| 1. |
- Schael, S, et al.
(författare)
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Precision electroweak measurements on the Z resonance
- 2006
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Ingår i: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
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Forskningsöversikt (refereegranskat)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
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| 6. |
- Markljung, Ellen, et al.
(författare)
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ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth
- 2009
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Ingår i: PLoS biology. - : Public Library of Science (PLoS). - 1544-9173 .- 1545-7885. ; 7:12, s. e1000256-
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Tidskriftsartikel (refereegranskat)abstract
- A single nucleotide substitution in intron 3 of IGF2 in pigs abrogates a binding site for a repressor and leads to a 3-fold up-regulation of IGF2 in skeletal muscle. The mutation has major effects on muscle growth, size of the heart, and fat deposition. Here, we have identified the repressor and find that the protein, named ZBED6, is previously unknown, specific for placental mammals, and derived from an exapted DNA transposon. Silencing of Zbed6 in mouse C2C12 myoblasts affected Igf2 expression, cell proliferation, wound healing, and myotube formation. Chromatin immunoprecipitation (ChIP) sequencing using C2C12 cells identified about 2,500 ZBED6 binding sites in the genome, and the deduced consensus motif gave a perfect match with the established binding site in Igf2. Genes associated with ZBED6 binding sites showed a highly significant enrichment for certain Gene Ontology classifications, including development and transcriptional regulation. The phenotypic effects in mutant pigs and ZBED6-silenced C2C12 myoblasts, the extreme sequence conservation, its nucleolar localization, the broad tissue distribution, and the many target genes with essential biological functions suggest that ZBED6 is an important transcription factor in placental mammals, affecting development, cell proliferation, and growth.
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| 7. |
- Pertl, Leonhard, et al.
(författare)
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Exports and Productivity : Comparable Evidence for 14 Countries
- 2007
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Ingår i: Policy Research Working Papers. - New York : World Bank. - 1813-9450.
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Rapport (refereegranskat)abstract
- The authors use comparable micro level panel data for 14 countries and a set of identically specified empirical models to investigate the relationship between exports and productivity. The overall results are in line with the big picture that is by now familiar from the literature: Exporters are more productive than non-exporters when observed and unobserved heterogeneity are controlled for, and these exporter productivity premia tend to increase with the share of exports in total sales; there is strong evidence in favour of self-selection of more productive firms into export markets, but nearly no evidence in favour of the learning-by-exporting hypothesis. The authors document that the exporter premia differ considerably across countries in identically specified empirical models. In a meta-analysis of their results the authors find that countries that are more open and have more effective government report higher productivity premia. However, the level of development per se does not appear to be an explanation for the observed cross-country differences.
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| 8. |
- Sjögren, Anna-Karin, 1980, et al.
(författare)
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GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer
- 2007
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Ingår i: J Clin Invest. - 0021-9738. ; 117:5, s. 1294-304
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Tidskriftsartikel (refereegranskat)abstract
- Protein geranylgeranyltransferase type I (GGTase-I) is responsible for the posttranslational lipidation of CAAX proteins such as RHOA, RAC1, and cell division cycle 42 (CDC42). Inhibition of GGTase-I has been suggested as a strategy to treat cancer and a host of other diseases. Although several GGTase-I inhibitors (GGTIs) have been synthesized, they have very different properties, and the effects of GGTIs and GGTase-I deficiency are unclear. One concern is that inhibiting GGTase-I might lead to severe toxicity. In this study, we determined the effects of GGTase-I deficiency on cell viability and K-RAS-induced cancer development in mice. Inactivating the gene for the critical beta subunit of GGTase-I eliminated GGTase-I activity, disrupted the actin cytoskeleton, reduced cell migration, and blocked the proliferation of fibroblasts expressing oncogenic K-RAS. Moreover, the absence of GGTase-I activity reduced lung tumor formation, eliminated myeloproliferative phenotypes, and increased survival of mice in which expression of oncogenic K-RAS was switched on in lung cells and myeloid cells. Interestingly, several cell types remained viable in the absence of GGTase-I, and myelopoiesis appeared to function normally. These findings suggest that inhibiting GGTase-I may be a useful strategy to treat K-RAS-induced malignancies.
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| 9. |
- Ahlford, Marianne, et al.
(författare)
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Uppsala Underdogs - A Robot Soccer Project
- 2006
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Rapport (populärvet., debatt m.m.)abstract
- In this paper, we describe the four-legged soccer team Uppsala Underdogs developed by a group of 4th year computer science students at Uppsala University during the fall of 2004. The project is based on the experience from two similar previous projects. This year the emphasis of the project has been on distribution of data and on support for evaluation and reconfiguration of strategies. To support data distribution, a middleware has been developed, which implements a replication algorithm and provides a clean interface for the other software modules (or behaviors). To enable easy reconfiguration of strategies, an automata-based graphical description language has been developed, which can be compiled into code that uses the database and the lower level modules, such as tactics and positioning, to make decisions and control the robot. In addition, a graphical simulator has been developed in which the strategies can be evaluated.
