| 1. |
- Aguilar, J A, et al.
(författare)
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Transmission of light in deep sea water at the site of the ANTARES neutrino telescope
- 2005
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Ingår i: Astroparticle physics. - : Elsevier. - 0927-6505 .- 1873-2852. ; 23:1, s. 131-155
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Tidskriftsartikel (refereegranskat)abstract
- The ANTARES neutrino telescope is a large photomultiplier array designed to detect neutrino-induced upward-going muons by their Cherenkov radiation. Understanding the absorption and scattering of light in the deep Mediterranean is fundamental to optimising the design and performance of the detector. This paper presents measurements of blue and UV light transmission at the ANTARES site taken between 1997 and 2000. The derived values for the scattering length and the angular distribution of particulate scattering were found to be highly correlated, and results are therefore presented in terms of an absorption length;,ab, and an effective scattering length lambda(sct)(eff). The values for blue (UV) light are found to be lambda(abs) similar or equal to 60(26) m, lambda(sct)(eff similar or equal to) 265(122) m, with significant (similar to15%) time variability. Finally, the results of ANTARES simulations showing the effect of these water properties on the anticipated performance of the detector are presented. (C) 2004 Elsevier B.V. All rights reserved.
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| 2. |
- De Silva, G. M., et al.
(författare)
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Chemical homogeneity in collinder 261 and implications for chemical tagging
- 2007
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Ingår i: Astronomical Journal. - : American Astronomical Society. - 0004-6256 .- 1538-3881. ; 133:3, s. 1161-1175
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents abundances for 12 red giants of the old open cluster Collinder 261 based on spectra from the Very Large Telescope UVES. Abundances were derived for Na, Mg, Si, Ca, Mn, Fe, Ni, Zr, and Ba. We find that the cluster has a solar-level metallicity of [Fe/H] = -0.03 dex. However, most alpha- and s-process elements were found to be enhanced. The star-to-star scatter was consistent with the expected measurement uncertainty for all elements. The observed rms scatter is as follows: Na = 0.07, Mg = 0.05, Si = 0.06, Ca = 0.05, Mn = 0.03, Fe = 0.02, Ni = 0.04, Zr = 0.12, and Ba = 0.03 dex. The intrinsic scatter was estimated to be less than 0.05 dex. Such high levels of homogeneity indicate that chemical information remains preserved in this old open cluster. We use the chemical homogeneity we have now established in Cr 261, the Hyades, and the HR 1614 moving group to examine the uniqueness of the individual cluster abundance patterns, i.e., chemical signatures. We demonstrate that the three studied clusters have unique chemical signatures and discuss how other such signatures may be searched for in the future. Our findings support the prospect of chemically tagging disk stars to common formation sites in order to unravel the dissipative history of the Galactic disk.
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| 3. |
- Steinmuller, S. J., et al.
(författare)
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Effect of substrate roughness on the magnetic properties of thin fcc Co films
- 2007
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 76:5, s. 054429-
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Tidskriftsartikel (refereegranskat)abstract
- We present a study of the influence of substrate roughness on the magnetic properties of thin fcc Co films (7 and 17 nm thick) grown on Cu(001)/Si(001). A significant decrease in cubic anisotropy with increasing film roughness was observed with Brillouin light scattering and magneto-optical Kerr effect magnetometry. In addition, the rougher samples showed a substantial broadening of the spin wave peaks. Both effects were found to be more pronounced for the thinner Co layers. Our observations are discussed in the framework of a theoretical model which takes into account the morphology of the Co films as measured by atomic force microscopy. While roughness effects are usually discussed in the context of Néel's "orange-peel" model, we propose a qualitatively different effect in this work whereby the magnetization follows coherently the substrate morphology ("undulating" state) resulting in the absence of magnetic surface charges. This magnetic configuration gives rise to a reduction in the magnetic anisotropy of epitaxial thin films, which is in good qualitative agreement with the experimental observations.
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| 4. |
- Steinmuller, S. J., et al.
(författare)
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Influence of substrate roughness on the magnetic properties of thin fcc Co films
- 2007
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Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 101:9, s. 09D113-
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Tidskriftsartikel (refereegranskat)abstract
- We present a study of the influence of substrate roughness on the magnetic properties of thin fcc Co films (7 and 17 nm thick) grown on Cu (001) Si (001). A significant decrease in cubic anisotropy with increasing film roughness was observed with Brillouin light scattering. In addition, the rougher samples exhibited a substantial broadening of the spin wave peaks. Both effects were found to be more pronounced for the thinner Co layers. We propose a magnetic configuration with the magnetization following coherently the substrate morphology ("undulating" state) resulting in the absence of magnetic surface charges. This configuration gives rise to a reduction in the magnetic anisotropy of epitaxial thin films, in good qualitative agreement with the experimental observations.
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| 5. |
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| 6. |
- Hertel, N T, et al.
