| 61. |
- Sun, Lilei, et al.
(författare)
-
Two-view attention-guided convolutional neural network for mammographic image classification
- 2022
-
Ingår i: CAAI Transactions on Intelligence Technology. - : Institution of Engineering and Technology (IET). - 2468-6557 .- 2468-2322.
-
Tidskriftsartikel (refereegranskat)abstract
- Deep learning has been widely used in the field of mammographic image classification owing to its superiority in automatic feature extraction. However, general deep learning models cannot achieve very satisfactory classification results on mammographic images because these models are not specifically designed for mammographic images and do not take the specific traits of these images into account. To exploit the essential discriminant information of mammographic images, we propose a novel classification method based on a convolutional neural network. Specifically, the proposed method designs two branches to extract the discriminative features from mammographic images from the mediolateral oblique and craniocaudal (CC) mammographic views. The features extracted from the two-view mammographic images contain complementary information that enables breast cancer to be more easily distinguished. Moreover, the attention block is introduced to capture the channel-wise information by adjusting the weight of each feature map, which is beneficial to emphasising the important features of mammographic images. Furthermore, we add a penalty term based on the fuzzy cluster algorithm to the cross-entropy function, which improves the generalisation ability of the classification model by maximising the interclass distance and minimising the intraclass distance of the samples. The experimental results on The Digital database for Screening Mammography INbreast and MIAS mammography databases illustrate that the proposed method achieves the best classification performance and is more robust than the compared state-of-the-art classification methods.
|
|
| 62. |
- Sun, Yong, et al.
(författare)
-
Decomposition of physical processes controlling EASM precipitation changes during the mid-Piacenzian : new insights into data–model integration
- 2024
-
Ingår i: npj Climate and Atmospheric Science. - 2397-3722. ; 7
-
Tidskriftsartikel (refereegranskat)abstract
- The mid-Piacenzian warm period (MPWP, ~3.264–3.025 Ma) has gained widespread interest due to its partial analogy with future climate. However, quantitative data–model comparison of East Asian Summer Monsoon (EASM) precipitation during the MPWP is relatively rare, especially due to problems in decoding the imprint of physical processes to climate signals in the records. In this study, pollen-based precipitation records are reconstructed and compared to the multi-model ensemble mean of the Pliocene Model Intercomparison Project Phase 2 (PlioMIP2). We find spatially consistent precipitation increase in most simulations but a spatially divergent change in MPWP records. We reconcile proxy data and simulation by decomposing physical processes that control precipitation. Our results 1) reveal thermodynamic control of an overall enhancement of EASM precipitation and 2) highlight a distinct control of thermodynamic and dynamical processes on increases of tropical and subtropical EASM precipitation, reflecting the two pathways of water vapor supply that enhance EASM precipitation, respectively.
|
|
| 63. |
- Wang, Yafeng, 1985, et al.
(författare)
-
Autophagy Inhibition Reduces Irradiation-Induced Subcortical White Matter Injury Not by Reducing Inflammation, but by Increasing Mitochondrial Fusion and Inhibiting Mitochondrial Fission
- 2022
-
Ingår i: Molecular Neurobiology. - : Springer Science and Business Media LLC. - 0893-7648 .- 1559-1182. ; 59:2, s. 1199-1213
-
Tidskriftsartikel (refereegranskat)abstract
- Radiotherapy is an effective tool in the treatment of malignant brain tumors, but irradiation-induced late-onset toxicity remains a major problem. The purpose of this study was to investigate if genetic inhibition of autophagy has an impact on subcortical white matter development in the juvenile mouse brain after irradiation. Ten-day-old selective neural Atg7 knockout (KO) mice and wild-type (WT) littermates were subjected to a single 6-Gy dose of whole-brain irradiation and evaluated at 5 days after irradiation. Neural Atg7 deficiency partially prevented myelin disruption compared to the WT mice after irradiation, as indicated by myelin basic protein staining. Irradiation induced oligodendrocyte progenitor cell loss in the subcortical white matter, and Atg7 deficiency partly prevented this. There was no significant change between the KO and WT mice in the number of microglia and astrocytes in the subcortical white matter after irradiation. Transcriptome analysis showed that the GO mitochondrial gene expression pathway was significantly enriched in the differentially expressed genes between the KO and WT group after irradiation. Compared with WT mice, expression of the mitochondrial fusion protein OPA1 and phosphorylation of the mitochondrial fission protein DRP1 (P-DRP1) were dramatically decreased in KO mice under physiological conditions. The protein levels of OPA1and P-DRP1 showed no differences in WT mice between the non-irradiated group and the irradiated group but had remarkably increased levels in the KO mice after irradiation. These results indicate that inhibition of autophagy reduces irradiation-induced subcortical white matter injury not by reducing inflammation, but by increasing mitochondrial fusion and inhibiting mitochondrial fission.
|
|
| 64. |
- Wen, Yehui, et al.
