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1.
  • Stoop, Thomas F., et al. (författare)
  • Pathological complete response in patients with resected pancreatic adenocarcinoma after preoperative chemotherapy
  • 2024
  • Ingår i: JAMA Network Open. - : American Medical Association (AMA). - 2574-3805. ; 7:6
  • Tidskriftsartikel (refereegranskat)abstract
    • Importance: Preoperative chemo(radio)therapy is increasingly used in patients with localized pancreatic adenocarcinoma, leading to pathological complete response (pCR) in a small subset of patients. However, multicenter studies with in-depth data about pCR are lacking.Objective: To investigate the incidence, outcome, and risk factors of pCR after preoperative chemo(radio)therapy.Design, Setting, and Participants: This observational, international, multicenter cohort study assessed all consecutive patients with pathology-proven localized pancreatic adenocarcinoma who underwent resection after 2 or more cycles of chemotherapy (with or without radiotherapy) in 19 centers from 8 countries (January 1, 2010, to December 31, 2018). Data collection was performed from February 1, 2020, to April 30, 2022, and analyses from January 1, 2022, to December 31, 2023. Median follow-up was 19 months.Exposures: Preoperative chemotherapy (with or without radiotherapy) followed by resection.Main Outcomes and Measures: The incidence of pCR (defined as absence of vital tumor cells in the sampled pancreas specimen after resection), its association with OS from surgery, and factors associated with pCR. Factors associated with overall survival (OS) and pCR were investigated with Cox proportional hazards and logistic regression models, respectively.Results: Overall, 1758 patients (mean [SD] age, 64 [9] years; 879 [50.0%] male) were studied. The rate of pCR was 4.8% (n = 85), and pCR was associated with OS (hazard ratio, 0.46; 95% CI, 0.26-0.83). The 1-, 3-, and 5-year OS rates were 95%, 82%, and 63% in patients with pCR vs 80%, 46%, and 30% in patients without pCR, respectively (P < .001). Factors associated with pCR included preoperative multiagent chemotherapy other than (m)FOLFIRINOX ([modified] leucovorin calcium [folinic acid], fluorouracil, irinotecan hydrochloride, and oxaliplatin) (odds ratio [OR], 0.48; 95% CI, 0.26-0.87), preoperative conventional radiotherapy (OR, 2.03; 95% CI, 1.00-4.10), preoperative stereotactic body radiotherapy (OR, 8.91; 95% CI, 4.17-19.05), radiologic response (OR, 13.00; 95% CI, 7.02-24.08), and normal(ized) serum carbohydrate antigen 19-9 after preoperative therapy (OR, 3.76; 95% CI, 1.79-7.89).Conclusions and Relevance: This international, retrospective cohort study found that pCR occurred in 4.8% of patients with resected localized pancreatic adenocarcinoma after preoperative chemo(radio)therapy. Although pCR does not reflect cure, it is associated with improved OS, with a doubled 5-year OS of 63% compared with 30% in patients without pCR. Factors associated with pCR related to preoperative chemo(radio)therapy regimens and anatomical and biological disease response features may have implications for treatment strategies that require validation in prospective studies because they may not universally apply to all patients with pancreatic adenocarcinoma.
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2.
  • Akins, Hollis B., et al. (författare)
  • ALMA Reveals Extended Cool Gas and Hot Ionized Outflows in a Typical Star-forming Galaxy at Z=7.13
  • 2022
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 934:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We present spatially resolved morphological properties of [C II] 158 mu m, [O III] 88 mu m, dust, and rest-frame ultraviolet (UV) continuum emission for A1689-zD1, a strongly lensed, sub-L* galaxy at z = 7.13, by utilizing deep Atacama Large Millimeter/submillimeter Array (ALMA) and Hubble Space Telescope (HST) observations. While the [O III] line and UV continuum are compact, the [C II] line is extended up to a radius of r similar to 12 kpc. Using multi-band rest-frame far-infrared continuum data ranging from 52 to 400 mu m, we find an average dust temperature and emissivity index of Tdust=41-14+17 beta=1.7-0.7+1.1 6 galaxies.
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3.
