| 31. |
- Aapro, M, et al.
(författare)
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Guidance on the use of bisphosphonates in solid tumours: recommendations of an international expert panel
- 2008
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Ingår i: Annals of Oncology. - : Elsevier BV. - 1569-8041 .- 0923-7534. ; 19:3, s. 420-432
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Tidskriftsartikel (refereegranskat)abstract
- Bisphosphonates (BP) prevent, reduce, and delay cancer-related skeletal complications in patients, and have substantially decreased the prevalence of such events since their introduction. Today, a broad range of BP with differences in potency, efficacy, dosing, and administration as well as approved indications is available. In addition, results of clinical trials investigating the efficacy of BP in cancer treatment-induced bone loss (CTIBL) have been recently published. The purpose of this paper is to review the current evidence on the use of BP in solid tumours and provide clinical recommendations. An interdisciplinary expert panel of clinical oncologists and of specialists in metabolic bone diseases assessed the widespread evidence and information on the efficacy of BP in the metastatic and nonmetastatic setting, as well as ongoing research on the adjuvant use of BP. Based on available evidence, the panel recommends amino-bisphosphonates for patients with metastatic bone disease from breast cancer and zoledronic acid for patients with other solid tumours as primary disease. Dosing of BP should follow approved indications with adjustments if necessary. While i.v. administration is most often preferable, oral administration (clodronate, IBA) may be considered for breast cancer patients who cannot or do not need to attend regular hospital care. Early-stage cancer patients at risk of developing CTIBL should be considered for preventative BP treatment. The strongest evidence in this setting is now available for ZOL. Overall, BP are well-tolerated, and most common adverse events are influenza-like syndrome, arthralgia, and when used orally, gastrointestinal symptoms. The dose of BP may need to be adapted to renal function and initial creatinine clearance calculation is mandatory according to the panel for use of any BP. Subsequent monitoring is recommended for ZOL and PAM, as described by the regulatory authority guidelines. Patients scheduled to receive BP (mainly every 3-4 weeks i.v.) should have a dental examination and be advised on appropriate measures for reducing the risk of jaw osteonecrosis. BP are well established as supportive therapy to reduce the frequency and severity of skeletal complications in patients with bone metastases from different cancers.
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| 32. |
- Aaris-Sorensen, K, et al.
(författare)
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Late Pleistocene remains of giant deer (Megaloceros giganteus Blumenbach) in Scandinavia: chronology and environment
- 2004
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Ingår i: Boreas. - : Wiley. - 1502-3885 .- 0300-9483. ; 33:1, s. 61-73
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Tidskriftsartikel (refereegranskat)abstract
- This article presents new data on the Late Pleistocene giant deer, Megaloceros giganteus (Blumenbach), describing its distribution in time and space, geographical and sexual variation and general biology. Twenty-three south Scandinavian fossils found in situ in lacustrine sediments or redeposited in glaciofluvial material form the basis of this investigation. Fourteen C-14 dates show that the giant deer inhabited southern Scandinavia in the ice-free late Middle Weichselian from c. 40000 to 28000 BP (the Sandnes Interstadial) and again in the Late Weichselian from c. 12000 to 10700 BP (Older Dryas, Allerod and early Younger Dryas Chronozones), corresponding to a calibrated range from c. 14300 to 12400 cal. yr BP. Osteometric analyses show that the Scandinavian giant deer belonged to the upper size range of the lateglacial Irish population and that a marked sexual dimorphism existed, the males being 10-11% larger than the females. Investigations furthermore point at an antler cycle similar to that among extant northern cervids, and subsequently at a rutting season in autumn. The skeletal remains also prove the occurrence of twin delivery and the possibility of reaching an ontogenetic age of at least 23 years. During both occurrences the Scandinavian giant deer population was part of the northernmost distribution of the species in Europe and the palaeogeographical settings and palaeoenvironmental conditions of the two periods show striking similarities. Clearly, the giant deer were able to colonize and survive in a landscape dominated by grasses and sedges with scattered shrubs and dwarf shrubs. They came as close as 200-250 km to the ice front and their distribution included coastal areas along a cold sea with drifting icebergs. They were present in the area at least from March until November. However, the pure arctic conditions created during the early phase of the Younger Dryas event led to a new local extinction around 10700 C-14 yr BP. This was the beginning of a total Eurasian extinction which, at least in Europe, was completed before the Pleistocene/Holocene transition.