(författare)
-
Amorphous (lysine)2PbI2 layer enhanced perovskite photovoltaics
- 2024
-
Ingår i: Nature Communications. - : NATURE PORTFOLIO. - 2041-1723. ; 15:1
-
Tidskriftsartikel (refereegranskat)abstract
- Passivation materials play a crucial role in a wide range of high-efficiency, high-stability photovoltaic applications based on crystalline silicon and state-of-the-art perovskite materials. Currently, for perovskite photovoltaic, the mainstream passivation strategies routinely rely on crystalline materials. Herein, we have invented a new amorphous (lysine)(2)PbI2 layer-enhanced halide perovskite. By utilizing a solid phase reaction between PbI2 and lysine molecule, an amorphous (lysine)(2)PbI2 layer is formed at surface/grain boundaries in the perovskite films. The amorphous (lysine)2PbI(2) with fewer dangling bonds can effectively neutralize surface/interface defects, achieving an impressive efficiency of 26.27% (certified 25.94%). Moreover, this amorphous layer not only reduces crystal lattice stress but also functions as a barrier against the decomposition of organic components, leading to suppressed de-structuring of perovskite and highly stable perovskite solar cells.
|
|
| 65. |
- Yang, Xia, et al.
(författare)
-
Integrated assessment of indoor and outdoor ventilation in street canyons with naturally-ventilated buildings by various ventilation indexes
- 2020
-
Ingår i: Building and Environment. - : Elsevier. - 0360-1323 .- 1873-684X. ; 169
-
Tidskriftsartikel (refereegranskat)abstract
- The integrated assessments of indoor and outdoor ventilation are still rare so far. As a novelty, this paper aims to quantify the influence of street aspect ratios (building height/street width, H/W = 0.5–5) and window sizes (1 m × 1 m, 1.5 m × 1.5 m) on indoor-outdoor ventilation in two-dimensional streets with single-sided naturally-ventilated buildings. Numerical simulations with RNG k-ε model are validated against experimental data and the grid independence are tested as well. Air change rates per hour (ACH, h−1) are adopted for assessing indoor-outdoor ventilation by mean flows (ACHmean) and turbulent fluctuations (ACHturb) respectively. Age of air(τ), purging flow rate (PFR) and its corresponding ACHPFR are used to evaluate overall ventilation capacities.Shallower streets experience better indoor-outdoor ventilation. Outdoor ACHPFR drop from 14.69 to 17.55 h−1 to 3.96–3.97 h−1 as H/W rises from 0.5 to 3. In extremely deep canyon (H/W = 5), two-counter-rotating vortices produce much smaller velocity at low-level regions (U/Uref~10−3-10−5), resulting in small ACHPFR for outdoor (~0.76–0.91 h−1) and indoor in 1–13th floors (~0.03–0.61 h−1). When H/W = 0.5–1, leeward 5–6th floors experience smaller ACHPFR(e.g.~1.13–1.40 h−1 as H/W = 1) than the other floors (e.g. ~1.54–9.52 h−1 as H/W = 1). Particularly, as H/W = 2–3, leeward-side indoor ACHPFR in the middle floors (except the first and top two floors) are nearly constants (~1.02–1.69 h−1) and much smaller than windward-side ACHPFR(~1.41–4.35 h−1) which increase toward upper floors. Besides, the smaller window size reduces indoor ACHPFR by 19.38%~88.28%, but hardly influences outdoor ventilation. Moreover, both outdoor and indoor ACHPFR are greater than ACHmean but smaller than ACHmean + ACHturb. Although further investigations are still required, this paper provides an insight and scientific foundation on integrated indoor-outdoor ventilation evaluation with various effective ventilation indexes.
|
|
| 66. |
- Yao, Xiangyu, et al.
