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SIDT1 plays a key r...
SIDT1 plays a key role in type I IFN responses to nucleic acids in plasmacytoid dendritic cells and mediates the pathogenesis of an imiquimod-induced psoriasis model
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- Morell, Maria (författare)
- Karolinska Institutet
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- Varela, Nieves (författare)
- Univ Granada, Andalusian Reg Govt, Ctr Genom & Oncol Res Pfizer, GENYO, Avda Ilustrac 114, Granada 18016, Spain
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- Castillejo-Lopez, Casimiro (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
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- Coppard, Celine (författare)
- Univ Granada, Andalusian Reg Govt, Ctr Genom & Oncol Res Pfizer, GENYO, Avda Ilustrac 114, Granada 18016, Spain
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- Jose Luque, Maria (författare)
- Univ Granada, Andalusian Reg Govt, Ctr Genom & Oncol Res Pfizer, GENYO, Avda Ilustrac 114, Granada 18016, Spain
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- Wu, Ying-Yu (författare)
- Oklahoma Med Res Fdn, Arthrit & Clin Immunol Program, 825 NE 13th St, Oklahoma City, OK 73104 USA
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- Martin-Morales, Natividad (författare)
- Univ Granada, Sch Med, Dept Pathol, Granada, Spain.;Univ Granada, Sch Dent, Dept Oral Surg, Granada, Spain
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- Perez-Cozar, Francisco (författare)
- Univ Granada, Andalusian Reg Govt, Ctr Genom & Oncol Res Pfizer, GENYO, Avda Ilustrac 114, Granada 18016, Spain
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- Gomez-Hernandez, Gonzalo (författare)
- Univ Granada, Andalusian Reg Govt, Ctr Genom & Oncol Res Pfizer, GENYO, Avda Ilustrac 114, Granada 18016, Spain
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- Kumar, Ramesh (författare)
- Oklahoma Med Res Fdn, Arthrit & Clin Immunol Program, 825 NE 13th St, Oklahoma City, OK 73104 USA
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- O'Valle, Francisco (författare)
- Univ Granada, Sch Med, Dept Pathol, Granada, Spain.;Ibs GRANADA, Granada, Spain.;IBIMER Inst, Granada, Spain
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- Alarcon-Riquelme, Marta E. (författare)
- Univ Granada, Andalusian Reg Govt, Ctr Genom & Oncol Res Pfizer, GENYO, Avda Ilustrac 114, Granada 18016, Spain.;Karolinska Inst, Inst Environm Med, Stockholm, Sweden
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- Maranon, Concepcion (författare)
- Univ Granada, Andalusian Reg Govt, Ctr Genom & Oncol Res Pfizer, GENYO, Avda Ilustrac 114, Granada 18016, Spain
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 76
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background Type I IFN (IFN-I) is a family of cytokines involved in the pathogenesis of autoimmune and autoinflammatory diseases such as psoriasis. SIDT1 is an ER-resident protein expressed in the lymphoid lineage, and involved in anti-viral IFN-I responses in vivo, through an unclear mechanism. Herein we have dissected the role of SIDT1 in the natural IFN-producing cells, the plasmacytoid dendritic cells (pDC).Methods The function of SIDT1 in pDC was determined by silencing its expression in human primary pDC and GEN2.2 cell line. SIDT1 role in vivo was assessed using the imiquimod-induced psoriasis model in the SIDT1-deficient mice (sidt1-/-).Findings Silencing of SIDT1 in GEN2.2 led to a blockade of the IFN-I response after stimulation of TLR7 and TLR9, without affecting the pro-inflammatory responses or upregulation of maturation markers. We found that SIDT1 migrates from the ER to the endosomal and lysosomal compartments together with TLR9 after CpG stimulation, participating in the access of the TLR9-CpG complex to lysosome-related vesicles, and therefore mediating the activation of TBK1 and the nuclear migration of IRF7, but not of NF -KB. sidt1-/- mice showed a significant decrease in severity parameters of the imiquimod-induced acute psoriasis-like model, associated with a decrease in the production of IFN-I and IFN-dependent chemokines.Interpretation Our findings indicate that SIDT1 is at the cross-road between the IFN-I and the proinflammatory pathways and constitutes a promising drug target for psoriasis and other diseases mediated by IFN-I responses.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- SIDT1
- pDC
- IFN-I
- Proinflammatory cytokines
- TLR7
- TLR9
- IRF7
- Psoriasis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Morell, Maria
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Varela, Nieves
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Castillejo-Lopez ...
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Coppard, Celine
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Jose Luque, Mari ...
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Wu, Ying-Yu
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visa fler...
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Martin-Morales, ...
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Perez-Cozar, Fra ...
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Gomez-Hernandez, ...
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Kumar, Ramesh
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O'Valle, Francis ...
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Alarcon-Riquelme ...
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Maranon, Concepc ...
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Uppsala universitet
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