| 1. |
- Fu, Jiahong, et al.
(författare)
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Enhanced heat transfer research in liquid-cooled channel based on piezoelectric vibrating cantilever
- 2021
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Ingår i: Thermal Science. - 0354-9836. ; 25:2 Part A, s. 823-832
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Tidskriftsartikel (refereegranskat)abstract
- In order to study the variation of vortices and heat transfer enhancement characteristics of piezoelectric vibrating cantilever in liquid-cooled channels, the effects of fluid density and viscosity, mainstream velocity, and excitation voltage on vortices were analyzed. The theoretical and numerical simulation of piezoelectric vortices was carried out by using fluid-solid coupling method. On the basis of hydrodynamic function considering the additional effect of liquid viscosity and density on piezoelectric vibrator, the vortex structure of piezoelectric vibrator was analyzed by panel method free-wake model. It is found that the larger the density of the liquid, the smaller the vortex shedding strength and the radius of the core. The larger the viscosity of the liquid, the easier to fully develop the vortex generated by the excitation. The increase of the mainstream flow velocity is beneficial to the development of the vortex structure and the increase of the vorticity intensity. Compared with the increase of the mainstream flow velocity, the excitation voltage is more conducive to the enhancement of the vorticity structure, then make it easier to mix hot and cold fluids, thus enhancing heat transfer.
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| 2. |
- Zhang, Yichen, et al.
(författare)
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A GPU-based computational framework that bridges neuron simulation and artificial intelligence
- 2023
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Biophysically detailed multi-compartment models are powerful tools to explore computational principles of the brain and also serve as a theoretical framework to generate algorithms for artificial intelligence (AI) systems. However, the expensive computational cost severely limits the applications in both the neuroscience and AI fields. The major bottleneck during simulating detailed compartment models is the ability of a simulator to solve large systems of linear equations. Here, we present a novel Dendritic Hierarchical Scheduling (DHS) method to markedly accelerate such a process. We theoretically prove that the DHS implementation is computationally optimal and accurate. This GPU-based method performs with 2-3 orders of magnitude higher speed than that of the classic serial Hines method in the conventional CPU platform. We build a DeepDendrite framework, which integrates the DHS method and the GPU computing engine of the NEURON simulator and demonstrate applications of DeepDendrite in neuroscience tasks. We investigate how spatial patterns of spine inputs affect neuronal excitability in a detailed human pyramidal neuron model with 25,000 spines. Furthermore, we provide a brief discussion on the potential of DeepDendrite for AI, specifically highlighting its ability to enable the efficient training of biophysically detailed models in typical image classification tasks.
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| 3. |
- Bogaerts, Wim, et al.
(författare)
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Scaling programmable silicon photonics circuits
- 2023
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Ingår i: Silicon Photonics XVIII. - : SPIE-Intl Soc Optical Eng.
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Konferensbidrag (refereegranskat)abstract
- We give an overview the progress of our work in silicon photonic programmable circuits, covering the techn stack from the photonic chip over the driver electronics, packaging technologies all the way to the sof layers. On the photonic side, we show our recent results in large-scale silicon photonic circuits with diff tuning technologies, including heaters, MEMS and liquid crystals, and their respective electronic driving sch We look into the scaling potential of these different technologies as the number of tunable elements in a ci increases. Finally, we elaborate on the software routines for routing and filter synthesis to enable the pho programmer.
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| 4. |
- Fedriani, Rubén, 1991, et al.
(författare)
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The SOFIA Massive (SOMA) Star Formation Survey. IV. Isolated Protostars
- 2023
-
Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 942:1
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Tidskriftsartikel (refereegranskat)abstract
- We present similar to 10-40 mu m SOFIA-FORCAST images of 11 isolated protostars as part of the SOFIA Massive (SOMA) Star Formation Survey, with this morphological classification based on 37 mu m imaging. We develop an automated method to define source aperture size using the gradient of its background-subtracted enclosed flux and apply this to build spectral energy distributions (SEDs). We fit the SEDs with radiative transfer models, developed within the framework of turbulent core accretion (TCA) theory, to estimate key protostellar properties. Here, we release the sedcreator python package that carries out these methods. The SEDs are generally well fitted by the TCA models, from which we infer initial core masses M ( c ) ranging from 20-430 M (circle dot), clump mass surface densities sigma(cl) similar to 0.3-1.7 g cm(-2), and current protostellar masses m (*) similar to 3-50 M (circle dot). From a uniform analysis of the 40 sources in the full SOMA survey to date, we find that massive protostars form across a wide range of clump mass surface density environments, placing constraints on theories that predict a minimum threshold sigma(cl) for massive star formation. However, the upper end of the m (*)-sigma(cl) distribution follows trends predicted by models of internal protostellar feedback that find greater star formation efficiency in higher sigma(cl) conditions. We also investigate protostellar far-IR variability by comparison with IRAS data, finding no significant variation over an similar to 40 yr baseline.
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| 5. |
- Gardiner, Emiko C., et al.
