| 1. |
- Adami, Johanna, et al.
(författare)
-
Smoking and the risk of leukemia, lymphoma, and multiple myeloma (Sweden)
- 1998
-
Ingår i: Cancer Causes and Control. - 0957-5243 .- 1573-7225. ; 9:1, s. 49-56
-
Tidskriftsartikel (refereegranskat)abstract
- While several epidemiologic studies have indicated a link between smoking and the risk of developing hematolymphoproliferative cancers (chiefly leukemias, lymphomas, and multiple myelomas), in particular myeloid leukemia, the role of tobacco in the etiology of these neoplasms remains unclear. To evaluate the potential impact of tobacco use on development of leukemia, lymphoma, and multiple myeloma, we conducted a cohort study of 334,957 Swedish construction workers using prospectively collected exposure-information with complete long-term follow-up. A total of 1,322 incident neoplasms occurred during the study period, 1971-91. We found no significant association between smoking status, number of cigarettes smoked, or duration of smoking and the risk of developing leukemias, lymphomas, or multiple myeloma. There was a suggestion of a positive association between smoking and the risk of developing Hodgkin's disease, although the rate ratios were not significantly elevated, except for young current smokers. No positive dose-risk trends emerged. Our study provides no evidence that smoking bears any major relationship to the occurrence of leukemias, non-Hodgkin's lymphomas, or multiple myeloma.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Rosén, Stefan, et al.
(författare)
-
A multispecific saline-soluble lectin from the parasitic fungus Arthrobotrys oligospora. Similarities in the binding specificities compared with a lectin from the mushroom agaricus bisporus.
- 1996
-
Ingår i: European journal of biochemistry / FEBS. - : Wiley. - 0014-2956 .- 1432-1033. ; 238:3, s. 830-7
-
Tidskriftsartikel (refereegranskat)abstract
- Several fungi can express high levels of saline-soluble and low-molecular-mass lectins that bind to glycoproteins such as fetuin and different mucins but not bind to any monosaccharides. In this paper, we report the binding specificities of such a lectin (designated AOL) isolated from the nematophagous fungus Arthrobotrys oligospora. The results show that AOL is a multispecific lectin that interacts with the following ligands: (a) Several sulfated glycoconjugates including sulfatide, dextran sulfate, and fucoidan. The specificity of this binding was indicated by experiments showing that none of the tested neutral- and sialic-acid-containing glycolipids, chondroitin sulfates B and C, heparin, and polyvinyl sulfate bound to AOL; (b) Phosphatidic acid and phospatidylglycerol, two out of several tested phospholipids. (c) N-linked and O-linked sugar chains bound to intact fetuin. The involvement of such sugar structures was demonstrated by analyzing the binding of AOL to chemically deglycosylated (trifluoromethanesulfonic acid) fetuin. Treating fetuin with O-glycosidase and N-glycosidase indicated that AOL bound to Gal beta GaLNAc alpha-Ser/Thr and to some N-linked complex sugars, respectively. Further assays demonstrated that AOL could interact with several other glycoproteins containing O-linked and/or N-linked sugar chains. The observations that AOL did not bind to free N-linked sugars isolated from fetuin, or to fetuin treated with trypsin or pronase, or to any of the tested neoglycoproteins and glycolipids with neutral- or sialic acid-containing sugars, indicated that the sugar chains need to be bound to an intact peptide backbone to interact with AOL. We have recently shown that the deduced primary structure of AOL has a high similarity to the sequence of a saline-soluble lectin isolated from the mushroom Agaricus bisporus (ABL) (Rosén, S., Kata, M., Persson, Y., Lipniunas, P. H., Wikström, M., van den Hondel, C. A. M. J. J., van den Brink, J. M., Rask, L., Hedén L.-O. and Tunlid, A., see companion paper). It is well known that ABL binds to Gal beta 3GaLNAc alpha-Ser/Thr, and in this paper we demonstrate that ABL binds to sulfatide, phosphatidic acid, phospatidylglycerol, and possibly also to the same N-linked complex sugars as AOL. The above data indicate that AOL and ABL are members of a novel family of fungal lectins sharing similar primary structure and binding properties.
|
|
| 5. |
|
|
| 6. |
- Antoni, Gunnar, et al.
