| 1. |
- Bergemalm, Daniel, 1977-, et al.
(författare)
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Systemic Inflammation in Preclinical Ulcerative Colitis
- 2021
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Ingår i: Gastroenterology. - : AGA Institute. - 0016-5085 .- 1528-0012. ; 161:5, s. 1526-1539.e9
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Tidskriftsartikel (refereegranskat)abstract
- Background & Aims: Preclinical ulcerative colitis is poorly defined. We aimed to characterize the preclinical systemic inflammation in ulcerative colitis, using a comprehensive set of proteins.Methods: We obtained plasma samples biobanked from individuals who developed ulcerative colitis later in life (n = 72) and matched healthy controls (n = 140) within a population-based screening cohort. We measured 92 proteins related to inflammation using a proximity extension assay. The biologic relevance of these findings was validated in an inception cohort of patients with ulcerative colitis (n = 101) and healthy controls (n = 50). To examine the influence of genetic and environmental factors on these markers, a cohort of healthy twin siblings of patients with ulcerative colitis (n = 41) and matched healthy controls (n = 37) were explored.Results: Six proteins (MMP10, CXCL9, CCL11, SLAMF1, CXCL11 and MCP-1) were up-regulated (P < .05) in preclinical ulcerative colitis compared with controls based on both univariate and multivariable models. Ingenuity Pathway Analyses identified several potential key regulators, including interleukin-1β, tumor necrosis factor, interferon-gamma, oncostatin M, nuclear factor-κB, interleukin-6, and interleukin-4. For validation, we built a multivariable model to predict disease in the inception cohort. The model discriminated treatment-naïve patients with ulcerative colitis from controls with leave-one-out cross-validation (area under the curve = 0.92). Consistently, MMP10, CXCL9, CXCL11, and MCP-1, but not CCL11 and SLAMF1, were significantly up-regulated among the healthy twin siblings, even though their relative abundances seemed higher in incident ulcerative colitis.Conclusions: A set of inflammatory proteins are up-regulated several years before a diagnosis of ulcerative colitis. These proteins were highly predictive of an ulcerative colitis diagnosis, and some seemed to be up-regulated already at exposure to genetic and environmental risk factors.
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| 2. |
- Falk Erhag, Hanna, et al.
(författare)
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Concluding Remarks
- 2022
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Ingår i: A Multidisciplinary Approach to Capability in Age and Ageing. - Chem : Springer. - 9783030780654 ; 18:2, s. 143-144
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- James, Stefan, 1964-, et al.
(författare)
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Bivalirudin Versus Heparin Monotherapy in ST-Segment-Elevation Myocardial Infarction
- 2021
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Ingår i: Circulation. Cardiovascular Interventions. - : Lippincott Williams & Wilkins. - 1941-7640 .- 1941-7632. ; 14:12
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Bivalirudin was not superior to unfractionated heparin in patients with myocardial infarction (MI) treated with percutaneous coronary intervention and no planned use of GPI (glycoprotein IIb/IIIa inhibitors) in contemporary clinical practice of radial access and potent P2Y12-inhibitors in the VALIDATE-SWEDEHEART randomized clinical trial (Bivalirudin Versus Heparin in STEMI and NSTEMI Patients on Modern Antiplatelet Therapy-Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies Registry).METHODS: In this prespecified separately powered subgroup analysis, we included patients with ST-segment-elevation MI undergoing primary percutaneous coronary intervention with the primary composite end point of all-cause death, MI, or major bleeding event within 180 days.RESULTS: Among the 6006 patients enrolled in the trial, 3005 patients with ST-segment-elevation MI were randomized to receive bivalirudin or heparin. The mean age was 66.8 years. According to protocol recommendations, 87% were treated with potent oral P2Y12-inhibitors before start of angiography and radial access was used in 90%. GPI was used in 51 (3.4%) and 74 (4.9%) of patients randomized to receive bivalirudin and heparin, respectively. The primary end point occurred in 12.5% (187 of 1501) and 13.0% (196 of 1504; hazard ratio [HR], 0.95 [95% CI, 0.78-1.17], P=0.64) with consistent results in all major subgroups. All-cause death occurred in 3.9% versus 3.9% (HR, 1.00 [0.70-1.45], P=0.98), MI in 1.7% versus 2.2% (HR, 0.76 [0.45-1.28], P=0.30), major bleeding in 8.3% versus 8.0% (HR, 1.04 [0.81-1.33], P=0.78), and definite stent thrombosis in 0.5% versus 1.3% (HR, 0.42 [0.18-0.96], P=0.04).CONCLUSIONS: In patients with ST-segment-elevation MI undergoing primary percutaneous coronary intervention with radial access and receiving current recommended treatments with potent P2Y12-inhibitors rate of the composite of all-cause death, MI, or major bleeding was not lower in those randomized to receive bivalirudin as compared with heparin.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02311231.