(författare)
-
A highly sensitive bead-based flow cytometric competitive binding assay to detect SARS-CoV-2 neutralizing antibody activity
- 2022
-
Ingår i: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 13
-
Tidskriftsartikel (refereegranskat)abstract
- Accurate detection of SARS-CoV-2 neutralizing antibody (nAb) is critical for assessing the immunity levels after virus infection or vaccination. As fast, cost-effective alternatives to viral infection-based assays, competitive binding (CB) assays were developed to quantitate nAb by monitoring the ability of sera to inhibit the binding of viral spike (S) protein to the angiotensin converting enzyme 2 (ACE2) receptor. Herein, we established a bead-based flow cytometric CB assay and tested the detection performance of six combination models, i.e. immobilized ACE2 and soluble Fc-tagged S1 subunit of S protein (iACE2/S1-Fc), immobilized ACE2 and soluble Fc-tagged receptor binding domain (RBD) of S protein (iACE2/RBD-Fc), immobilized S1 and soluble Fc-tagged ACE2 (iS1/ACE2-Fc), immobilized S1 and soluble His-tagged ACE2 (iS1/ACE2-His), immobilized RBD and soluble Fc-tagged ACE2 (iRBD/ACE2-Fc), and immobilized RBD and soluble His-tagged ACE2 (iRBD/ACE2-His). Using SARS-CoV-2 monoclonal antibodies and sera of convalescent COVID-19 patients and vaccinated subjects, the combination models iACE2/RBD-Fc, iACE2/S1-Fc and iS1/ACE2-His were identified to be able to specifically detect SARS-CoV-2 nAb, among which iACE2/RBD-Fc model showed the highest sensitivity, superior to a commercial SARS-CoV-2 surrogate virus neutralization test (sVNT) ELISA kit. Further studies demonstrated that the sensitivity and specificity of CB assays were affected by the tag of ACE2, type of spike and method of measuring binding rate between ACE2 and spike. Moreover, the iACE2/RBD-Fc model showed good performance in detecting kinetic development of nAb against both the prototype SARS-CoV-2 strain and an omicron variant of SARS-CoV-2 in people immunized by an inactivated SARS-CoV-2 vaccine, and the results of iACE2/RBD-Fc model are correlated well with those of live virus-based and pseudovirus-based neutralization tests, demonstrating the potential to be developed into a highly sensitive, specific, versatile and high-throughput method for detecting SARS-CoV-2 nAb in clinical practice.
|
|
| 67. |
- Yi, Chang, et al.
(författare)
-
Intermediate-phase-assisted low-temperature formation of gamma-CsPbI3 films for high-efficiency deep-red light-emitting devices
- 2020
-
Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 11:1
-
Tidskriftsartikel (refereegranskat)abstract
- Black phase CsPbI3 is attractive for optoelectronic devices, while usually it has a high formation energy and requires an annealing temperature of above 300 degrees C. The formation energy can be significantly reduced by adding HI in the precursor. However, the resulting films are not suitable for light-emitting applications due to the high trap densities and low photoluminescence quantum efficiencies, and the low temperature formation mechanism is not well understood yet. Here, we demonstrate a general approach for deposition of gamma -CsPbI3 films at 100 degrees C with high photoluminescence quantum efficiencies by adding organic ammonium cations, and the resulting light-emitting diode exhibits an external quantum efficiency of 10.4% with suppressed efficiency roll-off. We reveal that the low-temperature crystallization process is due to the formation of low-dimensional intermediate states, and followed by interionic exchange. This work provides perspectives to tune phase transition pathway at low temperature for CsPbI3 device applications. Exploiting low-temperature formed black phase CsPbI3 for light-emitting applications remains a challenge. Here, the authors propose a method to enable the deposition of gamma -CsPbI3 films at 100C and demonstrate a light-emitting diode with an external quantum efficiency of 10.4% with suppressed efficiency roll-off.
|
|
| 68. |
- Yin, Hang, et al.
(författare)
-
Analysis of heat dissipation characteristics of three-dimensional graphene-carbon nanotube composite structures
- 2020
-
Ingår i: 2020 21ST INTERNATIONAL CONFERENCE ON ELECTRONIC PACKAGING TECHNOLOGY (ICEPT). - 9781728168265
-
Konferensbidrag (refereegranskat)abstract
- With the rapid development of electronic materials and technologies, the working frequencies of electronic components and devices have been greatly improved and the volume of electronic products has been shrinking. The integration density has increased significantly, which puts forward higher requirements for thermal management. One of the keys to the heat dissipation of electronic components is to transfer the heat rapidly to the radiator through the heat conducting medium. Therefore, the development of high conductive materials has become a research hotspot of high-density integrated devices and systems. Due to their excellent heat transfer properties, carbon nanomaterials such as carbon nanotube and graphene have attracted extensive attention. The thermal conductivities of carbon nanotube and graphene have obvious anisotropy, which limited their applications to some extent. In this paper, three-dimensional composite structures composed of graphene sheets and carbon nanotubes are considered. The heat transfer processes are simulated by molecular dynamics method and the heat transfer characteristics of van der Waals interaction and chemical bond structures are analyzed. The effects of heat flow and nanotube layout on the thermal properties of three-dimensional composite structures are discussed.
|
|
| 69. |
- Zhang, Bin, et al.
