| 1. |
- Kalman, L. V., et al.
(författare)
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Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting
- 2016
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Ingår i: Clinical Pharmacology and Therapeutics. - : WILEY-BLACKWELL. - 0009-9236 .- 1532-6535. ; 99:2, s. 172-185
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Tidskriftsartikel (refereegranskat)abstract
- This article provides nomenclature recommendations developed by an international workgroup to increase transparency and standardization of pharmacogenetic (PGx) result reporting. Presently, sequence variants identified by PGx tests are described using different nomenclature systems. In addition, PGx analysis may detect different sets of variants for each gene, which can affect interpretation of results. This practice has caused confusion and may thereby impede the adoption of clinical PGx testing. Standardization is critical to move PGx forward.
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| 2. |
- Farmer, A. D., et al.
(författare)
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Regional gastrointestinal contractility parameters using the wireless motility capsule : inter-observer reproducibility and influence of age, gender and study country
- 2018
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Ingår i: Alimentary Pharmacology and Therapeutics. - : Wiley. - 0269-2813 .- 1365-2036. ; 47:3, s. 391-400
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Tidskriftsartikel (refereegranskat)abstract
- Background:The wireless motility capsule concurrently measures temperature, pH and pressure as it traverses the gastrointestinal tract. Aims: To describe normative values for motility/contractility parameters across age, gender and testing centres.Methods:Healthy participants underwent a standardised wireless motility capsule assessment following an overnight fast and consumption of a meal of known nutritional content. Traces were divided into regions of interest and analysed using 2 software packages (MotiliGI and GIMS Data Viewer). Inter-observer agreement was independently assessed by 2 investigators.Results:Normative data for motility/contractility parameters (maximum amplitude, mean peak amplitude, contraction frequency and motility index) are presented for 107 individuals (62 male, median age 40years, range 18-78). MotiliGI-Gastric, small bowel and colonic maximal contraction amplitude correlated with age (r = .24, P = .01; r = .22, P = .02; and r = .2, P = .04 respectively). Small bowel motility index was higher in females than males (150.412 vs 122 +/- 7.6, P = .04). Inter-observer agreement was excellent for transit times, pH and contractility/motility parameters. GIMS Data viewer-Gastric, small bowel and colonic log(e) motility index correlated with the respective area under the contraction curve, total contractions, sum of amplitudes and contraction frequency (all r>.35, P < .0003) but not with transit times.Conclusions: Our analysis provides normative data for motility/contractility parameters. Log motility index summarises a number of measures. In future, the measurement of contractile activity with the wireless motility capsule may potentially aid in the diagnosis of disease states such as visceral myopathic disorders.
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| 3. |
- Polenz, S., et al.
(författare)
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Wavelength dependent laser material processing of ceramic materials
- 2019
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Ingår i: Journal of laser applications. - : Laser Institute of America. - 1042-346X .- 1938-1387. ; 31:2
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Tidskriftsartikel (refereegranskat)abstract
- In the future, ceramic materials will find even more applications in aerospace, energy, and drive technology. Reasons for this are the comparatively low density and good long-term stability at high temperatures for applications for components exposed to high temperatures, e.g., of engines. By using increasing combustion temperatures through the use of ceramics increases the efficiency of modern drive systems [Ohnabe, Masaki, Onozuka, Miyahara, and Sasa, Compos. Part A Appl. Sci. Manuf. 30, 489–496 (1999)]. Despite the high interest of the aviation industry to increase the use of ceramic materials, the time- and energy-consuming classical production of these materials and the concomitant limiting factors in terms of shape and size are still a drawback [Krenkel, Ceramic Matrix Composites Fiber Reinforced Ceramics and their Applications (WIY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2008)]. This paper follows a new approach to producing ceramic matrix composites (CMCs). The laser material deposition (LMD) and selective laser melting techniques were used to investigate the coupling of different laser wavelengths into ceramic materials. By combining different energy sources and utilizing wavelength-dependent energy coupling, the additive manufacturing application of ceramic materials to metallic substrates was tested. With the knowledge gained from wavelength-dependent energy coupling, the potential for the production of CMCs should be demonstrated by means of LMD
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