| 1. |
- Yao, W-M, et al.
(författare)
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Review of Particle Physics
- 2006
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Ingår i: Journal of Physics G: Nuclear and Particle Physics. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 33:1, s. 1-1
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Villa, Luisa L., et al.
(författare)
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Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18
- 2006
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Ingår i: Vaccine. - : Elsevier BV. - 1873-2518 .- 0264-410X. ; 24:27-28, s. 5571-5583
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Tidskriftsartikel (refereegranskat)abstract
- Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenicity in baseline HPV 6/11/16 or 18-naive and previously infected subjects. All three formulations were highly immunogenic. At Month 2 (postdose 1), among women with vaccine-type antibodies at baseline, vaccine-induced anti-HPV responses were similar to 12- to 26-fold higher than those observed in baseline-naive women, suggesting an anamnestic response. Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported. (c) 2006 Elsevier Ltd. All rights reserved.
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| 9. |
- Rice, A. M., et al.
(författare)
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Development and characterization of nine polymorphic microsatellite markers for Mexican spadefoot toads (Spea multiplicata) with cross-amplification in Plains spadefoot toads (S-bombifrons)
- 2008
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Ingår i: Molecular Ecology Resources. - : Wiley. - 1755-098X .- 1755-0998. ; 8:6, s. 1386-1389
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Tidskriftsartikel (refereegranskat)abstract
- We developed nine polymorphic microsatellite markers for the Mexican spadefoot toad, Spea multiplicata. Allele numbers range from five to 12, with observed heterozygosities from 0.48 to 0.87. Because two loci are in linkage disequilibrium, these nine loci provide eight independent markers. Three loci exhibit departure from Hardy-Weinberg equilibrium, possibly resulting from null alleles or population admixture. These markers will be useful for assessing population structure and relatedness in S. multiplicata. Based on our success at cross-amplification in the Plains spadefoot toad (Spea bombifrons), these loci also may be useful in this species with additional optimization.
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| 13. |
- Brose, Ulrich, et al.
(författare)
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Body sizes of consumers and their resources
- 2005
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Ingår i: Ecology. - : Ecological Society of America. - 0012-9658 .- 1939-9170. ; 86:9, s. 2545-2545
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Tidskriftsartikel (refereegranskat)abstract
- Trophic information—who eats whom—and species’ body sizes are two of the most basic descriptions necessary to understand community structure as well as ecological and evolutionary dynamics. Consumer–resource body size ratios between predators and their prey, and parasitoids and their hosts, have recently gained increasing attention due to their important implications for species’ interaction strengths and dynamical population stability. This data set documents body sizes of consumers and their resources. We gathered body size data for the food webs of Skipwith Pond, a parasitoid community of grass-feeding chalcid wasps in British grasslands; the pelagic community of the Benguela system, a source web based on broom in the United Kingdom; Broadstone Stream, UK; the Grand Caric¸aie marsh at Lake Neuchaˆtel, Switzerland; Tuesday Lake, USA; alpine lakes in the Sierra Nevada of California; Mill Stream, UK; and the eastern Weddell Sea Shelf, Antarctica. Further consumer–resource body size data are included for planktonic predators, predatory nematodes, parasitoids, marine fish predators, freshwater invertebrates, Australian terrestrial consumers, and aphid parasitoids. Containing 16 807 records, this is the largest data set ever compiled for body sizes of consumers and their resources. In addition to body sizes, the data set includes information on consumer and resource taxonomy, the geographic location of the study, the habitat studied, the type of the feeding interaction (e.g., predacious, parasitic) and the metabolic categories of the species (e.g., invertebrate, ectotherm vertebrate). The present data set was gathered with the intent to stimulate research on effects of consumer–resource body size patterns on food-web structure, interaction-strength distributions, population dynamics, and community stability. The use of a common data set may facilitate cross-study comparisons and understanding of the relationships between different scientific approaches and models.
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| 14. |
- de Groot, Kirsten, et al.
