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- Seixas, AAA, et al.
(författare)
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Anxiety disorders and rheumatic Fever: is there an association?
- 2008
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Ingår i: CNS spectrums. - : Cambridge University Press (CUP). - 1092-8529 .- 2165-6509. ; 13:12, s. 1039-
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Tidskriftsartikel (refereegranskat)abstract
- Introduction:Findings suggest that obsessive-compulsive disorder (OCD) and related disorders, referred to as obsessive-compulsive spectrum disorders (OCSDs), are more common in patients with rheumatic fever (RF).Objectives:To determine whether RF or Sydenham's chorea increases the probability of anxiety disorders in the relatives of individuals with RF with and without SC.Methods:This was a case-control family study in which 98 probands and 389 first-degree relatives (FDRs) were assessed using structured psychiatric interviews. A Poisson regression model was used to determine whether the presence of any disorder in one family member influences the rate of disorders in the remaining family members.Results:Generalized anxiety disorder (GAD) occurred more frequently in the FDRs of RF probands than in those of control probands (P=.018). The presence of RF, GAD, or separation anxiety disorder in one family member significantly increased the chance of OCSDs in another member of the family.
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| 3. |
- Maingay, Matthew, et al.
(författare)
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Viral Vector Mediated Overexpression of Human alpha-Synuclein in the Nigrostriatal Dopaminergic Neurons: A New Model for Parkinson's Disease.
- 2005
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Ingår i: CNS Spectrums. - 1092-8529. ; 10:3, s. 235-244
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Forskningsöversikt (refereegranskat)abstract
- Parkinson’s disease is predominantly a dopamine deficiency syndrome, which is produced in the brain by the loss of cells located in a small area in the ventral midbrain called the substantia nigra. Complete unilateral dopamine lesions, based on the administration of toxic substances (ie, 6-hydroxy-dopamine in rats and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice and primates) have been extremely useful in testing strategies of replacement. For example, the functional and biochemical impact of the transplanted ventral mesencephalic dopaminergic progenitors has been characterized to a large extent, using the complete lesion model in rats. Over the last decade, however, studies addressing the ability of neurotrophic factors to protect injured dopamine cells prompted researchers to make available partial and progressive lesion models to allow a window of opportunity to interfere the disease progression. Recent findings relating α-synuclein with Parkinson’s disease pathology have opened new possibilities to develop alternative models based on the overexpression of this protein using recombinant adeno-associated viral vectors, which is valuable not only for helping to better understand its involvement in the disease process, but also to more closely resemble the neurodegeneration found in Parkinson’s disease.
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