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- Huang, GI, et al.
(författare)
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Nonlinear plasma oscillation with a fractional harmonics and analysis in the time-frequency spectrum
- 1997
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Ingår i: CHINESE PHYSICS LETTERS. - : ALLERTON PRESS INC. - 0256-307X. ; 14:11, s. 857-860
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In the observations of Freja satellite in the energization legion of the low aurora(1700km), a new nonlinear plasma oscillation with a turbulent spectrum at the fractional harmonics of the local proton gyrofrequencies is reported and analyzed with the wav
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- Salhi-Benachenhou, Nessima, et al.
(författare)
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Theoretical study of the ethylene radical cation : geometry and hyperfine structure
- 1998
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Ingår i: Chemical Physics. - 0301-0104 .- 1873-4421. ; 236:1-3, s. 53-61
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Tidskriftsartikel (refereegranskat)abstract
- The geometry and the hyperfine structure in the ethylene radical cation have been studied by means of a number of high-level post-SCF ab initio methods, including quadratic CI with single and double substitutions and perturbative triple corrections, QCISD(T), coupled cluster with single and double substitutions and perturbative triple corrections, CCSD(T), and individually selected multi-reference CI with B-K correction, (MRD-CI)/B-K. A value of 20.2 degrees has been computed for the torsion angle in this cation with the QCISD(T)/6-311G(d, p) method, which compares favourably with the experimentally reported angle of similar to 25 degrees. The computed potential barrier to inversion through the planar conformation, as obtained at the QCISD(T)/6-311 + + G(2df, p)//QCISD(T)/6-31 1G(d, p) level (1.24 kJ/mol), is smaller than the experimental value of similar to 3 kJ/mol, but an order of magnitude better than in previous work. The hyperfine coupling constants of the protons and of C-13 are calculated by the (MRD-CI)/B-K method with a relatively large basis set, yielding somewhat larger absolute values than the experimental couplings (-4.0 G for the protons and +6.0 G for C-13, as compared with -2.4 and +4.0 G, respectively). For both the geometrical parameters and the hyperfine couplings, the results of the present study are in considerably better agreement with experiment than previously reported theoretical results.
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| 6. |
- Gunnarsson, I, et al.
(författare)
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Association between ongoing anti-C1q antibody production in peripheral blood and proliferative nephritis in patients with active systemic lupus erythematosus.
- 1997
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Ingår i: British Journal of Rheumatology. - : Oxford University Press (OUP). - 0263-7103 .- 1460-2172. ; 36, s. 32-
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to compare ongoing production of anti-C1q antibodies (anti-C1q) in peripheral blood with serum anti-C1q levels in patients with systemic lupus erythematosus (SLE), especially in patients with nephritis. Using the ELISPOT technique for the detection of IgG and IgA anti-C1q production, 21 patients with active SLE were investigated. ELISAs for IgG and IgA anti-C1q were compared with the ELISPOT results. Six of the patients were found to have proliferative nephritis (WHO grade III/IV) confirmed by renal biopsy. High numbers of IgG anti-C1q spot-forming cells (SFC), defined as > 20/10(5) plated peripheral blood mononuclear cells (PBMC), were exclusively observed in patients with proliferative nephritis (P < 0.0001). Serum levels of IgG anti-C1q were significantly increased in patients with proliferative nephritis (P = 0.039). High ongoing IgG anti-C1q production was observed in all patients with proliferative nephritis, which may be a contributory factor in the pathogenesis of this disorder. The detection of IgG anti-C1q production may be valuable in the clinical investigation of patients with suspected SLE nephritis.
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| 8. |
- Huang, GL, et al.
(författare)
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The eigenmode of solitary kinetic Alfven waves observed by Freja satellite
- 1997
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Ingår i: JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS. - : AMER GEOPHYSICAL UNION. ; 102:A4, s. 7217-7224
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The properties of the solitary kinetic Alfven waves (SKAWs) observed by Freja satellite are studied statistically for a typical event on March 7, 1994. The eigenmode of the SKAWs observed is still recognized by their anisotropic structure (1000 km x 1 km)
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| 10. |
- Huang, QW, et al.
