| 1. |
- Sen, Partha, et al.
(författare)
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Novel FOXF1 Mutations in Sporadic and Familial Cases of Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins Imply a Role for its DNA Binding Domain
- 2013
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Ingår i: Human Mutation. - : Hindawi Limited. - 1059-7794. ; 34:6, s. 801-811
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Tidskriftsartikel (refereegranskat)abstract
- Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a rare and lethal developmental disorder of the lung defined by a constellation of characteristic histopathological features. Nonpulmonary anomalies involving organs of gastrointestinal, cardiovascular, and genitourinary systems have been identified in approximately 80% of patients with ACD/MPV. We have collected DNA and pathological samples from more than 90 infants with ACD/MPV and their family members. Since the publication of our initial report of four point mutations and 10 deletions, we have identified an additional 38 novel nonsynonymous mutations of FOXF1 (nine nonsense, seven frameshift, one inframe deletion, 20 missense, and one no stop). This report represents an up to date list of all known FOXF1 mutations to the best of our knowledge. Majority of the cases are sporadic. We report four familial cases of which three show maternal inheritance, consistent with paternal imprinting of the gene. Twenty five mutations (60%) are located within the putative DNA-binding domain, indicating its plausible role in FOXF1 function. Five mutations map to the second exon. We identified two additional genic and eight genomic deletions upstream to FOXF1. These results corroborate and extend our previous observations and further establish involvement of FOXF1 in ACD/MPV and lung organogenesis.
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| 2. |
- Gavagnin, Marco, et al.
(författare)
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Free-Standing Magnetic Nanopillars for 3D Nanomagnet Logic
- 2014
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 6:22, s. 20254-20260
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Tidskriftsartikel (refereegranskat)abstract
- Nanomagnet logic (NML) is a relatively new computation technology that uses arrays of shape-controlled nanomagnets to enable digital processing. Currently, conventional resist-based lithographic processes limit the design of NML circuitry to planar nanostructures with homogeneous thicknesses. Here, we demonstrate the focused electron beam induced deposition of Fe-based nanomaterial for magnetic in-plane nanowires and out-of-plane nanopillars. Three-dimensional (3D) NML was achieved based on the magnetic coupling between nanowires and nanopillars in a 3D array. Additionally, the same Fe-based nanomaterial was used to produce tilt-corrected high-aspect-ratio probes for the accurate magnetic force microscopy (MFM) analysis of the fabricated 3D NML gate arrays. The interpretation of the MFM measurements was supported by magnetic simulations using the Object Oriented MicroMagnetic Framework. Introducing vertical out-of-plane nanopillars not only increases the packing density of 3D NML but also introduces an extra magnetic degree of freedom, offering a new approach to input/output and processing functionalities in nanomagnetic computing.
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| 3. |
- Gavagnin, Marco, et al.
(författare)
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Magnetic force microscopy study of shape engineered FEBID iron nanostructures
- 2014
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Ingår i: Physica Status Solidi (a) applications and materials science. - : Wiley. - 1862-6300 .- 1862-6319. ; 211:2, s. 368-374
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Tidskriftsartikel (refereegranskat)abstract
- The capability to control matter down to the nanoscale level in combination with the novel magnetic properties of nanomaterials have attracted increasing attention in the last few decades due to their applications in magnetic sensing, hard disc data storage and logic devices. Therefore, many efforts have been devoted to the implementation of both nanofabrication methods as well as characterization of magnetic nanoelements. In this study, Fe-based nanostructures have been synthesized on Si(100) by focused electron beam induced deposition (FEBID) utilizing iron pentacarbonyl as precursor. The so obtained nanostructures exhibit a remarkably high iron content (Fe>80at.%), expected to give rise to a ferromagnetic behaviour. For that reason, magnetic force microscopy (MFM) analyses were performed on the obtained FEBID Fe nanostructures. Moreover, object oriented micromagnetic framework (OOMMF) magnetic simulations have been executed to study the influence of the geometry on the magnetic properties of iron single-domain nanowires. FEBID is a mask-less nanofabrication method based on the injection of precursor gas molecules in proximity of the deposition area where their decomposition is locally induced by a focused electron beam.
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| 4. |
- Mohammadnezhad, Gholamhossein, et al.
(författare)
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Two polymorphs of a lead(II) complex with 8-hydroxy-2-methylquinoline and thiocyanate
- 2010
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Ingår i: Acta Crystallographica Section C: Crystal Structure Communications. - 0108-2701 .- 1600-5759. ; C66:2, s. m44-m47
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Tidskriftsartikel (refereegranskat)abstract
- Two distinct polymorphs of bis(μ2-methylquinolin-8-olato)-κ3N,O:O;κ3O:N,O-bis[(isothiocyanato-κN)lead(II)], [Pb2(C10H8NO)2(NCS)2], (I), forming dinuclear complexes from a methanolic solution containing lead(II) nitrate, 2-methylquinolin-8-ol (M-Hq) and KSCN, crystallized concomitantly as colourless prisms [form (Ia)] and long thin colourless needles [form (Ib)]. In both cases, the complexes lie across a centre of inversion. The polymorphs differ substantially in their conformation and in their interactions, viz. Pb...S and π-π for form (Ia) and Pb...S, Pb...π and C-H...π for form (Ib).
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| 5. |
- Pournik, O, et al.
(författare)
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Reliability and validity of Persian version of World Health Organization health and work performance questionnaire in Iranian health care workers
- 2012
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Ingår i: The international journal of occupational and environmental medicine. - 2008-6520. ; 3:1, s. 33-38
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND:The effect of health status on productivity has widely been studied and discussed in literature. Valid and reliable tools are needed to evaluate the levels of health and productivity and provide detailed information, before any intervention is implemented. World Health Organization Health and Work Performance Questionnaire (HPQ) is a widely used instrument in estimating the workplace costs of health problems in terms of reduced job performance, sickness absence, and work-related accidents and injuries.OBJECTIVE:To assess the reliability and validity of Persian version of HPQ in Iranian health care workers.METHODS:The questionnaire was translated to Persian and back translated. 102 health care workers completed the questionnaire. Absence and sick-leave data was extracted from administrative records.RESULTS:Factor analysis revealed acceptable validity for the questionnaire in part A (health). Cronbach's alpha was >0.73 for all scales of Parts B (work) and C (demographic). Questions targeting days of absence and sick-leave had acceptable correlation with administrative records (Pearson's r >0.75), while questions on total hours worked showed lower correlation.CONCLUSION:Persian version of HPQ can be considered a reliable and valid tool in Iranian health workers.
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