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Träfflista för sökning "WFRF:(Padoan L) srt2:(1985-1989)"

Sökning: WFRF:(Padoan L) > (1985-1989)

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1.
  • Pyykkö, I., et al. (författare)
  • The effects of TTS-scopolamine, dimenhydrinate, lidocaine, and tocainide on motion sickness, vertigo, and nystagmus
  • 1985
  • Ingår i: Aviation Space and Environmental Medicine. - 0095-6562. ; 56:8, s. 82-777
  • Tidskriftsartikel (refereegranskat)abstract
    • The effects of TTS-scopolamine, dimenhydrinate, lidocaine, and tocainide on motion sickness and vertigo and on caloric and postrotatory nystagmus were evaluated in healthy volunteers. TTS-scopolamine was administered transdermally (delivering approximately 10 micrograms X h-1 scopolamine base) and 100 mg dimenhydrinate orally. Lidocaine and tocainide were administered intravenously (average plasma concentration of lidocaine 6 mol X L-1 and of tocainide 20 mol X L-1). TTS-scopolamine and dimenhydrinate significantly reduced vertigo induced by calorization of the ears, nausea provoked with Coriolis maneuvre, and nystagmus in caloric and rotatory tests. During treatment with lidocaine and tocainide no alleviation of vertigo and nausea was observed. Caloric nystagmus was reduced but rotation induced nystagmus was virtually unchanged. Presumably the motion sickness drugs act at the brain stem where TTS-scopolamine and dimenhydrinate have their target cells in the vestibular nuclei. Furthermore, the alleviation of motion sickness was linked to a decline of nystagmus. Lidocaine and tocainide, the action of which in vertigo and nausea in patients is proposed to be on the vestibular end organs and the supratentorial brain structures, consistently failed to alleviate motion sickness.
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2.
  • Schalén, L, et al. (författare)
  • Effects of intravenous diazepam and thiopental on the vestibulo-ocular reflex in man
  • 1989
  • Ingår i: Acta Oto-Laryngologica. - : Informa UK Limited. - 1651-2251 .- 0001-6489. ; 108:S468, s. 9-165
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • The effects of i.v. injection of diazepam 0.3 mg/kg and thiopental 6.0 mg/kg on vestibulo-ocular reflex (VOR) were studied in 9 healthy volunteers. One hour after injection of both diazepam and thiopental VOR gain was reduced and time constant shortened. Four hours after intravenous injection of diazepam the VOR gain was still significantly reduced and had not yet returned to control 8 h after injection. Although both drugs were detected in blood still 8 h after the injection, there were no longer significant effects on VOR. Moreover, individual values of VOR gain and time constant did not correlate with the blood concentrations of the drugs. Decrease of VOR gain and shortening of time constant after i.v. given diazepam and thiopental in man are interpreted as resulting from both specific effects on VOR and non-specific reduction of alertness.
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