(författare)
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Disk Wind Feedback from High-mass Protostars. IV. Shock-ionized Jets
- 2024
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Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 967:2
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Tidskriftsartikel (refereegranskat)abstract
- Massive protostars launch accretion-powered, magnetically collimated outflows, which play crucial roles in the dynamics and diagnostics of the star formation process. Here we calculate the shock heating and resulting free-free radio emission in numerical models of outflows of massive star formation within the framework of the Turbulent Core Accretion model. We postprocess 3D magnetohydrodynamic simulation snapshots of a protostellar disk wind interacting with an infalling core envelope, and calculate shock temperatures, ionization fractions, and radio free-free emission. We find heating up to ∼107 K and near-complete ionization in shocks at the interface between the outflow cavity and infalling envelope. However, line-of-sight averaged ionization fractions peak around ∼10%, in agreement with values reported from observations of massive protostar G35.20-0.74N. By calculating radio-continuum fluxes and spectra, we compare our models with observed samples of massive protostars. We find our fiducial models produce radio luminosities similar to those seen from low- and intermediate-mass protostars that are thought to be powered by shock ionization. Comparing to more massive protostars, we find our model radio luminosities are ∼10-100 times less luminous. We discuss how this apparent discrepancy either reflects aspects of our modeling related to the treatment of cooling of the post-shock gas or a dominant contribution in the observed systems from photoionization. Finally, our models exhibit 10 yr radio flux variability of ∼5%, especially in the inner 1000 au region, comparable to observed levels in some hypercompact H ii regions.
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| 6. |
- Gorai, Prasanta, 1991, et al.
(författare)
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Astrochemical Diagnostics of the Isolated Massive Protostar G28.20-0.05
- 2024
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Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 960:2
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Tidskriftsartikel (refereegranskat)abstract
- We study the astrochemical diagnostics of the isolated massive protostar G28.20-0.05. We analyze data from Atacama Large Millimeter/submillimeter Array 1.3 mm observations with a resolution of 0.″2 (∼1000 au). We detect emission from a wealth of species, including oxygen-bearing (e.g., H2CO, CH3OH, CH3OCH3), sulfur-bearing (SO2, H2S), and nitrogen-bearing (e.g., HNCO, NH2CHO, C2H3CN, C2H5CN) molecules. We discuss their spatial distributions, physical conditions, correlation between different species, and possible chemical origins. In the central region near the protostar, we identify three hot molecular cores (HMCs). HMC1 is part of a millimeter continuum ring-like structure, is closest in projection to the protostar, has the highest temperature of ∼300 K, and shows the most line-rich spectra. HMC2 is on the other side of the ring, has a temperature of ∼250 K, and is of intermediate chemical complexity. HMC3 is further away, ∼3000 au in projection, cooler (∼70 K), and is the least line-rich. The three HMCs have similar mass surface densities (∼10 g cm−2), number densities (n H ∼ 109 cm−3), and masses of a few solar masses. The total gas mass in the cores and in the region out to 3000 au is ∼25 M ⊙, which is comparable to that of the central protostar. Based on spatial distributions of peak line intensities as a function of excitation energy, we infer that the HMCs are externally heated by the protostar. We estimate column densities and abundances of the detected species and discuss the implications for hot core astrochemistry.
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| 7. |
- Guo, Yichen, et al.
(författare)
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DNA Methylation of LRRC3B : A Biomarker for Survival of Early-Stage Non-Small Cell Lung Cancer Patients
- 2018
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Ingår i: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. - 1538-7755. ; 27:12, s. 1527-1535
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Tidskriftsartikel (refereegranskat)abstract
- Background: Previous studies support a tumor-suppressor role for LRRC3B across various types of cancers. We aimed to investigate the association between DNA methylation of LRRC3B and overall survival (OS) for patients with early-stage non-small cell lung cancer (NSCLC).Methods: This study included 1,230 patients with early-stage NSCLC. DNA was extracted from lung tumor tissues and DNA methylation was measured using Illumina Infinium HumanMethylation450 BeadChips. The association between DNA methylation and OS was first tested using Cox regression on a discovery cohort and then validated in an independent cohort. Next, the association between DNA methylation and gene expression was investigated in two independent cohorts. Finally, the association between gene expression and OS was investigated in three independent groups of patients.Results: Three novel DNA methylation sites in LRRC3B were significantly associated with OS in two groups of patients. Patients with hypermethylation in the DNA methylation sites had significantly longer survival than the others in both the discovery cohort (HR, 0.62; P = 2.02 × 10-05) and validation cohort (HR, 0.55; P = 4.44 × 10-04). The three DNA methylation sites were significantly associated with LRRC3B expression, which was also associated with OS.Conclusions: Using clinical data from a large population, we illustrated the association between DNA methylation of LRRC3B and OS of early-stage NSCLC.Impact: We provide evidence of plausibility for building biomarkers on DNA methylation of LRRC3B for OS of early-stage NSCLC, thus filling a gap between previous in vitro studies and clinical applications. Cancer Epidemiol Biomarkers Prev; 27(12); 1-9. ©2018 AACR.
