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1.	Aktas, A., et al. (author) Elastic J/psi production at HERA 2006 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 46:3, s. 585-603 Journal article (peer-reviewed)abstract Cross sections for elastic production of J/psi mesons in photoproduction and electroproduction are measured in electron proton collisions at HERA using an integrated luminosity of 55 pb(-1). Results are presented for photon virtualities Q(2) up to 80 GeV2. The dependence on the photon-proton centre of mass energy W-gamma p is analysed in the range 40 <= W-gamma p <= 305 GeV in photoproduction and 40 <= W-gamma p <= 160 GeV in electroproduction. The W-gamma p dependences of the cross sections do not change significantly with Q(2) and can be described by models based on perturbative QCD. Within such models, the data show a high sensitivity to the gluon density of the proton in the domain of low Bjorken x and low Q(2). Differential cross sections d sigma/dt, where t is the squared four-momentum transfer at the proton vertex, are measured in the range vertical bar t vertical bar < 1.2 GeV2 as functions of W-gamma p and Q(2). Effective Pomeron trajectories are determined for photoproduction and electroproduction. The J/psi production and decay angular distributions are consistent with s-channel helicity conservation. The ratio of the cross sections for longitudinally and transversely polarised photons is measured as a function of Q(2) and is found to be described by perturbative QCD based models.
2.	Aktas, A., et al. (author) Forward jet production in deep inelastic scattering at HERA 2006 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 46:1, s. 27-42 Journal article (peer-reviewed)abstract The production of forward jets has been measured in deep inelastic ep collisions at HERA. The results are presented in terms of single differential cross sections as a function of the Bjorken scaling variable (xB(j)) and as triple differential cross sections d3 sigma/dx(Bj)dQ(2)dp(t)(,jet)(2), where Q(2) is the four momentum transfer squared and p(t)(,iet)(2) is the squared transverse momentum of the forward jet. Also cross sections for events with a di-jet system in addition to the forward jet are measured as a function of the rapidity separation between the forward jet and the two additional jets. The measurements are compared with next-to-leading order QCD calculations and with the predictions of various QCD-based models.
3.	Aktas, A., et al. (author) Measurement of event shape variables in deep-inelastic scattering at HERA 2006 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 46:2, s. 343-356 Journal article (peer-reviewed)abstract Deep-inelastic ep scattering data taken with the H1 detector at HERA and corresponding to an integrated luminosity of 106 pb(-1) are used to study the differential distributions of event shape variables. These include thrust, jet broadening, jet mass and the C-parameter. The four-momentum transfer Q is taken to be the relevant energy scale and ranges between 14 GeV and 200 GeV. The event shape distributions are compared with perturbative QCD predictions, which include resummed contributions and analytical power law corrections, the latter accounting for non-perturbative hadronisation effects. The data clearly exhibit the running of the strong coupling alpha(s)(Q) and are consistent with a universal power correction parameter alpha(0) for all event shape variables. A combined QCD fit using all event shape variables yields alpha(s)(m(Z)) = 0.1198 +/- 0.0013 (+0.0056)(-0.0043) and alpha(0) = 0.476 +/- 0.008 (+0.018)(-0.059).
4.	Aktas, A., et al. (author) Photoproduction of dijets with high transverse momenta at HERA 2006 In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 639:1, s. 21-31 Journal article (peer-reviewed)abstract Differential dijet cross sections are measured in photoproduction in the region of photon virtualities Q(2) < 1 GeV2 with the H1 detector at the HERA ep collider using an integrated luminosity of 66.6 pb(-1). Jets are defined with the inclusive k perpendicular to algorithm and a minimum transverse momentum of the leading jet of 25 GeV is required. Dijet cross sections are measured indirect and resolved photon enhanced regions separately. Longitudinal proton momentum fractions up to 0.7 are reached. The data compare well with predictions from Monte Carlo event generators based on leading order QCD and parton showers and with next-to-leading order QCD calculations corrected for hadronisation effects.
5.	Aktas, A, et al. (author) A direct search for stable magnetic monopoles produced in positron-proton collisions at HERA 2005 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 41, s. 133-141 Journal article (peer-reviewed)abstract A direct search has been made for magnetic monopoles produced in e(+)p collisions at a centre of mass energy of 300 GeV at HERA. The beam pipe surrounding the interaction region in 1995-1997 was investigated using a SQUID magnetometer to look for stopped magnetic monopoles. During this time an integrated luminosity of 62 pb(-1) was delivered. No magnetic monopoles were observed and charge and mass dependent upper limits on the e(+)p production cross section are set.
