth from Dadaab attempt to challenge their status as non-citizens through secondary education. Our study underscores that achieving citizenship rights, as well as civic participation and belonging, are key aspirations for these young people independent of whether they remain in Dadaab or (re)turn to Mogadishu. Yet, their ideas about what these key aspects of citizenship are and how to achieve them shift with their geographical location and in the presence or absence of citizenship rights.
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| 223. |
- Adermark, Louise, 1974, et al.
(författare)
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Astrocytes modulate extracellular neurotransmitter levels and excitatory neurotransmission in dorsolateral striatum via dopamine D2 receptor signaling
- 2022
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Ingår i: Neuropsychopharmacology. - : Springer Science and Business Media LLC. - 0893-133X .- 1740-634X. ; 47:8, s. 1493-1502
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Tidskriftsartikel (refereegranskat)abstract
- Astrocytes provide structural and metabolic support of neuronal tissue, but may also be involved in shaping synaptic output. To further define the role of striatal astrocytes in modulating neurotransmission we performed in vivo microdialysis and ex vivo slice electrophysiology combined with metabolic, chemogenetic, and pharmacological approaches. Microdialysis recordings revealed that intrastriatal perfusion of the metabolic uncoupler fluorocitrate (FC) produced a robust increase in extracellular glutamate levels, with a parallel and progressive decline in glutamine. In addition, FC significantly increased the microdialysate concentrations of dopamine and taurine, but did not modulate the extracellular levels of glycine or serine. Despite the increase in glutamate levels, ex vivo electrophysiology demonstrated a reduced excitability of striatal neurons in response to FC. The decrease in evoked potentials was accompanied by an increased paired pulse ratio, and a reduced frequency of spontaneous excitatory postsynaptic currents, suggesting that FC depresses striatal output by reducing the probability of transmitter release. The effect by FC was mimicked by chemogenetic inhibition of astrocytes using G(i)-coupled designer receptors exclusively activated by designer drugs (DREADDs) targeting GFAP, and by the glial glutamate transporter inhibitor TFB-TBOA. Both FC- and TFB-TBOA-mediated synaptic depression were inhibited in brain slices pre-treated with the dopamine D2 receptor antagonist sulpiride, but insensitive to agents acting on presynaptic glutamatergic autoreceptors, NMDA receptors, gap junction coupling, cannabinoid 1 receptors, mu-opioid receptors, P2 receptors or GABA(A) receptors. In conclusion, our data collectively support a role for astrocytes in modulating striatal neurotransmission and suggest that reduced transmission after astrocytic inhibition involves dopamine.
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| 224. |
- Adermark, Louise, 1974, et al.
(författare)
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Astrocytic Regulation of Endocannabinoid-Dependent Synaptic Plasticity in the Dorsolateral Striatum
- 2024
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Ingår i: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - 1661-6596 .- 1422-0067. ; 25:1
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Tidskriftsartikel (refereegranskat)abstract
- Astrocytes are pivotal for synaptic transmission and may also play a role in the induction and expression of synaptic plasticity, including endocannabinoid-mediated long-term depression (eCB-LTD). In the dorsolateral striatum (DLS), eCB signaling plays a major role in balancing excitation and inhibition and promoting habitual learning. The aim of this study was to outline the role of astrocytes in regulating eCB signaling in the DLS. To this end, we employed electrophysiological slice recordings combined with metabolic, chemogenetic and pharmacological approaches in an attempt to selectively suppress astrocyte function. High-frequency stimulation induced eCB-mediated LTD (HFS-LTD) in brain slices from both male and female rats. The metabolic uncoupler fluorocitrate (FC) reduced the probability of transmitter release and depressed synaptic output in a manner that was independent on cannabinoid 1 receptor (CB1R) activation. Fluorocitrate did not affect the LTD induced by the CB1R agonist WIN55,212-2, but enhanced CB1R-dependent HFS-LTD. Reduced neurotransmission and facilitated HFS-LTD were also observed during chemogenetic manipulation using Gi-coupled DREADDs targeting glial fibrillary acidic protein (GFAP)-expressing cells, during the pharmacological inhibition of connexins using carbenoxolone disodium, or during astrocytic glutamate uptake using TFB-TBOA. While pretreatment with the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphonopentanoic acid (APV) failed to prevent synaptic depression induced by FC, it blocked the facilitation of HFS-LTD. While the lack of tools to disentangle astrocytes from neurons is a major limitation of this study, our data collectively support a role for astrocytes in modulating basal neurotransmission and eCB-mediated synaptic plasticity.
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| 225. |
- Adermark, Louise, 1974, et al.
(författare)
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Prospective association between use of electronic cigarettes and use of conventional cigarettes: a systematic review and meta-analysis
- 2021
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Ingår i: Erj Open Research. - Sheffield : European Respiratory Society (ERS). - 2312-0541. ; 7:3
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Tidskriftsartikel (refereegranskat)abstract
- Objective The aim of this systematic review and meta-analysis was to assess the association between e-cigarette use and subsequent initiation or recurrence of cigarette smoking. Data sources A systematic literature search was finalised on 11 November 2019 using PubMed (including MEDLINE), EMBASE, Cochrane Library, Scopus, PubMed Health, NICE Evidence Search, PROSPERO, CRD and PsycInfo. Study selection Studies were included if meeting the following criteria: reporting empirical results; longitudinal observational design with a minimum of 3 months of follow-up; including general population samples; allowing for the comparison between users and nonusers of e-cigarettes. Studies rated as having high risk of bias were excluded. Studies were independently assessed by at least two authors. The procedures described by PRISMA were followed, and the quality of evidence was rated using GRADE. Data synthesis 30 longitudinal studies from 22 different cohorts assessing e-cigarette use among nonsmokers or never-smokers at baseline, and subsequent use of cigarette smoking at follow-up, were included in this review. A random-effects meta-analysis based on 89076 participants showed a pooled unadjusted odds ratio (OR) of cigarette smoking among baseline nonsmoker e-cigarette users compared with nonusers of 4.68 (CI 3.64-6.02), while the adjusted OR was 3.37 (CI 2.68-4.24). These results were consistent irrespective of whether the outcome was measured as ever-smoking or as past 30-day smoking. The evidence was graded as moderate. Conclusions Use of e-cigarettes may predict the initiation or recurrence of cigarette smoking.
