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- Bengtsson, I, et al.
(författare)
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A 14-year follow-up study of chest pain patients including stress hormones and mental stress at index event
- 2012
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Ingår i: International Journal of Cardiology. - : Elsevier Ireland Ltd. - 0167-5273 .- 1874-1754. ; 154:3, s. 306-311
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Tidskriftsartikel (refereegranskat)abstract
- Background Knowledge of long-term outcome in chest pain patients is limited. We reinvestigated patients who 14 years earlier had visited the emergency department due to chest pain, and were discharged without hospitalization. Extensive examinations were made at that time on 484 patients including full medical history, exercise test, a battery of stress questions and stress hormone sampling. Methods From a previously conducted chest pain study patients still alive after 14 years were approached. Hospitalization or deaths with a diagnosis of ischemic heart disease or cerebrovascular disease were used as end point. Results During the follow-up period 24 patients had died with a diagnosis of ischemic heart or cerebrovascular disease, and 50 patients had been given such a diagnosis at hospital discharge. Age (OR 1.12, CI 1.06–1.19), previous history of angina pectoris (OR 9.69, CI 2.06–71.61), pathological ECG at emergency department visit (OR 3.27, CI 1.23–8.67), hypertension (OR 5.03, CI 1.90–13.76), smoking (OR 3.04, CI 1.26–7.63) and lipid lowering medication (OR 14.9, CI 1.60–152.77) were all associated with future ischemic heart or cerebrovascular events. Noradrenalin levels were higher in the event group than in the non-event group, mean (SD) 2.44 (1.02) nmol/L versus 1.90 (0.75) nmol/L. When noradrenalin was included in the regression model high maximal exercise capacity was protective of an event (OR 0.986, CI 0.975–0.997). Conclusion In chest pain patients previous history of angina pectoris, hypertension, smoking, pathological ECG at primary examination, and age were the main risk factors associated with future cardiovascular or cerebrovascular events.
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- Eriksson, Leif E. B., et al.
(författare)
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Evaluation of new spaceborne SAR sensors for sea-ice monitoring in the Baltic Sea
- 2010
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Ingår i: Canadian journal of remote sensing. - : CANADIAN AERONAUTICS SPACE INST. - 0703-8992 .- 1712-7971. ; 36, s. S56-S73
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Tidskriftsartikel (refereegranskat)abstract
- In this study, synthetic aperture radar (SAR) data from the Advanced Land Observing Satellite (ALOS) and the Envisat, RADARSAT-2, and TerraSAR-X satellites were compared to evaluate their usefulness for sea-ice monitoring in the Baltic Sea. Radar signature characteristics at different frequencies, polarizations, and spatial resolutions are presented for three examples from 2009. C-band like-polarization data, which have been used for operational sea-ice mapping since the early 1990s, serve as a reference. Advantages and disadvantages were identified for the different SAR systems and imaging modes. One conclusion is that cross-polarized data improve the discrimination between sea ice and open water. Another observation is that it is easier to identify ice ridges in L-band data than in images from shorter wavelengths. The information content of X-and C-band images is largely equivalent, whereas L-band data provide complementary information. L-band SAR also seems to be less sensitive to wet snow cover on the ice.
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- Karlson, EW, et al.
(författare)
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Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk
- 2010
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Ingår i: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 69:6, s. 1077-1085
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Tidskriftsartikel (refereegranskat)abstract
- Recent discoveries of risk alleles have made it possible to define genetic risk profiles for patients with rheumatoid arthritis (RA). This study examined whether a cumulative score based on 22 validated genetic risk alleles for seropositive RA would identify high-risk, asymptomatic individuals who might benefit from preventive interventions.MethodsEight human leucocyte antigen (HLA) alleles and 14 single-nucleotide polymorphisms representing 13 validated RA risk loci were genotyped among 289 white seropositive cases and 481 controls from the US Nurses' Health Studies (NHS) and 629 white cyclic-citrullinated peptide antibody-positive cases and 623 controls from the Swedish Epidemiologic Investigation of Rheumatoid Arthritis (EIRA). A weighted genetic risk score (GRS) was created, in which the weight for each risk allele is the log of the published odds ratio (OR). Logistic regression was used to study associations with incident RA. Area under the curve (AUC) statistics were compared from a clinical-only model and clinical plus genetic model in each cohort.ResultsPatients with GRS >1.25 SD of the mean had a significantly higher OR of seropositive RA in both NHS (OR=2.9, 95%CI 1.8 to 4.6) and EIRA (OR 3.4, 95% CI 2.3 to 5.0) referent to the population average. In NHS, the AUC for a clinical model was 0.57 and for a clinical plus genetic model was 0.66, and in EIRA was 0.63 and 0.75, respectively.ConclusionThe combination of 22 risk alleles into a weighted GRS significantly stratifies individuals for RA risk beyond clinical risk factors alone. Given the low incidence of RA, the clinical utility of a weighted GRS is limited in the general population.
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