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Heart failure with ...
Heart failure with reduced ejection fraction
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- Bloom, Michelle W. (författare)
- SUNY Stony Brook, NY 11794 USA
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- Greenberg, Barry (författare)
- University of Calif San Diego, CA 92093 USA
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- Jaarsma, Tiny (författare)
- Linköpings universitet,Avdelningen för omvårdnad,Medicinska fakulteten,Australian Catholic University, Australia
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- Januzzi, James L. (författare)
- Harvard University, MA USA
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- Lam, Carolyn S. P. (författare)
- National Heart Centre Singapore, Singapore; Duke National University of Singapore, Singapore
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- Maggioni, Aldo P. (författare)
- Italian Assoc Hospital Cardiologists ANMCO Research Centre, Italy
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- Trochu, Jean-Noel (författare)
- CHU Nantes, France; University of Nantes, France; INSERM, France; INSERM, France
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- Butler, Javed (författare)
- SUNY Stony Brook, NY 11794 USA
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(creator_code:org_t)
- 2017-08-24
- 2017
- Engelska.
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Ingår i: NATURE REVIEWS DISEASE PRIMERS. - : NATURE PUBLISHING GROUP. - 2056-676X. ; 3
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Heart failure is a global public health problem that affects more than 26 million people worldwide. The global burden of heart failure is growing and is expected to increase substantially with the ageing of the population. Heart failure with reduced ejection fraction accounts for approximately 50% of all cases of heart failure in the United States and is associated with substantial morbidity and reduced quality of life. Several diseases, such as myocardial infarction, certain infectious diseases and endocrine disorders, can initiate a primary pathophysiological process that can lead to reduced ventricular function and to heart failure. Initially, ventricular impairment is compensated for by the activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system, but chronic activation of these pathways leads to worsening cardiac function. The symptoms of heart failure can be associated with other conditions and include dyspnoea, fatigue, limitations in exercise tolerance and fluid accumulation, which can make diagnosis difficult. Management strategies include the use of pharmacological therapies and implantable devices to regulate cardiac function. Despite these available treatments, heart failure remains incurable, and patients have a poor prognosis and high mortality rate. Consequently, the development of new therapies is imperative and requires further research.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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