  • Bakx, Tom J. L. C., et al. (författare)
  • ALMA uncovers the [C II] emission and warm dust continuum in a z=8.31 Lyman break galaxy
  • 2020
  • Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 493:3, s. 4294-4307
  • Tidskriftsartikel (refereegranskat)abstract
    • We report on the detection of the [C II] 157.7 mu m emission from the Lyman break galaxy (LBG) MACS0416_Y1 at z = 8.3113, by using the Atacama Large Millimeter/submillimeter Array (ALMA). The luminosity ratio of [O III] 88 mu m (from previous campaigns) to [CII] is 9.3 +/- 2.6, indicative of hard interstellar radiation fields and/or a low covering fraction of photodissociation regions. The emission of [C II] is cospatial to the 850 mu m dust emission (90 mu m rest frame, from previous campaigns), however the peak [C II] emission does not agree with the peak [O III] emission, suggesting that the lines originate from different conditions in the interstellar medium. We fail to detect continuum emission at 1.5 mm (160 mu m rest frame) down to 18 mu Jy (3 sigma). This non-detection places a strong limits on the dust spectrum, considering the 137 +/- 26 mu Jy continuum emission at 850 mu m. This suggests an unusually warm dust component (T > 80 K, 90 per cent confidence limit), and/or a steep dust-emissivity index (beta(dust) > 2), compared to galaxy-wide dust emission found at lower redshifts (typically T similar to 30-50 K, beta(dust) similar to 1-2). If such temperatures are common, thiswould reduce the required dust mass and relax the dust production problem at the highest redshifts. We therefore warn against the use of only single-wavelength information to derive physical properties, recommend a more thorough examination of dust temperatures in the early Universe, and stress the need for instrumentation that probes the peak of warm dust in the Epoch of Reionization.
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4.
  • Fudamoto, Yoshinobu, et al. (författare)
  • The Extended [C II] under Construction? : Observation of the Brightest High-z Lensed Star-forming Galaxy at z=6.2
  • 2024
  • Ingår i: Astrophysical Journal. - : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 961:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We present results of [C ii] 158 μm emission line observations, and report the spectroscopic redshift confirmation of a strongly lensed (μ ∼ 20) star-forming galaxy, MACS0308-zD1 at z = 6.2078 ± 0.0002. The [C ii] emission line is detected with a signal-to-noise ratio >6 within the rest-frame UV-bright clump of the lensed galaxy (zD1.1) and exhibits multiple velocity components; the narrow [C ii] has a velocity full width half maximum (FWHM) of 110 ± 20 km s−1, while broader [C ii] is seen with an FWHM of 230 ± 50 km s−1. The broader [C ii] component is blueshifted (−80 ± 20 km s−1) with respect to the narrow [C ii] component, and has a morphology that extends beyond the UV-bright clump. We find that, while the narrow [C ii] emission is most likely associated with zD1.1, the broader component is possibly associated with a physically distinct gas component from zD1.1 (e.g., outflowing or inflowing gas). Based on the nondetection of λ158μm dust continuum, we find that MACS0308-zD1's star formation activity occurs in a dust-free environment indicated by a strong upper limit of infrared luminosity ≲9 × 108L⊙. Targeting this strongly lensed faint galaxy for follow-up Atacama Large Millimeter/submillimeter Array and JWST observations will be crucial to characterize the details of typical galaxy growth in the early Universe.
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5.