(författare)
-
Synthesis of l-2,4-Diamino[4-11C]butyric acid and its use in some In vitro and In vivo tumour models
- 1997
-
Ingår i: Nuclear Medicine and Biology. - 0969-8051 .- 1872-9614. ; 24:6, s. 595-601
-
Tidskriftsartikel (refereegranskat)abstract
- l-2,4-Diamino[4-11C]butyric acid (DAB) was synthesized by an enzyme catalysed carrier added (0.1 μmol KCN) reaction of hydrogen [11C]cyanide with O-acetyl-l-serine followed by reduction. l-[11C]DAB was obtained with a radiochemical purity higher than 96% and with a decay corrected radiochemical yield of 30–40% within a 32 min reaction time. The enantiomeric excess was 98%. The uptake of l-[11C]DAB was investigated in multicellular aggregates of six different cell lines and animal tumour models. l-[11C]DAB is potentially useful for the assessment of pharmacokinetics of l-DAB in vivo for part of its evaluation as an antitumoural agent, although its use for diagnostic purposes seems limited.
|
|
| 7. |
- Bergström, Anders, 1971, et al.
(författare)
-
Code-Book Driven Glottal Pulse Analysis
- 1989
-
Ingår i: Proc. IEEE Int. Conf. ICASSP-89, Glasgow, Scotland. ; 1, s. 53-56
-
Konferensbidrag (refereegranskat)
|
|
| 8. |
- Bergström, Anders, 1965-
(författare)
-
Einem christlichen und aufgeklärteren Volk angemessen
- 1992
-
Ingår i: Grabgebäude der Deutschen St. Gertruds Gemeinde in Stockholm 1716–1992. - Stockholm : Deutsche St. Gertruds Gemeinde. ; , s. 5-7
-
Bokkapitel (populärvet., debatt m.m.)abstract
- In the Old Town of Stockholm, the main part of a burial complex for the German congregation still exists, constructed at the beginning of the 18th century. Construction work started already in 1716, but work was delayed until mid 1720s, and the building was first completed in 1735, to the design of sculptor Burchardt Precht. The original building complex had the character of a closed courtyard. In the great fire of 1878, however, adjacent parts were destroyed, and the current building represents only one part of the original burial complex.
|
|
| 9. |
|
|
| 10. |
- Bergström, Anders, 1965-
(författare)
-
Flitig Anders Tengbom SARs hedersledamot
- 1998
-
Ingår i: Arkitekttidningen. - Stockholm : Svenska arkitekters riksförbund. - 0004-2005. ; :12, s. 7-7
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Anders Tengbom inledde sin arkitektbana vid KTH hösten 1930, samtidigt som Stockholmsutställningen stängde sina portar. Kontors- och sjukhusprojektering blev Tengboms bidrag till efterkrigstidens stora samhällsbygge. I samarbete med Ralph Erskine och Léonie Geisendorf kom han också att representera den alternativa visionen av Stockholms city, en vision som hävdade det viktiga sambandet mellan Nedre Norrmalm och stadslandskapet kring Strömmen och Norrbro.
|
|
| 11. |
- Bergström, Anders, 1965-
(författare)
-
Från mur till arkitektur : En tolkning av mötet mellan gotik och renässans
- 1998
-
Ingår i: Holland-Belgien 1997. Rapport från en doktorandresa. - Stockholm : Konstvetenskapliga institutionen vid Stockholms universitet. ; , s. 1-9
-
Bokkapitel (refereegranskat)abstract
- Den nordeuropeiska renässansarkitekturen har ibland lite föraktfullt tolkats som en produkt av konstlösa mönsterböcker. Den översvallande brosk- eller beslagsornamentiken kunde vid sekelskiftet 1900 uppfattas som en parallell till "l'art noveau", ett sätt att bygga som det fanns anledning att varna för. Men som en tidig tolkning av renässansen i ett regionalt sammanhang erbjöd dessa byggnader samtidigt ett alternativ till 1800-talets stiltänkande. Genom att förena kunskapen om antiken med den lokala traditionen kunde de också fungera som förebilder för det tidiga 1900-talets arkitektur.
