| 1. |
- Coustenis, A., et al.
(författare)
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TandEM : Titan and Enceladus mission
- 2009
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Ingår i: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 23:3, s. 893-946
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Tidskriftsartikel (refereegranskat)abstract
- TandEM was proposed as an L-class (large) mission in response to ESA's Cosmic Vision 2015-2025 Call, and accepted for further studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini-Huygens mission. These bodies still hold mysteries requiring a complete exploration using a variety of vehicles and instruments. TandEM is an ambitious mission because its targets are two of the most exciting and challenging bodies in the Solar System. It is designed to build on but exceed the scientific and technological accomplishments of the Cassini-Huygens mission, exploring Titan and Enceladus in ways that are not currently possible (full close-up and in situ coverage over long periods of time). In the current mission architecture, TandEM proposes to deliver two medium-sized spacecraft to the Saturnian system. One spacecraft would be an orbiter with a large host of instruments which would perform several Enceladus flybys and deliver penetrators to its surface before going into a dedicated orbit around Titan alone, while the other spacecraft would carry the Titan in situ investigation components, i.e. a hot-air balloon (MontgolfiSre) and possibly several landing probes to be delivered through the atmosphere.
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| 2. |
- Hannukainen, J, et al.
(författare)
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In Vivo Measurements of Glucose Uptake in Human Achilles Tendon During Different Exercise Intensities
- 2005
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Ingår i: International Journal of Sports Medicine. - : Georg Thieme Verlag KG. - 0172-4622 .- 1439-3964. ; 26, s. 727-731
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Tidskriftsartikel (refereegranskat)abstract
- Muscular contraction and loading of adjacent tendons has been demonstrated to cause increased blood flow and metabolic activity in the peritendinous region. However, it is poorly known to what extent the human tendon itself takes up glucose during exercise. Thus, the purpose of this study was to measure tendon glucose uptake with increasing exercise intensity and to compare it to muscle glucose uptake at the same intensities. Eight young men were examined on three separate days during which they performed 35 min of cycling at 30, 55 and 75 % of VO2max, respectively. Glucose uptake was measured directly by positron emission tomography (PET) with 2-[ (18)F]fluoro-2-deoxyglucose ([18F]FDG). [18F]FDG was injected after 10 min of exercise that was continued for a further 25 min after the injection. PET scanning of the thigh and Achilles region was performed after the exercise. Glucose uptake of the Achilles tendon (AT) remained unchanged (7.1 +/- 1.5, 6.6 +/- 1.1, and 6.0 +/- 1.1 micromol.kg(-1).min(-1)) with the increasing workload, although the glucose uptake in m. quadriceps femoris simultaneously clearly increased (48 +/- 35, 120 +/- 35, and 152 +/- 74 micromol.kg(-1).min(-1), p < 0.05). In conclusion, the AT takes up glucose during exercise but in significantly smaller amounts than the skeletal muscle does. Furthermore, glucose uptake in the AT is not increased with the increasing exercise intensity. This may be partly explained by the cycle ergometry exercise used in the present study, which probably causes only a little increase in strain to the AT with increasing exercise intensity.
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| 3. |
- Horbury, T., et al.
(författare)
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Cross-scale : A multi-spacecraft mission to study cross-scale coupling in space plasmas
- 2006
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Ingår i: European Space Agency, (Special Publication) ESA SP. ; , s. 561-568
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Konferensbidrag (refereegranskat)abstract
- Collisionless astrophysical plasmas exhibit complexity on many scales: if we are to understand their properties and effects, we must measure this complexity. We can identify a small number of processes and phenomena, one of which is dominant in almost every space plasma region of interest: shocks, reconnection and turbulence. These processes act to transfer energy between locations, scales and modes. However, this transfer is characterised by variability and 3D structure on at least three scales: electron kinetic, ion kinetic and fluid. It is the nonlinear interaction between physical processes at these scales that is the key to understanding these phenomena and predicting their effects. However, current and planned multi-spacecraft missions such as Cluster and MMS only study variations on one scale in 3D at any given time - we must measure the three scales simultaneously fully to understand the energy transfer processes. We propose a mission, called Cross-Scale, to study these processes. Cross-Scale would comprise three nested groups, each consisting of up to four spacecraft. Each group would have a different spacecraft separation, at approximately the electron and ion gyroradii, and a larger MHD scale. We would therefore be able to measure variations on all three important physical scales, simultaneously, for the first time. The spacecraft would fly in formation through key regions of near-Earth space: The solar wind, bowshock, magnetosheath, magnetopause and magnetotail.
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| 4. |
- Conte, Valeria, et al.
