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Identification of i...
Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials—GPPAD-02 study design and first results
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- Winkler, Christiane (author)
- Helmholtz Zentrum München
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- Haupt, Florian (author)
- Helmholtz Zentrum München
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- Heigermoser, Martin (author)
- Helmholtz Zentrum München
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- Zapardiel-Gonzalo, Jose (author)
- Helmholtz Zentrum München
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- Ohli, Jasmin (author)
- Helmholtz Zentrum München
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- Faure, Theresa (author)
- Helmholtz Zentrum München
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- Kalideri, Evdokia (author)
- Helmholtz Zentrum München
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- Hommel, Angela (author)
- Dresden University of Technology
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- Delivani, Petrina (author)
- Dresden University of Technology
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- Berner, Reinhard (author)
- Medizinsche Klinik und Poliklinik I, Dresden
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- Kordonouri, Olga (author)
- Children's Hospital Auf der Bult
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- Roloff, Frank (author)
- Children's Hospital Auf der Bult
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- von dem Berge, Thekla (author)
- Children's Hospital Auf der Bult
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- Lange, Karin (author)
- Hannover Medical School
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- Oltarzewski, Mariusz (author)
- National Research Institute of Mother and Child
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- Glab, Ryszard (author)
- National Research Institute of Mother and Child
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- Szypowska, Agnieszka (author)
- Medical University of Warsaw
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- Snape, Matthew D. (author)
- University of Oxford
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- Vatish, Manu (author)
- University of Oxford
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- Todd, John A. (author)
- University of Oxford
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- Larsson, Helena E. (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital
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- Ramelius, Anita (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Kördel, Jeanette (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Casteels, Kristina (author)
- Catholic University of Leuven,University Hospitals Leuven
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- Paulus, Jasmin (author)
- University Hospitals Leuven
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- Ziegler, Anette G. (author)
- Helmholtz Zentrum München,Klinikum rechts der Isar
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- Bonifacio, Ezio (author)
- Dresden University of Technology
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(creator_code:org_t)
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- 2019-06-13
- 2019
- English 8 s.
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In: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X .- 1399-5448. ; 20:6, s. 720-727
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Abstract
Subject headings
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- Primary prevention of type 1 diabetes (T1D) requires intervention in genetically at-risk infants. The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) has established a screening program, GPPAD-02, that identifies infants with a genetic high risk of T1D, enrolls these into primary prevention trials, and follows the children for beta-cell autoantibodies and diabetes. Genetic testing is offered either at delivery, together with the regular newborn testing, or at a newborn health care visits before the age of 5 months in regions of Germany (Bavaria, Saxony, Lower Saxony), UK (Oxford), Poland (Warsaw), Belgium (Leuven), and Sweden (Region Skåne). Seven clinical centers will screen around 330 000 infants. Using a genetic score based on 46 T1D susceptibility single-nucleotide polymorphisms (SNPs) or three SNPS and a first-degree family history for T1D, infants with a high (>10%) genetic risk for developing multiple beta-cell autoantibodies by the age of 6 years are identified. Screening from October 2017 to December 2018 was performed in 50 669 infants. The prevalence of high genetic risk for T1D in these infants was 1.1%. Infants with high genetic risk for T1D are followed up and offered to participate in a randomized controlled trial aiming to prevent beta-cell autoimmunity and T1D by tolerance induction with oral insulin. The GPPAD-02 study provides a unique path to primary prevention of beta-cell autoimmunity in the general population. The eventual benefit to the community, if successful, will be a reduction in the number of children developing beta-cell autoimmunity and T1D.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- beta-cell autoantibodies
- genetic risk for type 1 diabetes
- type 1 diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Winkler, Christi ...
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Haupt, Florian
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Heigermoser, Mar ...
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Zapardiel-Gonzal ...
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Ohli, Jasmin
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Faure, Theresa
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show more...
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Kalideri, Evdoki ...
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Hommel, Angela
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Delivani, Petrin ...
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Berner, Reinhard
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Kordonouri, Olga
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Roloff, Frank
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von dem Berge, T ...
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Lange, Karin
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Oltarzewski, Mar ...
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Glab, Ryszard
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Szypowska, Agnie ...
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Snape, Matthew D ...
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Vatish, Manu
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Todd, John A.
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Larsson, Helena ...
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Ramelius, Anita
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Kördel, Jeanette
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Casteels, Kristi ...
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Paulus, Jasmin
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Ziegler, Anette ...
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Bonifacio, Ezio
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Pediatrics
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Pediatric Diabet ...
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Lund University