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| 8. |
- Law, Chi Yan, 1990, et al.
(författare)
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Isolated Massive Star Formation in G28.20-0.05
- 2022
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 939:2
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Tidskriftsartikel (refereegranskat)abstract
- We report high-resolution 1.3 mm continuum and molecular line observations of the massive protostar G28.20-0.05 with Atacama Large Millimeter/submillimeter Array. The continuum image reveals a ring-like structure with 2000 au radius, similar to morphology seen in archival 1.3 cm Very Large Array observations. Based on its spectral index and associated H30α emission, this structure mainly traces ionized gas. However, there is evidence for ∼30 M ⊙ of dusty gas near the main millimeter continuum peak on one side of the ring, as well as in adjacent regions within 3000 au. A virial analysis on scales of ∼2000 au from hot core line emission yields a dynamical mass of ∼80 M ⊙. A strong velocity gradient in the H30α emission is evidence for a rotating, ionized disk wind, which drives a larger-scale molecular outflow. An infrared spectral energy distribution (SED) analysis indicates a current protostellar mass of m * ∼ 40 M ⊙ forming from a core with initial mass M c ∼ 300 M ⊙ in a clump with mass surface density of Σcl ∼ 0.8 g cm−2. Thus the SED and other properties of the system can be understood in the context of core accretion models. A structure-finding analysis on the larger-scale continuum image indicates G28.20-0.05 is forming in a relatively isolated environment, with no other concentrated sources, i.e., protostellar cores, above ∼1 M ⊙ found from ∼0.1 to 0.4 pc around the source. This implies that a massive star can form in relative isolation, and the dearth of other protostellar companions within the ∼1 pc environs is a strong constraint on massive star formation theories that predict the presence of a surrounding protocluster.
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| 9. |
- Liu, Mengyao, et al.
(författare)
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The SOFIA Massive (SOMA) Star Formation Survey. II. High Luminosity Protostars
- 2019
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 874:1
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Forskningsöversikt (refereegranskat)abstract
- We present multiwavelength images observed with SOFIA-FORCAST from similar to 10 to 40 mu m of seven high luminosity massive protostars, as part of the SOFIA Massive Star Formation Survey. Source morphologies at these wavelengths appear to be influenced by outflow cavities and extinction from dense gas surrounding the protostars. Using these images, we build spectral energy distributions (SEDs) of the protostars, also including archival data from Spitzer, Herschel, and other facilities. Radiative transfer (RT) models of Zhang & Tan, based on Turbulent Core Accretion theory, are then fit to the SEDs to estimate key properties of the protostars. Considering the best five models fit to each source, the protostars have masses m* similar to 12-64 M circle dot accreting at rates of m* similar to 10(-4) -10(-3) M circle dot yr(-1) inside cores of initial masses M-c similar to 100-500 M circle dot embedded in clumps with mass surface densities Sigma(cl) similar to 0.1-3 g cm(-2) and span a luminosity range of 10(4) -10(6) L circle dot. Compared with the first eight protostars in Paper I, the sources analyzed here are more luminous and, thus, likely to be more massive protostars. They are often in a clustered environment or have a companion protostar relatively nearby. From the range of parameter space of the models, we do not see any evidence that Sigma(cl) needs to be high to form these massive stars. For most sources, the RT models provide reasonable fits to the SEDs, though the cold clump material often influences the long wavelength fitting. However, for sources in very clustered environments, the model SEDs may not be such a good description of the data, indicating potential limitations of the models for these regions.
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| 10. |
- Liu, Mengyao, et al.
(författare)
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The SOFIA Massive (SOMA) Star Formation Survey. III. From Intermediate- to High-mass Protostars
- 2020
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 904:1
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Tidskriftsartikel (refereegranskat)abstract
- We present similar to 10-40 mm SOFIA-FORCAST images of 14 intermediate-mass protostar candidates as part of the SOFIA Massive (SOMA) Star Formation Survey. We build spectral energy distributions, also using archival Spitzer, Herschel, and IRAS data. We then fit the spectral energy distributions with radiative transfer models of Zhang & Tan, based on turbulent core accretion theory, to estimate key protostellar properties. With the addition of these intermediate-mass sources, based on average properties derived from SED fitting, SOMA protostars span luminosities from similar to 10(2) to 10(6) L-circle dot, current protostellar masses from similar to 0.5 to 35 M-circle dot, and ambient clump mass surface densities, Scl, from 0.1 to g cm(-2). A wide range of evolutionary states of the individual protostars and of the protocluster environments is also probed. We have also considered about 50 protostars identified in infrared dark clouds that are expected to be at the earliest stages of their evolution. With this global sample, most of the evolutionary stages of high- and intermediate-mass protostars are probed. The best-fitting models show no evidence that a threshold value of the protocluster clump mass surface density is required to form protostars up to similar to 25 M.. However, to form more massive protostars, there is tentative evidence that Sigma(cl) needs to be greater than or similar to 1 g cm(-2). We discuss how this is consistent with expectations from core accretion models that include internal feedback from the forming massive star.