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| 10. |
- Ahlgren, Erik, 1962, et al.
(författare)
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Biokombi Rya - slutrapporter från ingående delprojekt
- 2007
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Inom projektet Biokombi Rya har ett flertal olika forskargrupper samarbetat för att studera system¬effekterna av förgasning av biobränsle ur olika aspekter. Syftet med projektet är att öka kunskapen om biobränsleförgasning i Sverige samt att utreda förutsättningar för att sådana anläggningar ska vara ekonomiskt och miljömässigt intressanta. En referensgrupp har varit kopplad till projektet där förutsättningar, resultat och slutsatser har behandlats.I denna underlagsrapport har slutrapporterna från projektets delprojekt samlats. De beskriver förutsättningar, metodansatser, använda data och resultat utförligt och utgör på så sätt ett viktigt komplement till den mer övergripande beskrivningen i projektets syntesrapport. De delrapporter som ingår har valts för att täcka in samtliga delar av projektet som är av allmänt intresse. Projektresultat som publicerats på annat sätt berörs dock mer kortfattat.Projektet Biokombi Rya har pågått under två år (2005-2006) och drivits av Chalmers EnergiCentrum. Förutom de omfattande analysinsatser som författarna till denna rapport står för, har Avdelningen för kemisk teknologi vid KTH, Siemens Industrial Turbines AB och Göteborg Energi AB bidragit med expertstöd. CIT Industriell Energianalys, med undertecknad som projektledare, har stått för projektledning och koordination.Projektet har finansierats av Energimyndigheten, Göteborg Energis forsknings¬stiftelse samt Göteborg Energi AB.
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| 11. |
- Al-Najjar, Basim, 1954-, et al.
(författare)
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A Model to Describe the Relationships Man–Machine–Maintenance–Economy (MMME)
- 2007
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Ingår i: IMECS 2007. - 9789889867140 ; , s. 2127-2132
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Bokkapitel (refereegranskat)abstract
- In the globalisation spirit, one of the major objectives of companies is how to reduce the production losses cost-effectively for continuously enhancement of competitiveness and profitability. However, this area has been neglected by scientists and not given the attention justified considering its obvious link to company profitability. To fill this gap, better understanding of the relations and interactions between man, machine/production process, maintenance and economy is vital. Also, it is important for identifying and eliminating root causes of the losses. In this paper, we develop a model to describe these interactions using the most relevant factors, such as maintenance organisation, personnel commitment, machine condition and characteristics, and the impact of maintenance performance on production time. The use of the model and its potential benefits are tested using an application example. This example illustrates how the above mentioned factors affect the production time and is thereafter derived to financial results. The result is accordingly a model that can help all producing companies categorise the causes behind losses and identify where losses arise and where to focus their work of continuous cost-effective improvements.
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| 15. |
- Andersson, Charlotta S, et al.
(författare)
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A Mycobacterium tuberculosis ligand-binding Mn/Fe protein reveals a new cofactor in a remodeled R2-protein scaffold
- 2009
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490 .- 0027-8424. ; 106:14, s. 5633-8
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Tidskriftsartikel (refereegranskat)abstract
- Chlamydia trachomatis R2c is the prototype for a recently discovered group of ribonucleotide reductase R2 proteins that use a heterodinuclear Mn/Fe redox cofactor for radical generation and storage. Here, we show that the Mycobacterium tuberculosis protein Rv0233, an R2 homologue and a potential virulence factor, contains the heterodinuclear manganese/iron-carboxylate cofactor but displays a drastic remodeling of the R2 protein scaffold into a ligand-binding oxidase. The first structural characterization of the heterodinuclear cofactor shows that the site is highly specific for manganese and iron in their respective positions despite a symmetric arrangement of coordinating residues. In this protein scaffold, the Mn/Fe cofactor supports potent 2-electron oxidations as revealed by an unprecedented tyrosine-valine crosslink in the active site. This wolf in sheep's clothing defines a distinct functional group among R2 homologues and may represent a structural and functional counterpart of the evolutionary ancestor of R2s and bacterial multicomponent monooxygenases.
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| 16. |
- Andersson, J. Christer, et al.
