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- Berglund, P., et al.
(författare)
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Altering the specificity of subtilisin B. lentus by combining site-directed mutagenesis and chemical modification
- 1996
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Ingår i: Bioorganic & Medicinal Chemistry Letters. - 0960-894X .- 1464-3405. ; 6:21, s. 2507-2512
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Tidskriftsartikel (refereegranskat)abstract
- The thiol side chain of the M222C mutant of the subtilisin from Bacillus lentus (SBL) has been chemically modified by methyl-, aminoethyl-, and sulfonatoethylthiosulfonate reagents. Introduction of charged residues into the active site of the enzyme reduced the catalytic efficiency with Suc-AAPF-pNA as the substrate, but resulted in better binding of sterically demanding boronic acid inhibitors.
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- Gold, J, et al.
(författare)
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Chemical characterization and reactivity of iron chelator-treated amphibole asbestos
- 1997
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Ingår i: ENVIRONMENTAL HEALTH PERSPECTIVES. - : US DEPT HEALTH HUMAN SERVICES PUBLIC HEALTH SERVICE. - 0091-6765. ; 105, s. 1021-1030
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Iron in amphibole asbestos is implicated in the pathogenicity of inhaled fibers. Evidence includes the observation that iron chelators can suppress fiber-induced tissue damage. This is believed to occur via the diminished production of fiber-associated re
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