(författare)
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TrkB gene transfer does not alter hippocampal neuronal loss and cognitive deficits following traumatic brain injury in mice
- 2008
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Ingår i: Restorative Neurology and Neuroscience. - 0922-6028 .- 1878-3627. ; 26:1, s. 45-56
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The ability of brain-derived neurotrophic factor (BDNF) to attenuate secondary damage and influence behavioral outcome after experimental traumatic brain injury (TBI) remains controversial. Because TBI can result in decreased expression of the trkB receptor, thereby preventing BDNF from exerting potential neuroprotective effects, the contribution of both BDNF and its receptor trkB to hippocampal neuronal loss and cognitive dysfunction were evaluated. METHODS: Full-length trkB was overexpressed in the left hippocampus of adult C57Bl/6 mice using recombinant adeno-associated virus serotype 2/5 (rAAV 2/5). EGFP (enhanced green fluorescent protein) expression was present at two weeks after AAV-EGFP injection and remained sustained up to four weeks after the injection. At 2 weeks following gene transduction, mice were subjected to parasagittal controlled cortical impact (CCI) brain injury, followed by either BDNF or PBS infusion into the hippocampus. RESULTS: No differences were observed in learning ability at two weeks post-injury or in motor function from 48 hours to two weeks among treatment groups. The number of surviving pyramidal neurons in the CA2-CA3 region of the hippocampus was also not different among treatment groups. CONCLUSIONS: These data suggest that neither overexpression of trkB, BNDF infusion or their combination affects neuronal survival or behavioral outcome following experimental TBI in mice.
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| 5. |
- Eastwood, J.P., et al.
(författare)
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Multi-point observations of the Hall electromagnetic field and secondary island formation during magnetic reconnection
- 2007
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 112:A6, s. A06235-
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Tidskriftsartikel (refereegranskat)abstract
- A key feature of collisionless magnetic reconnection is the formation of Hall magnetic and electric field structure in the vicinity of the diffusion region. Here we present multi‐point Cluster observations of a reconnection event in the near‐Earth magnetotail where the diffusion region was nested by the Cluster spacecraft; we compare observations made simultaneously by different spacecraft on opposite sides of the magnetotail current sheet. This allows the spatial structure of both the electric and magnetic field to be probed. It is found that, close to the diffusion region, the magnetic field displays a symmetric quadrupole structure. The Hall electric field is symmetric, observed to be inwardly directed on both sides of the current sheet. It is large (∼40 mV m−1) on the earthward side of the diffusion region, but substantially weaker on the tailward side, suggesting a reduced reconnection rate reflected by a similar reduction in Ey. A small‐scale magnetic flux rope was observed in conjunction with these observations. This flux rope, observed very close to the reconnection site and entrained in the plasma flow, may correspond to what have been termed secondary islands in computer simulations. The core magnetic field inside the flux rope is enhanced by a factor of 3, even though the lobe guide field is negligible. Observations of the electric field inside the magnetic island show extremely strong (∼100 mV m−1) fields which may play a significant role in the particle dynamics during reconnection.
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| 6. |
- Hasegawa, H., et al.
(författare)
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Kelvin-Helmholtz waves at the Earth's magnetopause : Multiscale development and associated reconnection
- 2009
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 114:12, s. A12207-
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Tidskriftsartikel (refereegranskat)abstract
- We examine traversals on 20 November 2001 of the equatorial magnetopause boundary layer simultaneously at similar to 1500 magnetic local time (MLT) by the Geotail spacecraft and at similar to 1900 MLT by the Cluster spacecraft, which detected rolled-up MHD-scale vortices generated by the Kelvin-Helmholtz instability (KHI) under prolonged northward interplanetary magnetic field conditions. Our purpose is to address the excitation process of the KHI, MHD-scale and ion-scale structures of the vortices, and the formation mechanism of the low-latitude boundary layer (LLBL). The observed KH wavelength (>4 x 10(4) km) is considerably longer than predicted by the linear theory from the thickness (similar to 1000 km) of the dayside velocity shear layer. Our analyses suggest that the KHI excitation is facilitated by combined effects of the formation of the LLBL presumably through high-latitude magnetopause reconnection and compressional magnetosheath fluctuations on the dayside, and that breakup and/or coalescence of the vortices are beginning around 1900 MLT. Current layers of thickness a few times ion inertia length similar to 100 km and of magnetic shear similar to 60 degrees existed at the trailing edges of the vortices. Identified in one such current sheet were signatures of local reconnection: Alfvenic outflow jet within a bifurcated current sheet, nonzero magnetic field component normal to the sheet, and field-aligned beam of accelerated electrons. Because of its incipient nature, however, this reconnection process is unlikely to lead to the observed dusk-flank LLBL. It is thus inferred that the flank LLBL resulted from other mechanisms, namely, diffusion and/or remote reconnection unidentified by Cluster.
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| 7. |
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| 8. |
- Nakamura, R., et al.