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| 33. |
- Aarnio, Harri, et al.
(författare)
-
Recombination studies in a polyfluorene copolymer for photovoltaic applications
- 2005
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Ingår i: Synthetic Metals. - : Elsevier BV. - 0379-6779. ; 155:2, s. 299-302
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Tidskriftsartikel (refereegranskat)abstract
- We present detailed continuous wave (cw) and transient photoinduced absorption (PA) measurements in thin films of a novel alternating polyfluorene copolymer, poly[2,7-(9,9-dioctyl-fluorene)-alt-5,5-(4',7'-di-2-thienyl-2',1',3-benzo-thiadiazole)] (DiO-PFDTBT), and its blends with the sol. fullerene deriv. [6,6]-phenyl-C61-butyric acid Me ester (PCBM) in wt. ratios of 1:0, 4:1 and 1:4. We measure the frequency, intensity and temp. dependence of the PA signal in the frequency domain, and compare with the results obtained from the transient PA decay measurements in the time domain. In all blends, the PA spectrum shows a broad high energy PA band ranging from .apprx.1 eV to 2 eV as well as a low energy band peaking at .apprx.0.35 eV. We attribute the low energy band to the P1 transition of polarons and part of the high energy band to the correlated P2 transition of polarons. Both frequency and time domain measurements show that the high energy band has two decay components, a faster component in the microsecond time regime and a slower component in the millisecond time regime. The slow component is strongly dispersive, whereas the fast component is practically non-dispersive. [on SciFinder (R)]
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| 34. |
- Aaron, F. D., et al.
(författare)
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A general search for new phenomena at HERA
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 674:4-5, s. 257-268
-
Tidskriftsartikel (refereegranskat)abstract
- A model-independent search for deviations from the Standard Model prediction is performed using the full e(+/-) p data sample collected by the H1 experiment at HERA. All event topologies involving isolated electrons, photons, muons, neutrinos and jets with transverse momenta above 20 GeV are investigated in a single analysis. Events are assigned to exclusive classes according to their final state. A dedicated algorithm is used to search for deviations from the Standard Model in the distributions of the scalar sum of transverse momenta or the invariant mass of final state particles and to quantify their significance. Variables related to angular distributions and energy sharing between final state particles are also introduced to study the final state topologies. No significant deviation from the Standard Model expectation is observed in the phase space covered by this analysis. (C) 2009 Elsevier B.V. All rights reserved.
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| 35. |
- Aaron, F. D., et al.
(författare)
-
A precision measurement of the inclusive ep scattering cross section at HERA
- 2009
-
Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 64:4, s. 561-587
-
Tidskriftsartikel (refereegranskat)abstract
- A measurement of the inclusive deep inelastic neutral current e(+) p scattering cross section is reported in the region of four-momentum transfer squared, 12GeV(2) <= Q(2) <= 150 GeV2, and Bjorken x, 2 x 10(-4) <= x <= 0.1. The results are based on data collected by the H1 Collaboration at the ep collider HERA at positron and proton beam energies of E-e = 27.6 GeV and E-p = 920 GeV, respectively. The data are combined with previously published data, taken at E-p = 820 GeV. The accuracy of the combined measurement is typically in the range of 1.3-2%. A QCD analysis at next-to-leading order is performed to determine the parton distributions in the proton based on H1 data.
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| 36. |
- Aaron, F. D., et al.
(författare)
-
A search for excited neutrinos in e(-) p collisions at HERA
- 2008
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 663:5, s. 382-389
-
Tidskriftsartikel (refereegranskat)abstract
- A search for first generation excited neutrinos is performed using the full e(-) p data sample collected by the HI experiment at HERA at a centre-of-mass energy of 319 GeV, corresponding to a total luminosity of 184 pb(-1). The electroweak decays of excited neutrinos nu* -> nu gamma, v* -> nu Z and nu* -> eW with subsequent hadronic or leptonic decays of the W and Z bosons are considered. No evidence for excited neutrino production is found. Mass dependent exclusion limits on nu* production cross sections and on the ratio of the coupling to the compositeness scale f/boolean AND are derived within gauge mediated models. A limit on f/boolean AND A, independent of the relative couplings to the SU(2) and U(1) gauge bosons, is also determined. These limits extend the excluded region to higher masses than has been possible in previous excited neutrino searches. (c) 2008 Elsevier B.V. All rights reserved.