(författare)
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Effects of inhaled nitric oxide and high-frequency ventilation in rabbits with meconium aspiration
- 1999
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Ingår i: Biology of the neonate. - : S. Karger AG. - 0006-3126. ; 76:6, s. 374-382
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To evaluate effects of inhaled nitric oxide (iNO) in experimental meconium aspiration treated with high-frequency (HFV) or conventional mechanical ventilation (CMV). Ventilated adult rabbits had meconium instilled intratracheally resulting in respiratory failure as evidenced by more than 50% reduction of dynamic lung compliance (Cdyn) and increase in mean oxygenation index (OI) from 1 to 16. The animals were then allocated to 2 groups treated without (control) or with iNO at 20 ppm (NO). In each group the animals were initially ventilated with CMV or HFV mode for 3 h and then in a crossover fashion with HFV or CMV for another 3 h (CMV→HFV, HFV→CMV), respectively. In the first 3 h of treatment, the animals subjected to HFV-CMV in the control, and those with both HFV-CMV and CMV-HFV in the NO group had significantly reduced OI. In the subsequent 3 h, the animals in the control group with CMV-HFV did not improve in OI and those with HFV-CMV had deteriorated. In the NO group with both CMV-HFV and HFV-CMV moderate improvement of OI was observed. Platelet aggregation capability and counts were significantly decreased and bleeding time prolonged in animals receiving iNO treatment. These results suggest that both HFV alone and a combined treatment of iNO with either CMV or HFV are more effective in improving blood oxygenation than that of CMV in this animal model. The influence of iNO on platelet aggregation should be considered.
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| 20. |
- Nicholson, L B, et al.
(författare)
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Monoclonal antibodies to the human TSH receptor: epitope mapping and binding to the native receptor on the basolateral plasma membrane of thyroid follicular cells.
- 1996
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Ingår i: Journal of molecular endocrinology. - 0952-5041. ; 16:2, s. 159-70
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Tidskriftsartikel (refereegranskat)abstract
- We have characterized four murine monoclonal antibodies (mAbs) to the extracellular domain of the human TSH receptor (TSH-R.E), the target autoantigen of Graves' disease. Recombinant TSH-R.E used as immunogen, was produced in E. coli as a fusion protein with glutathione-S-transferase or in a baculovirus-insect cell system, as a non-fusion glycoprotein. To increase the epitope specificity of the mAbs, two different strains of mice (H-2(b) and H-2(d)) were immunized. The epitopes recognized by the mAbs were characterized by immunoblotting with various recombinant constructs of TSH-R.E and by binding to overlapping synthetic peptides of the receptor. The four IgG mAbs characterized recognized epitopes localized to different regions on the TSH-R.E; amino acids 22-35 (A1O and A11, both IgG2b from H-2(b) animals), amino acids 402-415 (A7, IgG2b from H-2(b) animals) and amino acids 147-228 (A9, IgG1 from H-2(d) animals). Immunolocalization studies showed that mAb A9 recognized TSH-R.E on unfixed cryostat sections, where binding was localized to the basolateral plasma membrane of thyroid follicular cells, suggesting that this antibody reacts with the native receptor on thyroid cells. The binding of the mAbs A7, A10 and A11 was also restricted to the basal surface of thyroid cells, but only after acetone fixation of the sections, implying that the epitopes recognized on the amino and carboxyl terminus of the extracellular region of the receptor are not accessible on the native molecule. None of the mAbs stimulated cyclic AMP responses in COS-7 cells transiently transfected with full-length functioning TSH-R.E, whilst weak inhibition of binding of radiolabelled TSH to porcine membranes in a radioreceptor assay was apparent with mAb A10 and A11, but only at high concentrations of IgG. The ability of mAb A9 to bind to the native receptor without stimulating activity or inhibition of TSH binding suggests that antibody can bind to the central region of the TSH-R.E without perturbing receptor function. The availability of mAbs that recognize epitopes on different regions of the extracellular domain of TSH-R will lead to a better understanding of the autoantigenic regions on TSH-R implicated in disease activity.
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