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Three Versus Six Mo...
Three Versus Six Months of Adjuvant Doublet Chemotherapy for Patients With Colorectal Cancer : A Multi-Country Cost-Effectiveness and Budget Impact Analysis
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- Hanna, Catherine R. (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, 1053 Great Western Rd, Glasgow G12 0YN, Lanark, Scotland.
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- Robles-Zurita, Jose A. (författare)
- Univ Glasgow, Inst Hlth & Wellbeing, Hlth Econ & Hlth Technol Assessment, Glasgow, Lanark, Scotland.
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- Briggs, Andrew (författare)
- London Sch Hyg & Trop Med, London, England.
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- Harkin, Andrea (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, 1053 Great Western Rd, Glasgow G12 0YN, Lanark, Scotland.
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- Kelly, Caroline (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, 1053 Great Western Rd, Glasgow G12 0YN, Lanark, Scotland.
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- McQueen, John (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, 1053 Great Western Rd, Glasgow G12 0YN, Lanark, Scotland.
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- Allan, Karen (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, 1053 Great Western Rd, Glasgow G12 0YN, Lanark, Scotland.
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- Pearson, Sarah (författare)
- Univ Oxford, Dept Oncol, Oncol Clin Trials Off, Oxford, England.
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- Hollander, Henrik (författare)
- Zealand Univ Hosp, Dept Oncol, Naestved, Denmark.
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- Glimelius, Bengt (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Salazar, Ramon (författare)
- Hosp Llobregat, Bellvitge Biomed Res Inst IDIBELL CIBERONC, Catalon Inst Oncol, Dept Med Oncol,Oncobell Program, Barcelona, Spain.
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- Segelov, Eva (författare)
- Monash Hlth, Clayton, Vic, Australia.;Monash Univ, Clayton, Vic, Australia.
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- Saunders, Mark (författare)
- Christie NHS Fdn Trust, Manchester, Lancs, England.
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- Iveson, Tim (författare)
- Univ Hosp Southampton, Southampton Gen Hosp, Southampton, Hants, England.
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- Jones, Robert J. (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, 1053 Great Western Rd, Glasgow G12 0YN, Lanark, Scotland.
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- Boyd, Kathleen A. (författare)
- Univ Glasgow, Inst Hlth & Wellbeing, Hlth Econ & Hlth Technol Assessment, Glasgow, Lanark, Scotland.
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Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, 1053 Great Western Rd, Glasgow G12 0YN, Lanark, Scotland Univ Glasgow, Inst Hlth & Wellbeing, Hlth Econ & Hlth Technol Assessment, Glasgow, Lanark, Scotland. (creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Clinical colorectal cancer. - : Elsevier. - 1533-0028. ; 20:3, s. 236-244
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://www.clinical-...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- This study widens the transferability of cost-utility results from the SCOT trial showing that administering 3 months of adjuvant, oxaliplatin-based chemotherapy is cost-effective and cost saving compared to 6 months from the perspective of all countries recruited to SCOT. The impact on healthcare budgets if the findings are implemented as predicted will amount to savings of at least US$150 million over 5 years. Background: The Short Course Oncology Treatment (SCOT) trial demonstrated non-inferiority, less toxicity, and cost-effectiveness from a UK perspective of 3 versus 6 months of oxaliplatin-based chemotherapy for patients with colorectal cancer. This study assessed the cost-effectiveness of shorter treatment and the budget impact of implementing trial findings from the perspectives of all countries recruited to SCOT: Australia, Denmark, New Zealand, Spain, Sweden, and the United Kingdom. Patients and Methods: Individual cost-utility analyses were performed from the perspective of each country. Resource, quality of life, and survival estimates from the SCOT trial (N = 6065) were used. Probabilistic sensitivity analysis and subgroup analyses were undertaken. Using undiscounted costs from these cost-utility analyses, the impact on country-specific healthcare budgets of implementing the SCOT trial findings was calculated over a 5-year period. The currency used was US dollars (US$), and 2019 was the base year. One-way and scenario sensitivity analysis addressed uncertainty within the budget impact analysis. Results: Three months of treatment were cost saving and cost-effective compared to 6 months from the perspective of all countries. The incremental net monetary benefit per patient ranged from US$8972 (Spain) to US$13,884 (Denmark). The healthcare budget impact over 5 years for the base-case scenario ranged from US$3.6 million (New Zealand) to US$61.4 million (UK) and totaled over US$150 million across all countries. Conclusion: This study has widened the transferability of results from the SCOT trial, showing that shorter treatment is cost-effective from a multi-country perspective. The vast savings from implementation could fully justify the investment in conducting the SCOT trial.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
Nyckelord
- Clinical trial
- Cost analysis
- Drug therapy
- International
- Neoplasm
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- ref (ämneskategori)
- art (ämneskategori)
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Hanna, Catherine ...
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Robles-Zurita, J ...
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Briggs, Andrew
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Harkin, Andrea
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Kelly, Caroline
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McQueen, John
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visa fler...
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Allan, Karen
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Pearson, Sarah
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Hollander, Henri ...
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Glimelius, Bengt
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Salazar, Ramon
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Segelov, Eva
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Saunders, Mark
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Iveson, Tim
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Jones, Robert J.
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Boyd, Kathleen A ...
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