|
|
| 12. |
- Bergström, Anders, 1965-
(författare)
-
"För ett christeligt och mera upplyst folk anständigt"
- 1992
-
Ingår i: Historik över Tyska församlingens gravkor 1716–1992. - Stockholm : Tyska S:ta Gertruds församling. ; , s. 5-7
-
Bokkapitel (populärvet., debatt m.m.)abstract
- I Gamla stan i Stockholm finns ännu huvuddelen bevarad av den gravbyggnad som uppfördes av Tyska församlingen i början av 1700-talet. Anläggningen påbörjades redan 1716 men arbetet avstannade och återupptogs först i mitten av 1720-talet. Slutbesiktningen hölls 1735 i närvaro av bland andra bildhuggaren Burchardt Precht, som stod för utformningen av gravbyggnaden. Anläggningen sträckte sig ursprungligen kring tre av kyrkogårdens sidor och var sammanbyggd med kyrka och församlingshus. Efter den stora tornbranden 1878 revs de anslutande delarna, och den nuvarande byggnaden utgör därför endast en del av den ursprungliga gravanläggningen.
|
|
| 13. |
|
|
| 14. |
- Bergström, Anders, 1965-
(författare)
-
Medresen som byggnadstyp
- 1997
-
Ingår i: Exkursion till Turkiet 1996. - Stockholm : Konstvetenskapliga institutionen vid Stockholms universitet i samarbete med Svenska forskningsinstitutet i Istanbul. ; , s. 25-36
-
Bokkapitel (refereegranskat)
|
|
| 15. |
|
|
| 16. |
- Bergström, Anders, 1965-
(författare)
-
Stadsgestaltning, Liljeholmen
- 1990
-
Ingår i: Arkitektur. - Stockholm : Arkitektur Förlag. - 0004-2021. ; :3, s. 16-17
-
Tidskriftsartikel (populärvet., debatt m.m.)
|
|
| 17. |
|
|
| 18. |
- Bergström, Mats, et al.
(författare)
-
In vivo demonstration of enzyme activity in endocrine pancreatic tumors : decarboxylation of carbon-11-DOPA to carbon-11-dopamine
- 1996
-
Ingår i: Journal of Nuclear Medicine. - 0161-5505 .- 1535-5667. ; 37:1, s. 32-37
-
Tidskriftsartikel (refereegranskat)abstract
- METHODS:We used PET to characterize the uptake and decarboxylation of 11C-L-DOPA in vivo in two patients with endocrine pancreatic tumors: one glucagonoma and one gastrinoma.RESULTS:With L-DOPA labeled with 11C in the beta position, in which the radioactive label follows the molecule through decarboxylation to dopamine, significant uptake was observed in the tumors. With L-DOPA labeled in the carboxyl group, in which the label is rapidly eliminated from the tissue as 11CO2 if decarboxylation takes place, an almost complete lack of uptake is noted.CONCLUSION:This study shows that, using selective position labeling, an in vivo action of enzymatic activity can be observed with PET and that significant decarboxylation occurs in the tested endocrine pancreatic tumors. Also, marked retention of radioactivity occurs after treatment with somatostatin analogs. It is hypothesized that this is a reflection of a reduction of exocytosis which is induced by this treatment.
|
|
| 19. |
- Bergström, Mats, et al.