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| 37. |
- Aaron, F.D., et al.
(författare)
-
Charged particle production in high Q^2 deep-inelastic scattering at HERA
- 2007
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693. ; 654:5-6, s. 148-159
-
Tidskriftsartikel (refereegranskat)abstract
- The average charged track multiplicity and the normalised distribution of the scaled momentum, xp, of charged final state hadrons are measured in deep-inelastic ep scattering at high Q2 in the Breit frame of reference. The analysis covers the range of photon virtuality Click to view the MathML source. Compared with previous results presented by HERA experiments this analysis has a significantly higher statistical precision and extends the phase space to higher Q2 and to the full range of xp. The results are compared with e+e− annihilation data and with various calculations based on perturbative QCD using different models of the hadronisation process.
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| 38. |
- Aaron, F. D., et al.
(författare)
-
Deeply virtual Compton scattering and its beam charge asymmetry in e(+/-)p collisions at HERA
- 2009
-
Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 681:5, s. 391-399
-
Tidskriftsartikel (refereegranskat)abstract
- A measurement of elastic deeply virtual Compton scattering gamma*p --> gamma p using e(+) p and e(-) p collision data recorded with the HI detector at HERA is presented. The analysed data sample corresponds to an integrated luminosity of 306 pb(-1), almost equally shared between both beam charges. The cross section is measured as a function of the virtuality Q(2) of the exchanged photon and the centre-of-mass energy W of the gamma*p system in the kinematic domain 6.5 < Q(2) < 80 GeV2, 30 < W < 140 GeV and |t| < 1 GeV2, where t denotes the squared momentum transfer at the proton vertex. The cross section is determined differentially in t for different Q(2) and W values and exponential t-slope parameters are derived. Using e(+) p and e(-) p data samples, a beam charge asymmetry is extracted for the first time in the low Biorken x kinematic domain. The observed asymmetry is attributed to the interference between Bethe-Heitler and deeply virtual Compton scattering processes. Experimental results are discussed in the context of two different models, one based on generalised parton distributions and one based on the dipole approach. (C) 2009 Elsevier B.V. All rights reserved.
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| 39. |
- Aaron, F. D., et al.
(författare)
-
Events with isolated leptons and missing transverse momentum and measurement of W production at HERA
- 2009
-
Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 64:2, s. 251-271
-
Tidskriftsartikel (refereegranskat)abstract
- Events with high energy isolated electrons, muons or tau leptons and missing transverse momentum are studied using the full e(+/-)p data sample collected by the H1 experiment at HERA, corresponding to an integrated luminosity of 474 pb(-1). Within the Standard Model, events with isolated leptons and missing transverse momentum mainly originate from the production of single W bosons. The total single W boson production cross section is measured as 1.14 +/- 0.25 (stat.) +/- 0.14 (sys.) pb, in agreement with the Standard Model expectation. The data are also used to establish limits on the WW gamma gauge couplings and for a measurement of the W boson polarisation.
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| 40. |
- Aaron, F. D., et al.
(författare)
-
Inclusive photoproduction of rho(0), K*(0) and phi mesons at HERA H1 Collaboration
- 2009
-
Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 673:2, s. 119-126
-
Tidskriftsartikel (refereegranskat)abstract
- Inclusive non-diffractive photoproduction of rho(770)(0), K*(892)(0) and phi(1020) mesons is investigated with the H1 detector in ep collisions at HERA. The corresponding average gamma p centre-of-mass energy is 210 GeV. The mesons are measured in the transverse momentum range 0.5 < p(T) < 7 GeV and the rapidity range vertical bar y(lab)vertical bar < 1. Differential cross sections are presented as a function of transverse momentum and rapidity, and are compared to the predictions of hadroproduction models. (C) 2009 Elsevier B.V. All rights reserved.
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