Pharmacodynamic and pharmacokinetic studies in rats of S-8-(2-furyl)- and R-8-phenyl-2-(di-n-propylamino)tetralin, two novel 5-HT1A receptor agonists in-vitro with different properties in-vivo

• R- and S-8-(2-Furyl)- and R- and S-8-phenyl-2-(di-n-propylamino)tetralins (R- and S-LY-55 and R- and S-LY-49, respectively), novel enantiopure dipropylaminotetralins, have been screened as 5-HT1A receptor ligands. All had nanomolar affinities for 5-HT1A

Nyckelord

BLOOD-BRAIN-BARRIER; ADENYLATE-CYCLASE; P-GLYCOPROTEIN; INHIBITION; 5-HYDROXYTRYPTAMINE; INVIVO; 2-(DIPROPYLAMINO)TETRALIN; PHARMACOLOGY; DERIVATIVES; ANTAGONIST

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