(författare)
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Cluster observations of an ion-scale current sheet in the magnetotail under the presence of a guide field
- 2008
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 113:A7, s. A07S16-
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Tidskriftsartikel (refereegranskat)abstract
- We report on Cluster observations of a thin current sheet interval under the presence of a strong vertical bar B-Y vertical bar during a fast earthward flow interval between 1655 UT and 1703 UT on 17 August 2003. The strong vertical bar B-Y vertical bar in the tail could be associated with a strong IMF vertical bar B-Y vertical bar, but the large fluctuations in B-Y, not seen in the IMF, suggest that a varying reconnection rate causes a varying transport of B-Y-dominated magnetic flux and/or a change in B-Y due to the Hall-current system. During the encounter of the high-speed flow, an intense current layer was observed around 1655: 53 UT with a peak current density of 182 nA/m(2), the largest current density observed by the Cluster four-spacecraft magnetic field measurement in the magnetotail. The half width of this current layer was estimated to be similar to 290 km, which was comparable to the ion-inertia length. Its unique signature is that the strong current is mainly field-aligned current flowing close to the center of the plasma sheet. The event was associated with parallel heating of electrons with asymmetries, which suggests that electrons moving along the field lines can contribute to a strong dawn-to-dusk current when the magnetotail current sheet becomes sufficiently thin and active in a strong guide field case.
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| 9. |
- Retino, A., et al.
(författare)
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Cluster observations of energetic electrons and electromagnetic fields within a reconnecting thin current sheet in the Earth's magnetotail
- 2008
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 113:A12
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Tidskriftsartikel (refereegranskat)abstract
- We study the acceleration of energetic electrons during magnetotail reconnection by using Cluster simultaneous measurements of three-dimensional electron distribution functions, electric and magnetic fields, and waves in a thin current sheet. We present observations of two consecutive current sheet crossings where the flux of electrons 35 127 keV peaks within an interval of tailward flows. The first crossing shows the signatures of a tailward moving flux rope. The observed magnetic field and density indicate that the flux rope was very dynamic, and a comparison with numerical simulation suggests a crossing right after coalescence of smaller flux ropes. The second crossing occurs within the ion diffusion region. The flux of electrons is largest within the flux rope where they are mainly directed perpendicular to the magnetic field. At the magnetic separatrices, the fluxes are smaller, but the energy spectra are harder and electrons are mainly field aligned. Reconnection electric fields E-Y similar to 7 mV/m are observed within the diffusion region, whereas in the flux rope, EY are much smaller. Waves around lower hybrid frequency do not show a clear correlation with energetic electrons. We interpret the field-aligned electrons at the separatrices as directly accelerated by the reconnection electric field in the diffusion region, whereas we interpret the perpendicular electrons as trapped within the flux rope and accelerated by a combination of betatron acceleration with nonadiabatic pitch-angle scattering. Our observations indicate that thin current sheets during dynamic reconnection are important for in situ production of energetic electrons and that simultaneous measurements of electrons and electromagnetic fields within thin sheets are crucial to understand the acceleration mechanisms.
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| 10. |
- Schwartz, Steven J., et al.
(författare)
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Cross-scale : multi-scale coupling in space plasmas
- 2009
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Ingår i: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 23:3, s. 1001-1015
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Tidskriftsartikel (refereegranskat)abstract
- Most of the visible universe is in the highly ionised plasma state, and most of that plasma is collision-free. Three physical phenomena are responsible for nearly all of the processes that accelerate particles, transport material and energy, and mediate flows in systems as diverse as radio galaxy jets and supernovae explosions through to solar flares and planetary magnetospheres. These processes in turn result from the coupling amongst phenomena at macroscopic fluid scales, smaller ion scales, and down to electron scales. Cross-Scale, in concert with its sister mission SCOPE (to be provided by the Japan Aerospace Exploration Agency-JAXA), is dedicated to quantifying that nonlinear, time-varying coupling via the simultaneous in-situ observations of space plasmas performed by a fleet of 12 spacecraft in near-Earth orbit. Cross-Scale has been selected for the Assessment Phase of Cosmic Vision by the European Space Agency.
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| 11. |
- Shell, Y. H., et al.
(författare)
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A generic symbiotic simulation framework
- 2006
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Ingår i: Proceedings - Workshop on Principles of Advanced and Distributed Simulation, PADS. - 0769525873 - 9780769525877
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Konferensbidrag (refereegranskat)abstract
- A symbiotic or online simulation is defined as one that interacts with the physical system in a mutually beneficial way. The simulation is driven by real time data collected from a physical system under control and needs to meet the real-time requirements of the physical system. In turn, the results from the "what-if experiments performed by the simulator can be used to control the dynamic behaviour of the physical system. Such a simulation tool is for real-time planning and is to foresee and advise on real time problems. It aims to improve performance, to adapt to sudden and unexpected events and to improve aspects of safety and security of the physical system. There are some research efforts, for example, the Dynamic Data-Driven Application Systems (DDDAS) which are currently advocated by the National Science Foundation (NSF) of the United States. However, work in this area is far from complete and many of the research issues are not fully addressed. We see the need for a general framework for symbiotic simulation. In this project, simulators based on the same general framework will be developed using symbiotic simulation techniques and will be used to provide adaptive decision support to manage the resources in several application environments. The objectives of this project are: To develop a generic, agent-based, symbiotic simulation system architecture. To develop mechanisms to support dynamic coupling between the symbiotic simulation system and the physical system. To conduct pilot case studies of the simulation framework. To explore and evaluate the service oriented architecture approach for parallel simulation in the multi-agent symbiotic simulation framework.
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| 12. |
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