6.	Aktas, A, et al. (author) Inclusive production of D+, D-0, D-s(+) and D(+) mesons in deep inelastic scattering at HERA 2005 In:* European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 38:4, s. 447-459 Journal article (peer-reviewed)abstract Inclusive production cross sections are measured in deep inelastic scattering at HERA for meson states composed of a charm quark and a light antiquark or the charge conjugate. The measurements cover the kinematic region of photon virtuality 2 < Q(2) < 100 GeV2, inelasticity 0.05 < y < 0.7, D meson transverse momenta p(t)( D) greater than or equal to 2.5 GeV and pseudorapidity \|eta( D)\| less than or equal to 1.5. The identification of the D-meson decays and the reduction of the combinatorial background profit from the reconstruction of displaced secondary vertices by means of the H1 silicon vertex detector. The production of charmed mesons containing the light quarks u, d and s is found to be compatible with a description in which the hard scattering is followed by a factorisable and universal hadronisation process.
7.	Aktas, A, et al. (author) Measurement of prompt photon cross sections in photoproduction at HERA 2005 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 38:4, s. 437-445 Journal article (peer-reviewed)abstract Results are presented on the photoproduction of isolated prompt photons, inclusively and associated with jets, in the gammap center of mass energy range 142 < W < 266 GeV. The cross sections are measured for the transverse momentum range of the photons 5 < E. T < 10 GeV and for associated jets with E-T(jet) > 4.5 GeV. They are measured differentially as a function of E-T(gamma), E-T(jet), the pseudorapidities eta(gamma) and eta(jet) and estimators of the momentum fractions x(gamma) and x(p) of the incident photon and proton carried by the constituents participating in the hard process. In order to further investigate the underlying dynamics, the angular correlation between the prompt photon and the jet in the transverse plane is studied. Predictions by perturbative QCD calculations in next to leading order are about 30% below the inclusive prompt photon data after corrections for hadronisation and multiple interactions, but are in reasonable agreement with the results for prompt photons associated with jets. Comparisons with the predictions of the event generators PYTHIA and HERWIG are also presented.
8.	Aktas, A, et al. (author) A determination of electroweak parameters at HERA 2006 In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 632:1, s. 35-42 Journal article (peer-reviewed)abstract Using the deep inelastic e(+) p and e(-) p charged and neutral current scattering cross sections previously published, a combined electroweak and QCD analysis is performed to determine electroweak parameters accounting for their correlation with parton distributions. The data used have been collected by the HI experiment in 1994-2000 and correspond to an integrated luminosity of 117.2 pb(-1). A measurement is obtained of the W propagator mass in charged current ep scattering. The weak mixing angle sin(2)theta w is determined in the on-mass-shell renormalisation scheme. A first measurement at HERA is made of the light quark weak couplings to the Z(0) boson and a possible contribution of right-handed isospin components to the weak couplings is investigated. (c) 2005 Elsevier B.V. All rights reserved.
9.	Aktas, A, et al. (author) First measurement of charged current cross sections at HERA with longitudinally polarised positrons 2006 In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 634:2-3, s. 173-179 Journal article (peer-reviewed)abstract Data taken with positrons of different longitudinal polarisation states in collision with unpolarised protons at HERA are used to measure the total cross sections of the charged current process, e(+) p -> nu X, for negative four-momentum transfer squared Q(2) > 400 GeV2 and inelasticity gamma < 0.9. Together with the corresponding cross section obtained from the previously published unpolarised data, the polarisation dependence of the charged current cross section is measured for the first time at high Q(2) and found to be in agreement with the Standard Model prediction. (c) 2006 Elsevier B.V. All rights reserved.
10.	Aktas, A, et al. (author) Measurement of beauty production at HERA using events with muons and jets 2005 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 41:4, s. 453-467 Journal article (peer-reviewed)abstract A measurement of the beauty production cross section in ep collisions at a centre-of-mass energy of 319 GeV is presented. The data were collected with the H1 detector at the HERA collider in the years 1999-2000. Events are selected by requiring the presence of jets and muons in the final state. Both the long lifetime and the large mass of b-flavoured hadrons are exploited to identify events containing beauty quarks. Differential cross sections are measured in photoproduction, with photon virtualities Q(2) < 1 GeV2, and in deep inelastic scattering, where 2 < Q(2) < 100 GeV2. The results are compared with perturbative QCD calculations to leading and next-to-leading order. The predictions are found to be somewhat lower than the data.
