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- Kleiner, A., et al.
(författare)
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Current and pressure gradient triggering and nonlinear saturation of low-n edge harmonic oscillations in tokamaks
- 2019
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP PUBLISHING LTD. - 0741-3335 .- 1361-6587. ; 61:8
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Tidskriftsartikel (refereegranskat)abstract
- Non-axisymmetric free-boundary equilibrium computations are shown to represent nonlinearly saturated external kink modes and external kink-like sidebands coupled to pressure-driven infernal modes. In this study of edge harmonic oscillations associated with QH-mode plasmas, two different driving mechanisms for external kink type-modes are identified. It is found that standard current-driven external kinks are linearly unstable, and nonlinearly stable in a wide parameter range, especially where q(edge) less than or similar to m/n. But, where standard current-driven kinks are linearly stable coupling of pressure-driven infernal modes can cause instability, and their upper sideband drives edge corrugations that appear to have external kink features. Both types of modes are identified with the VMEC equilibrium code, and the spectra are compared favourably with those of linear numerical approaches and analytic methods. Pressure-driven external infernal modes are shown to robustly occur in sophisticated modelling where the separatrix effect on the q profile is accounted for.
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- Dwivedi, Om Prakash, et al.
(författare)
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Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
- 2019
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; , s. 1-22
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Tidskriftsartikel (refereegranskat)abstract
- A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited relatives of the identified carriers and showed that protection was associated with better insulin secretion due to enhanced glucose responsiveness and proinsulin conversion, particularly when compared with individuals matched for the genotype of a common T2D-risk allele in SLC30A8, p.Arg325. In genome-edited human induced pluripotent stem cell (iPSC)-derived β-like cells, we establish that the p.Arg138* allele results in reduced SLC30A8 expression due to haploinsufficiency. In human β cells, loss of SLC30A8 leads to increased glucose responsiveness and reduced KATP channel function similar to isolated islets from carriers of the T2D-protective allele p.Trp325. These data position ZnT8 as an appealing target for treatment aimed at maintaining insulin secretion capacity in T2D.
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- Kleiner, A., et al.
(författare)
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Free boundary 3D ideal MHD equilibrium calculations for non-linearly saturated current driven external kink modes in tokamaks
- 2018
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 58:7
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Tidskriftsartikel (refereegranskat)abstract
- It is shown that free boundary 3D equilibrium calculations in tokamak geometry are capable of capturing the physics of non-linearly saturated external kink modes for monotonic current and q profiles typical of standard (baseline) plasma scenarios. The VMEC ideal MHD equilibrium model exhibits strong flux surface corrugations of the plasma vacuum boundary, driven by the core current profile. A method is presented which conveniently extracts the amplitude of the corrugation in terms of Fourier components in straight field line coordinates. The Fourier spectrum, and condition for non-linear corrugation agrees well with linear simulations, and the saturated amplitude agrees well with non-linear analytic calculations.
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