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| 11. |
- Marklund, Erik G., Teknologie doktor, 1979-, et al.
(författare)
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Structural and functional aspects of the interaction partners of the small heat-shock protein in Synechocystis
- 2018
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Ingår i: Cell stress & chaperones (Print). - : Springer Science and Business Media LLC. - 1355-8145 .- 1466-1268. ; 23:4, s. 723-732
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Tidskriftsartikel (refereegranskat)abstract
- The canonical function of small heat-shock proteins (sHSPs) is to interact with proteins destabilized under conditions of cellular stress. While the breadth of interactions made by many sHSPs is well-known, there is currently little knowledge about what structural features of the interactors form the basis for their recognition. Here, we have identified 83 in vivo interactors of the sole sHSP in the cyanobacterium Synechocystis sp. PCC 6803, HSP16.6, reflective of stable associations with soluble proteins made under heat-shock conditions. By performing bioinformatic analyses on these interactors, we identify primary and secondary structural elements that are enriched relative to expectations from the cyanobacterial genome. In addition, by examining the Synechocystis interactors and comparing them with those identified to bind sHSPs in other prokaryotes, we show that sHSPs associate with specific proteins and biological processes. Our data are therefore consistent with a picture of sHSPs being broadly specific molecular chaperones that act to protect multiple cellular pathways.
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| 12. |
- Moser, Emily, et al.
(författare)
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The High-mass Protostellar Population of a Massive Infrared Dark Cloud
- 2020
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 897:2
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Tidskriftsartikel (refereegranskat)abstract
- We conduct a census of the high-mass protostellar population of the similar to 70,000Minfrared dark cloud (IRDC) G028.37+00.07, identifying 35 sources based on their 70 mu m emission, as reported in the Herschel Hi-GAL catalog of Molinari et al. We perform aperture photometry to construct spectral energy distributions, which are then fit with the massive protostar models of Zhang & Tan. We find that the sources span a range of isotropic luminosities from similar to 20 to 4500L. The most luminous sources are predicted to have current protostellar masses ofm(*) similar to 10Mforming from cores of massM(c) similar to 40 to 400M. The least luminous sources in our sample are predicted to be protostars with masses as low as similar to 0.5Mforming from cores withM(c) similar to 10M, which are the minimum values explored in the protostellar model grid. The detected protostellar population has a total estimated protostellar mass ofM(*) similar to 100M. Allowing for completeness corrections, which are constrained by comparison with an ALMA study in part of the cloud, we estimate a star formation efficiency per freefall time of similar to 3% in the IRDC. Finally, analyzing the spatial distribution of the sources, we find relatively low degrees of central concentration of the protostars. The protostars, including the most massive ones, do not appear to be especially centrally concentrated in the protocluster as defined by the IRDC boundary.
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| 13. |
- Rosero, Viviana, et al.
(författare)
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The SOMA Radio Survey. I. Comprehensive SEDs of High-mass Protostars from Infrared to Radio and the Emergence of Ionization Feedback
- 2019
-
Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 873:1
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Forskningsöversikt (refereegranskat)abstract
- We study centimeter continuum emission of eight high- and intermediate-mass protostars that are part of the SOFIA Massive Star Formation Survey, thus building extended spectral energy distributions (SEDs) from the radio to the infrared. We discuss the morphology seen in the centimeter continuum images, which are mostly derived from archival Very Large Array data, and the relation to infrared morphology. We use the SEDs to test new models of high-mass star formation including radiative and disk-wind feedback and associated free-free and dust continuum emission. We show that interferometric data of the centimeter continuum flux densities provide additional, stringent tests of the models by constraining the ionizing luminosity of the source; they also help to break degeneracies encountered when modeling the infrared-only SEDs, especially for the protostellar mass. Our derived parameters are consistent with physical parameters estimated by other methods, such as dynamical protostellar masses. We find a few examples of additional stellar sources in the vicinity of the high-mass protostars, which may be low-mass young stellar objects. However, the stellar multiplicity of the regions, at least as traced by radio continuum emission, appears to be relatively low.
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| 14. |
- Shen, Sipeng, et al.
