| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Lindblad, Per, 1953-, et al.
(författare)
-
The role of diabetes mellitus in the aetiology of renal cell cancer
- 1999
-
Ingår i: Diabetologia. - New York, USA : Springer. - 0012-186X .- 1432-0428. ; 42:1, s. 107-12
-
Tidskriftsartikel (refereegranskat)abstract
- To investigate the relation between diabetes mellitus and the risk of renal cell cancer we carried out a population-based retrospective cohort study. Patients identified in the Swedish Inpatient Register who were discharged from hospitals with a diagnosis of diabetes mellitus between 1965 and 1983 formed a cohort of 153852 patients (80005 women and 73847 men). The cohort members were followed up to 1989 by record linkage to three nation-wide registries. Standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) were computed using age-specific sex-specific and period-specific incidence and mortality rates derived from the entire Swedish population. After exclusion of the first year of observation, a total of 267 incidences of renal cell cancer (ICD-7:180.0) occurred in diabetic patients compared with the 182.4 that had been expected. Increased risks were observed in both women (SIR = 1.7, 95% confidence interval, CI = 1.4-2.0) and men (SIR = 1.3; 95 % CI = 1.1-1.6) throughout the duration of follow-up (1-25 years). A higher risk was seen for kidney cancer (ICD-7:180) mortality (SMR = 1.9; 95% CI = 1.7-2.2, women; SMR 1.7, 95% CI = 1.4-1.9, men). In comparison with the general population, patients with diabetes mellitus have an increased risk of renal cell cancer.
|
|
| 5. |
- Waldeck, A. Reginald, et al.
(författare)
-
Electron paramagnetic resonance studies of succinate:ubiquinone oxidoreductase from Paracoccus denitrificans : Evidence for a magnetic interaction between the 3Fe-4S cluster and cytochrome b
- 1997
-
Ingår i: Journal of Biological Chemistry. - : Elsevier BV. - 1083-351X .- 0021-9258.
-
Tidskriftsartikel (refereegranskat)abstract
- Electron paramagnetic resonance (EPR) studies of succinate:ubiquinone oxidoreductase (SQR) from Paracoccus denitrificans have been undertaken in the purified and membrane-bound states, Spectroscopic ''signatures'' accounting for the three iron-sulfur clusters (2Fe-2S, 3Fe-4S, and 4Fe-4S), cytochrome b, flavin, and protein-bound ubisemiquinone radicals have been obtained in air-oxidized, succinate-reduced, and dithionite-reduced preparations at 4-10 K. Spectra obtained at 170 K in the presence of excess succinate showed a signal typical of that of a flavin radical, but superimposed with another signal. The superimposed signal originated from two bound ubisemiquinones, as shown by spectral simulations, Power saturation measurements performed on the air-oxidized enzyme provided evidence for a weak magnetic dipolar interaction operating between the oxidized 3Fe-4S cluster and the oxidized cytochrome b. Power saturation experiments performed on the succinate- and dithionite-reduced forms of the enzyme demonstrated that the 4Fe-4S cluster is coupled weakly to both the 2Fe-2S and the 3Fe-4S clusters, Quantitative interpretation of these power saturation experiments has been achieved through redox calculations. They revealed that a spin-spin interaction between the reduced 3Fe-4S cluster and the cytochrome b (oxidized) may also exist. These findings form the first direct EPR evidence for a close proximity (less than or equal to 2 nm) of the high potential 3Fe-4S cluster, situated in the succinate dehydrogenase part of the enzyme, and the low potential, low spin b-heme in the membrane anchor of the enzyme.
|
|
| 6. |
- Bonner, Richard, et al.
(författare)
-
A Hybrid Intelligent System in Managing Foreign Exchange Rate Risk
- 1995
-
Ingår i: IFAC/IFIP/IFORS/SEDC Symposium on Modelling and Control of National and Regional Economies 1995. ; , s. 467-472
-
Konferensbidrag (refereegranskat)abstract
- Firms engaging in international trade are subject to risk from fluctuation of currency exchange rates. Although such risk can be actively managed with suitable hedging strategies, the problem is a complex one, and small firms rarely have access to required expertise. This paper proposes a hybrid intelligent system, called HYNES, which integrates neural network and expert system technologies, to support exchange rate risk management in small firms. The three phases of the development of HYNES, the analysis, design and implementation, are briefly discussed, giving some attention to the open problems of general intelligent systems development.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
- Frey, Sharon, et al.
(författare)
-
Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine
- 1999
-
Ingår i: Journal of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 180:6, s. 2018-2022
-
Tidskriftsartikel (refereegranskat)abstract
- A randomized trial comparing 3 manufacturing consistency lots of a combination hepatitis A/hepatitis B vaccine to each other and to hepatitis A vaccine and hepatitis B vaccine given separately and concurrently was done to evaluate safety, tolerability, and immunogenicity. Healthy volunteers >/=11 years of age were divided into 4 groups. Each of 3 groups received a separate consistency lot of the combination vaccine, and 1 group received separate but concurrent injections of hepatitis A and hepatitis B vaccines. Injections were given at weeks 0 and 24. The combination vaccine was generally well tolerated. The hepatitis A portion of the combination vaccine produced clinically acceptable high seropositivity rates 4 and 52 weeks after the first injection. The hepatitis B portion of the vaccine did not produce clinically acceptable seropositivity rates 4 weeks after the second injection. Lack of antibody production may be attributed, at least in part, to immunologic interference.
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
- Sanzogni, L., et al.
(författare)
-
Perceptrons with polynomial post-processing
- 1996
-
Ingår i: Proceedings of the International Conference on Tools with Artificial Intelligence. ; , s. 472-474
-
Konferensbidrag (refereegranskat)abstract
- Introduces tensor-product neural networks, composed of a layer of univariate neurons followed by a net of polynomial post-processing. We look at the general approximation problem by these networks observing in particular their relationship to the Stone-Weierstrass theorem for uniform function algebras. The implementation of the post-processing as a two-layer network with logarithmic and exponential neurons leads to potentially important 'generalised' product networks which, however, require a complex approximation theory of the Müntz-Szasz-Ehrenpreis type. A backpropagation algorithm for product networks is presented and used in three computational experiments. In particular, approximation by a sigmoid product network is compared to that of a single-layer radial basis network and a multiple-layer sigmoid network.
|
|
| 16. |
|
|
| 17. |
- Zhang, Yong Yuan, et al.
(författare)
-
Greater diversity of hepatitis C virus genotypes found in Hong Kong than in mainland China
- 1995
-
Ingår i: Journal of Clinical Microbiology. - 1098-660X. ; 33:11, s. 2931-2934
-
Tidskriftsartikel (refereegranskat)abstract
- A hepatitis C virus (HCV) genotyping PCR assay based on type-specific primers was expanded to include genotype 6a as well as genotypes 1a, 1b, 2a, and 3a. The nucleotide sequences of a 194-bp fragment in the center of the HCV core gene showed that the homologies between genotype 6a and genotypes 1a, 1b, 2a, 2b, 3a, and 5 were 81.2, 82.1, 73.8, 77.3, 81.4, and 78.9%, respectively. A high degree of homology (99.6%) was seen in the amplified core region among eight clinically unrelated genotype 6a isolates. Although the Hong Kong Chinese patients had predominantly genotype 1b (70%), it was noteworthy that genotype 6a was the second most common genotype (14%). Four other HCV genotypes--1a, 1b, 2a, and 2b--were also present. In contrast, HCV infection by mainland China was confined to genotypes 1b and 2a. Thus, we found a greater diversity of HCV genotypes in Hong Kong than in mainland China.
|
|