(författare)
-
PET with [11C]-Metomidate for the Visualization of Adrenocortical Tumors and Discrimination from Other Lesions
- 1999
-
Ingår i: Clinical Positron Imaging. - 1095-0397 .- 1878-5751. ; 2:6, s. 339-
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose:The purpose of the study was to evaluate the potential role of PET with the adrenocortical-specific tracer 11C-metomidate in the characterization of incidentally found adrenal cortical lesions and in adrenocortical carcinomas.Methods:PET with 11C-metomidate was performed in 15 patients with unilateral adrenal mass confirmed by CT (incidentalomas) and in 9 additional patients with adrenocortical cancer. All incidentalomas subsequently underwent surgery, except 2 subjected to biopsy only. These lesions were histopathologically examined and diagnosed as adrenal cortical adenoma (n = 6; 3 nonfunctioning), adrenocortical carcinoma (n = 2) and nodular hyperplasia (n = 1). The remaining were non-cortical lesions including 1 pheochromocytoma, 1 myelolipoma, 2 adrenal cysts, and 2 metastases.Results:All lesions, except 1, with an adrenocortical origin were easily identified due to exceedingly high uptake of 11C-metomidate, whereas the non-cortical lesions showed very low uptake. The 1 false negative was a cancer that at surgery was found to be extensively necrotic. High uptake was also seen in normal adrenal glands. The tracer uptake kinetics indicated trapping of the tracer in the cortical lesions. For quantitative evaluation of tracer binding in individual lesions, the simple SUV concept was found to be equally accurate as more elaborate kinetic analyses.Conclusion:The patients presented and altogether over 40 PET investigations have demonstrated 11C-metomidate to be an attractive tracer for the characterization of adrenal masses with the ability to discriminate lesions of adrenal cortical origin from non-cortical lesions. Additionally the method allows the assessment of metastases from adrenocortical cancers, and the very high contrast has allowed partial whole-body examinations.
|
|
| 20. |
|
|
| 21. |
- Eriksson, B, et al.
(författare)
-
[PET in neuroendocrine tumors].
- 1998
-
Ingår i: Nordisk Medicin. - 0029-1420. ; 113:9, s. 308-312
-
Tidskriftsartikel (refereegranskat)abstract
- With the radionuclide tracers available today, 50-90 per cent of neuroendocrine tumours of the gastro-intestinal tract can be visualised with PET (positron-emission tomography). PET also enables the effect of tumour treatment to be monitored in terms of biochemical and functional variables, which is not possible with other radiological techniques. Owing to the very good tumour resolution possible with PET, it serves as a complement to other routine methods such as computed tomography and ultrasonography, and can be used to screen the chest and abdomen for small primary tumours that can not be detected with other methods. In several pre-operative trials PET has been shown to demonstrate more changes in the pancreas and liver than was possible with other methods. In the near future it will be possible to demonstrate the presence of and quantify growth factor receptors, hormones, enzymes, DNA synthesis, mRNA synthesis and protein synthesis. Access to these tumour biological data will be of crucial importance to the individualisation of treatment.
|
|
| 22. |
- Eriksson, Barbro, et al.
(författare)
-
Positron emission tomography in neuroendocrine tumours
- 1999
-
Ingår i: The Italian Journal of Gastroenterology and Hepatology. - 1125-8055. ; Suppl 2, s. S167-S171
-
Tidskriftsartikel (refereegranskat)abstract
- Positron emission tomography is an in vivo tracer and imaging technique that utilizes short-lived positron emitting radionuclides (11C, 15O, 13N, 18F) with half-lives ranging between 2 min and 2 hours. These radionuclides are interesting from the labelling viewpoint since they are natural constituents of most biologically active compounds. The short half-life is an advantage with regard to the irradiation dose to the patient but it is also a limitation since it requires the production of these radionuclides in close vicinity to the positron emission tomography camera.
|
|
| 23. |
- Eriksson, Barbro, et al.