(författare)
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The Aspo Pillar Stability Experiment : Part II-Rock mass response to coupled excavation-induced and thermal-induced stresses
- 2009
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Ingår i: International Journal of Rock Mechanics And Mining Sciences. - : Elsevier BV. - 1365-1609 .- 1873-4545. ; 46:5, s. 879-895
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Tidskriftsartikel (refereegranskat)abstract
- A 1-m-thick pillar was subject to coupled excavation- and thermal-induced stresses to induce brittle rock mass yielding. The yielding strength of the heterogeneous and fractured rock mass consisting of Aspo diorite was evaluated at eighteen discrete locations using data from the displacement, acoustic emission, and thermal monitoring systems. The average rock mass yielding strength was determined to be 0.59 of the uniaxial compressive strength. The onset of dilation in uniaxial laboratory tests, determined from strain gauge data, was found to occur at approximately 0.45 of the uniaxial compressive strength. It was shown that that the onset of acoustic emission events in situ also occurred when the tangential stress exceeded 0.43 of the uniaxial compressive strength. For sites with absence of in situ data it is recommended that this lower-bound value determined from laboratory data may be used for assessing the in situ rock mass yielding strength. Visual observation and displacement monitoring showed that extent of rock mass yielding is sensitive to small changes in the tangential stress magnitudes. It was determined using three-dimensional modelling that changes in the tangential stress magnitude of approximately 1 MPa was sufficient to cause yielding of the pillar to propagate in what appeared to be intact rock. Observations suggest that without this small stress change yielding of the rock mass would not occur. In other words, there appeared to be a well defined boundary, and if the stresses reached this boundary yielding was observed. However, if stresses were only slightly below this boundary yielding or time-dependant processes were not observed over the monitoring period used in the experiment.
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| 17. |
- Andersson, Jonas, et al.
(författare)
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Interoperabilitet
- 2009
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Effektiv medverkan i expeditionära insatser ställer höga krav på förmågan att samverka med andra nationers förband på alla krigföringsnivåer och inom ett stort antal sakområden. Interoperabilitet betecknar förmågan att utbyta tjänster i syfte att nå gemensam effekt. "Expeditionär förmåga" ställer nya krav på Försvarsmakten avseende interoperabilitet med andra nationer och organisationer.Denna rapport sammanfattar en studie i form av en kunskapsinventering som gjorts inom ramen för FoT temaområde Expeditionär förmåga. Avsikten med rapporten är att sammanställa befintlig kunskap inom området, att skapa en nuläges- och problemområdesbeskrivning samt att ta fram förslag till inriktning för det fortsatta studiearbetet. Studien sammanställer erfarenheter och kunskaper avseende begreppet interoperabilitet utifrån ett flertal infallsvinklar, bland annat kulturella, tekniska och organisatoriska. Inriktningen har legat på källor som har bedömts kunna vara av intresse för att bidra till att höja effekten av svenska expeditionära insatser. Kunskapsinsamlingen har baserats på öppna källor i form av böcker, rapporter, studier, uppsatser och artiklar samt intervjuer med svenska officerare.Rapporten beskriver kortfattat begreppet interoperabilitet med utgångspunkt i befintliga definitioner, sakområden och organisatoriska nivåer. Vidare ges en nulägesbeskrivning som dels redogör för konkreta problem i den operativa verkligheten under insats och övning och dels för ett antal organisationers och nationers forskning och utveckling inom området. I rapporten läggs även vikt på att sammanfatta metoder och ramverk för att validera och mäta interoperabiliteten hos ett förband eller ett tekniskt system. Rapporten avslutas med en diskussion om praktiska vägar till "rätt" interoperabilitet samt slutsatser och rekommendationer för fortsatt studiearbete.