11.	Aktas, A, et al. (author) Measurement of charm and beauty photoproduction at HERA using Dmu correlations 2005 In:* Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 621:1-2, s. 56-71 Journal article (peer-reviewed)abstract A measurement of charm and beauty photoproduction at the electron proton collider HERA is presented based on the simultaneous detection of a D(+/-) meson and a muon. The correlation between the D meson and the muon serves to separate the charm and beauty contributions and the analysis provides comparable sensitivity to both. The total and differential experimental cross sections are compared to LO and NLO QCD calculations. The measured charm cross section is in good agreement with QCD predictions including higher order effects while the beauty cross section is higher.
12.	Aktas, A, et al. (author) Measurement of deeply virtual Compton scattering at HERA 2005 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 44:1, s. 1-11 Journal article (peer-reviewed)abstract A measurement is presented of elastic deeply virtual Compton scattering gamma* p -> gamma p made using e(+) p collision data corresponding to a luminosity of 46.5 pb(-1), taken with the H1 detector at HERA. The cross section is measured as a function of the photon virtuality, Q(2), the invariant mass of the gamma* p system, W, and for the first time, differentially in the squared momentum transfer at the proton vertex, t, in the kinematic range 2 < Q(2) < 80 GeV2, 30 < W < 140 GeV and vertical bar t vertical bar < 1 GeV2. QCD based calculations at next-to-leading order using generalized parton distributions can describe the data, as can colour dipole model predictions.
13.	Aktas, A, et al. (author) Measurement of dijet cross sections in ep interactions with a leading neutron at HERA 2005 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 41:3, s. 273-286 Journal article (peer-reviewed)abstract Measurements are reported of the production of dijet events with a leading neutron in ep interactions at HERA. Differential cross sections for photoproduction and deep inelastic scattering are presented as a function of several kinematic variables. Leading order QCD simulation programs are compared with the measurements. Models in which the real or virtual photon interacts with a parton of an exchanged pion are able to describe the data. Next-to-leading order perturbative QCD calculations based on pion exchange are found to be in good agreement with the measured cross sections. The fraction of leading neutron dijet events with respect to all dijet events is also determined. The dijet events with a leading neutron have a lower fraction of resolved photon processes than do the inclusive dijet data.
14.	Aktas, A, et al. (author) Measurement of F-2(c(c)over-bar) and F-2(b(b)over-bar) at high Q(2) using the H1 vertex detector at HERA 2005 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 40:3, s. 349-359 Journal article (peer-reviewed)abstract Measurements are presented of inclusive charm and beauty cross sections in e(+)p collisions at HERA for values of photon virtuality Q(2) > 150 GeV2 and of inelasticity 0.1 < y < 0.7. The charm and beauty fractions are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured by the H1 vertex detector. The data are divided into four regions in Q(2) and Bjorken x, and values for the structure functions F-2(c (c) over bar) and F-2(b (b) over bar) are obtained. The results are found to be compatible with the predictions of perturbative quantum chromodynamics.
15.	Aktas, A, et al. (author) Measurement of Fc(c)over-bar(2) and Fb(b)over-bar(2) at low Q(2) and x using the H1 vertex detector at HERA 2006 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 45:1, s. 23-33 Journal article (peer-reviewed)abstract Measurements are presented of inclusive charm and beauty cross sections in e(+)p collisions at HERA for values of photon virtuality 12 <= Q(2) = 60 GeV2 and of the Bjorken scaling variable 0.0002 <= x <= 0.005. The fractions of events containing charm and beauty quarks are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured by the H1 vertex detector. Values for the structure functions F-2(cc) and F-2(bb) are obtained. This is the first measurement of F-2(bb) in this kinematic range. The results are found to be compatible with the predictions of perturbative quantum chromodynamics and with previous measurements of F-2(cc).
