| 1. |
- Berntorp, Erik, et al.
(författare)
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Consensus perspectives on prophylactic therapy for haemophilia: summary statement.
- 2003
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Ingår i: Haemophilia. - : Wiley. - 1351-8216. ; 9:Suppl 1, s. 41278-41278
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Tidskriftsartikel (refereegranskat)abstract
- Participants in an international conference on prophylactic therapy for severe haemophilia developed a consensus summary of the findings and conclusions of the conference. In the consensus, participants agreed upon revised definitions for primary and secondary prophylaxis and also made recommendations concerning the need for an international system of pharmacovigilance. Considerations on starting prophylaxis, monitoring outcomes, and individualizing treatment regimens were discussed. Several research questions were identified as needing further investigation, including when to start and when to stop prophylaxis, optimal dosing and dose interval, and methods for assessment of long-term treatment effects. Such studies should include carefully defined cohorts, validated orthopaedic and quality-of-life assessment instruments, and cost-benefit analyses.
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| 2. |
- Björkman, Leif, et al.
(författare)
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Long-term history of land-use and vegetation at Ire, an agriculturally marginal area in Blekinge, south Sweden
- 2003
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Ingår i: Vegetation History and Archaeobotany. - : Springer Science and Business Media LLC. - 0939-6314 .- 1617-6278. ; 12:1, s. 61-74
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Tidskriftsartikel (refereegranskat)abstract
- Pollen records from a small lake and a small peatland at Ire in northern Blekinge, Sweden, reveal that until A.D. 300 there was a mixed deciduous type of woodland dominated by Quercus, Tilia and Corylus, with Betula, Pinus, Populus, Fraxinus, Ulmus and Acer as important constituents. The first, but weak, signs of human influence on the vegetation are detected around 2300 B.C. At this time, the area was probably used for woodland grazing. The regional expansion of Fagus occurred around 100 B.C.-A.D. 200, and later, at about A.D. 500, woods dominated by Fagus were common in the area. Around A.D. 600-700 an isolated farmstead may have been established in the area, as single pollen grains of Secale (rye) were found. This farmstead may represent the first permanent settlement in the area. A more widespread opening of the vegetation occurred around A.D. 1000, probably as an effect of a more pronounced use of the area, and an expansion of settlements in the region. The openness of the area seems to have peaked around A.D. 1400-1800, and during this period the vegetation was highly fragmented with small stands of woodland, intensively grazed pastures, and arable fields where Secale and Triticum were mainly cultivated. Around A.D. 1600 Fagus pollen percentages sharply decrease, most probably caused by a deliberate and selective felling of beech trees for the production of potash, which consumed enormous amounts of wood. Picea seems to have been established around A.D. 1600, but it did not become a regional dominant until the first part of the 20th century, when land use decreased and it became favoured by forestry.
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| 3. |
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| 4. |
- Fu, Huamei, 1979, et al.
(författare)
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The two neutrophil members of the formylpeptide receptor family activate the NADPH-oxidase through signals that differ in sensitivity to a gelsolin derived phosphoinositide-binding peptide
- 2004
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Ingår i: BMC cell biology. - : Springer Science and Business Media LLC. - 1471-2121. ; 5:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The formylpeptide receptor family members FPR and FPRL1, expressed in myeloid phagocytes, belong to the G-protein coupled seven transmembrane receptor family (GPCRs). They share a high degree of sequence similarity, particularly in the cytoplasmic domains involved in intracellular signaling. The established model of cell activation through GPCRs states that the receptors isomerize from an inactive to an active state upon ligand binding, and this receptor transformation subsequently activates the signal transducing G-protein. Accordingly, the activation of human neutrophil FPR and FPRL1 induces identical, pertussis toxin-sensitive functional responses and a transient increase in intracellular calcium is followed by a secretory response leading to mobilization of receptors from intracellular stores, as well as a release of reactive oxygen metabolites. RESULTS: We report that a cell permeable ten amino acid peptide (PBP10) derived from the phosphatidylinositol 4,5-bisphosphate (PIP2) binding region of gelsolin (an uncapper of actin filaments) blocks granule mobilization as well as secretion of oxygen radicals. The inhibitory effect of PBP10 is, however, receptor specific and affects the FPRL1-, but not the FPR-, induced cellular response. The transient rise in intracellular calcium induced by the active receptors is not affected by PBP10, suggesting that the blockage occurs in a parallel, novel signaling pathway used by FPRL1 to induce oxygen radical production and secretion. Also the FPR can activate neutrophils through a PBP10-sensitive signaling pathway, but this signal is normally blocked by the cytoskeleton. CONCLUSIONS: This study demonstrates that the two very closely related chemoattractant receptors, FPR and FPRL1, use distinct signaling pathways in activation of human neutrophils. The PIP2-binding peptide PBP10 selectively inhibits FPRL1-mediated superoxide production and granule mobilization. Furthermore, the activity of this novel PBP10 sensitive pathway in neutrophils is modulated by the actin cytoskeleton network.