(författare)
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A multi-omic study reveals BTG2 as a reliable prognostic marker for early-stage non-small cell lung cancer
- 2018
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Ingår i: Molecular Oncology. - : Wiley. - 1574-7891 .- 1878-0261. ; 12:6, s. 913-924
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Tidskriftsartikel (refereegranskat)abstract
- B-cell translocation gene 2 (BTG2) is a tumour suppressor protein known to be downregulated in several types of cancer. In this study, we investigated a potential role for BTG2 in early-stage non-small cell lung cancer (NSCLC) survival. We analysed BTG2 methylation data from 1230 early-stage NSCLC patients from five international cohorts, as well as gene expression data from 3038 lung cancer cases from multiple cohorts. Three CpG probes (cg01798157, cg06373167, cg23371584) that detected BTG2 hypermethylation in tumour tissues were associated with lower overall survival. The prognostic model based on methylation could distinguish patient survival in the four cohorts [hazard ratio (HR) range, 1.51-2.21] and the independent validation set (HR = 1.85). In the expression analysis, BTG2 expression was positively correlated with survival in each cohort (HR range, 0.28-0.68), which we confirmed with meta-analysis (HR = 0.61, 95% CI 0.54-0.68). The three CpG probes were all negatively correlated with BTG2 expression. Importantly, an integrative model of BTG2 methylation, expression and clinical information showed better predictive ability in the training set and validation set. In conclusion, the methylation and integrated prognostic signatures based on BTG2 are stable and reliable biomarkers for early-stage NSCLC. They may have new applications for appropriate clinical adjuvant trials and personalized treatments in the future.
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| 15. |
- Staff, Jan, 1977, et al.
(författare)
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Disk Wind Feedback from High-mass Protostars. II. The Evolutionary Sequence
- 2023
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Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 947:1
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Tidskriftsartikel (refereegranskat)abstract
- Star formation is ubiquitously associated with the ejection of accretion-powered outflows that carve bipolar cavities through the infalling envelope. This feedback is expected to be important for regulating the efficiency of star formation from a natal prestellar core. These low-extinction outflow cavities greatly affect the appearance of a protostar by allowing the escape of shorter-wavelength photons. Doppler-shifted CO line emission from outflows is also often the most prominent manifestation of deeply embedded early-stage star formation. Here, we present 3D magnetohydrodynamic simulations of a disk wind outflow from a protostar forming from an initially 60 M ⊙ core embedded in a high-pressure environment typical of massive star-forming regions. We simulate the growth of the protostar from m * = 1 M ⊙ to 26 M ⊙ over a period of ∼100,000 yr. The outflow quickly excavates a cavity with a half opening angle of ∼10° through the core. This angle remains relatively constant until the star reaches 4 M ⊙. It then grows steadily in time, reaching a value of ∼50° by the end of the simulation. We estimate a lower limit to the star formation efficiency (SFE) of 0.43. However, accounting for continued accretion from a massive disk and residual infall envelope, we estimate that the final SFE may be as high as ∼0.7. We examine observable properties of the outflow, especially the evolution of the cavity's opening angle, total mass, and momentum flux, and the velocity distributions of the outflowing gas, and compare with the massive protostars G35.20-0.74N and G339.88-1.26 observed by the Atacama Large Millimeter/submillimeter Array (ALMA), yielding constraints on their intrinsic properties.
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| 16. |
- Tanaka, Kei E. I., et al.
(författare)
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Multiple Feedback in Low-Metallicity Massive Star Formation
- 2019
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Ingår i: Proceedings of the International Astronomical Union. - 1743-9213 .- 1743-9221. ; 14:S344, s. 190-194
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Konferensbidrag (refereegranskat)abstract
- We theoretically investigate the impact of feedback and its metallicity dependence in massive star formation from prestellar cores at all metallicity range. We include the feedback by MHD disk winds, radiation pressure, and photoevaporation solving the evolution of protostars and accretion flows self-consistently. Interestingly, we find that the feedback does not set the upper mass limit of stellar birth mass at any metallicity. At the solar metallicity, the MHD disk wind is the dominant feedback to set the star formation efficiencies (SFEs) from the prestellar cores similar to low-mass star formation. The SFE is found to be lower at lower surface density environment. The photoevaporation becomes significant at the low metallicity of Z < 10(-2) Z(circle dot). Considering this efficient photoevaporation, we conclude that the IMF slope is steeper, i.e., massive stars are rarer at the extremely metal-poor environment of 10(-5)-10(-3)Z(circle dot). Our study raises a question on the common assumption of the universal IMF with a truncated at 100M(circle dot). Since the total feedback strength in the cluster/galaxy scale is sensitive to the number fraction of massive stars, the re-evaluations of IMF at various environments are necessary.
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| 17. |
- Tanaka, Kei E. I., et al.
(författare)
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Salt, Hot Water, and Silicon Compounds Tracing Massive Twin Disks
- 2020
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Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 900:1
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Tidskriftsartikel (refereegranskat)abstract
- We report results of 0.''. 05-resolution observations toward the O-type proto-binary system IRAS 16547-4247 with the Atacama Large Millimeter/submillimeter Array. We present dynamical and chemical structures of the circumbinary disk, circumstellar disks, outflows, and jets, illustrated by multi-wavelength continuum and various molecular lines. In particular, we detect sodium chloride, silicon compounds, and vibrationally excited water lines as probes of the individual protostellar disks at a scale of 100 au. These are complementary to typical hot-core molecules tracing the circumbinary structures on a 1000 au scale. The H2O line tracing inner disks has an upper-state energy of E-u/k > 3000 K, indicating a high temperature of the disks. On the other hand, despite the detected transitions of NaCl, SiO, and SiS not necessarily having high upper-state energies, they are enhanced only in the vicinity of the protostars. We posit that these molecules are the products of dust destruction, which only happens in the inner disks. This is the second detection of alkali metal halide in protostellar systems after the case of the disk of Orion Source I, and also one of few massive protostellar disks associated with high-energy transition water and silicon compounds. These new results suggest that these "hot-disk" lines may be common in innermost disks around massive protostars, and have great potential for future research of massive star formation. We also tentatively find that the twin disks are counter-rotating, which might give a hint of the origin of the massive protobinary system IRAS 16547-4247.