(författare)
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Pulse Versus Daily Oral Cyclophosphamide for Induction of Remission in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis A Randomized Trial
- 2009
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Ingår i: Annals of Internal Medicine. - 0003-4819. ; 150:10, s. 3-670
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Tidskriftsartikel (refereegranskat)abstract
- Background: Current therapies for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis are limited by toxicity. Objective: To compare pulse cyclophosphamide with daily oral cyclophosphamide for induction of remission. Design: Randomized, controlled trial. Random assignments were computer-generated; allocation was concealed by faxing centralized treatment assignment to providers at the time of enrollment. Patients, investigators, and assessors of outcomes were not blinded to assignment. Setting: 42 centers in 12 European countries. Patients: 149 patients who had newly diagnosed generalized ANCA-associated vasculitis with renal involvement but not immediately life-threatening disease. Intervention: Pulse cyclophosphamide, 15 mg/kg every 2 to 3 weeks (76 patients), or daily oral cyclophosphamide, 2 mg/kg per day (73 patients), plus prednisolone. Measurement: Time to remission (primary outcome); change in renal function, adverse events, and cumulative dose of cyclophosphamide (secondary outcomes). Results: Groups did not differ in time to remission (hazard ratio, 1.098 [95% CI, 0.78 to 1.55]; P = 0.59) or proportion of patients who achieved remission at 9 months (88.1% vs. 87.7%). Thirteen patients in the pulse group and 6 in the daily oral group achieved remission by 9 months and subsequently had relapse. Absolute cumulative cyclophosphamide dose in the daily oral group was greater than that in the pulse group (15.9 g [interquartile range, 11 to 22.5 g] vs. 8.2 g [interquartile range, 5.95 to 10.55 g]; P < 0.001). The pulse group had a lower rate of leukopenia (hazard ratio, 0.41 [CI, 0.23 to 0.71]). Limitations: The study was not powered to detect a difference in relapse rates between the 2 groups. Duration of follow-up was limited. Conclusion: The pulse cyclophosphamide regimen induced remission of ANCA-associated vasculitis as well as the daily oral regimen at a reduced cumulative cyclophosphamide dose and caused fewer cases of leukopenia. Primary Funding Source: The European Union.
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| 18. |
- Hellstrom-Lindberg, E, et al.
(författare)
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Lead poisoning from souvenir earthenware
- 2006
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Ingår i: International archives of occupational and environmental health. - : Springer Science and Business Media LLC. - 0340-0131 .- 1432-1246. ; 79:2, s. 165-168
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Tidskriftsartikel (refereegranskat)
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| 19. |
- Hoel, Ole Andreas, 1968-
(författare)
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Diversity and Life Habits of Silurian Strophomenide Brachiopods of Gotland
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The Superfamily Strophomenoidea is a very diverse group of brachiopods in the Early Palaeozoic. In the Silurian succession on Gotland, they are among the most easily identifiable, and commonly found fossils. However, there are few detailed studies of this group from Gotland, and no new strophomenide taxa have been described from this area since 1869. The life habits of strophomenides are also poorly understood, partly because their morphology differs greatly from that of living brachiopods. The succession on Gotland yielded 27 species belonging to the Strophomenoidea, of which two species and two subspecies are new. The remaining species have been described earlier from Gotland or Great Britain. The most important group is the Leptaeninae, which occurs commonly throughout the entire succession on Gotland. Five species (one new), two new subspecies and two taxa treated under open nomenclature were found. Leptaena rhomboidalis and Lepidoleptaena poulseni were specialized for life in shallow water environments, retaining a large apical pedicle; the remaining leptaenines were ambitopic. The Furcitellininae is represented by three genera comprising six species, of which only one persisted into the Ludlow. All were ambitopic, except Pentlandina loveni, which was specialized for high-energy environments. Six species of “strophodontids” from Gotland, belonging to the Leptostrophidae, the Strophodontidae and the Shaleriidae, share a shallow-bodied, variably concavo-convex shell with costellate ornament. Mesoleptostrophia and Brachyprion (Brachyprion) were long-ranged and ecologically tolerant, while B. (Erinostrophia), Strophodonta and Shaleria had short ranges and were ecologically specialized. The two earliest known cementing strophomenides occur on Gotland, and their hitherto unknown dorsal valves have been identified: Liljevallia was found to belong to the Douvillinidae. The cementing Leptaenoidea silurica was found to be conspecific with the ambitopic Scamnomena rugata; it was able to live ambitopically if removed from the substrate. The thickened dorsal valves allow reconstruction of its lophophore.
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| 20. |
- Monoranu, Camelia Maria, et al.
