| 26. |
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| 27. |
- Imbeaux, F., et al.
(author)
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Data structure for the European Integrated Tokamak Modelling Task Force
- 2008
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In: 35th European Physical Society Conference on Plasma Physics, EPS 2008 Combined with the 10th International Workshop on Fast Ignition of Fusion Targets; Hersonissos, Crete; Greece; 9 June 2008 through 13 June 2008. - 9781622763351 ; 32:2, s. 1126-1129
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Conference paper (peer-reviewed)
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| 28. |
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| 29. |
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| 30. |
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| 31. |
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| 32. |
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| 33. |
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| 34. |
- Nowinski, Daniel, 1972-
(author)
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Regulation of Fibroblast Activity by Keratinocytes
- 2005
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Doctoral thesis (other academic/artistic)abstract
- In the healing of cutaneous wounds, paracrine communication between keratinocytes and fibroblasts regulates cell differentiation, proliferation and synthesis of extracellular matrix. Deficient epidermal coverage, as seen in burn-wounds, frequently results in hypertrophic scars. Previous studies suggest that keratinocytes downregulate the production of collagen and profibrotic factors in fibroblasts. We hypothesized that keratinocytes downregulate the expression of the profibrotic factor connective tissue growth factor (CTGF) in fibroblasts, and regulate fibroblast expression of genes important to wound healing. In keratinocyte-fibroblast cocultures, keratinocytes downregulated CTGF mRNA and protein in fibroblasts, through the secretion of interleukin-1 (IL-1) α. Using Affymetrix DNA microarrays, it was demonstrated that factors from keratinocytes regulate the expression of 69 genes important to wound healing. The regulation of 16 of these genes was confirmed by Northern blotting, and IL-1α from keratinocytes regulated all the 16 genes examined. IL-1-mediated CTGF gene regulation was further investigated. Both IL-1 isoforms, α and β, suppressed CTGF expression through an inhibition of CTGF promoter activity. Interestingly, transforming growth factor-β-stimulated Smad phosphorylation was not affected by IL-1. Finally, we hypothesized that CTGF is downregulated in burn wound by split-thickness skin grafting and that the expression of CTGF is suppressed during reepithelialization. The expression of CTGF protein was decreased in successfully skin-grafted wound areas, and increased in open, granulating burn wounds. Moreover, CTGF protein expression was absent beneath the migrating edge of reepithelialization ex vivo. In conclusion, we demonstrate that, in in vitro models, keratinocyte-derived IL-1α regulates the expression of CTGF and other genes with importance to wound healing. Furthermore, it is shown that CTGF expression is suppressed by epidermal wound coverage i burn wounds. These findings may have implications for the understanding of keratinocyte-fibroblast interplay during wound healing and in hypertrophic scar pathogenesis.
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| 35. |
- Ongena, J., et al.
(author)
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Overview of recent results on Heating and Current Drive in JET
- 2007
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In: RADIO FREQUENCY POWER IN PLASMAS. - : AIP. ; , s. 249-256
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Conference paper (peer-reviewed)abstract
- Recent progress on heating and current drive on JET is reported. Topics discussed are: high power coupling of ICRF/LH at ITER relevant antenna/launcher-separatrix distances, succesfull demonstration of 3 dB couplers for ELM tolerance of the ICRF system, influence of ICRF on LH operation, rotation studies in plasma without external momentum with standard and enhanced JET toriodal field ripple, studies of different ICRF heating schemes and of NTM avoidance schemes using Ion Cyclotron Current Drive. A brief outlook on future plans for experiments at JET is given.
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| 36. |
- Sharapov, S. E., et al.