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| 4. |
- Mellqvist, Johan, 1965, et al.
(författare)
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Methane emissions from industrial activities using drones
- 2023
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Innovative drone-based methods have been developed to map and quantify methane leakages from various industrial activities, such as refineries, Liquified Natural Gas (LNG) terminals, landfills, and water treatment facilities. These methods use a high-speed, high-sensitivity laser sensor and were validated through controlled gas releases. They were also compared to a ground-based infrared absorption-based technique. This initiative is supported by the Swedish Governmental Agency for Innovation Systems (Vinnova) and aligns with UN Sustainable Development Goals 9, 11, and 13. The goal is to reduce methane emissions significantly, aiding Sweden in achieving net-zero greenhouse gas emissions by 2045. Accurate measurements enable effective, targeted, and trackable measures to minimize emissions, resulting in a rapid positive climate impact. The project has led to the development of two distinct drone-based methods: the wall approach and the tracer approach. The wall approach measures gas concentrations across the entire cross-section of the plume, whereas the tracer approach measures the ratio of leaking gas to source gas. Depending on the source's size, one approach may be preferred over the other, with the tracer method being more suitable for point sources and the wall approach for larger sources. The custom-designed drone in this project, provided and operated by Gerdes Solution. is equipped with a high-sensitivity laser sensor and has a flight duration of about 12 minutes while carrying a 3 kg payload. This limitation presents a challenge when conducting wall measurements, which require approximately 25 minutes of flight time for the studied sources. Due to the drone's limited flight time, it necessitates landing and battery replacement, which complicates the process and limits the number of repeat measurements. In future endeavors, employing a drone with a longer flight duration would be advantageous. In total, the study detected about 220 kg/h of methane emissions and 3 kg/h of nitrous oxide emissions, equivalent to an emission rate of about 7 tons/h of carbon dioxide. The emissions were dominated by the water treatment plant and landfills, with relatively little coming from the refinery and LNG plant. However, the wall measurements in thus study serve as demonstrations of how the technique can be used and do not provide a comprehensive picture of the actual emissions from the individual sites; this would require more statistical data in terms of repeat measurements and measurement days. It is shown that drone measurements using the new high sensitivity laser is a valuable tool for mapping methane concentrations from various types of industrial sources, which are challenging to investigate today due to diffuse emissions, large dimensions, and complex geometries. The validation studies show that both the wall approach and controlled tracer releases can be used to quantify emissions, achieving an accuracy of up to 10 % for a simple, single, source. However, in the real measurement situation, the wall approach may be difficult to execute due to practical challenges like flying restrictions and the need for spatially dense data that can be interpolated to a homogenous grid and repeated measurements. In several cases, when the drone had to fly relatively close to the plumes, downwind of large buildings in complex and turbulent wind fields, the wall approach yielded large variability in the resulting flux. It is hence evident that the wall approach requires a thorough understanding of the measurement situation, and that repeated measurements are needed, at different distances from the source and in varying wind directions. The tracer approach was therefore preferred choice for obtaining emission rates in this study, although it is challenging to carry out representative tracer releases for larger sources and for cases when the measurements are performed near to the source, and in this case the wall approach is preferred. It was also shown that the drone-based tracer approach is advantageous to the ground based since it is then easier to capture the full plume.
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| 5. |
- Nemati, Nasrin, 1988, et al.
