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- Sharma, Manu, et al.
(author)
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Large-scale replication and heterogeneity in Parkinson disease genetic loci
- 2012
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In: Neurology. - 1526-632X. ; 79:7, s. 67-659
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Journal article (peer-reviewed)abstract
- OBJECTIVE: Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown.METHODS: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium were invited to participate in the study. A total of 11 SNPs were genotyped in 8,750 cases and 8,955 controls. Fixed as well as random effects models were used to provide the summary risk estimates for these variants. We evaluated between-study heterogeneity and heterogeneity between populations of different ancestry.RESULTS: In the overall analysis, single nucleotide polymorphisms (SNPs) in 9 loci showed significant associations with protective per-allele odds ratios of 0.78-0.87 (LAMP3, BST1, and MAPT) and susceptibility per-allele odds ratios of 1.14-1.43 (STK39, GAK, SNCA, LRRK2, SYT11, and HIP1R). For 5 of the 9 replicated SNPs there was nominally significant between-site heterogeneity in the effect sizes (I(2) estimates ranged from 39% to 48%). Subgroup analysis by ethnicity showed significantly stronger effects for the BST1 (rs11724635) in Asian vs Caucasian populations and similar effects for SNCA, LRRK2, LAMP3, HIP1R, and STK39 in Asian and Caucasian populations, while MAPT rs2942168 and SYT11 rs34372695 were monomorphic in the Asian population, highlighting the role of population-specific heterogeneity in PD.CONCLUSION: Our study allows insight to understand the distribution of newly identified genetic factors contributing to PD and shows that large-scale evaluation in diverse populations is important to understand the role of population-specific heterogeneity.
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- Pauly, Daniel, et al.
(author)
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China's distant-water fisheries in the 21st century
- 2014
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In: Fish and Fisheries. - : Wiley. - 1467-2960 .- 1467-2979. ; 15:3, s. 474-488
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Journal article (peer-reviewed)abstract
- We conservatively estimate the distant-water fleet catch of the People's Republic of China for 2000-2011, using a newly assembled database of reported occurrence of Chinese fishing vessels in various parts of the world and information on the annual catch by vessel type. Given the unreliability of official statistics, uncertainty of results was estimated through a regionally stratified Monte Carlo approach, which documents the presence and number of Chinese vessels in Exclusive Economic Zones and then multiplies these by the expected annual catch per vessel. We find that China, which over-reports its domestic catch, substantially under-reports the catch of its distant-water fleets. This catch, estimated at 4.6 million t year(-1) (95% central distribution, 3.4-6.1 million t year(-1)) from 2000 to 2011 (compared with an average of 368 000 t year(-1) reported by China to FAO), corresponds to an ex-vessel landed value of 8.93 billion year(-1) (95% central distribution, 6.3-12.3 billion). Chinese distant-water fleets extract the largest catch in African waters (3.1 million t year(-1), 95% central distribution, 2.0-4.4 million t), followed by Asia (1.0 million t year(-1), 0.56-1.5 million t), Oceania (198 000 t year(-1), 144 000-262 000 t), Central and South America (182 000 t year-1, 94 000299 000 t) and Antarctica (48 000 t year(-1), 8 000-129 000 t). The uncertainty of these estimates is relatively high, but several sources of inaccuracy could not be fully resolved given the constraints inherent in the underlying data and method, which also prevented us from distinguishing between legal and illegal catch.
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