(författare)
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pH measurement as quality control on human post mortem brain tissue : a study of the BrainNet Europe consortium
- 2009
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Ingår i: Neuropathology and Applied Neurobiology. - : Wiley. - 0305-1846 .- 1365-2990. ; 35:3, s. 329-337
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: Most brain diseases are complex entities. Although animal models or cell culture experiments mimic some disease aspects, human post mortem brain tissue remains essential to advance our understanding of brain diseases using biochemical and molecular techniques. Post mortem artefacts must be properly understood, standardized, and either eliminated or factored into such experiments. Here we examine the influence of several premortem and post mortem factors on pH, and discuss the role of pH as a biochemical marker for brain tissue quality. METHODS: We assessed brain tissue pH in 339 samples from 116 brains provided by 8 different European and 2 Australian brain bank centres. We correlated brain pH with tissue source, post mortem delay, age, gender, freezing method, storage duration, agonal state and brain ischaemia. RESULTS: Our results revealed that only prolonged agonal state and ischaemic brain damage influenced brain tissue pH next to repeated freeze/thaw cycles. CONCLUSIONS: pH measurement in brain tissue is a good indicator of premortem events in brain tissue and it signals limitations for post mortem investigations.
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| 23. |
- Sundqvist, J. O., et al.
(författare)
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MgI emission lines at 12 and 18 mu m in K giants
- 2008
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 486:3, s. 985-993
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Tidskriftsartikel (refereegranskat)abstract
- Context. The solar mid-infrared metallic emission lines have already been observed and analyzed well, and the formation scenario of the Mg I 12 mu m lines has been known for more than a decade. Detections of stellar emission at 12 mu m have, however, been limited to Mg I in very few objects. Previous modeling attempts have been made only for Procyon and two cool evolved stars, with unsatisfactory results for the latter. This prevents the lines' long predicted usage as probes of stellar magnetic fields. Aims. We want to explain our observed Mg I emission lines at 12 mu m in the K giants Pollux, Arcturus, and Aldebaran and at 18 mu m in Pollux and Arcturus. We discuss our modeling of these lines and particularly how various aspects of the model atom affect the emergent line profiles. Methods. High-resolution observational spectra were obtained using TEXES at Gemini North and the IRTF. To produce synthetic line spectra, we employed standard one-dimensional, plane-parallel, non-LTE modeling for trace elements in cool stellar atmospheres. We computed model atmospheres with the MARCS code, applied a comprehensive magnesium model atom, and used the radiative transfer code MULTI to solve for the magnesium occupation numbers in statistical equilibrium. Results. The Mg I emission lines at 12 mu m in the K giants are stronger than in the dwarfs observed so far. We present the first observed stellar emission lines from Mg I at 18 mu m and from Al I, Si I, and presumably Ca I at 12 mu m. We successfully reproduce the observed Mg I emission lines simultaneously in the giants and in the Sun, but show how the computed line profiles depend critically on atomic data input and how the inclusion of energy levels with n > ;= 10 and collisions with neutral hydrogen are necessary to obtain reasonable fits.
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| 24. |
- Thunell, S, et al.
(författare)
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Porphyria in Sweden
- 2006
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Ingår i: Physiological research. - 0862-8408. ; 5555 Suppl 2, s. S109-S118
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Tidskriftsartikel (refereegranskat)
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| 25. |
- Villa, LL, et al.
(författare)
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Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial
- 2005
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Ingår i: The Lancet Oncology. - 1474-5488 .- 1470-2045. ; 6:5, s. 271-278
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Tidskriftsartikel (refereegranskat)abstract
- Background A randomised double-blind placebo-controlled phase II study was done to assess the efficacy of a prophylactic quadrivalent vaccine targeting the human papillomavirus (HPV) types associated with 70% of cervical cancers (types 16 and 18) and with 90% of genital warts (types 6 and 11). Methods 277 young women (mean age 20.2 years [SD 1.7]) were randomly assigned to quadrivalent HPV (20 μ g type 6, 40 μ g type 11, 40 μ g type 16, and 20 μ g type 18) L1 virus-like-particle (VLP) vaccine and 275 (mean age 20.0 years [1.7]) to one of two placebo preparations at day 1, month 2, and month 6. For 36 months, participants underwent regular gynaecological examinations, cervicovaginal sampling for HPV DNA, testing for serum antibodies to HPV, and Pap testing. The primary endpoint was the combined incidence of infection with HPV 6, 11, 16, or 18, or cervical or external genital disease (ie, persistent HPV infection, HPV detection at the last recorded visit, cervical intraepithelial neoplasia, cervical cancer, or external genital lesions caused by the HPV types in the vaccine). Main analyses were done per protocol. Findings Combined incidence of persistent infection or disease with HPV 6, 11, 16, or 18 fell by 90% (95% CI 71-97, p< 0.0001) in those assigned vaccine compared with those assigned placebo. Interpretation A vaccine targeting HPV types 6, 11, 16, 18 could substantially reduce the acquisition of infection and clinical disease caused by common HPV types.
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