(författare)
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Experimental Investigation of the Effect of Random Packings on Heat Transfer and Particle Segregation in Packed-Fluidized Bed
- 2021
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Ingår i: Industrial & Engineering Chemistry Research. - : American Chemical Society (ACS). - 1520-5045 .- 0888-5885. ; 60:28, s. 10365-10375
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Tidskriftsartikel (refereegranskat)abstract
- The heat transfer coefficient, pressure drop, and vertical segregation in a bubbling fluidized bed reactor containing random packings were investigated. The bed material was silica sand in the size range of 90−400 μm. Experiments were done for bed temperatures ranging from 400 to 900 °C and superficial gas velocities up to 0.411 m/s. Five different types of packings were evaluated: (i) RMSR (25 mm stainless steel thread saddle ring), (ii) Hiflow (25 mm stainless steel pall ring), (iii) RR6 (6 mm ceramic Raschig ring), (iv) RR10 (10 mm ceramic Raschig ring), and (v) ASB (12.7 mm aluminum silicate balls). The RMSR packing showed an increase in the heat transfer coefficient (up to 1243 W/m2 K), as compared to bubbling beds with no packings (up to 1124 W/m2 K). Also, beds with RMSR and Hiflow packings had a lower pressure drop and vertical segregation compared to low void factor packings such as RR6, RR10, and ASB.
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| 6. |
- Svensson, Marika, 1989, et al.
(författare)
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Hybrid Quantum-Classical Heuristic to Solve Large-Scale Integer Linear Programs
- 2023
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Ingår i: Physical Review Applied. - 2331-7019. ; 20:3
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Tidskriftsartikel (refereegranskat)abstract
- We present a method that integrates any quantum algorithm capable of finding solutions to integer linear programs into the branch-and-price algorithm, which is regularly used to solve large-scale integer linear programs with a specific structure. The role of the quantum algorithm is to find integer solutions to subproblems appearing in branch-and-price. Obtaining optimal or near-optimal integer solutions to these subproblems can increase the quality of solutions and reduce the depth and branching factor of the branch-and-price algorithm and hence reduce the overall running time. We investigate the viability of the approach by considering the tail assignment problem and the quantum approximate optimization algorithm (QAOA). Here, the master problem is the optimization problem set partitioning or its decision version exact cover and can be expressed as finding the ground state of an Ising spin glass Hamiltonian. For exact cover, our numerical results indicate that the required algorithm depth decreases with the number of feasible solutions for a given success probability of finding a feasible solution. For set partitioning, on the other hand, we find that for a given success probability of finding the optimal solution, the required algorithm depth can increase with the number of feasible solutions if the Hamiltonian is balanced poorly, which in the worst case is exponential in the problem size. We therefore address the significance of properly balancing the objective and constraint parts of the Hamiltonian. We empirically find that the approach is viable with QAOA if polynomial algorithm depth can be realized on quantum devices.
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| 7. |
- Vikstål, Pontus, 1993, et al.
(författare)
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Applying the Quantum Approximate Optimization Algorithm to the Tail-Assignment Problem
- 2020
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Ingår i: Physical Review Applied. - 2331-7019. ; 14:3
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Tidskriftsartikel (refereegranskat)abstract
- Airlines today are faced with a number of large-scale scheduling problems. One such problem is the tail-assignment problem, which is the task of assigning individual aircraft to a given set of flights, minimizing the overall cost. Each aircraft is identified by the registration number on its tail fin. In this paper, we simulate the quantum approximate optimization algorithm (QAOA) applied to instances of this problem derived from real-world data. The QAOA is a variational hybrid quantum-classical algorithm recently introduced and likely to run on near-term quantum devices. The instances are reduced to fit on quantum devices with 8, 15, and 25 qubits. The reduction procedure leaves only one feasible solution per instance, which allows us to map the tail-assignment problem onto the exact-cover problem. We find that repeated runs of the QAOA identify the feasible solution with close to unit probability for all instances. Furthermore, we observe patterns in the variational parameters such that an interpolation strategy can be employed, which significantly simplifies the classical optimization part of the QAOA. Finally, we empirically find a relation between the connectivity of the problem graph and the single-shot success probability of the algorithm.
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