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Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

Wain, Louise V (author)
Shrine, Nick (author)
Artigas, María Soler (author)
show more...
Erzurumluoglu, A Mesut (author)
Noyvert, Boris (author)
Bossini-Castillo, Lara (author)
Obeidat, Ma'en (author)
Henry, Amanda P (author)
Portelli, Michael A (author)
Hall, Robert J (author)
Billington, Charlotte K (author)
Rimington, Tracy L (author)
Fenech, Anthony G (author)
John, Catherine (author)
Blake, Tineka (author)
Jackson, Victoria E (author)
Allen, Richard J (author)
Prins, Bram P (author)
Campbell, Archie (author)
Porteous, David J (author)
Jarvelin, Marjo-Riitta (author)
Wielscher, Matthias (author)
James, Alan L (author)
Hui, Jennie (author)
Wareham, Nicholas J (author)
Zhao, Jing Hua (author)
Wilson, James F (author)
Joshi, Peter K (author)
Stubbe, Beate (author)
Rawal, Rajesh (author)
Schulz, Holger (author)
Imboden, Medea (author)
Probst-Hensch, Nicole M (author)
Karrasch, Stefan (author)
Gieger, Christian (author)
Deary, Ian J (author)
Harris, Sarah E (author)
Marten, Jonathan (author)
Rudan, Igor (author)
Enroth, Stefan (author)
Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
Gyllensten, Ulf B. (author)
Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
Kerr, Shona M (author)
Polasek, Ozren (author)
Kähönen, Mika (author)
Surakka, Ida (author)
Vitart, Veronique (author)
Hayward, Caroline (author)
Lehtimäki, Terho (author)
Raitakari, Olli T (author)
Evans, David M (author)
Henderson, A John (author)
Pennell, Craig E (author)
Wang, Carol A (author)
Sly, Peter D (author)
Wan, Emily S (author)
Busch, Robert (author)
Hobbs, Brian D (author)
Litonjua, Augusto A (author)
Sparrow, David W (author)
Gulsvik, Amund (author)
Bakke, Per S (author)
Crapo, James D (author)
Beaty, Terri H (author)
Hansel, Nadia N (author)
Mathias, Rasika A (author)
Ruczinski, Ingo (author)
Barnes, Kathleen C (author)
Bossé, Yohan (author)
Joubert, Philippe (author)
van den Berge, Maarten (author)
Brandsma, Corry-Anke (author)
Paré, Peter D (author)
Sin, Don D (author)
Nickle, David C (author)
Hao, Ke (author)
Gottesman, Omri (author)
Dewey, Frederick E (author)
Bruse, Shannon E (author)
Carey, David J (author)
Kirchner, H Lester (author)
Jonsson, Stefan (author)
Thorleifsson, Gudmar (author)
Jonsdottir, Ingileif (author)
Gislason, Thorarinn (author)
Stefansson, Kari (author)
Schurmann, Claudia (author)
Nadkarni, Girish (author)
Bottinger, Erwin P (author)
Loos, Ruth J F (author)
Walters, Robin G (author)
Chen, Zhengming (author)
Millwood, Iona Y (author)
Vaucher, Julien (author)
Kurmi, Om P (author)
Li, Liming (author)
Hansell, Anna L (author)
Brightling, Chris (author)
Zeggini, Eleftheria (author)
Cho, Michael H (author)
Silverman, Edwin K (author)
Sayers, Ian (author)
Trynka, Gosia (author)
Morris, Andrew P (author)
Strachan, David P (author)
Hall, Ian P (author)
Tobin, Martin D (author)
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 (creator_code:org_t)
2017-02-06
2017
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:3, s. 416-425
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (∼6 alleles) (95% confidence interval) = 1.24 (1.20-1.27), P = 5.05 × 10(-49)), and we observed a 3.7-fold difference in COPD risk between individuals in the highest and lowest genetic risk score deciles in UK Biobank. The 97 signals show enrichment in genes for development, elastic fibers and epigenetic regulation pathways. We highlight targets for drugs and compounds in development for COPD and asthma (genes in the inositol phosphate metabolism pathway and CHRM3) and describe targets for potential drug repositioning from other clinical indications.

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By the author/editor
Wain, Louise V
Shrine, Nick
Artigas, María S ...
Erzurumluoglu, A ...
Noyvert, Boris
Bossini-Castillo ...
show more...
Obeidat, Ma'en
Henry, Amanda P
Portelli, Michae ...
Hall, Robert J
Billington, Char ...
Rimington, Tracy ...
Fenech, Anthony ...
John, Catherine
Blake, Tineka
Jackson, Victori ...
Allen, Richard J
Prins, Bram P
Campbell, Archie
Porteous, David ...
Jarvelin, Marjo- ...
Wielscher, Matth ...
James, Alan L
Hui, Jennie
Wareham, Nichola ...
Zhao, Jing Hua
Wilson, James F
Joshi, Peter K
Stubbe, Beate
Rawal, Rajesh
Schulz, Holger
Imboden, Medea
Probst-Hensch, N ...
Karrasch, Stefan
Gieger, Christia ...
Deary, Ian J
Harris, Sarah E
Marten, Jonathan
Rudan, Igor
Enroth, Stefan
Gyllensten, Ulf ...
Kerr, Shona M
Polasek, Ozren
Kähönen, Mika
Surakka, Ida
Vitart, Veroniqu ...
Hayward, Carolin ...
Lehtimäki, Terho
Raitakari, Olli ...
Evans, David M
Henderson, A Joh ...
Pennell, Craig E
Wang, Carol A
Sly, Peter D
Wan, Emily S
Busch, Robert
Hobbs, Brian D
Litonjua, August ...
Sparrow, David W
Gulsvik, Amund
Bakke, Per S
Crapo, James D
Beaty, Terri H
Hansel, Nadia N
Mathias, Rasika ...
Ruczinski, Ingo
Barnes, Kathleen ...
Bossé, Yohan
Joubert, Philipp ...
van den Berge, M ...
Brandsma, Corry- ...
Paré, Peter D
Sin, Don D
Nickle, David C
Hao, Ke
Gottesman, Omri
Dewey, Frederick ...
Bruse, Shannon E
Carey, David J
Kirchner, H Lest ...
Jonsson, Stefan
Thorleifsson, Gu ...
Jonsdottir, Ingi ...
Gislason, Thorar ...
Stefansson, Kari
Schurmann, Claud ...
Nadkarni, Girish
Bottinger, Erwin ...
Loos, Ruth J F
Walters, Robin G
Chen, Zhengming
Millwood, Iona Y
Vaucher, Julien
Kurmi, Om P
Li, Liming
Hansell, Anna L
Brightling, Chri ...
Zeggini, Elefthe ...
Cho, Michael H
Silverman, Edwin ...
Sayers, Ian
Trynka, Gosia
Morris, Andrew P
Strachan, David ...
Hall, Ian P
Tobin, Martin D
show less...
Articles in the publication
Nature Genetics
By the university
Uppsala University

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