16.	Aktas, A, et al. (author) Search for light gravitinos in events with photons and missing transverse momentum at HERA 2005 In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 616:1-2, s. 31-42 Journal article (peer-reviewed)abstract A search for gravitinos produced in e(+/-)p collisions is performed using the H1 detector at HERA. The data were taken at a centre-of-mass energy of 319 GeV and correspond to an integrated luminosity of 64.3 pb(-1) for e(+)p collisions and 13.5 pb(-1) for e(-)p collisions. If R-parity is not conserved, the t-channel exchange of a selectron can produce a neutralino, which, in models where the gravitino is the lightest supersymmetric particle, subsequently decays into a photon and a light gravitino. The resulting event signature, which involves an isolated photon, a jet and missing transverse energy, is analysed for the first time at HERA. No deviation from the Standard Model is found. Exclusion limits on the cross section and on R-parity-violating Yukawa couplings are derived in a Gauge Mediated Supersymmetry Breaking scenario. The results are independent of the squark sector. Neutralinos and supersymmetric partners of the left-handed electron with masses up to 112 GeV and 164 GeV, respectively, can be ruled out at the 95% confidence level for R-parity-violating couplings lambda' equal to 1, in some parts of the parameter space of the considered model.
17.	Journeau, C., et al. (author) European Research on the Corium issues within the SARNET network of excellence 2008 In: International Conference on Advances in Nuclear Power Plants, ICAPP 2008. - 9781605607870 ; , s. 1172-1181 Conference paper (peer-reviewed)abstract Within SARNET, the corium topic covers all the behaviors of corium from early phase of core degradation to in or ex-vessel corium recovery with the exception of corium interaction with water, direct containment heating and fission product release. The corium topic regroups in three work packages the critical mass of competence required to improve significantly the corium behavior knowledge. The spirit of the SARNET networking is to share the knowledge, the facilities and the simulation tools for severe accidents, so to reach a better efficiency and to rationalize the R&D effort at European level. Extensive benchmarking has been launched in most of the areas of research. These benchmarks were mainly dedicated to the recalculation of experiments, while, in the next periods, a larger focus will be given to integral experiments or reactor applications. Eventually, all the knowledge will be accumulated in the ASTEC severe accident simulation code through physical model improvements and extension of validation database. This paper summarizes the progress that has been achieved in the frame of the networking activities. A special focus is placed on the melt pool and debris coolability and corium-concrete interaction, in which, the effects due to multidimensional geometries and heterogeneities has been shown, during SARNET, to play a crucial role and for which further research is still needed.
18.	Dormandy, J. A., et al. (author) Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial 2005 In: Lancet. - 1474-547X. ; 366:9493, s. 1279-89 Journal article (peer-reviewed)abstract BACKGROUND: Patients with type 2 diabetes are at high risk of fatal and non-fatal myocardial infarction and stroke. There is indirect evidence that agonists of peroxisome proliferator-activated receptor gamma (PPAR gamma) could reduce macrovascular complications. Our aim, therefore, was to ascertain whether pioglitazone reduces macrovascular morbidity and mortality in high-risk patients with type 2 diabetes. METHODS: We did a prospective, randomised controlled trial in 5238 patients with type 2 diabetes who had evidence of macrovascular disease. We recruited patients from primary-care practices and hospitals. We assigned patients to oral pioglitazone titrated from 15 mg to 45 mg (n=2605) or matching placebo (n=2633), to be taken in addition to their glucose-lowering drugs and other medications. Our primary endpoint was the composite of all-cause mortality, non fatal myocardial infarction (including silent myocardial infarction), stroke, acute coronary syndrome, endovascular or surgical intervention in the coronary or leg arteries, and amputation above the ankle. Analysis was by intention to treat. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN NCT00174993. FINDINGS: Two patients were lost to follow-up, but were included in analyses. The average time of observation was 34.5 months. 514 of 2605 patients in the pioglitazone group and 572 of 2633 patients in the placebo group had at least one event in the primary composite endpoint (HR 0.90, 95% CI 0.80-1.02, p=0.095). The main secondary endpoint was the composite of all-cause mortality, non-fatal myocardial infarction, and stroke. 301 patients in the pioglitazone group and 358 in the placebo group reached this endpoint (0.84, 0.72-0.98, p=0.027). Overall safety and tolerability was good with no change in the safety profile of pioglitazone identified. 6% (149 of 2065) and 4% (108 of 2633) of those in the pioglitazone and placebo groups, respectively, were admitted to hospital with heart failure; mortality rates from heart failure did not differ between groups. INTERPRETATION: Pioglitazone reduces the composite of all-cause mortality, non-fatal myocardial infarction, and stroke in patients with type 2 diabetes who have a high risk of macrovascular events.