(author)
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Chapter 5 - Burning plasma studies at jet
- 2008
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In: Fusion science and technology. - 1536-1055 .- 1943-7641. ; 53:4, s. 989-1022
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Journal article (peer-reviewed)abstract
- Studies establishing key phenomena and developing diagnostics for energetic particle physics, which are essential for the next step burning plasma experiments such as the International Thermonuclear Experimental Reactor (ITER), have been performed at the Joint European Torus (JET). Experiments have demonstrated clear self-heating of deuterium-tritium (D-T) plasma by alpha particles as a maximum in electron temperature at an optimum mixture of 60 +/- 20% tritium. The change in electron temperature produced by alpha heating, Delta T-e(0) = 1.3 +/- 0.23 keV, was as expected from classical heating, whereas the heating of thermal ions was higher than expected from reference deuterium discharges. Alfven eigenmodes were stable in the highest fusion performance D-T plasmas, in agreement with the modeling. Systematic studies on the existence and properties of Alfven eigenmodes with external antenna driving and detecting Alfven eigenmodes are presented. The formation of fuel ion tails due to alpha-particle knock-on effects is described as derived from neutral particle analyzer and neutron emission spectrometry in D-T experiments. The gamma-ray diagnostics are shown to measure Profiles and energy distribution functions of high-energy ions and alpha particles. Time- and space-resolved gamma-ray images demonstrated for the first time the possibility of measuring several types of energetic ions simultaneously. The novel technique of detecting unstable Alfven eigenmodes with interferometry is found to be superior in detecting core-localized Alfven eigenmodes.
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| 37. |
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| 38. |
- Wahlund, Jan Erik, et al.
(author)
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On the amount of heavy molecular ions in Titan's ionosphere
- 2009
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In: Planetary and Space Science. - : Elsevier BV. - 0032-0633 .- 1873-5088. ; 57:14-15, s. 1857-1865
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Journal article (peer-reviewed)abstract
- We present observational evidence that the ionosphere of Titan below an altitude of 1150 km is a significant source of heavy (> 100 amu) molecular organic species. This study is based on measurements by five instruments (RPWS/LP, RPWS/E, INMS, CAPS/ELS, CAPS/IBS) onboard the Cassini spacecraft during three flybys (T17, T18, T32) of Titan. The ionospheric peaks encountered at altitudes of 950-1300 km had densities in the range 900-3000 cm(-3). Below these peaks the number densities of heavy positively charged ions reached 100-2000 cm(-3) and approached 50-70% of the total ionospheric density with an increasing trend toward lowest measured altitudes. Simultaneously measured negatively charged ion densities were in the range 50-150 cm(-3). These results imply that similar to 10(5)similar to 10(6) heavy positively charged ions/m(3)/s are continuously recombining into heavy neutrals and supply the atmosphere of Titan. The ionosphere may in this way produce 0.1-1 Mt/yr of heavy organic compounds and is therefore a sizable source for aerosol formation. We also predict that Titan's ionosphere is dominated by heavy (> 100 amu) molecular ions below 950 km.
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| 39. |
- Wahlund, J E, et al.
(author)
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Science opportunities with a double Langmuir probe and electric field experiment for JIMO
- 2005
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In: PLANETARY ATMOSPHERES, IONOSPHERES, AND MAGNETOSPHERES. - : Elsevier BV. ; , s. 2110-2119
-
Conference paper (peer-reviewed)abstract
- The three icy Galilean moons of Jupiter: Callisto, Ganymede, and Europa, offer a range of exciting science opportunities for space physics and aeronomy. They all have thin atmospheres with residence times of a few days at most. The surface interactions with the space environment determine the atmospheric and ionospheric properties. The Jupiter Icy Moons Orbiter (JIMO) gives possibilities to investigate the weathering properties of their surfaces and volatile material expelled from their interiors. The atmospheres and the ionized ionospheric components of the Galilean moons (including the volcanic moon Io) interact strongly with the co-rotating magnetosphere of Jupiter. This interaction is dynamic and for example triggers energy transfer processes that give rise to auroral signatures at Jupiter. The icy moon's ionospheres are likewise highly variable in time and estimated peak electron densities vary between 1000 and 20,000 cm(-3) near their surfaces. A particularly interesting interaction occurs between the magnetosphere of Jupiter and the mini-magnetosphere of Ganymede and its ionosphere. A double-Langmuir probe (LP) experiment orbiting the moons at a short distance for several months will give valuable insight into these processes. Foremost the LP measures in situ plasma density and temperatures of the ionospheric components of the moons with high time resolution and thereby provides estimates of key parameters for the dynamical behaviour of surface weathering and magnetospheric influences. In addition many other physical parameters important to the dynamics of these systems can be estimated with such an instrument, like the plasma flow and the DC electric field. Recent results from the LP part of the Radio and Plasma Wave Science (RPWS) on board the Cassini/Huygens spacecraft orbiting Saturn show that an LP works in extended plasma parameter domains with very good science return.
