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- Coustenis, A., et al.
(författare)
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TandEM : Titan and Enceladus mission
- 2009
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Ingår i: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 23:3, s. 893-946
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Tidskriftsartikel (refereegranskat)abstract
- TandEM was proposed as an L-class (large) mission in response to ESA's Cosmic Vision 2015-2025 Call, and accepted for further studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini-Huygens mission. These bodies still hold mysteries requiring a complete exploration using a variety of vehicles and instruments. TandEM is an ambitious mission because its targets are two of the most exciting and challenging bodies in the Solar System. It is designed to build on but exceed the scientific and technological accomplishments of the Cassini-Huygens mission, exploring Titan and Enceladus in ways that are not currently possible (full close-up and in situ coverage over long periods of time). In the current mission architecture, TandEM proposes to deliver two medium-sized spacecraft to the Saturnian system. One spacecraft would be an orbiter with a large host of instruments which would perform several Enceladus flybys and deliver penetrators to its surface before going into a dedicated orbit around Titan alone, while the other spacecraft would carry the Titan in situ investigation components, i.e. a hot-air balloon (MontgolfiSre) and possibly several landing probes to be delivered through the atmosphere.
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- van Ree, R, et al.
(författare)
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The CREATE project: development of certified reference materials for allergenic products and validation of methods for their quantification.
- 2008
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Ingår i: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 63:3, s. 310-26
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Tidskriftsartikel (refereegranskat)abstract
- Allergen extracts have been used for diagnosis and treatment of allergy for around 100 years. During the second half of 20th century, the notion increasingly gained foothold that accurate standardization of such extracts is of great importance for improvement of their quality. As a consequence, manufacturers have implemented extensive protocols for standardization and quality control. These protocols have overall IgE-binding potencies as their focus. Unfortunately, each company is using their own in-house reference materials and their own unique units to express potencies. This does not facilitate comparison of different products. During the last decades, most major allergens of relevant allergen sources have been identified and it has been established that effective immunotherapy requires certain minimum quantities of these allergens to be present in the administered maintenance dose. Therefore, the idea developed to introduce major allergens measurements into standardization protocols. Such protocols based on mass units of major allergen, quantify the active ingredients of the treatment and will at the same time allow comparison of competitor products. In 2001, an EU funded project, the CREATE project, was started to support introduction of major allergen based standardization. The aim of the project was to evaluate the use of recombinant allergens as reference materials and of ELISA assays for major allergen measurements. This paper gives an overview of the achievements of the CREATE project.
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- Neubauer, Bernd A., et al.
(författare)
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KCNQ2 and KCNQ3 mutations contribute to different idiopathic epilepsy syndromes
- 2008
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Ingår i: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 0028-3878 .- 1526-632X. ; 71:3, s. 177-183
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To explore the involvement of M-type potassium channels KCNQ2, Q3, and Q5 in the pathogenesis of common idiopathic epilepsies. METHODS: Sequence analysis of the KCNQ2, Q3, and Q5 coding regions was performed in a screening sample consisting of 58 nuclear families with rolandic epilepsy. Subsequently, an association study was conducted for all discovered variants in a case-control sample comprising 459 German patients with idiopathic generalized epilepsy (IGE) and 462 population controls. RESULTS: An in-frame deletion of codon 116 in KCNQ2 (p.Lys116del) and a missense mutation in KCNQ3 (p.Glu299Lys) were detected in two index cases exhibiting rolandic epilepsy and benign neonatal convulsions. Both mutations resulted in reduced potassium current amplitude in Xenopus oocytes. Mutation analysis of families with rolandic epilepsy without neonatal seizures discovered three novel missense variations (KCNQ2 p.Ile592Met, KCNQ3 p.Ala381Val, KCNQ3 p.Pro574Ser). The KCNQ2 p.Ile592Met variant displayed a significant reduction of potassium current amplitude in Xenopus oocytes and was present only once in 552 controls. Both missense variants identified in KCNQ3 (p.Ala381Val and p.Pro574Ser) were present in all affected family members and did not occur in controls, but did not show obvious functional abnormalities. The KCNQ3 missense variant p.Pro574Ser was also detected in 8 of 455 IGE patients but not in 454 controls (p = 0.008). In KCNQ2, a silent single nucleotide polymorphism (rs1801545) was found overrepresented in both epilepsy samples (IGE, p = 0.004). CONCLUSION: Sequence variations of the KCNQ2 and KCNQ3 genes may contribute to the etiology of common idiopathic epilepsy syndromes.
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- Bertucci, C., et al.