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| 226. |
- Adermark, Louise, 1974, et al.
(författare)
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Weight gain and neuroadaptations elicited by high fat diet depend on fatty acid composition.
- 2021
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Ingår i: Psychoneuroendocrinology. - : Elsevier BV. - 1873-3360 .- 0306-4530. ; 126
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Tidskriftsartikel (refereegranskat)abstract
- Overconsumption of food is a major health concern in the western world. Palatable food has been shown to alter the activity of neural circuits, and obesity has been linked to alterations in the connectivity between the hypothalamus and cortical regions involved in decision-making and reward processing, putatively modulating the incentive value of food. Outlining neurophysiological adaptations induced by dietary intake of high fat diets (HFD) is thus valuable to establish how the diet by itself may promote overeating. To this end, C57BL/6 mice were fed HFD rich in either saturated fatty acids (HFD-S) or polyunsaturated fatty acids (HFD-P), or a low-fat control diet (LFD) for four weeks. Food and energy intake were monitored and ex vivo electrophysiology was employed to assess neuroadaptations in lateral hypothalamus (LH) and corticostriatal circuits, previously associated with food intake. In addition, the effects of dietary saturated and polyunsaturated fatty acids on the gene expression of NMDA, AMPA and GABAA receptor subunits in the hypothalamus were investigated. Our data shows that mice fed HFD-P had increased daily food and energy intake compared with mice fed HFD-S or LFD. However, this increase in energy intake had no obesogenic effects. Electrophysiological recordings demonstrated that HFD-P had a selective effect on glutamatergic neurotransmission in the LH, which was concomitant with a change in mRNA expression of AMPA receptor subtypes Gria1, Gria3 and Gria4, with no effect on the mRNA expression of NMDA receptor subtypes or GABAA receptor subtypes. Furthermore, while synaptic output from corticostriatal subregions was not significantly modulated by diet, synaptic plasticity in the form of long-term depression (LTD) was impaired in the dorsomedial striatum of mice fed HFD-S. In conclusion, this study suggests that the composition of fatty acids in the diet not only affects weight gain, but may also modulate neuronal function and plasticity in brain regions involved in food intake.
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| 227. |
- Adermon, Adrian, 1981-, et al.
(författare)
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Dynastic Human Capital, Inequality, and Intergenerational Mobility
- 2021
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Ingår i: American Economic Review. - : American Economic Association. - 0002-8282 .- 1944-7981. ; 111:5, s. 1523-1548
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Tidskriftsartikel (refereegranskat)abstract
- We estimate long-run intergenerational persistence in human capital using information on outcomes for the extended family: the dynasty. A dataset including the entire Swedish population, linking four generations, allows us to identify parents' siblings and cousins, their spouses, and spouses' siblings. Using various human capital measures, we show that traditional parent-child estimates underestimate long-run intergenerational persistence by at least one-third. By adding outcomes for more distant ancestors, we show that almost all of the persistence is captured by the parental generation. Data on adoptees show that at least one-third of -long-term persistence is attributed to environmental factors.
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| 228. |
- Ades, M., et al.
(författare)
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GLOBAL CLIMATE
- 2020
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Ingår i: BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY. - 0003-0007 .- 1520-0477. ; 101:8
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Tidskriftsartikel (refereegranskat)
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| 229. |
- Adesam, Yvonne, 1975, et al.
(författare)
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A lexical resource for computational historical linguistics
- 2021
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Ingår i: The Swedish FrameNet++. Harmonization, integration, method development and practical language technology applications. - Amsterdam / Philadelphia : John Benjamins Publishing Company. - 1567-8202. - 978 90 272 5848 9 ; , s. 98-121
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Bokkapitel (refereegranskat)abstract
- In this chapter we present the diachronic dimension of Swedish FrameNet++. We describe the historical lexical resources currently available for Swedish, linked to the Contemporary Swedish lexicon Saldo. We present a case study of how interlinking the dictionaries simultaneously allows us to study lexical change. We also present a method of linking text words to lexicon entries, facilitating interactive exploration of historical texts. Diachronical language resources present both a high-variation challenge from a wider language technology perspective, and an interesting object of linguistic study. While a number of improvements of the parts of the diachronic lexical macroresource are still needed, this resource is invaluable for analysing and accessing historical texts, as well as for both synchronic historical and diachronic lexical studies.
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| 230. |
- Adesam, Yvonne, 1975, et al.
(författare)
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Part-of-speech tagging of Swedish texts in the neural era
- 2021
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Ingår i: Proceedings of the 23rd Nordic Conference on Computational Linguistics, NoDaLiDa, May 31–2 June, 2021, Reykjavik, Iceland (online) / eds Simon Dobnik and Lilja Øvrelid. - Linköping : Linköping University Electronic Press. - 1650-3686 .- 1650-3740. - 9789179296148
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Konferensbidrag (refereegranskat)
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