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| 40. |
- Aad, G., et al.
(author)
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The ATLAS Experiment at the CERN Large Hadron Collider
- 2008
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In: Journal of Instrumentation. - 1748-0221. ; 3:S08003
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Research review (peer-reviewed)abstract
- The ATLAS detector as installed in its experimental cavern at point 1 at CERN is described in this paper. A brief overview of the expected performance of the detector when the Large Hadron Collider begins operation is also presented.
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| 41. |
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| 42. |
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| 43. |
- Akkerman, V., et al.
(author)
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Mechanism of fast flame acceleration in cylindrical tubes with obstacles
- 2009
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In: Fall Meeting of the Eastern States Section of the Combustion Institute 2009; College Park; United States; 18 October 2009 through 21 October 2009. - 9781615676682 ; , s. 301-307
-
Conference paper (peer-reviewed)abstract
- The physical mechanism of fast flame acceleration in tubes with obstacles is explained by recognizing that delayed burning between the obstacles creates a powerful jet flow which drives the acceleration. It is demonstrated theoretically and computationally that this mechanism is unlimited in time and independent of the Reynolds number, and it is much stronger and qualitatively different from the classical Shelkin mechanism of flame acceleration due to wall friction. As long as the gas compression is weak, the flame accelerates exponentially, with an enormous acceleration rate. We present formulae describing evolution of the flame tip, as well as its velocity and acceleration rate. Furthermore, it is shown that flames accelerate noticeably stronger in the axisymmetric cylindrical geometry as compared to the planar one.
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| 44. |
- Antzutkin, Oleg, et al.
(author)
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Binding of Aluminium(III)-Citrate Complexes, [Al3(H-1Cit)3(OH)]-4 and [Al3(H-1Cit)3(OH)4]-7, to Alzheimer's A-beta(1-40) Peptides : In situ Atomic Force, Electron Microscopy and Solid State 13C and 27Al NMR Studies
- 2005
-
In: Sixth Keele Meeting on Aluminium. - : Centro de Estudos do Ambiente e Mar, Universidade de Aveiro. ; , s. 16-
-
Conference paper (other academic/artistic)abstract
- It is believed that Alzheimer's disease (AD) amyloid-β-peptide (Aβ) deposits contribute directly to the disease's progressive neurodegeneration. Aggregation cascade for Aβ peptides, its relevance to neurotoxicity in the course of AD, various factors modulating Aβ aggregation kinetics and experimental methods useful for these studies were recently discussed [1]. Al(III), Zn(II), Cu(II) and Fe(III) ions are often colocalized at the center of the core of Alzheimer's amyloid plaques [2] and are suggested to promote aggregation of physiological concentrations of Aβ [3]. It has also been suggested that Al can block calcium permeable putative Aβ-peptide channels in bilayer membranes [4]. Therefore studies of complexation of metal ions with Aβ-oligomers and fibrils are important in the search for the causes of and potential treatments for AD.We studied effects of highly soluble and biologically relevant aluminium(III)-citrate compounds, [Al3(H-1Cit)3(OH)]-4 and [Al3(H-1Cit)3(OH)4]-7, on the fibrillogenesis of Aβ(1-40). All resonances in 156.37 MHz 27Al and 90.52 MHz 13C MAS NMR spectra of powder Al(III)-citrate complexes were assigned. 27Al MAS NMR of dialysed samples of Aβ(1-40) co-incubated with the Al(III)-citrate complexes at different concentrations in TRIS buffer solutions, pH 7.4, shows that Al(III)-citrates bind to Aβ(1-40) as [Al3(H-1Cit)3(OH)]-4 and either accelerate ([Al3(H-1Cit)3(OH)]-4 complex) or retard ([Al3(H-1Cit)3(OH)4]-7 compound) aggregation of Aβ(1-40) as revealed by AFM. [1] ON Antzutkin, Magn. Reson. Chem. 42 (2004) 231; [2] MA Lovell et al., J. Neurol. Sci. 158 (1998) 47; Ch Exley et al., Al and Alzheimer's disease, Ch Exley (Ed)1998) 47; Ch Exley , Ch Exley (Ed) Elsevier Science, 2001, 421; [3] PW Mantyh et al., J. Neurochem. 61 (1993) 1171; [4] N Arispe et al, PNAS 90 (1993) 567.