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| 18. |
- Tanaka, Kei E.I., et al.
(författare)
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The Impact of Feedback in Massive Star Formation. II. Lower Star Formation Efficiency at Lower Metallicity
- 2018
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 861:1
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Tidskriftsartikel (refereegranskat)abstract
- We conduct a theoretical study of the formation of massive stars over a wide range of metallicities from 10-5to and evaluate the star formation efficiencies (SFEs) from prestellar cloud cores taking into account multiple feedback processes. Unlike for simple spherical accretion, feedback processes in the case of disk accretion do not set upper limits on stellar masses. At solar metallicity, launching of magneto-centrifugally driven outflows is the dominant feedback process to set SFEs, while radiation pressure, which has been regarded as pivotal, makes only a minor contribution even in the formation of stars over 100 M⊙. Photoevaporation becomes significant in the formation of stars over 20 M⊙at low metallicities of ≲ 10-2Z⊙, where dust absorption of ionizing photons is inefficient. We conclude that if initial prestellar core properties are similar, then massive stars are rarer in extremely metal-poor environments of 10-5-10-3Z⊙. Our results give new insight into the high-mass end of the initial mass function and its potential variation with galactic and cosmological environments.
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| 19. |
- Taniguchi, Kotomi, et al.
(författare)
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Vibrationally Excited Lines of HC3N Associated with the Molecular Disk around the G24.78+0.08 A1 Hypercompact H ii Region
- 2022
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 931:2
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Tidskriftsartikel (refereegranskat)abstract
- We have analyzed Atacama Large Millimeter/submillimeter Array Band 6 data of the hypercompact H ii region G24.78+0.08 A1 (G24 HC H ii) and report the detection of vibrationally excited lines of HC3N (v (7) = 2, J = 24 - 23). The spatial distribution and kinematics of a vibrationally excited line of HC3N (v (7) = 2, J = 24 - 23, l = 2e) are found to be similar to the CH3CN vibrationally excited line (v (8) = 1), which indicates that the HC3N emission is tracing the disk around the G24 HC H ii region previously identified by the CH3CN lines. We derive the (CH3CN)-C-13/(HCCCN)-C-13 abundance ratios around G24 and compare them to the CH3CN/HC3N abundance ratios in disks around Herbig Ae and T Tauri stars. The (CH3CN)-C-13/(HCCCN)-C-13 ratios around G24 (similar to 3.0-3.5) are higher than the CH3CN/HC3N ratios in the other disks (similar to 0.03-0.11) by more than 1 order of magnitude. The higher CH3CN/HC3N ratios around G24 suggest that the thermal desorption of CH3CN in the hot dense gas and efficient destruction of HC3N in the region irradiated by the strong UV radiation are occurring. Our results indicate that the vibrationally excited HC3N lines can be used as a disk tracer of massive protostars at the HC H ii region stage, and the combination of these nitrile species will provide information of not only chemistry but also physical conditions of the disk structures.
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| 20. |
- Wei, Yongyue, et al.
(författare)
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Epigenetic modifications inlysine demethylases associate with survival of early-stage NSCLC
- 2018
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Ingår i: Clinical Epigenetics. - : Springer Science and Business Media LLC. - 1868-7075 .- 1868-7083. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Background: KDMlysine demethylase family members are related to lung cancer clinical outcomes and are potential biomarkers for chemotherapeutics. However, little is known about epigenetic alterations inKDMgenes and their roles in lung cancer survival.Methods: Tumor tissue samples of 1230 early-stage non-small cell lung cancer (NSCLC) patients were collected from the five independent cohorts. The 393 methylation sites inKDMgenes were extracted from epigenome-wide datasets and analyzed by weighted random forest (Ranger) in discovery phase and validation dataset, respectively. The variable importance scores (VIS) for the sites in top 5% of both discovery and validation sets were carried forward for Cox regression to further evaluate the association with patient's overall survival. TCGA transcriptomic data were used to evaluate the correlation with the corresponding DNA methylation.Results: DNA methylation at sites cg11637544 inKDM2Aand cg26662347 inKDM1Awere in the top 5% of VIS in both discovery phase and validation for squamous cell carcinomas (SCC), which were also significantly associated with SCC survival (HRcg11637544 = 1.32, 95%CI, 1.16-1.50,P = 1.1 × 10-4;HRcg26662347 = 1.88, 95%CI, 1.37-2.60,P = 3.7 × 10-3), and correlated with corresponding gene expression (cg11637544 forKDM2A,P = 1.3 × 10-10; cg26662347 forKDM1A P = 1.5 × 10-5). In addition, by using flexible criteria for Ranger analysis followed by survival classification tree analysis, we identified four clusters for adenocarcinomas and five clusters for squamous cell carcinomas which showed a considerable difference of clinical outcomes with statistical significance.Conclusions: These findings highlight the association between somatic DNA methylation inKDMgenes and early-stage NSCLC patient survival, which may reveal potential epigenetic therapeutic targets.
