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Sökning: WFRF:(Svensson Olof) > (2015-2019)

  • Resultat 81-83 av 83
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81.
  • Wärmefjord, Kristina, 1976, et al. (författare)
  • Welding of non-nominal geometries : physical tests
  • 2016
  • Ingår i: Procedia CIRP. - : Elsevier BV. - 2212-8271. ; 43, s. 136-141
  • Tidskriftsartikel (refereegranskat)abstract
    • The geometrical quality of a welded assembly is to some extent depending part positions before welding. Here, a design of experiment is set up in order to investigate this relation using physical tests in a controlled environment. Based on the experimental results it can be concluded that the influence of part position before welding is significant for geometrical deviation after welding. Furthermore, a working procedure for a completely virtual geometry assurance process for welded assemblies is outlined. In this process, part variations, assembly fixture variations and welding induced variations are important inputs when predicting the capability of the final assembly.
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82.
  • Zeng, Jianwen, et al. (författare)
  • Vasopressin-induced mouse urethral contraction is modulated by caveolin-1.
  • 2015
  • Ingår i: European Journal of Pharmacology. - : Elsevier BV. - 1879-0712 .- 0014-2999. ; 750, s. 59-65
  • Tidskriftsartikel (refereegranskat)abstract
    • Caveolae are 50-100nm large invaginations in the cell membrane that are considered to play roles in receptor signaling. Here we aimed to investigate the expression and distribution of the arginine-vasopressin (AVP) V1a receptor and its functional dependence on caveolin-1 (Cav1) in the mouse urethra. Female Cav1 knockout (KO) and wild type (WT) mice were used, and urethral preparations were micro-dissected for mechanical experiments. Methyl-β-cyclodextrin (mβcd) was used to deplete cholesterol and to disrupt caveolae. Protein expression and localization was determined using immunofluorescence and western blotting and transcript expression was determined by qRT-PCR. We found that Cav1 and AVP V1a receptors were expressed in urethral smooth muscle cells with apparent co-localization at the cell membrane. AVP caused urethral contraction that was inhibited by the V1a receptor antagonist SR49059. Concentration-response curves for AVP were right-shifted and maximal contraction was reduced in Cav1 KO mice and after mβcd treatment. In addition to caveolin-1 we also detected caveolin-2, cavin-1 and cavin-3 in the mouse urethra by western blotting. Caveolin-2, cavin-1 and cavin-3 as well as V1a receptor expression was reduced in KO urethra. We conclude that AVP regulates urethral contractility via the V1a receptor through a Cav1-dependent mechanism involving, in part, altered V1a receptor expression.
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83.
  • Zhu, Baoyi, et al. (författare)
  • Array profiling reveals contribution of Cthrc1 to growth of the denervated rat urinary bladder
  • 2018
  • Ingår i: American Journal of Physiology - Renal Physiology. - : American Physiological Society. - 1931-857X .- 1522-1466. ; 314:5, s. f893-f905
  • Tidskriftsartikel (refereegranskat)abstract
    • Bladder denervation and bladder outlet obstruction are urological conditions that cause bladder growth. Transcriptomic surveys in outlet obstruction have identified differentially expressed genes, but similar studies following denervation have not been done. This was addressed using a rat model in which the pelvic ganglia were cryo-ablated followed by bladder microarray analyses. At 10 days following denervation, bladder weight had increased 5.6-fold, and 2,890 mRNAs and 135 micro-RNAs (miRNAs) were differentially expressed. Comparison with array data from obstructed bladders demonstrated overlap between the conditions, and 10% of mRNAs changed significantly and in the same direction. Many mRNAs, including collagen triple helix repeat containing 1 (Cthrc1), Prc1, Plod2, and Dkk3, and miRNAs, such as miR-212 and miR-29. resided in the shared signature. Discordantly regulated transcripts in the two models were rare, making up for <0.07% of all changes, and the gene products in this category localized to the urothelium of normal bladders. These transcripts may potentially be used to diagnose sensory denervation. Western blotting demonstrated directionally consistent changes at the protein level, with increases of, e.g., Cthrc1, Prc1, Plod2, and Dkk3. We chose Cthrc1 for further studies and found that Cthrcl was induced in the smooth muscle cell (SMC) layer following denervation. TGF-beta 1 stimulation and miR-30d-5p inhibition increased Cthrc1 in bladder SMCs, and knockdown and overexpression of Cthrc1 reduced and increased SMC proliferation. This work defines common and distinguishing features of bladder denervation and obstruction and suggests a role for Cthrc1 in bladder growth following denervation.
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