| 26. |
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| 29. |
- Mattsson, Sven, et al.
(författare)
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[The pediatrician's approach to bed-wetting. A survey shows that hospital clinics adhere to current recommendations]
- 2003
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Ingår i: Läkartidningen. - 0023-7205. ; 100:26-27, s. 2300-2
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Tidskriftsartikel (refereegranskat)abstract
- On behalf of the Swedish Enuresis Academy a survey how children with primary enuresis nocturna are handled, a questionnaire about investigation and treatment of the condition was sent to all pediatric clinics in Sweden. It was found, that the care of children with enuresis nocturna is initiated at the age of 5-6 years. After a careful history (especially to exclude daytime incontinence problems or signs of bladder dysfunction), a clinical investigation of the child and an urinalysis (dipslide), treatment is started with bedalarm or desmopressin owing to what the child and parents have chosen after having been offered both alternatives. Bedalarm is available at all pediatric clinics, mostly for hire. Follow up is usually performed by telephone by a specialist nurse or urotherapist. Most children with enuresis nocturna are handled at primary care clinics by general practitioners. To complete the survey a similar study in the primary health care system is therefore suggested.
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| 30. |
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| 31. |
- Melander, Arne, 1948-, et al.
(författare)
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Sheet metal forming of ultra high strength steels
- 2009
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Ingår i: Proceedings of The International 3’rd Swedish Production Symposium, SPS’09. - Göteborg. ; , s. 342-347, s. 342-347
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Konferensbidrag (refereegranskat)
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| 32. |
- Melander, Arne, 1948-, et al.
(författare)
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Spring back evaluation for high and ultra high strength sheet steels with the bending under tension machine
- 2015
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Ingår i: International Journal of Material Forming. - : Springer. - 1960-6206 .- 1960-6214. ; 8:1, s. 137-144
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Tidskriftsartikel (refereegranskat)abstract
- The Bending Under Tension (BUT) machine is used for evaluation of spring back in sheet metal forming. A strip is drawn over a rotating cylindrical die with different restraining forces. The strip is allowed to spring back after drawing and the curvature of the strip is measured. The loading sequence is typical to wall sections of pressed components, side wall curl, where the material has been bent, unbent and finally unloaded. The test was performed on four high and ultra high strength steels with tensile strengths in the range from 800 MPa to 1300 MPa. A clear separation of the data for the four steels was demonstrated. It was analysed to what extent the differences in spring back between the different steels was related to the differences in tensile strengths. A finite element simulation model was used to simulate the strip curvature after BUT testing. The material parameters of the model were fitted to monotonic uniaxial and equibiaxial tests and uniaxial cyclic tests. The model could describe the experimental data in a satisfactory way.
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| 37. |
- Nevéus, Tryggve, et al.
(författare)
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Nocturnal enuresis
- 2007. - 2
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Ingår i: Pediatric Urology. - Philadelphia : Saunders Elsevier. - 9781416032045
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 38. |
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| 41. |
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| 43. |
- Stenberg, Arne, et al.
(författare)
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Treatment of vesicoureteral reflux in children using stabilized non-animal hyaluronic acid/dextranomer gel (NASHA/DX) : A long-term observational study
- 2007
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Ingår i: Journal of Pediatric Urology. - : Elsevier BV. - 1477-5131. ; 3:2, s. 80-85
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Vesicoureteral reflux (VUR) can be treated with open surgery, antibiotic therapy or endoscopic injection. A goal in children is to reduce the incidence of febrile urinary tract infections (UTIs). The present long-term observational study investigated outcomes and experiences of endoscopic treatment with stabilized non-animal hyaluronic acid/dextranomer, NASHAtrade mark/Dx. PATIENTS AND METHODS: Children treated with NASHA/Dx between 1993 and 1998 were sent a questionnaire by mail in 2005. Patients included in the study (n=231) had VUR grade III-V before treatment and grade 0-II afterwards. Patients completed 21 questions, with parental assistance if required. The questionnaire assessed clinical outcome, and the attitudes of both patients and their parents to their experiences of treatment with NASHA/Dx gel. Patients reporting UTI after treatment were contacted and their records analyzed. RESULTS: Questionnaires were completed by 179 eligible patients. Most (72%) received a single injection of NASHA/Dx gel, and all experienced febrile UTI before treatment. After treatment, 45 patients (25%) experienced UTI; 25 of these reported fever. Patient records and telephone interviews revealed no evidence of febrile UTI in 19 cases; febrile UTI was confirmed in six cases, an incidence of 3.4%. When asked about the worst aspect of VUR treatment, 9% indicated treatment with NASHA/Dx compared to 19% for medication and 72% for voiding cystourethrogram (VCUG); parent-rated responses were 19%, 24% and 57%, respectively. CONCLUSIONS: Endoscopic treatment with NASHA/Dx gel was associated with a low number of febrile UTIs following treatment, viewed positively and considered less bothersome than medication or VCUG. These findings support this treatment as a primary intervention for VUR.
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| 44. |
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| 45. |
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| 46. |
- Stenberg, Simon, et al.