(författare)
-
Positron emission tomography (PET) in neuroendocrine gastrointestinal tumors
- 1993
-
Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 32:2, s. 189-196
-
Tidskriftsartikel (refereegranskat)abstract
- Positron emission tomography (PET) makes it possible to study effects of medical treatment in vivo. Carcinoid tumors with liver metastases, especially those of midgut origin, produce serotonin via the precursors tryptophan and 5-hydroxytryptophan (5-HTP) and this overproduction contributes to the clinical symptoms of the carcinoid syndrome. Seven patients with histopathologically verified neuroendocrine tumors and liver metastases, five of whom with ileal carcinoids, one a lung carcinoid and one an endocrine pancreatic tumor, were included in the study. All patients had elevation of urinary 5-HIAA with the exception of one patient with a solitary liver metastasis of midgut origin. After an intravenous injection of 11C-5-HTP, PET was performed and the uptake of radioactivity in tumor tissue, normal liver and plasma were compared. All patients with elevated urinary 5-HIAA and also the patient with a solitary liver metastasis and normal urinary 5-HIAA had high accumulation and signs of a high rate of binding of 5-HTP in the liver metastases. The uptake was relatively homogeneous in midgut carcinoid liver metastases but in large necrotic metastases the radioactivity was localized to the periphery. In three patients PET examination was repeated after 3 months of interferon treatment and in agreement with circulating tumor markers and ultrasonography the uptake of 5-HTP was unchanged. Another patient who received the somatostatin analog somatuline progressed on treatment and accordingly the uptake of 5-HTP also increased. The experience with PET in neuroendocrine gastrointestinal tumors is very limited. Our results so far indicate that 5-HTP can be used to visualize serotonin-producing neuroendocrine tumors and furthermore it might prove to be of value to monitor the effects of treatment, possibly also as an early predictive test of the outcome of treatment.
|
|
| 24. |
- Fernell, Elisabeth, 1948, et al.
(författare)
-
Possible effects of tetrahydrobiopterin treatment in six children with autism--clinical and positron emission tomography data: a pilot study.
- 1997
-
Ingår i: Developmental Medicine and Child Neurology. - 0012-1622. ; 39:5, s. 313-318
-
Tidskriftsartikel (refereegranskat)abstract
- Six children, between 3 and 5 years of age, having infantile autism according to DSM-III-R, were treated for 3 months with 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-BH4), a cofactor for tyrosine hydroxylases in the biosynthetic pathway of catecholamines and serotonin. A criterion for inclusion in the study was a relatively low level of R-BH4 in the cerebrospinal fluid. For clinical evaluation, the Parental Satisfaction Survey (PASS) was used every fourth week and the Griffiths Developmental Scales were used before starting and 3 months after completing the treatment. During the treatment period, all parents reported improvements in the child's social functioning-mainly eye contact and desire to interact-and in the number of words or sounds which the child used. Small positive changes were noted on the Griffiths Developmental Scales between the two testing occasions. R-BH4 levels in CSF increased significantly after treatment. The positron emission tomography (PET) study showed that the high value of dopamine D2 receptor binding in the caudate and putamen decreased by about 10% towards the normal level after treatment with R-BH4. The observations in this open study indicate that the drug might be useful for a subgroup of children with autism, but there is a need for a larger double-blind study with a longer treatment period.
|
|
| 25. |
- Galanti, M. Rosaria, et al.
(författare)
-
Diet and the risk of papillary and follicular thyroid carcinoma : A population-based case-control study in Sweden and Norway
- 1997
-
Ingår i: Cancer Causes and Control. - 0957-5243 .- 1573-7225. ; 8:2, s. 205-214
-
Tidskriftsartikel (refereegranskat)abstract
- A population-based case-control study was conducted in two regions of Sweden and Norway to investigate the association between dietary habits and the risk of thyroid cancer. The consumption of selected foods was reported in a self-completed food-frequency questionnaire by 246 cases with histologically confirmed papillary (n = 209) and follicular (n = 37) thyroid carcinoma, and 440 age- and gender-matched controls. Odds ratios (OR) and their 95 percent confidence interval (CI) were calculated as estimates of the relative risk using conditional logistic regression. High consumption of butter (OR = 1.6, CI = 1.1-2.5) and cheese (OR = 1.5, CI = 1.0-2.4) was associated with increased risks. Residence in areas of endemic goiter in Sweden was associated with an elevated risk, especially among women (OR = 2.5, CI = 1.3-4.9). High consumption of cruciferous vegetables was associated with increased risk only in persons who ever lived in such areas. A decreased risk was associated with consumption of iodized salt in northern Norway, and with use of iodized salt during adolescence among women (OR = 0.6, CI = 0.6-1.0). The results of this study suggest a role of diet and environment in the risk of thyroid cancer.
|
|