  • Fujimoto, Seiji, et al. (författare)
  • JWST and ALMA Multiple-line Study in and around a Galaxy at z =8.496: Optical to Far-Infrared Line Ratios and the Onset of an Outflow Promoting Ionizing Photon Escape
  • 2024
  • Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 964:2
  • Tidskriftsartikel (refereegranskat)abstract
    • We present Atacama Large Millimeter/submillimeter Array (ALMA) deep spectroscopy for a lensed galaxy at z(spec) = 8.496 with log(M-star/M-circle dot) similar to 7.8 whose optical nebular lines and stellar continuum are detected by JWST/NIRSpec and NIRCam Early Release Observations in the field of SMACS J0723.3-7327. Our ALMA spectrum shows [O III] 88 mu m and [C II] 158 mu m line detections at 4.0 sigma and 4.5 sigma, respectively. The redshift and position of the [O III] line coincide with those of the JWST source, while the [C II] line is blueshifted by 90 km s(-1) with a spatial offset of 0.'' 5 (approximate to 0.5 kpc in the source plane) from the centroid of the JWST source. The NIRCam F444W image, including [O III] lambda 5007 and H beta line emission, spatially extends beyond the stellar components by a factor of >8. This indicates that the z = 8.5 galaxy has already experienced strong outflows as traced by extended [O III] lambda 5007 and offset [C II] emission, which would promote ionizing photon escape and facilitate reionization. With careful slit-loss corrections and the removal of emission spatially outside the galaxy, we evaluate the [O III] 88 mu m/lambda 5007 line ratio, and derive the electron density n (e) by photoionization modeling to be 220(-130)(+230) cm(-3), which is comparable with those of z similar to 2-3 galaxies. We estimate an [O III] 88 mu m/[C II] 158 mu m line ratio in the galaxy of >4, as high as those of known z similar to 6-9 galaxies. This high [O III] 88 mu m/[C II] 158 mu m line ratio is generally explained by the high n(e) as well as the low metallicity (Z(gas)/Z(circle dot)=0.04(-0.02)(+0.02)), high ionization parameter (log U > -2.27), and low carbon-to-oxygen abundance ratio (log(C/O) = [-0.52: -0.24]) obtained from the JWST/NIRSpec data; further [C II] follow-up observations will constrain the covering fraction of photodissociation regions.
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6.
  • Hashimoto, Takuya, et al. (författare)
  • Big Three Dragons: Molecular Gas in a Bright Lyman-break Galaxy at z = 7.15
  • 2023
  • Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 952:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We report Atacama Large Millimeter/submillimeter Array Band 3 observations of CO(6−5), CO(7−6), and [C i](2−1) in B14-65666 (“Big Three Dragons”), one of the brightest Lyman-break galaxies at z > 7 in the rest-frame ultraviolet continuum, far-infrared continuum, and emission lines of [O iii] 88 μm and [C ii] 158 μm. CO(6−5), CO(7−6), and [C i](2−1), whose 3σ upper limits on the luminosities are approximately 40 times fainter than the [C ii] luminosity, are all not detected. The L [C II]/L CO(6-5) and L [C II]/L CO(7-6) ratios are higher than the typical ratios obtained in dusty star-forming galaxies or quasar host galaxies at similar redshifts, and they may suggest a lower gas density in the photodissociated region in B14-65666. By using the (1) [C ii] luminosity, (2) dust mass-to-gas mass ratio, and (3) a dynamical mass estimate, we find that the molecular gas mass (M mol) is (0.05-11) × 1010 M ⊙. This value is consistent with the upper limit inferred from the nondetection of mid-J CO and [C i](2−1). Despite the large uncertainty in M mol, we estimate a molecular gas-to-stellar mass ratio (μ gas) of 0.65-140 and a gas depletion time (τ dep) of 2.5-550 Myr; these values are broadly consistent with those of other high-redshift galaxies. B14-65666 could be an ancestor of a passive galaxy at z ≳ 4 if no gas is fueled from outside the galaxy.
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7.
  • Micheva, Genoveva, et al. (författare)
  • Spatially Resolved C iii] λ1909 Emission in Haro 11
  • 2020
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 903:2
  • Tidskriftsartikel (refereegranskat)abstract
    • The C iii] 1909 (hereafter C iii]) line is the strongest ultraviolet emission line after Ly alpha and is therefore of interest to high-redshift studies of star-forming (SF) galaxies near the epoch of reionization. It is thought that C iii] emission is strongest in galaxies with subsolar metallicity and low mass; however, spectral observations of numerous such galaxies at high and low redshift produce inconclusive or even contradictory results. We present the first-ever C iii] imaging, obtained with HST/STIS for the low-redshift SF galaxy Haro 11. Cluster parameters like stellar mass, dust fraction and attenuation, and ionization parameter, obtained through spectral energy distribution fitting, show no correlation with the C iii] equivalent width (EW), which may be due to a combination of the limitation of the models and the age homogeneity of the cluster population. Comparing the ratio of C iii] emission line flux from individual clusters to that of H alpha, [O iii], and [O ii], we find that the clusters with the highest EW(C iii]) can be reconciled only with Cloudy models with an extremely high C/O ratio of >= 1.4(C/O) for an ionizing population of single stars, binary stars, or a mixture of binary stars and active galactic nuclei. Given the pointlike nature of strong C iii], the integrated total strength of EW(C iii]) becomes dependent on the morphology of the galaxy, which would explain the large scatter in EW(C iii]) strengths observed in galaxies with otherwise similar SF properties and of similarly low metallicity and stellar mass.
