| 1. |
|
|
| 2. |
- Benton, S., et al.
(författare)
-
Impact of Next-generation Sequencing on Interobserver Agreement and Diagnosis of Spitzoid Neoplasms
- 2021
-
Ingår i: American Journal of Surgical Pathology. - : Ovid Technologies (Wolters Kluwer Health). - 0147-5185 .- 1532-0979. ; 45:12, s. 1597-1605
-
Tidskriftsartikel (refereegranskat)abstract
- Atypical Spitzoid melanocytic tumors are diagnostically challenging. Many studies have suggested various genomic markers to improve classification and prognostication. We aimed to assess whether next-generation sequencing studies using the Tempus xO assay assessing mutations in 1711 cancer-related genes and performing whole transcriptome mRNA sequencing for structural alterations could improve diagnostic agreement and accuracy in assessing neoplasms with Spitzoid histologic features. Twenty expert pathologists were asked to review 70 consultation level cases with Spitzoid features, once with limited clinical information and again with additional genomic information. There was an improvement in overall agreement with additional genomic information. Most significantly, there was increase in agreement of the diagnosis of conventional melanoma from moderate (kappa=0.470, SE=0.0105) to substantial (kappa=0.645, SE=0.0143) as measured by an average Cohen kappa. Clinical follow-up was available in all 70 cases which substantiated that the improved agreement was clinically significant. Among 3 patients with distant metastatic disease, there was a highly significant increase in diagnostic recognition of the cases as conventional melanoma with genomics (P<0.005). In one case, none of 20 pathologists recognized a tumor with BRAF and TERT promoter mutations associated with fatal outcome as a conventional melanoma when only limited clinical information was provided, whereas 60% of pathologists correctly diagnosed this case when genomic information was also available. There was also a significant improvement in agreement of which lesions should be classified in the Spitz category/WHO Pathway from an average Cohen kappa of 0.360 (SE=0.00921) to 0.607 (SE=0.0232) with genomics.
|
|
| 3. |
- Sharma, R., et al.
(författare)
-
Radio/X-ray correlations and variability in the X-ray binary LS I +61°303
- 2021
-
Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 500:3, s. 4166-4172
-
Tidskriftsartikel (refereegranskat)abstract
- The high-mass X-ray binary LS I +61°303 exhibits variability in its radio and X-ray emissions, ranging from minute to hour time-scales. At such short time-scales, not much is known about the possible correlations between these two emissions from this source, which might offer hints to their origin. Here, we study the relationship between these emissions using simultaneous X-ray and radio monitoring.We present new radio observations using the Arcminute Microkelvin Imager Large Array telescope at two frequency bands, 13-15.5 and 15.5-18 GHz.We also describe new X-ray observations performed using the XMM-Newton telescope. These X-ray and radio observations overlapped for five hours. We find for the first time that the radio and X-ray emission are correlated up to 81 per cent with their few per cent variability correlated up to 40 per cent. We discuss possible physical scenarios that produces the observed correlations and variability in the radio and X-ray emission of LS I +61°303.
|
|