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| 21. |
- Xu, Duo, et al.
(författare)
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Disk Wind Feedback from High-mass Protostars. III. Synthetic CO Line Emission
- 2024
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Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 966:1
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Tidskriftsartikel (refereegranskat)abstract
- To test theoretical models of massive star formation it is important to compare their predictions with observed systems. To this end, we conduct CO molecular line radiative transfer post-processing of 3D magnetohydrodynamic simulations of various stages in the evolutionary sequence of a massive protostellar core, including its infall envelope and disk wind outflow. Synthetic position-position-velocity cubes of various transitions of 12CO, 13CO, and C18O emission are generated. We also carry out simulated Atacama Large Millimeter/submillimeter Array (ALMA) observations of this emission. We compare the mass, momentum, and kinetic energy estimates obtained from molecular lines to the true values, finding that the mass and momentum estimates can have uncertainties of up to a factor of 4. However, the kinetic energy estimated from molecular lines is more significantly underestimated. Additionally, we compare the mass outflow rate and momentum outflow rate obtained from the synthetic spectra with the true values. Finally, we compare the synthetic spectra with real examples of ALMA-observed protostars and determine the best-fitting protostellar masses and outflow inclination angles. We then calculate the mass outflow rate and momentum outflow rate for these sources, finding that both rates agree with theoretical protostellar evolutionary tracks.
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| 22. |
- Zhang, Ruyang, et al.
(författare)
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EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC
- 2019
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Ingår i: Epigenetics. - : Informa UK Limited. - 1559-2294 .- 1559-2308. ; 14:2, s. 118-129
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Tidskriftsartikel (refereegranskat)abstract
- Hypoxia occurs frequently in human cancers and promotes stabilization and activation of hypoxia inducible factor (HIF). HIF-1α is specific for the hypoxia response, and its degradation mediated by three enzymes EGLN1, EGLN2 and EGLN3. Although EGLNs expression has been found to be related to prognosis of many cancers, few studies examined DNA methylation in EGLNs and its relationship to prognosis of early-stage non-small cell lung cancer (NSCLC). We analyzed EGLNs DNA methylation data from tumor tissue samples of 1,230 early-stage NSCLC patients, as well as gene expression data from The Cancer Genome Atlas. The sliding windows sequential forward feature selection method and weighted random forest were used to screen out the candidate CpG probes in lung adenocarcinomas (LUAD) and lung squamous cell carcinomas patients, respectively, in both discovery and validation phases. Then Cox regression was performed to evaluate the association between DNA methylation and overall survival. Among the 34 CpG probes in EGLNs, DNA methylation at cg25923056EGLN2 was identified to be significantly associated with LUAD survival (HR = 1.02, 95% CI: 1.01–1.03, P = 9.90 × 10–5), and correlated with EGLN2 expression (r =–0.36, P = 1.52 × 10–11). Meanwhile, EGLN2 expression was negatively correlated with HIF1A expression in tumor tissues (r =–0.30, P = 4.78 × 10–8) and significantly (P = 0.037) interacted with HIF1A expression on overall survival. Therefore, DNA methylation of EGLN2- HIF1A is a potential marker for LUAD prognosis and these genes are potential treatment targets for further development of HIF-1α inhibitors in lung cancer therapy.
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| 23. |
- Zhang, Ruyang, et al.
(författare)
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Independent Validation of Early-Stage Non-Small Cell Lung Cancer Prognostic Scores Incorporating Epigenetic and Transcriptional Biomarkers With Gene-Gene Interactions and Main Effects
- 2020
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Ingår i: Chest. - : Elsevier BV. - 0012-3692. ; 158:2, s. 808-819
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Tidskriftsartikel (refereegranskat)abstract
- Background: DNA methylation and gene expression are promising biomarkers of various cancers, including non-small cell lung cancer (NSCLC). Besides the main effects of biomarkers, the progression of complex diseases is also influenced by gene-gene (G×G) interactions. Research Question: Would screening the functional capacity of biomarkers on the basis of main effects or interactions, using multiomics data, improve the accuracy of cancer prognosis? Study Design and Methods: Biomarker screening and model validation were used to construct and validate a prognostic prediction model. NSCLC prognosis-associated biomarkers were identified on the basis of either their main effects or interactions with two types of omics data. A prognostic score incorporating epigenetic and transcriptional biomarkers, as well as clinical information, was independently validated. Results: Twenty-six pairs of biomarkers with G×G interactions and two biomarkers with main effects were significantly associated with NSCLC survival. Compared with a model using clinical information only, the accuracy of the epigenetic and transcriptional biomarker-based prognostic model, measured by area under the receiver operating characteristic curve (AUC), increased by 35.38% (95% CI, 27.09%-42.17%; P = 5.10 × 10–17) and 34.85% (95% CI, 26.33%-41.87%; P = 2.52 × 10–18) for 3- and 5-year survival, respectively, which exhibited a superior predictive ability for NSCLC survival (AUC3 year, 0.88 [95% CI, 0.83-0.93]; and AUC5 year, 0.89 [95% CI, 0.83-0.93]) in an independent Cancer Genome Atlas population. G×G interactions contributed a 65.2% and 91.3% increase in prediction accuracy for 3- and 5-year survival, respectively. Interpretation: The integration of epigenetic and transcriptional biomarkers with main effects and G×G interactions significantly improves the accuracy of prognostic prediction of early-stage NSCLC survival.
