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Träfflista för sökning "LAR1:gu srt2:(1990-1999)"

Sökning: LAR1:gu > (1990-1999)

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26.
  • Abrahamsson, Jonas, 1954, et al. (författare)
  • Bone marrow fibrosis and radiological changes of the long bones in children with acute megakaryocytic leukaemia.
  • 1998
  • Ingår i: Acta paediatrica (Oslo, Norway : 1992). - 0803-5253. ; 87:10, s. 1093-6
  • Tidskriftsartikel (refereegranskat)abstract
    • The diagnosis of acute megakaryocytic leukaemia (AMkL) may be difficult to establish owing to difficulties in obtaining adequate bone marrow aspirates secondary to bone marrow fibrosis. We describe three children without Down's syndrome under 2 y of age with AMkL. Although none of the patients had the non-random t(1;22) (p13;q13) translocation, bone marrow cells from all patients exhibited chromosome abnormalities with complex karyotypes, including trisomy 21 in two cases. All patients had profound bone marrow fibrosis and characteristic lamellar diaphyseal radiological changes of the long bones.
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27.
  • Abrahamsson, Jonas, 1954, et al. (författare)
  • Bone marrow immunoglobulin-secreting cells are not reduced in children with leukaemia as compared to children with solid tumours.
  • 1997
  • Ingår i: Acta paediatrica (Oslo, Norway : 1992). - 0803-5253. ; 86:2, s. 165-9
  • Tidskriftsartikel (refereegranskat)abstract
    • Children with leukaemia exhibit multiple immunological disturbances, including low circulating levels of immunoglobulins, caused by both the disease and chemotherapy. We investigated the number of isotype-specific immunoglobulin-secreting cells (ISCs) in the bone marrow at the time of diagnosis in 32 children and during therapy in 12 children with leukaemia. We compared these to the number of ISCs in 17 untreated children with solid tumours and related the ISCs to serum immunoglobulin levels, lymphocyte subsets, response to mitogenic stimulation and serum cytokine levels. Bone marrow specimens were analysed for isotype-specific (immunoglobulins G, A and M) ISCs using the ELISPOT method. At the time of diagnosis, for all isotypes, the total number of ISCs per millilitre of bone marrow in children with leukaemia was no different from that in children with solid tumours. Chemotherapy significantly decreased the number of ISCs. The quantitative relationship between the different isotypes was unaffected by both tumour type and therapy. It can be concluded that in childhood leukaemia, tumour replacement of bone marrow cells does not cause a decreased number of ISCs and can therefore not account for the low serum immunoglobulin levels observed at time of diagnosis. Chemotherapy reduces the number of ISCs without changing the isotype distribution.
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28.
  • Abrahamsson, Jonas, 1954, et al. (författare)
  • Immunoglobulin levels and lymphocyte response to mitogenic stimulation in children with malignant disease during treatment and follow-up.
  • 1995
  • Ingår i: Acta paediatrica (Oslo, Norway : 1992). - 0803-5253. ; 84:2, s. 177-82
  • Tidskriftsartikel (refereegranskat)abstract
    • Intensification of chemotherapeutic regimens has improved survival in childhood malignant disease. To characterize the impact of this intensified therapy on some aspects of the immune system, we have, in an unselected material of 220 children with malignant disease, investigated serum immunoglobulin levels and lymphocyte response at diagnosis and then subsequently during and up to 4 years after cessation of therapy. In leukemia and Hodgkin's disease, all immunoglobulin isotypes decreased during therapy. A profound depression of immunoglobulin M levels, lasting well after completion of therapy, was seen in all tumor types. The mitogenic response was attenuated in patients with leukemia at diagnosis but was rapidly restored after institution of therapy. Patients with solid tumors, particularly Hodgkin's disease, had a reduced mitogenic response during therapy. Thus these patients exhibit multiple immunological disturbances. The basis of the pronounced immunoglobulin M deficiency remains unclear.
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