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Apalutamide plus An...
Apalutamide plus Androgen Deprivation Therapy for Metastatic Castration-Sensitive Prostate Cancer : Analysis of Pain and Fatigue in the Phase 3 TITAN Study
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- Agarwal, Neeraj (författare)
- Huntsman Cancer Institute
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- McQuarrie, Kelly (författare)
- Janssen Pharmaceuticals, US
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- Bjartell, Anders (författare)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Chowdhury, Simon (författare)
- Guy's and St Thomas' NHS Foundation Trust
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- Pereira de Santana Gomes, Andrea J. (författare)
- Liga Norte Riograndense Contra o Câncer
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- Chung, Byung Ha (författare)
- Yonsei University
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- Özgüroğlu, Mustafa (författare)
- Istanbul University
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Juárez Soto, Álvaro (författare)
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- Merseburger, Axel S. (författare)
- University Medical Center Schleswig-Holstein
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- Uemura, Hirotsugu (författare)
- Kindai University Hospital
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- Ye, Dingwei (författare)
- Fudan University Shanghai Cancer Center (FUSCC)
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- Given, Robert (författare)
- Eastern Virginia Medical School
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- Basch, Ethan (författare)
- University of North Carolina
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- Miladinovic, Branko (författare)
- Janssen Research & Development, Mexico
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- Lopez-Gitlitz, Angela (författare)
- Janssen Research & Development, Mexico
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- Chi, Kim N. (författare)
- No affiliation available (private)
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(creator_code:org_t)
- 2021
- 2021
- Engelska 10 s.
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Ingår i: The Journal of urology. - 1527-3792. ; 206:4, s. 914-923
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- PURPOSE: We performed an exploratory analysis of prostate cancer-related pain and fatigue on health-related quality of life in patients with metastatic castration-sensitive prostate cancer receiving apalutamide (240 mg/day) or placebo, with continuous androgen deprivation therapy (ADT), in the phase 3, randomized, double-blind, placebo controlled TITAN trial (NCT02489318). MATERIALS AND METHODS: Patient-reported outcomes for pain and fatigue were evaluated using the Brief Pain Inventory-Short Form and Brief Fatigue Inventory. Time to deterioration (TTD) was estimated by Kaplan-Meier method; hazard ratios and 95% confidence intervals were calculated using Cox proportional hazards model. General estimating equations for logistic regression estimated treatment-related differences in the likelihood of worsening pain or fatigue. RESULTS: Compliance for completing the Brief Pain Inventory-Short Form and Brief Fatigue Inventory was high (96% to 97%) in the first year. Median followup times were similar between treatments (19 to 22 months). Median pain TTD was longer with apalutamide than placebo for "pain at its least in the last 24 hours" (28.7 vs 21.8 months, respectively; p=0.0146), "pain interfered with mood" (not estimable vs 22.4 months; p=0.0017), "pain interfered with walking ability" (28.7 vs 20.2 months; p=0.0027), "pain interfered with relations" (not estimable vs 23.0 months; p=0.0139) and "pain interfered with sleep" (28.7 vs 20.9 months; p=0.0167). Likelihood for fatigue and worsening fatigue were similar between groups. CONCLUSIONS: Patients with metastatic castration-sensitive prostate cancer receiving apalutamide plus ADT vs placebo plus ADT reported consistently favorable TTD of pain. No difference for change in fatigue was observed with apalutamide vs placebo.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- apalutamide
- neoplasm metastasis
- prostatic neoplasms
- quality of life
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Agarwal, Neeraj
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McQuarrie, Kelly
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Bjartell, Anders
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Chowdhury, Simon
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Pereira de Santa ...
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Chung, Byung Ha
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visa fler...
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Özgüroğlu, Musta ...
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Juárez Soto, Álv ...
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Merseburger, Axe ...
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Uemura, Hirotsug ...
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Ye, Dingwei
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Given, Robert
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Basch, Ethan
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Miladinovic, Bra ...
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Lopez-Gitlitz, A ...
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Chi, Kim N.
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