(författare)
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Structure of Titan's mid-range magnetic tail : Cassini magnetometer observations during the T9 flyby
- 2007
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Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 34:24, s. L24S02-
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Tidskriftsartikel (refereegranskat)abstract
- We analyze the magnetic structure of Titan's mid-range magnetic tail (5-6 Titan radii downstream from the moon) during Cassini's T9 flyby. Cassini magnetometer (MAG) measurements reveal a well-defined, induced magnetic tail consisting of two lobes and a distinct central current sheet. MAG observations also indicate that Saturn's background magnetic field is close to the moon's orbital plane and that the magnetospheric flow has a significant component in the Saturn-Titan direction. The analysis of MAG data in a coordinate system based on the orientation of the background magnetic field and an estimation of the incoming flow direction suggests that Titan's magnetic tail is extremely asymmetric. An important source of these asymmetries is the connection of the inbound tail lobe and the outbound tail lobe to the dayside and nightside hemispheres of Titan, respectively. Another source could be the perturbations generated by changes in the upstream conditions.
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- Cravens, T. E., et al.
(författare)
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Model-data comparisons for Titan's nightside ionosphere
- 2009
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Ingår i: Icarus. - : Elsevier BV. - 0019-1035 .- 1090-2643. ; 199:1, s. 174-188
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Tidskriftsartikel (refereegranskat)abstract
- Solar and X-ray radiation and energetic plasma from Saturn's magnetosphere interact with the upper atmosphere producing an ionosphere at Titan. The highly coupled ionosphere and upper atmosphere system mediates the interaction between Titan and the external environment. A model of Titan's nightside ionosphere will be described and the results compared with data from the Ion and Neutral Mass Spectrometer (INMS) and the Langmuir probe (LP) part of the Radio and Plasma Wave (RPWS) experiment for the T5 and T21 nightside encounters of the Cassini Orbiter with Titan. Electron impact ionization associated with the precipitation of magnetospheric electrons into the upper atmosphere is assumed to be the source of the nightside ionosphere, at least for altitudes above 1000 km. Magnetospheric electron fluxes measured by the Cassini electron spectrometer (CAPS ELS) are used as an input for the model. The model is used to interpret the observed composition and structure of the T5 and T21 ionospheres. The densities of many ion species (e.g., CH5+ and C2H5+) measured during T5 exhibit temporal and/or spatial variations apparently associated with variations in the fluxes of energetic electrons that precipitate into the atmosphere from Saturn's magnetosphere.
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- Ingesson, L. C., et al.
(författare)
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Progress on common aspects of the EU-supplied ITER diagnostics and prediction of diagnostic performance
- 2006
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Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 77:10, s. 10F502-
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Tidskriftsartikel (refereegranskat)abstract
- The European Union will supply a number of diagnostics for ITER. Significant progress has been made on the design and integration of these diagnostics. Specific topics, in common for several of the diagnostics, discussed are port-plug integration, simplification of labyrinths against neutron streaming, and design measures to protect and to be able to replace sensitive optical components. Performance analysis to predict the likely capability of the diagnostics to meet the ITER measurement requirements will be an important aspect of the design process. The interpretation of the measurement requirements, specifically of spatial resolution in the case of indirect measurements, is discussed on the basis of two examples, and methods of performance analysis are compared.
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- Suttrop, W., et al.
(författare)
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In-vessel saddle coils for MHD control in ASDEX Upgrade
- 2009
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Ingår i: Fusion engineering and design. - Lausanne : ELSEVIER SCIENCE SA. - 0920-3796 .- 1873-7196. ; 84:2-6, s. 290-294
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Tidskriftsartikel (refereegranskat)abstract
- A set of 24 in-vessel saddle coils is planned for MHD control experiments in ASDEX Upgrade. These coils can produce static and alternating error fields for suppression of Edge Localised Modes, locked mode rotation control and, together with additional conducting wall elements, resistive wall mode excitation and feedback stabilisation experiments. All of these applications address critical physics issues for the operation of ITER. This extension is implemented in several stages, starting with two poloidally separated rings of eight toroidally distributed saddle coils above and below the outer midplane. In stages 2 and 3, eight midplane coils around the large vessel access ports and 12 AC Power converters are added, respectively. Finally (stage 4), the existing passive stabilising loop (PSL), a passive conductor for vertical growth rate reduction, will be complemented by wall elements that allow helical Current patterns to reduce the RWM growth rate for active control within the accessible bandwidth. The system is capable of producing error fields with toroidal mode number n = 4 for plasma edge ergodisation with core island width well below the neo-classical tearing mode seed island width even without rotational shielding. Phase variation between the three toroidal coil rings allows to create or avoid resonances with the plasma safety factor profile, in order to test the importance of resonances for ELM suppression.
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