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8.
  • Onoue, Masafusa, et al. (författare)
  • A Candidate for the Least-massive Black Hole in the First 1.1 Billion Years of the Universe
  • 2023
  • Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 942:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We report a candidate of a low-luminosity active galactic nucleus (AGN) at z = 5 that was selected from the first near-infrared images of the JWST CEERS project. This source, named CEERS-AGN-z5-1 at absolute 1450 Å magnitude M 1450 = −19.5 ± 0.3, was found via a visual selection of compact sources from a catalog of Lyman break galaxies at z > 4, taking advantage of the superb spatial resolution of the JWST/NIRCam images. The 20 photometric data available from CFHT, Hubble Space Telescope, Spitzer, and JWST suggest that the continuum shape of this source is reminiscent of that for an unobscured AGN, and there is a clear color excess in the filters where the redshifted Hβ+[O iii] and Hα are covered. The estimated line luminosity is L Hβ+[O III] = 1043.0 erg s−1 and L Hα = 1042.9 erg s−1 with the corresponding rest-frame equivalent width EWHβ+[O III] = 1100 Å and EWHα = 1600 Å, respectively. Our spectral energy distribution fitting analysis favors the scenario that this object is either a strong broad-line emitter or even a super-Eddington accreting black hole (BH), although a possibility of an extremely young galaxy with moderate dust attenuation is not completely ruled out. The bolometric luminosity, L bol = 2.5 ± 0.3 × 1044 erg s−1, is consistent with those of z < 0.35 broad-line AGNs with M BH ∼ 106 M ⊙ accreting at the Eddington limit. This new AGN population in the first 1.1 billion years of the universe may close the gap between the observed BH mass range at high redshift and that of BH seeds. Spectroscopic confirmation is awaited to secure the redshift and its AGN nature.
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9.
  • Salak, Dragan, et al. (författare)
  • Molecular Outflow in the Reionization-epoch Quasar J2054-0005 Revealed by OH 119 μ m Observations
  • 2024
  • Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 962:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Molecular outflows are expected to play a key role in galaxy evolution at high redshift. To study the impact of outflows on star formation at the epoch of reionization, we performed sensitive Atacama Large Millimeter/submillimeter Array observations of OH 119 mu m toward J2054-0005, a luminous quasar at z = 6.04. The OH line is detected and exhibits a P-Cygni profile that can be fitted with a broad blueshifted absorption component, providing unambiguous evidence of an outflow, and an emission component at near-systemic velocity. The mean and terminal outflow velocities are estimated to be v(out )approximate to 670 and 1500 km s(-1), respectively, making the molecular outflow in this quasar one of the fastest at the epoch of reionization. The OH line is marginally spatially resolved for the first time in a quasar at z > 6, revealing that the outflow extends over the central 2 kpc region. The mass outflow rate is comparable to the star formation rate (M-out/SFR similar to 2), indicating rapid (similar to 10(7 )yr) quenching of star formation. The mass outflow rate in a sample of star-forming galaxies and quasars at 4 < z < 6.4 exhibits a positive correlation with the total infrared luminosity, although the scatter is large. Owing to the high outflow velocity, a large fraction (up to similar to 50%) of the outflowing molecular gas may be able to escape from the host galaxy into the intergalactic medium.
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10.
