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Träfflista för sökning "LAR1:gu srt2:(2000-2009)"

Sökning: LAR1:gu > (2000-2009)

  • Resultat 281-290 av 44672
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281.
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282.
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283.
  • Adolfsson, L. E., et al. (författare)
  • Short-term safety and tolerability of double-dose salmeterol/fluticasone propionate in adult asthmatic patients
  • 2005
  • Ingår i: Clin Drug Investig. - 1173-2563. ; 25:4, s. 231-41
  • Tidskriftsartikel (refereegranskat)abstract
    • INTRODUCTION: The incidence of asthma exacerbations in patients receiving salmeterol/fluticasone propionate (Seretidetrade mark or Advair((R))) is low. However, when asthma control deteriorates, clinicians may instruct patients to double the dose of their inhaled corticosteroid medication for a short period. The purpose of this study was to demonstrate that doubling the dose of Seretidetrade mark for a period of 2 weeks in subjects with persistent asthma is safe and well tolerated. METHODS: This randomised, double-blind, parallel-group study was conducted in primary-care centres. Adults with a post-bronchodilator forced expiratory volume in 1 second (FEV(1)) of >/=70% predicted were stratified to receive a single dose of Seretidetrade mark 50mug/100mug, 50mug/250mug or 50mug/500mug twice daily from a Diskustrade mark inhaler for a 4-week run-in period, dependent on the dose of inhaled corticosteroid on entry. Subjects were then randomised to receive either an extra inhalation of the same dose of Seretidetrade mark received during the run-in (double dose) or an inhalation of matching placebo (single dose) for 14 days in a 2 : 1 ratio. Subjects were asked to record any adverse events, morning and evening heart rate (HR), peak flow and relief medication use in daily record cards. The primary endpoint was tremor as perceived by the subject. Clinic evaluations included HR, 12-lead ECG, and potassium and glucose levels. RESULTS: 110 and 208 subjects received single- and double-dose Seretidetrade mark, respectively. Only one subject experienced tremor. This was classified as mild and occurred in a subject receiving double-dose Seretidetrade mark (50mug/100mug). There was no difference between the treatment groups in the incidence of tremor (difference <1%; 95% CI -6, 8). Other salmeterol-related adverse events (palpitations, muscle cramps and headache) and fluticasone propionate-related events (oral candidiasis and hoarseness) occurred in a similar percentage of subjects in each treatment group. The treatment differences for morning and evening HR measurements showed small differences between the two groups (<2 beats/min). The adjusted mean treatment difference (double dose - single dose) in morning HR was 1.1 beats/min (95% CI 0.2, 2.0) and evening HR was 0.9 beats/min (95% CI 0.1, 1.7). Seven percent of subjects receiving single-dose Seretidetrade mark and 8% receiving double-dose Seretidetrade mark had a QTc change from baseline in the interval 30-59 msec. No increases above 59 msec were seen in either group. There were no clinically significant changes from baseline for potassium levels. Two percent of subjects in the single dose and <1% in the double-dose group had a change from a non-clinically significant baseline blood glucose assessment to a clinically significant abnormality at the end of treatment. CONCLUSION: In circumstances in which a physician may be considering doubling the dose of Seretidetrade mark for a short period of time in adult asthmatics, this study demonstrates that doubling the dose for a period of 2 weeks is safe and well tolerated.
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284.
  • Adolfsson, Peter, 1963, et al. (författare)
  • Accuracy and reliability of continuous glucose monitoring in individuals with type 1 diabetes during recreational diving
  • 2009
  • Ingår i: Diabetes Technology & Therapeutics. - : Mary Ann Liebert. - 1557-8593 .- 1520-9156. ; 11:8, s. 493-7
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: This study evaluated the accuracy and function of the Continuous Glucose Monitoring System (CGMS, Minneapolis, MN) during recreational scuba diving in individuals with type 1 diabetes. METHODS: Twenty-four adults, 12 with type 1 diabetes and 12 healthy controls, were studied during five recreational scuba dives performed on three consecutive days. All the participants used the CGMS on all the days and during all the dives. Comparisons were made between plasma glucose at specific time intervals and the CGMS. RESULTS: The recording by the CGMS was robust, with few sensor problems. The mean sensor survival time was >48 h. Eighty-five percent of the individuals used one sensor during the entire length of the trial. The overall mean absolute difference (MAD) within the group with diabetes was 14.4 +/- 6%, and the corresponding daily figures were 23.2 +/- 19.3% on day 1, 11.6 +/- 4.5% on day 2, and 11.2 +/- 5.7% on day 3. A significant improvement regarding MAD when day 1 was compared with day 2 and 3 (P < 0.05). With a limit set at 70 mg/dL, hypoglycemia pre- and post-dive was detected with a positive predictive value of 0.39, negative predictive value of 0.98, sensitivity of 0.64, and specificity of 0.94. CONCLUSIONS: We demonstrate that the CGMS was used with accuracy in such difficult conditions as scuba diving and provided robust information on glucose variations.
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285.
  • Adolfsson, Petra, 1970, et al. (författare)
  • After Quantification: Quality Dialogue and Performance in a Swedish Municipality
  • 2007
  • Ingår i: Financial Accountability & Management. - 0267-4424. ; 23:1, s. 73-89
  • Tidskriftsartikel (refereegranskat)abstract
    • The article discusses the performance management and quality systems as widely accepted reform processes in the New Public Management (NPM). These reforms are said to be built on a rational model of decision making by gathering information from various accounting, auditing and accountability systems. The chief characteristic of this system is customer focus, which motivates the management and evaluation of an operation. The article further discusses how the model of quality dialogue was implemented by different administrations including the city administrative office, the upper secondary school, and the four districts of the City of Gothenburg.
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286.
  • Adolfsson, Petra, 1970, et al. (författare)
  • Closing words!
  • 2009
  • Ingår i: Adolfsson, P., Dobers, P. & Jonasson, M. (eds.) (2009) Guiding & guided tours. - Göteborg : Bokförlaget BAS. - 9789172462854 ; , s. 221-223
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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287.
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