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| 6. |
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| 7. |
- Rosbacke, M., et al.
(författare)
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Evaluation of using absolute versus relative base level when analyzing brain activation images using the scale-space primal sketch
- 2001
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Ingår i: Medical Image Analysis. - 1361-8415 .- 1361-8423. ; 5:2, s. 89-110
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Tidskriftsartikel (refereegranskat)abstract
- A dominant approach to brain mapping is to define functional regions in the brain by analyzing images of brain activation obtained from positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). This paper presents an evaluation of using one such tool, called the scale-space primal sketch, for brain activation analysis. A comparison is made concerning two possible definitions of a significance measure of blob structures in scale-space, where local contrast is measured either relative to a local or global reference level. Experiments on real brain data show that (i) the global approach with absolute base level has a higher degree of correspondence to a traditional statistical method than a local approach with relative base level, and that (ii) the global approach with absolute base level gives a higher significance to small blobs that are superimposed on larger scale structures, whereas the significance of isolated blobs largely remains unaffected. Relative to previously reported works, the following two technical improvements are also presented. (i) A post-processing tool is introduced for merging blobs that are multiple responses to image structures. This simplifies automated analysis from the scale-space primal sketch. (ii) A new approach is introduced for scale-space normalization of the significance measure, by collecting reference statistics of residual noise images obtained from the general Linear model.
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| 8. |
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| 9. |
- Wohlfarth, B, et al.
(författare)
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Unstable early-Holocene climatic and environmental conditions in northwestern Russia derived from a multidisciplinary study of a lake-sediment sequence from Pichozero, southeastern Russian Karelia
- 2004
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Ingår i: The Holocene. - : SAGE Publications. - 0959-6836 .- 1477-0911. ; 14:5, s. 732-746
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Tidskriftsartikel (refereegranskat)abstract
- A sediment core from Lake Pichozero (61degrees46'; N, 37degrees25'; E 118 m a.s.l.) provides information on the environmental and climatic conditions in southeastern Russian Karelia during the Lateglacial and early Holocene (12800-9300 cal. BP). The chronology of the sequence is constrained by varve counting and AMS C-14 measurement of terrestrial plant macrofossils. Multiproxy analyses (magnetic susceptibility, grain size, TOC, TN, TS, Rock Eval, pollen and macrofossils) imply that cold and dry regional climatic conditions with sparse Arctic vegetation prevailed prior to 11500 cal. BP. Coincident with the transition to the Holocene at 11500 cal. BP, air temperatures and lake productivity increased and Betula pubescens and Populus tremula started to migrate into the area, followed by Picea abies at 10750 cal. BP. Although lake productivity decreased at around 11000 cal. BP and remained low until 9600 cal. BP, pollen-based climate reconstructions imply variable climatic conditions in the region over time. Drier and colder summers prevailed from similar to11200 to 10900 cal. BP, followed by an interval of higher annual temperatures and precipitation from 10900 to 10750 cal. BP. Lower annual temperatures and drier conditions existed from 10750 to 10200 cal. BP, and higher temperatures and precipitation are inferred between 10200 and 10000 cal. BP. Finally, declining temperatures and precipitation occurred from 10000 cal. BP onwards, with a minimum at around 9600 cal. BP. These climatic shifts are temporally coincident with those recorded in North Atlantic terrestrial, marine and ice-core archives and indicate that relatively minor climate signals were transmitted further to the east.
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| 10. |
- Zagal, Juan Cristobal, et al.
(författare)
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Signficance determination for the scale-space primal sketch by comparison of statistics of scale-space blob volumes computed from PET signals vs. residual noise
- 2000
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Konferensbidrag (refereegranskat)abstract
- A dominant approach to brain mapping is to define functional regions in the brain by analyzing brain activation images obtained by PET or fMRI. In [1], it has been shown that the scale-space primal sketch provides a useful tool for such analysis. Some attractive properties of this method are that it only makes few assumptions about the data and the process for extracting activations is fully automatic.In the present version of the scale-space primal sketch, however, there is no method for determining p-values. The purpose here is to present a new methodology for addressing this question, by introducing a descriptor referred to as the -curve, which serves as a first step towards determining the probability of false positives, i.e. alpha.
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