  • Sugahara, Yuma, et al. (författare)
  • Big Three Dragons : A [N ii] 122 μm Constraint and New Dust-continuum Detection of a z = 7.15 Bright Lyman-break Galaxy with ALMA
  • 2021
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 923:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We present new Atacama Large Millimeter/submillimeter Array Band 7 observational results of a Lyman-break galaxy at z = 7.15, B14-65666 ("Big Three Dragons"), which is an object detected in [O iii] 88 μm, [C ii] 158 μm, and dust continuum emission during the epoch of reionization. Our targets are the [N ii] 122 μm fine-structure emission line and the underlying 120 μm dust continuum. The dust continuum is detected with a ∼19σ significance. From far-infrared spectral energy distribution sampled at 90, 120, and 160 μm, we obtain a best-fit dust temperature of 40 K (79 K) and an infrared luminosity of (12.1) at the emissivity index β = 2.0 (1.0). The [N ii] 122 μm line is not detected. The 3σ upper limit of the [N ii] luminosity is 8.1 × 107 L⊙. From the [N ii], [O iii], and [C ii] line luminosities, we use the Cloudy photoionization code to estimate nebular parameters as functions of metallicity. If the metallicity of the galaxy is high (Z > 0.4 Z⊙), the ionization parameter and hydrogen density are and nH ≃ 50–250 cm−3, respectively, which are comparable to those measured in low-redshift galaxies. The nitrogen-to-oxygen abundance ratio, N/O, is constrained to be subsolar. At Z < 0.4 Z⊙, the allowed U drastically increases as the assumed metallicity decreases. For high ionization parameters, the N/O constraint becomes weak. Finally, our Cloudy models predict the location of B14-65666 on the BPT diagram, thereby allowing a comparison with low-redshift galaxies.
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11.
  • Tamura, Yoichi, et al. (författare)
  • The 300 pc Resolution Imaging of a z=8.31 Galaxy : Turbulent Ionized Gas and Potential Stellar Feedback 600 Million Years after the Big Bang
  • 2023
  • Ingår i: Astrophysical Journal. - : Institute of Physics (IOP). - 0004-637X .- 1538-4357. ; 952:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We present the results of 300 pc resolution Atacama Large Millimeter/submillimeter Array imaging of the [O iii] 88 & mu;m line and dust continuum emission from a z = 8.312 Lyman-break galaxy MACS0416_Y1. The velocity-integrated [O iii] emission has three peaks that are likely associated with three young stellar clumps of MACS0416_Y1, while the channel map shows a complicated velocity structure with little indication of a global velocity gradient unlike what was found in [C ii] 158 & mu;m at a larger scale, suggesting random bulk motion of ionized gas clouds inside the galaxy. In contrast, dust emission appears as two individual clumps apparently separating or bridging the [O iii]/stellar clumps. The cross-correlation coefficient between dust and ultraviolet-related emission (i.e., [O iii] and ultraviolet continuum) is unity on a galactic scale, while it drops at <1 kpc, suggesting well-mixed geometry of multiphase interstellar media on subkiloparsec scales. If the cutoff scale characterizes different stages of star formation, the cutoff scale can be explained by gravitational instability of turbulent gas. We also report on a kiloparsec-scale off-center cavity embedded in the dust continuum image. This could be a superbubble producing galactic-scale outflows, since the energy injection from the 4 Myr starburst suggested by a spectral energy distribution analysis is large enough to push the surrounding media creating a kiloparsec-scale cavity.
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12.
  • Tokuoka, Tsuyoshi, et al. (författare)
  • Possible Systematic Rotation in the Mature Stellar Population of a z=9.1 Galaxy
  • 2022
  • Ingår i: Astrophysical Journal Letters. - : Institute of Physics Publishing (IOPP). - 2041-8205 .- 2041-8213. ; 933:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We present new observations with the Atacama Large Millimeter/submillimeter Array for a gravitationally lensed galaxy at z = 9.1, MACS1149-JD1. [O III] 88 mu m emission is detected at 10 sigma with a spatial resolution of similar to 0.3 kpc in the source plane, enabling the most distant morphokinematic study of a galaxy. The [O iii] emission is distributed smoothly without any resolved clumps and shows a clear velocity gradient with Delta V-obs/2 sigma(tot) = 0.84 +/- 0.23, where Delta V-obs is the observed maximum velocity difference and sigma(tot) is the velocity dispersion measured in the spatially integrated line profile, suggesting a rotating system. Assuming a geometrically thin self-gravitating rotation disk model, we obtain V-rot/sigma(V)=0.67-0.26+0.73, where V-rot and sigma (V) are the rotation velocity and velocity dispersion, respectively, still consistent with rotation. The resulting disk mass of 0.65-0.40+1.37x10(9) M-circle dot is consistent with being associated with the stellar mass identified with a 300 Myr old stellar population independently indicated by a Balmer break in the spectral energy distribution. We conclude that the most of the dynamical mass is associated with the previously identified mature stellar population that formed at z similar to 15.