(författare)
-
Single-Cell RNA-Seq Analysis Reveals Macrophages Are Involved in the Pathogenesis of Human Sporadic Acute Type A Aortic Dissection
- 2023
-
Ingår i: Biomolecules. - : MDPI. - 2218-273X. ; 13:2
-
Tidskriftsartikel (refereegranskat)abstract
- Macrophages play an important role in the progression of sporadic acute type A aortic dissection (ATAAD). The aim of this study was to characterize the cellular heterogeneity of macrophages in ATAAD tissues by scRNA-seq. Ascending aortic wall tissue from six ATAAD patients and three heart transplant donors was assessed by scRNA-seq and then analyzed and validated by various bioinformatic algorithms and histopathology experiments. The results revealed that the proportion of macrophages in ATAAD tissues (24.51%) was significantly higher than that in normal tissues (13.69%). Among the six macrophage subclusters, pro-inflammatory macrophages accounted for 14.96% of macrophages in the AD group and 0.18% in the normal group. Chemokine- and inflammation-related genes (CCL2, CCL20, S100A8, and S100A9) were expressed more intensively in macrophages in ATAAD tissue than in those in normal tissue. Additionally, intercellular communication analysis and transcription factor analysis indicated the activation of inflammation and degradation of the extracellular matrix in ATAAD tissue. Finally, immunohistochemistry, immunofluorescence, and Western blot experiments confirmed the overexpression of macrophage marker genes (CD68 and CD163) and matrix metalloproteinases (MMP9 and MMP2) in ATAAD tissue. Collectively, our study provides a preliminary evaluation of the role of macrophages in ATAAD, and the results could aid in the development of therapeutic options in the future.
|
|
| 70. |
- Zhang, Hanzhu, 1991-
(författare)
-
High-entropy boron-carbide and its composites
- 2020
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- High-entropy alloy (HEA) is a multicomponent alloy material that contains five or more principal elements in equi- or near equi-atomic ratios. The entropy stabilisation leads to the formation of a crystalline solid solution accommodating the principal elements. The HEA solid solution has characteristic features such as lattice distortion, sluggish diffusion and cocktail effect that contribute to the superior properties of HEA including high strength, high hardness, excellent thermal and chemical stability, etc. The concept of HEA has been extended to ceramic materials to process high-entropy ceramic (HEC) that consists of multiple ceramic compounds such as metallic oxides, nitrides or carbides. The HECs have shown entropy stabilisation and formed single-phase ceramic solid solutions. However, the formation mechanism of high-entropic phase in HECs remains unclear and unpredictable. Generally, in order to maximise the probability of forming a high-entropy solid solution in a ceramic system, ceramic compounds with least difference in the crystal structure, preferably with only one anionic constituent element, are favoured when designing HECs, which limits the potential of discovering and developing new HECs. In this project, a multicomponent ceramic system containing six ultra-high temperature ceramics (UHTCs), B4C, HfC, Mo2C, TaC, TiC and SiC, was used to investigate the formation of high-entropy ceramics, UHTC composites, as well as the microstructure evolution, properties and high temperature applications. A ceramic composite composed of SiC and a high-entropy boron-carbide with hexagonal crystal structure was successfully processed from the carbide system in spite of the difference in the crystal structures of precursors (face-centred cubic, hexagonal and rhombohedral). The hexagonal HEC solid solution exhibited a unique AlB2 structure with alternating layers of metal and non-metal C/B atoms according to the experimental and simulation investigations. The HEC/SiC composite showed superior mechanical properties such as ultra-high hardness, excellent wear and oxidation resistance. The addition of B4C was discovered to be the key factor in the formation of the hexagonal high-entropy boron-carbide solid solution, while the final phase composition was tailored by utilising precursors of different particle size. Additionally, SiC as the reinforcement component in the HEC/SiC composite was used to tailor the microstructure, phase evolution and mechanical properties of the high-entropy boron-carbide composite. Higher content of SiC resulted in enhanced mechanical properties such as hardness and fracture toughness, as well as promoted the formation of the hexagonal high-entropy boron-carbide solid solution. To extend the investigation on the high-entropy boron-carbide composite to application, B4C, HfC, Mo2C, TaC and TiC were consolidated into a target for magnetron sputtering. The target was used to deposit oxidation-resistant high-entropy coatings using magnetron sputtering on carbon-carbon composites. The coatings showed superior mechanical performance and high temperature oxidation resistance at 2000 °C on carbon-carbon composite, suggesting potential applications of high-entropy boron-carbide ceramics as a protective coating material against oxidation at elevated temperature. This work pointed out the possibilities of synthesising high-performance HECs with superior properties from components with vast elemental and structure diversity, and thereby advanced the design criteria of HECs and provided more potential research directions for the new high-performance ceramic materials.
|
|
