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Sökning: WFRF:(Munzel T.) > (2015-2019)

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  • van Setten, Jessica, et al. (författare)
  • PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity
  • 2018
  • Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 9
  • Tidskriftsartikel (refereegranskat)abstract
    • Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genomewide association study of over 92,000 European-descent individuals identifies 44 PR interval loci (34 novel). Examination of these loci reveals known and previously not-yet-reported biological processes involved in cardiac atrial electrical activity. Genes in these loci are overrepresented in cardiac disease processes including heart block and atrial fibrillation. Variants in over half of the 44 loci were associated with atrial or blood transcript expression levels, or were in high linkage disequilibrium with missense variants. Six additional loci were identified either by meta-analysis of similar to 105,000 African and European-descent individuals and/or by pleiotropic analyses combining PR interval with heart rate, QRS interval, and atrial fibrillation. These findings implicate developmental pathways, and identify transcription factors, ionchannel genes, and cell-junction/cell-signaling proteins in atrio-ventricular conduction, identifying potential targets for drug development.
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  • Münzel, Christiane, et al. (författare)
  • How large is the effect of financial incentives on electric vehicle sales? – A global review and European analysis
  • 2019
  • Ingår i: Energy Economics. - : Elsevier BV. - 0140-9883 .- 1873-6181. ; 84
  • Tidskriftsartikel (refereegranskat)abstract
    • Plug-in electric vehicles (PEV), both as battery electric vehicles and plug-in hybrid vehicles have noteworthy potential to reduce global and local emissions. However, several barriers still hinder a fast market diffusion of this new technology. Governments around the world have implemented monetary and non-monetary policies to accelerate PEV market diffusion. Their effectiveness is established in the literature, yet the effect size has been only scarcely estimated empirically and only for the US. Here, we review econometric studies on the effect size of purchase incentives and analyse data on PEV sales from 32 European countries from 2010 to 2017 with respect to the effect of financial incentives. We apply panel data regressions and control for other factors such as income and fuel prices. We find energy prices and financial incentives to influence PEV adoption positively. The range of point estimates for the effect of incentives is 5–7% relative sales share increase in different model specifications. Methodologically, the inclusion of a trend variable proved important to capture overall changes in the diffusion of this new technology. Our findings indicate that financial incentives have an impact on PEV sales and thus can facilitate their diffusion.
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  • Resultat 1-6 av 6

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