| 1. |
- Blösch, Günter, et al.
(författare)
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Twenty-three unsolved problems in hydrology (UPH) - a community perspective
- 2019
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Ingår i: Hydrological Sciences Journal. - : Informa UK Limited. - 0262-6667 .- 2150-3435. ; 64:10, s. 1141-1158
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Tidskriftsartikel (refereegranskat)abstract
- This paper is the outcome of a community initiative to identify major unsolved scientific problems in hydrology motivated by a need for stronger harmonisation of research efforts. The procedure involved a public consultation through online media, followed by two workshops through which a large number of potential science questions were collated, prioritised, and synthesised. In spite of the diversity of the participants (230 scientists in total), the process revealed much about community priorities and the state of our science: a preference for continuity in research questions rather than radical departures or redirections from past and current work. Questions remain focused on the process-based understanding of hydrological variability and causality at all space and time scales. Increased attention to environmental change drives a new emphasis on understanding how change propagates across interfaces within the hydrological system and across disciplinary boundaries. In particular, the expansion of the human footprint raises a new set of questions related to human interactions with nature and water cycle feedbacks in the context of complex water management problems. We hope that this reflection and synthesis of the 23 unsolved problems in hydrology will help guide research efforts for some years to come.
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| 2. |
- Floriancic, Marius G., et al.
(författare)
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Spatial variability in specific discharge and streamwater chemistry during low flows : Results from snapshot sampling campaigns in eleven Swiss catchments
- 2019
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Ingår i: Hydrological Processes. - : Wiley. - 0885-6087 .- 1099-1085. ; 33:22, s. 2847-2866
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Tidskriftsartikel (refereegranskat)abstract
- Catchments consist of distinct landforms that affect the storage and release of subsurface water. Certain landforms may be the main contributors to streamflow during extended dry periods, and these may vary for different catchments in a given region. We present a unique dataset from snapshot field campaigns during low-flow conditions in 11 catchments across Switzerland to illustrate this. The catchments differed in size (10 to 110 km(2)), varied from predominantly agricultural lowlands to Alpine areas, and covered a range of physical characteristics. During each snapshot campaign, we jointly measured streamflow and collected water samples for the analysis of major ions and stable water isotopes. For every sampling location (basin), we determined several landscape characteristics from national geo-datasets, including drainage area, elevation, slope, flowpath length, dominant land use, and geological and geomorphological characteristics, such as the lithology and fraction of quaternary deposits. The results demonstrate very large spatial variability in specific low-flow discharge and water chemistry: Neighboring sampling locations could differ significantly in their specific discharge, isotopic composition, and ion concentrations, indicating that different sources contribute to streamflow during extended dry periods. However, none of the landscape characteristics that we analysed could explain the spatial variability in specific discharge or streamwater chemistry in multiple catchments. This suggests that local features determine the spatial differences in discharge and water chemistry during low-flow conditions and that this variability cannot be assessed a priori from available geodata and statistical relations to landscape characteristics. The results furthermore suggest that measurements at the catchment outlet during low-flow conditions do not reflect the heterogeneity of the different source areas in the catchment that contribute to streamflow.
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| 3. |
- Schmidt, Amand F., et al.
(författare)
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Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
- 2019
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Ingår i: BMC Cardiovascular Disorders. - : BMC. - 1471-2261 .- 1471-2261. ; 19:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. Methods: Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score (GS). Seventeen randomized placebo controlled PCSK9 inhibitor trials were included, providing data on 79,578 participants. Results were scaled to a one mmol/L lower LDL-C concentration. Results: The PCSK9 GS (comprising 4 SNPs) associations with plasma lipid and apolipoprotein levels were consistent in direction with treatment effects. The GS odds ratio (OR) for myocardial infarction (MI) was 0.53 (95% CI 0.42; 0.68), compared to a PCSK9 inhibitor effect of 0.90 (95% CI 0.86; 0.93). For ischemic stroke ORs were 0.84 (95% CI 0.57; 1.22) for the GS, compared to 0.85 (95% CI 0.78; 0.93) in the drug trials. ORs with type 2 diabetes mellitus (T2DM) were 1.29 (95% CI 1.11; 1.50) for the GS, as compared to 1.00 (95% CI 0.96; 1.04) for incident T2DM in PCSK9 inhibitor trials. No genetic associations were observed for cancer, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, or Alzheimer's disease - outcomes for which large-scale trial data were unavailable. Conclusions: Genetic variation at the PCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI. While indicating an increased risk of T2DM, no other possible safety concerns were shown; although precision was moderate.
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