| 1. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Abgrall, N., et al.
(författare)
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The large enriched germanium experiment for neutrinoless double beta decay (LEGEND)
- 2017
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Ingår i: AIP Conference Proceedings. - : Author(s). - 1551-7616 .- 0094-243X. ; 1894
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Konferensbidrag (refereegranskat)abstract
- The observation of neutrinoless double-beta decay (0νββ) would show that lepton number is violated, reveal that neu-trinos are Majorana particles, and provide information on neutrino mass. A discovery-capable experiment covering the inverted ordering region, with effective Majorana neutrino masses of 15 - 50 meV, will require a tonne-scale experiment with excellent energy resolution and extremely low backgrounds, at the level of ∼0.1 count /(FWHM·t·yr) in the region of the signal. The current generation 76Ge experiments GERDA and the Majorana Demonstrator, utilizing high purity Germanium detectors with an intrinsic energy resolution of 0.12%, have achieved the lowest backgrounds by over an order of magnitude in the 0νββ signal region of all 0νββ experiments. Building on this success, the LEGEND collaboration has been formed to pursue a tonne-scale 76Ge experiment. The collaboration aims to develop a phased 0νββ experimental program with discovery potential at a half-life approaching or at 1028 years, using existing resources as appropriate to expedite physics results.
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| 3. |
- Litvinov, Dmitry, et al.
(författare)
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Probing the gravitational redshift with an Earth-orbiting satellite
- 2018
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Ingår i: Physics Letters, Section A: General, Atomic and Solid State Physics. - : Elsevier BV. - 0375-9601. ; 382:33, s. 2192-2198
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Tidskriftsartikel (refereegranskat)abstract
- We present an approach to testing the gravitational redshift effect using the RadioAstron satellite. The experiment is based on a modification of the Gravity Probe A scheme of nonrelativistic Doppler compensation and benefits from the highly eccentric orbit and ultra-stable atomic hydrogen maser frequency standard of the RadioAstron satellite. Using the presented techniques we expect to reach an accuracy of the gravitational redshift test of order 10−5, a magnitude better than that of Gravity Probe A. Data processing is ongoing, our preliminary results agree with the validity of the Einstein Equivalence Principle.
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| 4. |
- Gusev, A, et al.
(författare)
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Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
- 2016
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 10979-
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Tidskriftsartikel (refereegranskat)abstract
- Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.
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| 5. |
- Litvinov, D. A., et al.
(författare)
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RadioAstron gravitational redshift experiment: Status update
- 2018
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Ingår i: 14th Marcel Grossman Meeting On Recent Developments in Theoretical and Experimental General Relativity, Astrophysics and Relativistic Field Theories, Proceedings. - : WORLD SCIENTIFIC. - 9789813226593 ; , s. 3569-3575
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Konferensbidrag (refereegranskat)abstract
- A test of a cornerstone of general relativity, the gravitational redshift effect, is currently being conducted with the RadioAstron spacecraft, which is on a highly eccentric orbit around Earth. Using ground radio telescopes to record the spacecraft signal, synchronized to its ultra-stable on-board H-maser, we can probe the varying flow of time on board with unprecedented accuracy. The observations performed so far, currently being analyzed, have already allowed us to measure the effect with a relative accuracy of 4 × 10−4. We expect to reach 2.5 × 10−5 with additional observations in 2016, an improvement of almost a magnitude over the 40-year old result of the GP-A mission.
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| 6. |
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| 7. |
- Gusev, A. N., et al.
(författare)
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Synthesis and photophysical properties of Zn(II) Schiff base complexes possessing strong solvent-dependent solid-state fluorescence
- 2018
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Ingår i: Polyhedron. - : Elsevier Ltd. - 0277-5387 .- 1873-3719. ; 155, s. 202-208
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Tidskriftsartikel (refereegranskat)abstract
- The present article reports on the syntheses, crystal structures and luminescence properties of three solvate forms of a zinc(II) complex containing 4-{(E)-[(2-fluorophenyl)imino]methyl}-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (HL). The reaction of zinc(II)acetate with the HL ligand in ethanol and acetonitrile led to the formation of two solvate analogues [Zn(L)2]·Solv (Solv – ethanol (1) and acetonitrile (2)). The properties of the [Zn(L)2]·Solv complexes were investigated by UV–Vis absorption and fluorescence emission spectroscopy, and the density functional theory calculations. Bader's topological analysis was performed to investigate the electronic peculiarities of Zn(II) polyhedra and non-covalent interactions within crystal packing of studied solvates.
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| 8. |
- Carra, Serena, et al.
(författare)
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The growing world of small heat shock proteins : from structure to functions
- 2017
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Ingår i: Cell Stress and Chaperones. - : Springer Science and Business Media LLC. - 1355-8145 .- 1466-1268. ; 22:4, s. 601-611
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Tidskriftsartikel (refereegranskat)abstract
- Small heat shock proteins (sHSPs) are present in all kingdoms of life and play fundamental roles in cell biology. sHSPs are key components of the cellular protein quality control system, acting as the first line of defense against conditions that affect protein homeostasis and proteome stability, from bacteria to plants to humans. sHSPs have the ability to bind to a large subset of substrates and to maintain them in a state competent for refolding or clearance with the assistance of the HSP70 machinery. sHSPs participate in a number of biological processes, from the cell cycle, to cell differentiation, from adaptation to stressful conditions, to apoptosis, and, even, to the transformation of a cell into a malignant state. As a consequence, sHSP malfunction has been implicated in abnormal placental development and preterm deliveries, in the prognosis of several types of cancer, and in the development of neurological diseases. Moreover, mutations in the genes encoding several mammalian sHSPs result in neurological, muscular, or cardiac age-related diseases in humans. Loss of protein homeostasis due to protein aggregation is typical of many age-related neurodegenerative and neuromuscular diseases. In light of the role of sHSPs in the clearance of un/misfolded aggregation-prone substrates, pharmacological modulation of sHSP expression or function and rescue of defective sHSPs represent possible routes to alleviate or cure protein conformation diseases. Here, we report the latest news and views on sHSPs discussed by many of the world’s experts in the sHSP field during a dedicated workshop organized in Italy (Bertinoro, CEUB, October 12–15, 2016).