(författare)
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Control of mitochondrial superoxide production includes programmed mtDNA deletion and restoration
- 2020
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Deletion of mitochondrial DNA in eukaryotes is mainly attributed to rare accidental events associated with mitochondrial replication or repair of double-strand breaks. We report the discovery that yeast cells arrest harmful intramitochondrial superoxide production by shutting down respiration through genetically controlled deletion of mitochondrial oxidative phosphorylation genes. We show that the regulatory circuitry underlying this editing critically involves the antioxidant enzyme superoxide dismutase 2 and two-way mitochondrial-nuclear communication. While mitochondrial DNA homeostasis is rapidly restored after cessation of a short-term superoxide stress, long-term stress causes maladaptive persistence of the deletion process, leading to complete annihilation of the cellular pool of intact mitochondrial genomes and irrevocable loss of respiratory ability. Our results may therefore be of etiological as well as therapeutic importance with regard to age-related mitochondrial impairment and disease.One-Sentence SummaryGenetically controlled editing of mitochondrial DNA is an integral part of the yeast’s defenses against oxidative damage.
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| 47. |
- Stenberg, Simon, et al.
(författare)
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Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation
- 2022
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Ingår i: eLife. - : eLife Sciences Publications, Ltd. - 2050-084X. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Deletion of mitochondrial DNA in eukaryotes is currently attributed to rare accidental events associated with mitochondrial replication or repair of double-strand breaks. We report the discovery that yeast cells arrest harmful intramitochondrial superoxide production by shutting down respiration through genetically controlled deletion of mitochondrial oxidative phosphorylation genes. We show that this process critically involves the antioxidant enzyme superoxide dismutase 2 and two-way mitochondrial-nuclear communication through Rtg2 and Rtg3. While mitochondrial DNA homeostasis is rapidly restored after cessation of a short-term superoxide stress, long-term stress causes maladaptive persistence of the deletion process, leading to complete annihilation of the cellular pool of intact mitochondrial genomes and irrevocable loss of respiratory ability. This shows that oxidative stress-induced mitochondrial impairment may be under strict regulatory control. If the results extend to human cells, the results may prove to be of etiological as well as therapeutic importance with regard to age-related mitochondrial impairment and disease.
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| 48. |
- Stenberg, Simon, et al.
(författare)
-
Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation.
- 2022
-
Ingår i: eLife. - 2050-084X. ; 11
-
Tidskriftsartikel (refereegranskat)abstract
- Deletion of mitochondrial DNA in eukaryotes is currently attributed to rare accidental events associated with mitochondrial replication or repair of double-strand breaks. We report the discovery that yeast cells arrest harmful intramitochondrial superoxide production by shutting down respiration through genetically controlled deletion of mitochondrial oxidative phosphorylation genes. We show that this process critically involves the antioxidant enzyme superoxide dismutase 2 and two-way mitochondrial-nuclear communication through Rtg2 and Rtg3. While mitochondrial DNA homeostasis is rapidly restored after cessation of a short-term superoxide stress, long-term stress causes maladaptive persistence of the deletion process, leading to complete annihilation of the cellular pool of intact mitochondrial genomes and irrevocable loss of respiratory ability. This shows that oxidative stress-induced mitochondrial impairment may be under strict regulatory control. If the results extend to human cells, the results may prove to be of etiological as well as therapeutic importance with regard to age-related mitochondrial impairment and disease.
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| 49. |
- Stenberg, Åsa, et al.
(författare)
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Neutrophil apoptosis is associated with loss of signal regulatory protein alpha (SIRP alpha) from the cell surface
- 2013
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Ingår i: Journal of Leukocyte Biology. - : Oxford University Press (OUP). - 0741-5400 .- 1938-3673. ; 93:3, s. 403-412
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Tidskriftsartikel (refereegranskat)abstract
- Cells of the innate immune system, including monocytes, macrophages, and neutrophils, play a major role in the development of inflammatory diseases. During inflammation, large numbers of neutrophils are recruited from the blood and subsequently undergo apoptosis, which involves changes in the cell surface expression of a number of receptors. Neutrophils express the Ig superfamily member, SIRP alpha, which is a receptor involved in regulating cell adhesion and migration. As apoptotic neutrophils down-regulate their capacity for adhesion and migration, we here investigated whether neutrophil expression of SIRP alpha was affected during apoptosis. We found that apoptotic neutrophils lost SIRP alpha from their cell surface with kinetics similar to the loss of CD16. The majority of neutrophils with reduced SIRP alpha also expressed PS on their surface, and the loss of the receptor was reduced proportional to the reduction of apoptosis by caspase inhibitors during Fas-induced apoptosis but less so during spontaneous apoptosis. Neutrophil loss of SIRP alpha or CD16 was inhibited by the protease inhibitor TAPI-2, as well as specific inhibitors of MMP3 or -8, suggesting that proteolytic mechanisms were involved. Finally, SIRP alpha was also found on smaller membrane vesicles released from the cells during apoptosis. Our data suggest that neutrophils reduce their SIRP alpha expression during apoptosis, which may be part of the functional down-regulation seen in apoptotic neutrophils. J. Leukoc. Biol. 93: 403-412; 2013.
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