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| 24. |
- Zhang, Ruyang, et al.
(författare)
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SIPA1L3 methylation modifies the benefit of smoking cessation on lung adenocarcinoma survival : an epigenomic–smoking interaction analysis
- 2019
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Ingår i: Molecular Oncology. - : Wiley. - 1574-7891 .- 1878-0261. ; 13:5, s. 1235-1248
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Tidskriftsartikel (refereegranskat)abstract
- Smoking cessation prolongs survival and decreases mortality of patients with non-small-cell lung cancer (NSCLC). In addition, epigenetic alterations of some genes are associated with survival. However, potential interactions between smoking cessation and epigenetics have not been assessed. Here, we conducted an epigenome-wide interaction analysis between DNA methylation and smoking cessation on NSCLC survival. We used a two-stage study design to identify DNA methylation–smoking cessation interactions that affect overall survival for early-stage NSCLC. The discovery phase contained NSCLC patients from Harvard, Spain, Norway, and Sweden. A histology-stratified Cox proportional hazards model adjusted for age, sex, clinical stage, and study center was used to test DNA methylation–smoking cessation interaction terms. Interactions with false discovery rate-q ≤ 0.05 were further confirmed in a validation phase using The Cancer Genome Atlas database. Histology-specific interactions were identified by stratification analysis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) patients. We identified one CpG probe (cg02268510 SIPA 1L3 ) that significantly and exclusively modified the effect of smoking cessation on survival in LUAD patients [hazard ratio (HR) interaction = 1.12; 95% confidence interval (CI): 1.07–1.16; P = 4.30 × 10 –7 ]. Further, the effect of smoking cessation on early-stage LUAD survival varied across patients with different methylation levels of cg02268510 SIPA 1L3 . Smoking cessation only benefited LUAD patients with low methylation (HR = 0.53; 95% CI: 0.34–0.82; P = 4.61 × 10 –3 ) rather than medium or high methylation (HR = 1.21; 95% CI: 0.86–1.70; P = 0.266) of cg02268510 SIPA 1L3 . Moreover, there was an antagonistic interaction between elevated methylation of cg02268510 SIPA 1L3 and smoking cessation (HR interaction = 2.1835; 95% CI: 1.27–3.74; P = 4.46 × 10 −3 ). In summary, smoking cessation benefited survival of LUAD patients with low methylation at cg02268510 SIPA 1L3 . The results have implications for not only smoking cessation after diagnosis, but also possible methylation-specific drug targeting.
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| 25. |
- Zhang, Yichen, et al.
(författare)
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An Ordered Envelope-Disk Transition in the Massive Protostellar Source G339.88-1.26
- 2019
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 873:1
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Tidskriftsartikel (refereegranskat)abstract
- We report molecular line observations of the massive protostellar source G339.88-1.26 with the Atacama Large Millimeter/Submillimeter Array. The observations reveal a highly collimated SiO jet extending from the 1.3 mm continuum source, which connects to a slightly wider but still highly collimated CO outflow. Rotational features perpendicular to the outflow axis are detected in various molecular emissions, including SiO, SO 2 , H 2 S, CH 3 OH, and H 2 CO emissions. Based on their spatial distributions and kinematics, we find that they trace different parts of the envelope-disk system. The SiO emission traces the disk and inner envelope in addition to the jet. The CH 3 OH and H 2 CO emissions mostly trace the infalling-rotating envelope and are enhanced around the transition region between envelope and disk, i.e., the centrifugal barrier. The SO 2 and H 2 S emissions are enhanced around the centrifugal barrier and also trace the outer part of the disk. Envelope kinematics are consistent with rotating-infalling motion, while those of the disk are consistent with Keplerian rotation. The radius and velocity of the centrifugal barrier are estimated to be about 530 au and 6 , respectively, leading to a central mass of about 11 M o , consistent with estimates based on spectral energy distribution fitting. These results indicate that an ordered transition from an infalling-rotating envelope to a Keplerian disk through a centrifugal barrier, accompanied by changes of types of molecular line emissions, is a valid description of this massive protostellar source. This implies that at least some massive stars form in a similar way to low-mass stars via core accretion.
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