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| 18. |
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| 19. |
- Andersson, Jon Martin, 1976-
(författare)
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Controlling the Formation and Stability of Alumina Phases
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In this work, physical phenomena related to the growth and phase formation of alumina, Al2O3, are investigated by experiments and computer calculations. Alumina finds applications in a wide variety of areas, due to many beneficial properties and several existing crystalline phases. For example, the α and κ phases are widely used as wear-resistant coatings due to their hardness and thermal stability, while, e.g., the metastable γ and θ phases find applications as catalysts or catalyst supports, since their surface energies are low and, hence, they have large surface areas available for catalytic reactions.The metastable phases are involved in transition sequences, which all irreversibly end in the transformation to the stable α phase at about 1050 °C. As a consequence, the metastable aluminas, which can be grown at low temperatures, cannot be used in high temperature applications, since they are destroyed by the transformation into α. In contrast, α-alumina, which is the only thermodynamically stable phase, typically require high growth temperatures (~1000 °C), prohibiting the use of temperature sensitive substrates. Thus, there is a need for increasing the thermal stability of metastable alumina and decreasing the growth temperature of the α phase.In the experimental part of this work, hard and single-phased α-alumina thin films were grown by magnetron sputtering at temperatures down to 280 °C. This dramaticdecrease in growth temperature was achieved by two main factors. Firstly, the nucleation stage of growth was controlled by pre-depositing a chromia “template” layer, which is demonstrated to promote nucleation of α-alumina. Secondly, it is shown that energetic bombardment was needed to sustain growth of the α phase. Energy-resolved mass spectrometry measurements demonstrate that the likely source of energetic bombardment, in the present case, was oxygen ions/atoms originating from the target surface. Overall, these results demonstrate that low-temperature α-alumina growth is possible by controlling both the nucleation step of growth as well as the energetic bombardment of the growing film. In addition, the mass spectrometry studies showed that a large fraction of the deposition flux consisted of AlO molecules, which were sputtered from the target. Since the film is formed by chemical bonding between the depositing species, this observation is important for the fundamental understanding of alumina thin film growth.In the computational part of the work, the effect of additives on the phase stability of α- and θ-alumina was investigated by density functional theory calculations. A systematic study was performed of a large number of substitutional dopants in the alumina lattices. Most tested dopants tended to reverse the stability between α- and θ-alumina; so that, e.g., Modoping made the θ phase energetically favored. Thus, it is possible to stabilize the metastable phases by additives. An important reason for this is the physical size of the dopant ions with respect to the space available within the alumina lattices. For example, large ions induced θ stabilization, while ions only slightly larger than Al, e.g., Co and Cu, gave a slight increase in the relative stability of the α phase. We also studied the stability of some of these compounds with respect to pure alumina and other phases, containing the dopants, with the result that phase separations are energetically favored and will most likely occur at elevated temperatures.
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| 20. |
- Andersson, Jon Martin, et al.
(författare)
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Phase control of Al2O3 thin films grown at low temperatures
- 2006
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Ingår i: Thin Solid Films. - : Elsevier. - 0040-6090 .- 1879-2731. ; 513:1-2, s. 57-59
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Tidskriftsartikel (refereegranskat)abstract
- Low-temperature growth (500 °C) of α-Al2O3 thin films by reactive magnetron sputtering was achieved for the first time. The films were grown onto Cr2O3 nucleation layers and the effects of the total and O2 partial pressures were investigated. At 0.33 Pa total pressure and ≥ 16 mPa O2 partial pressure α-Al2O3 films formed, while at lower O2 pressure or higher total pressure (0.67 Pa), only γ phase was detected in the films (which were all stoichiometric). Based on these results we suggest that α phase formation was promoted by a high energetic bombardment of the growth surface. This implies that the phase content of Al2O3 films can be controlled by controlling the energy of the depositing species. The effect of residual H2O (10− 4 Pa) on the films was also studied, showing no change in phase content and no incorporated H (< 0.1%). Overall, these results are of fundamental importance in the further development of low-temperature Al2O3 growth processes.
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| 21. |
- Andersson, Jeanette, et al.
(författare)
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Results from the Swedish National Screening programme 2005. Sub report 1 Antibiotics, Anti-inflammatory substances and Hormones
- 2006
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Measurements of pharmaceuticals were performed in 179 samples of water, sludge, manure, sediment and biota at background sites, municipal STPs, landfills, hospital effluents and recipient water from STPs. Bioassays of hormone activity were performed for a selected number of water samples. The NSAIDs were the most frequently detected pharmaceuticals and occurred in the highest concentrations. There were large differences in concentrations both between substances and between sampling sites. A regional trend in the STP effluent water could be observed for the NSAIDs and for some antibiotics with increased concentrations in samples originating from the north. No pattern could be seen for the hormones. Estrogenic effects were detected in STP outlets to the aquatic environment while values obtained for androgenicity were in most samples close to or below the detection limit. Based on the risk asessment (MEC/PNEC) risk quotients >1 was obtained for estradiol, estriol, ethinylestradiol and ibuprofen.
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| 25. |
- Andersson, Kristin, 1976, et al.
(författare)
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Generation of restart states for manufacturing systems with discarded workpieces
- 2009
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Ingår i: 2009 IEEE Conference on Automation Science and Engineering, CASE 2009, Bangalore, India. - 9781424445783 ; , s. 191-196
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Konferensbidrag (refereegranskat)abstract
- In earlier work we presented a method for restart of manufacturing systems. After correction of an error, the system resumes normal production by returning to a certain restart state in the control function, and from there reexecutes parts of the work schedule. In the present paper the method is extended to handle also systems where some, but not necessarily all, workpieces are discarded during the error correction preceding the restart. The restart process must then replace the discarded workpieces with new ones. The workpieces that remain in the cell may limit the possibilities of executing certain operations needed to process the new workpieces correctly, thus complicating the restart. Properties of the restart states that guarantee a correct restart are defined, typical situations that make the system impossible to restart are presented, and some suggestions are given for modifications that make the system restartable.
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