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| 9. |
- Gusev, Alexey N., et al.
(författare)
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Novel Zinc Complex with an Ethylenediamine Schiff Base for High-Luminance Blue Fluorescent OLED Applications
- 2019
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Ingår i: The Journal of Physical Chemistry C. - : AMER CHEMICAL SOC. - 1932-7447 .- 1932-7455. ; 123:18, s. 11850-11859
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Tidskriftsartikel (refereegranskat)abstract
- To explore the photophysical properties of coordination compounds with bright blue fluorescence, an azomethin-zinc complex was synthesized and characterized by various techniques (elemental analysis, thermogravimetry, and IR-mass-spectroscopy). The crystal structure was determined by X-ray diffraction analysis. Through thermal characterization, this complex was proved to have good thermal stability. Photoluminescence spectra were recorded, both in solution and in the solid state, and the complexes showed noteworthy photoluminescence with a maximum in the blue region. The results of time-dependent density functional theory calculations indicated that the origin of luminescence for the title complex is a combination of monomer and excimer emissions. The light emission performance of the zinc complex in organic light emitting diodes was investigated, and the results indicated superior electroluminescence properties as a blue fluorescent light source (max. brightness 17 000 cd/m(2), max. EQE = 5%).
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| 10. |
- Pchelkin, Stepan S., et al.
(författare)
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On Orbital Stabilization for Industrial Manipulators : Case Study in Evaluating Performances of Modified PD plus and Inverse Dynamics Controllers
- 2017
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Ingår i: IEEE Transactions on Control Systems Technology. - 1063-6536 .- 1558-0865. ; 25:1, s. 101-117
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Tidskriftsartikel (refereegranskat)abstract
- Orbital stabilization is one of the available alternatives to the classical asymptotic stabilization, known as the reference tracking control, which is typically considered and implemented for controlling motions of industrial robot manipulators. Since asymptotic orbital stability means convergence of solutions of a closed-loop system to an orbit of a reference trajectory, instead of tracking it as a function of time, new feedback designs can potentially improve performance with respect to several key criteria for industrial manipulators such as absolute path accuracy for tool's motions and robustness to uncertainties in the model. The main outcomes of this paper are a new class of controllers that achieve asymptotic orbital stabilization of motions and a novel analytical method for analysis and redesign of system's dynamics using an excessive set of easy-to-compute transverse coordinates. The contributions have been validated in a series of experimental studies performed on a standard industrial robot ABB IRB 140 with the IRC5-system extended with an open control interface. The outcomes of the tests show that the proposed redesign allows achieving significantly reduced deviations of the actual trajectories from the desired ones at different ranges of speeds and for several different paths, often outperforming the state-of-the-art commercial implementations. A comprehensive discussion of one of such experiments is given.
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| 11. |
- Gusev, V. A., et al.
(författare)
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Nonlinear sound in a gas-saturated sediment layer
- 2015
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Ingår i: Acoustical Physics. - : Maik Nauka/Interperiodica. - 1063-7710 .- 1562-6865. ; 61:2, s. 152-164
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Tidskriftsartikel (refereegranskat)abstract
- Wave propagation in a near-bottom layer containing gas bubbles is analyzed. Evolution equations are derived for intense acoustic waves and wave beams in a medium with an inhomogeneous bubble distribution. The field of an intense beam along the axis of the focusing sound channel is calculated. The coefficients of reflection and passage of sound from a homogeneous medium into a bubble layer and back again are calculated. It is shown that the near-bottom layer can effectively trap rays incident on it and ensure a waveguide propagation character. The presence of bubbles increases both the interval of angles at which the wave penetrates the layer and the interval of angles at which rays undergo total internal reflection and do not depart the layer. The acoustic field in the layer from a point source is calculated.
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| 12. |
- Rudenko, Oleg, et al.
(författare)
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Self-similar solutions of a Burgers-type equation with quadratically cubic nonlinearity
- 2016
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Ingår i: Doklady. Mathematics. - : Maik Nauka/Interperiodica. - 1064-5624 .- 1531-8362. ; 93:1, s. 94-98
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Tidskriftsartikel (refereegranskat)abstract
- Self-similar solutions are found for a quadratically cubic second-order partial differential equation governing the behavior of nonlinear waves in various distributed systems, for example, in some metamaterials. They are compared with self-similar solutions of the Burgers equation. One of them describing a single unipolar pulse is shown to satisfy both equations. The other self-similar solutions of the quadratically cubic equation behave differently from the solutions of the Burgers equation. They are constructed by matching the positive and negative branches of the solution, so that the function itself and its first derivative are continuous. One of these solutions corresponds to an asymmetric solitary N-wave of the sonic shock type. Self-similar solutions of a quadratically cubic equation describing the propagation of cylindrically symmetric waves are also found.
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