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13.
  • Ura, Ryota, et al. (författare)
  • Detections of [C ii] 158 mu m and [O iii] 88 mu m in a Local Lyman Continuum Emitter, Mrk 54, and Its Implications to High-redshift ALMA Studies*
  • 2023
  • Ingår i: Astrophysical Journal. - : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 948:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We present integral field, far-infrared (FIR) spectroscopy of Mrk 54, a local Lyman continuum emitter, obtained with FIFI-LS on the Stratospheric Observatory for Infrared Astronomy. This is only the second time, after Haro 11, that [C ii] 158 mu m and [O iii] 88 mu m spectroscopy of the known LCEs have been obtained. We find that Mrk 54 has a strong [C ii] emission that accounts for similar to 1% of the total FIR luminosity, whereas it has only moderate [O iii] emission, resulting in the low [O iii]/[C ii] luminosity ratio of 0.22 +/- 0.06. In order to investigate whether [O iii]/[C ii] is a useful tracer of f (esc) (LyC escape fraction), we examine the correlations of [O iii]/[C ii] and (i) the optical line ratio of O-32 equivalent to [O iii] 5007 angstrom/[O ii] 3727 angstrom, (ii) specific star formation rate, (iii) [O iii] 88 mu m/[O i] 63 mu m ratio, (iv) gas-phase metallicity, and (v) dust temperature based on a combined sample of Mrk 54 and the literature data from the Herschel Dwarf Galaxy Survey and the LITTLE THINGS Survey. We find that galaxies with high [O iii]/[C ii] luminosity ratios could be the result of high ionization (traced by O-32), bursty star formation, high ionized-to-neutral gas volume filling factors (traced by [O iii] 88 mu m/[O i] 63 mu m), and low gas-phase metallicities, which is in agreement with theoretical predictions. We present an empirical relation between the [O iii]/[C ii] ratio and f (esc) based on the combination of the [O iii]/[C ii] and O-32 correlation, and the known relation between O-32 and f (esc). The relation implies that high-redshift galaxies with high [O iii]/[C ii] ratios revealed by the Atacama Large Millimeter/submillimeter Array may have f (esc) greater than or similar to 0.1, significantly contributing to the cosmic reionization.
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14.
  • Yamanaka, Satoshi, et al. (författare)
  • Testing an indirect method for identifying galaxies with high levels of Lyman continuum leakage
  • 2020
  • Ingår i: Monthly notices of the Royal Astronomical Society. - : OXFORD UNIV PRESS. - 0035-8711 .- 1365-2966. ; 498:3, s. 3095-3114
  • Tidskriftsartikel (refereegranskat)abstract
    • Using a sample of galaxies at z approximate to 3 with detected Lyman Continuum (LyC) leakage in the SSA22 field, we attempt to verify a proposed indirect method for identifying cases with high LyC escape fraction f(esc) based on measurements of the H beta equivalent width (EW) and the beta slope of the UV continuum. To this end, we present Keck/MOSFIRE H beta emission line flux measurements of LyC galaxies (LCGs) at spectroscopic redshifts z(spec) similar to 3.3, Lyman break galaxies (LBGs) at photometric redshifts z(phot) = 2.7-3.7, and Ly alpha emitters at z(phot) = 3.1. We also reconfirm the spectroscopic redshifts and measure the H beta emission-line fluxes from two LCGs and six LBGs. For the LCG in our sample with the most extreme f(esc), as revealed by the direct detection of LyC photons, we find that the EW(H beta)-beta method gives a broadly consistent estimate for f(esc), although the error bars remain very large. We also discuss how a combination of f(esc) measurements based on direct and indirect methods can shed light on the LyC escape mechanism and the anisotropy of the leakage.
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