(författare)
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Growth hormone treatment in 35 prepubertal children with achondroplasia: A five-year dose-response trial
- 2005
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Ingår i: Acta Pædiatrica. - : Wiley. - 1651-2227 .- 0803-5253. ; 94:10, s. 1402-1410
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Tidskriftsartikel (refereegranskat)abstract
- Background: Achondroplasia is a skeletal dysplasia with extreme, disproportionate, short stature. Aim: In a 5-y growth hormone (GH) treatment study including 1 y without treatment, we investigated growth and body proportion response in 35 children with achondroplasia. Methods: Patients were randomized to either 0.1 IU/kg (n=18) or 0.2 IU/kg (n=17) per day. GH treatment was interrupted for 12 mo after 2 y of treatment in prepubertal patients to study catch-down growth. Mean height SDS (HSDS) at start was -5.6 and -5.2 for the low- and high-dose groups, respectively, and mean age 7.3 and 6.6 y. Results: Mean growth velocity (baseline 4.5/4.6 cm/y for the groups) increased significantly by 1.9/3.6 cm/y during the first year and by 0.5/1.5 cm/y during the second year. During the third year, a decrease of growth velocity was observed at 1.9/1.3 cm/y below baseline values. HSDS increased significantly by 0.6/0.8 during the first year of treatment and in total by 1.3/1.6 during the 5 y of study. Sitting height SDS improved significantly from -2.1/-1.7 to -0.8/0.2 during the study. Body proportion (sitting height/total height) or arm span did not show any significant change. Conclusion: GH treatment of children with achondroplasia improves height during 4 y of therapy without adverse effect on trunk-leg disproportion. The short-term effect is comparable to that reported in Turner and Noonan syndrome and in idiopathic short stature.
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| 7. |
- Probert, Christopher S J, et al.
(författare)
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The effect of weaning on the clonality of alpha beta T-cell receptor T cells in the intestine of GF and SPF mice.
- 2007
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Ingår i: Developmental and comparative immunology. - : Elsevier BV. - 0145-305X. ; 31:6, s. 606-17
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Tidskriftsartikel (refereegranskat)abstract
- In humans, intestinal antigen exposure during neonatal life influences the T-cell receptor (TCR) repertoire. To define the relative effects of bacteria and food antigens in early life, we examined TCR diversity in the intestine of SPF and GF mice. TCR repertoire was assessed at a single time point pre-, peri- and post-weaning in the small and large intestine of SPF and GF mice using spectratyping and/or TCR-beta-chain sequencing. There was good concordance of data obtained by the two techniques. In SPF mice, the repertoire was polyclonal shortly after birth in the small and large intestine. After weaning, there was a significant change towards an oligoclonal repertoire in the small intestine. There was some evidence that specific clones were shared between the small and large intestine. In contrast, in GF mice, the repertoire was oligoclonal after birth, and remained restricted. These data show: firstly, that under SPF conditions, the intestine is seeded with a diverse T-cell population that becomes oligoclonal around the time of weaning; secondly, that GF mice were oligoclonal at each time point.
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| 8. |
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| 9. |
- Williams, Amanda M, et al.
(författare)
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Effects of microflora on the neonatal development of gut mucosal T cells and myeloid cells in the mouse.
- 2006
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Ingår i: Immunology. - : Wiley. - 0019-2805 .- 1365-2567. ; 119:4, s. 470-8
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Tidskriftsartikel (refereegranskat)abstract
- Colonization with commensal flora in very early life may profoundly influence intestinal lymphoid development and bias later immune responses. We defined gut-homing T cell phenotypes and the influence of flora on intestinal immune development in mice. Intestinal T cells were phenotyped and quantified in conventional (CV), germfree (GF) and conventionalized germfree (GF/CV) neonatal mice by immunohistochemistry. Mucosal adressin cell adhesion molecule 1 (MAdCAM-1) was expressed by mucosal vessels at birth in CV and GF mice and was more prevalent in CV than GF small intestine, but was distributed similarly and did not change with age. Less MAdCAM-1 was expressed in the colon; its distribution became restricted after weaning, with no difference between CV and GF mice. CD3(+)beta(7) (+) cells were present in similar numbers in CV and GF intestine at birth. They were CD62L(-) in CV mice and were accompanied by further CD3(+)beta(7) (+)CD62L(-) T cells as development progressed, but in GF and GF/CV intestine they expressed CD62L and numbers did not change. IEL numbers increased at weaning in CV mice in both small and large intestine, but showed delayed development in GF intestine. Macrophages were present at high levels from birth in GF intestine, but dendritic cells did not develop until day 16. Thus, fetus-derived T cells seed the intestinal lamina propria before birth via beta-MadCAM interactions. Their activation status depends on the microbiological status of the dam, and without a commensal flora they remain naive. We propose that these cells regulate antigen responsiveness of the developing mucosal T cell pool.
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