19.	Hicks, Andrew A., et al. (author) Genetic determinants of circulating sphingolipid concentrations in European populations 2009 In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 5:10, s. e1000672- Journal article (peer-reviewed)abstract Sphingolipids have essential roles as structural components of cell membranes and in cell signalling, and disruption of their metabolism causes several diseases, with diverse neurological, psychiatric, and metabolic consequences. Increasingly, variants within a few of the genes that encode enzymes involved in sphingolipid metabolism are being associated with complex disease phenotypes. Direct experimental evidence supports a role of specific sphingolipid species in several common complex chronic disease processes including atherosclerotic plaque formation, myocardial infarction (MI), cardiomyopathy, pancreatic β-cell failure, insulin resistance, and type 2 diabetes mellitus. Therefore, sphingolipids represent novel and important intermediate phenotypes for genetic analysis, yet little is known about the major genetic variants that influence their circulating levels in the general population. We performed a genome-wide association study (GWAS) between 318,237 single-nucleotide polymorphisms (SNPs) and levels of circulating sphingomyelin (SM), dihydrosphingomyelin (Dih-SM), ceramide (Cer), and glucosylceramide (GluCer) single lipid species (33 traits); and 43 matched metabolite ratios measured in 4,400 subjects from five diverse European populations. Associated variants (32) in five genomic regions were identified with genome-wide significant corrected p-values ranging down to 9.08×10−66. The strongest associations were observed in or near 7 genes functionally involved in ceramide biosynthesis and trafficking: SPTLC3, LASS4, SGPP1, ATP10D, and FADS1–3. Variants in 3 loci (ATP10D, FADS3, and SPTLC3) associate with MI in a series of three German MI studies. An additional 70 variants across 23 candidate genes involved in sphingolipid-metabolizing pathways also demonstrate association (p = 10−4 or less). Circulating concentrations of several key components in sphingolipid metabolism are thus under strong genetic control, and variants in these loci can be tested for a role in the development of common cardiovascular, metabolic, neurological, and psychiatric diseases.
20.	Soranzo, Nicole, et al. (author) A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium 2009 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:11, s. 38-1182 Journal article (peer-reviewed)abstract The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci reproducibly associated with these hematological parameters in 13,943 samples from six European population-based studies, including 6 associated with red blood cell parameters, 15 associated with platelet parameters and 1 associated with total white blood cell count. We further identified a long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction in 9,479 cases and 10,527 controls. We show that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.
21.	Vasan, Ramachandran S, et al. (author) Genetic variants associated with cardiac structure and function : a meta-analysis and replication of genome-wide association data 2009 In: Journal of the American Medical Association (JAMA). - : American Medical Association (AMA). - 0098-7484 .- 1538-3598. ; 302:2, s. 168-178 Journal article (peer-reviewed)abstract CONTEXT: Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease. OBJECTIVE: To identify common genetic variants associated with cardiac structure and function by conducting a meta-analysis of genome-wide association data in 5 population-based cohort studies (stage 1) with replication (stage 2) in 2 other community-based samples. DESIGN, SETTING, AND PARTICIPANTS: Within each of 5 community-based cohorts comprising the EchoGen consortium (stage 1; n = 12 612 individuals of European ancestry; 55% women, aged 26-95 years; examinations between 1978-2008), we estimated the association between approximately 2.5 million single-nucleotide polymorphisms (SNPs; imputed to the HapMap CEU panel) and echocardiographic traits. In stage 2, SNPs significantly associated with traits in stage 1 were tested for association in 2 other cohorts (n = 4094 people of European ancestry). Using a prespecified P value threshold of 5 x 10(-7) to indicate genome-wide significance, we performed an inverse variance-weighted fixed-effects meta-analysis of genome-wide association data from each cohort. MAIN OUTCOME MEASURES: Echocardiographic traits: LV mass, internal dimensions, wall thickness, systolic dysfunction, aortic root, and left atrial size. RESULTS: In stage 1, 16 genetic loci were associated with 5 echocardiographic traits: 1 each with LV internal dimensions and systolic dysfunction, 3 each with LV mass and wall thickness, and 8 with aortic root size. In stage 2, 5 loci replicated (6q22 locus associated with LV diastolic dimensions, explaining <1% of trait variance; 5q23, 12p12, 12q14, and 17p13 associated with aortic root size, explaining 1%-3% of trait variance). CONCLUSIONS: We identified 5 genetic loci harboring common variants that were associated with variation in LV diastolic dimensions and aortic root size, but such findings explained a very small proportion of variance. Further studies are required to replicate these findings, identify the causal variants at or near these loci, characterize their functional significance, and determine whether they are related to overt cardiovascular disease.

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