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- Birnbaum, Bernard A., et al.
(författare)
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Hepatic hemangiomas: diagnosis with fusion of MR, CT, and Tc-99m-labeled red blood cell SPECT images
- 1991
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Ingår i: Radiology. - : Radiological Society of North America. - 0033-8419 .- 1527-1315. ; 181:2, s. 469-474
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Tidskriftsartikel (refereegranskat)abstract
- A method of image analysis was developed for correlation of hemangiomas detected at computed tomography {(CT)} and/or magnetic resonance {(MR)} imaging with increased blood pool activity evident at single photon emission {CT} {(SPECT)} performed after labeling of red blood cells with technetium-99m. Image analysis was performed in 20 patients with 35 known hepatic hemangiomas. After section thickness and pixel sizes of the different studies were matched, intrinsic landmarks were chosen to identify anatomically corresponding locations. Regions of interest {(ROIs)} drawn on the {CT} and/or {MR} images were translated, rotated, and reprojected to match the areas of interest on the corresponding {SPECT} images by means of a two-dimensional polynomial-based warping algorithm. Analysis of {ROIs} on 30 {SPECT-MR} and 20 {SPECT-CT} pairs of registered images provided absolute confirmation that 34 suspected hemangiomas identified on {SPECT} images correlated exactly with lesions seen on {CT} and/or {MR} images. Accuracy of fusion was within an average of 1.5 pixels +/- 0.8 (+/- 1 standard deviation). The technique enabled diagnostic confirmation of hemangiomas as small as 1.0 cm and proved useful for evaluating lesions located adjacent to intrahepatic vessels.
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- Jacobsen, Steven J., et al.
(författare)
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Comparability of the tandem-R andIMx assays for the measurement of serum prostate-specific antigen
- 1994
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Ingår i: Urology. - 0090-4295. ; 44:4, s. 512-518
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Tidskriftsartikel (refereegranskat)abstract
- Objectives.: To assess the comparability of the Tandem-R and IMx serumprostate-specific antigen (PSA) assays across levels of the ratio of free-to-total serum PSA found in a community-based population of healthy men. Methods.: Banked serum samples from the baseline component of the Olmsted CountyStudy of Urinary Symptoms and Health Status Among Men were thawed and analyzed using the Tandem-R and IMx PSA assays. Serum levels also were determined for the free, noncomplexed form of PSA, PSA complexed to alpha-1 antichymotrypsin, and total PSA with a research-based immunofluorometric assay. Results.: The results of the Tandem-R and IMx assays were strongly correlated at alllevels of the ratio of free-to-total serum PSA. The Spearman correlation coefficients ranged from 0.87 to 0.98 (all p < 0.001). The relationship between the Tandem-R and IMx assays, however, differed at low levels of free-to-total serum PSA compared with high levels. In the lowest 10th percentile of the ratio of free-to-total serum PSA (0.04 to 0.18), the IMx assay read lower than the Tandem-R (slope ± standard error = 0.92±0.04, intercept ± standard error = 0.21 ± 0.14); whereas in the upper 10th percentile of free-to-total ratio (0.46 to 0.65) the IMx assay yielded values higher than the Tandem-R assay (slope = 1.21 ± 0.07, intercept = 0.14 ± 0.05). In the middle 90%, the slope did not statistically differ from 1.0. Conclusions.: For the majority of men, results of the Tandem-R and IMx PSA assays were virtually identical. The small differences found would not be of clinical significance for most men but should be considered when comparing results of different assays in sequential determinations for a specific man.
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- Kramer, Elissa L., et al.
(författare)
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Fusing of immunoscintigraphy SPECT with CT or MRI for improved multimodality image interpretation
- 1992
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Ingår i: Engineering in Medicine and Biology Society, 1992 14th Annual International Conference of the IEEE. - : IEEE. - 0780307852 ; , s. 1805-1806
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Konferensbidrag (refereegranskat)abstract
- Correlation of PET or SPECT functional with CT or MRI anatomic transaxial images often enhances the information available on these studies. Careful registraÂtion of images from two types of studies may be used to identify a structure containing to a PET or SPECT abnormality or to evaluate the functional or metabolic characteristics of an abnormal or normal structure. CTSPECT or PET image registration has been applied to brain imaging for metabolic and cerebral perfusion studies [1–3], more recently, to Ga-67 imaging of the chest [4], as well as to CT-SPECT correlation in cancer patients undergoing immunoscintigraphy [5–7]. We have applied an image registration technique to correlate CT or MRI of the abdomen and chest with SPECT images obtained after the administration of tumor-directed radiolabeled monoclonal antibodies. Correlation of PET or SPECT functional with CT or MRI anatomic transaxial images often enhances the information available on these studies. Careful registration of images from two types of studies may be used to identify a structure containing to a PET or SPECT abnormality or to evaluate the functional or metabolic characteristics of an attempt to improve our interpretation of these imaging studies.
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- Maguire Jr., Gerald Q., et al.
(författare)
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Graphics applied to medical image registration
- 1991
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Ingår i: IEEE Computer Graphics and Applications. - : IEEE. - 0272-1716 .- 1558-1756. ; 11:2, s. 20-27
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Tidskriftsartikel (refereegranskat)abstract
- Software that has been developed to automate and standardize comparison of 3D images is discussed. The major approaches to image registration are examined. The authors' registration and reconstruction software is described. Studies carried out to determine the relative accuracy of the present registration methods are reported. The main goal of the authors is to improve on commercial SPECT reconstruction algorithms and provide quantification accuracy sufficient for numerical assessment of tracer distribution.
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