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| 45. |
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| 46. |
- Bakhtadze, Ekaterine, et al.
(author)
-
Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients
- 2008
-
In: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 51:12, s. 2224-2232
-
Journal article (peer-reviewed)abstract
- Type 1 diabetes in children is characterised by autoimmune destruction of pancreatic beta cells and the presence of certain risk genotypes. In adults the same situation is often referred to as latent autoimmune diabetes in adults (LADA). We tested whether genetic markers associated with type 1 or type 2 diabetes could help to discriminate between autoimmune and non-autoimmune diabetes in young (15-34 years) and middle-aged (40-59 years) diabetic patients. In 1,642 young and 1,619 middle-aged patients we determined: (1) HLA-DQB1 genotypes; (2) PTPN22 and INS variable-number tandem repeat (VNTR) polymorphisms; (3) two single nucleotide polymorphisms (rs7903146 and rs10885406) in the TCF7L2 gene; (4) glutamic acid decarboxylase (GAD) and IA-2-protein tyrosine phosphatase-like protein (IA-2) antibodies; and (5) fasting plasma C-peptide. Frequency of risk genotypes HLA-DQB1 (60% vs 25%, p =9.4x10(-34); 45% vs 18%, p= 1.4x10(-16)), PTPN22 CT/TT (34% vs 26%, p=0.0023; 31% vs 23%, p=0.034), INS VNTR class I/I (69% vs 53%, p=1.3x10(-8); 69% vs 51%, p=8.5x10(-5)) and INS VNTR class IIIA/IIIA (75% vs 63%, p=4.3x10(-6); 73% vs 60%, p=0.008) was increased in young and middle-aged GAD antibodies (GADA)-positive compared with GADA-negative patients. The type 2 diabetes-associated genotypes of TCF7L2 CT/TT of rs7903146 were significantly more common in young GADA-negative than in GADA-positive patients (53% vs 43%; p=0.0004). No such difference was seen in middle-aged patients, in whom the frequency of the CT/TT genotypes of TCF7L2 was similarly increased in GADA-negative and GADA-positive groups (55% vs 56%). Common variants in the TCF7L2 gene help to differentiate young but not middle-aged GADA-positive and GADA-negative diabetic patients, suggesting that young GADA-negative patients have type 2 diabetes and that middle-aged GADA-positive patients are different from their young GADA-positive counterparts and share genetic features with type 2 diabetes.
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| 47. |
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| 48. |
- Baranovskiy, A. E., et al.
(author)
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Electronic structure, bulk and magnetic properties of MB6 and MB12 borides
- 2007
-
In: Journal of Alloys and Compounds. - : Elsevier BV. - 0925-8388 .- 1873-4669. ; 442:1-2, s. 228-230
-
Journal article (peer-reviewed)abstract
- The bulk and magnetic properties of MB6 and MB12 were investigated on the basis of first principles electronic structure calculations. The elastic constants were measured for ZrB12, HoB12, ErB12, TmB12, LuB12, YB6 and LaB6 compounds at low temperatures. The calculated equations of states and balanced crystal orbital overlap populations have allowed to analyse bonding and magnetic properties of MB6 and MB12 .
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| 49. |
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| 50. |
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