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Noggin overexpressi...
Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation.
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Sharov, Andrei A (författare)
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Weiner, Lorin (författare)
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Sharova, Tatyana Y (författare)
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visa fler...
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Siebenhaar, Frank (författare)
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Atoyan, Ruzanna (författare)
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Reginato, Anthony M (författare)
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McNamara, Coleen A (författare)
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- Funa, Keiko, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för anatomi och cellbiologi,Institute of Anatomy and Cell Biology
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Gilchrest, Barbara A (författare)
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Brissette, Janice L (författare)
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Botchkarev, Vladimir A (författare)
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visa färre...
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(creator_code:org_t)
- Wiley, 2003
- 2003
- Engelska.
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Ingår i: The EMBO journal. - : Wiley. - 0261-4189 .- 1460-2075. ; 22:12, s. 2992-3003
- Relaterad länk:
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https://europepmc.or...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Contact of developing sensory organs with the external environment is established via the formation of openings in the skin. During eye development, eyelids first grow, fuse and finally reopen, thus providing access for visual information to the retina. Here, we show that eyelid opening is strongly inhibited in transgenic mice overexpressing the bone morphogenetic protein (BMP) antagonist noggin from the keratin 5 (K5) promoter in the epidermis. In wild-type mice, enhanced expression of the kinase-inactive form of BMPR-IB mediated by an adenovirus vector also inhibits eyelid opening. Noggin overexpression leads to reduction of apoptosis and retardation of cell differentiation in the eyelid epithelium, which is associated with downregulation of expression of the apoptotic receptors (Fas, p55 kDa TNFR), Id3 protein and keratinocyte differentiation markers (loricrin, involucrin). BMP-4, but not EGF or TGF-alpha, accelerates opening of the eyelid explants isolated from K5-Noggin transgenic mice when cultured ex vivo. These data suggest that the BMP signaling pathway plays an important role in regulation of genetic programs of eyelid opening and skin remodeling during the final steps of eye morphogenesis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- Adenoviridae
- genetics
- metabolism
- Animals
- Apoptosis
- physiology
- Biological Markers
- Bone Morphogenetic Protein Receptors
- Bone Morphogenetic Proteins
- antagonists & inhibitors
- metabolism
- Carrier Proteins
- Cell Differentiation
- physiology
- Culture Techniques
- DNA-Binding Proteins
- metabolism
- Embryo
- Mammalian
- anatomy & histology
- physiology
- Epidermal Growth Factor
- metabolism
- Epidermis
- cytology
- growth & development
- physiology
- Eyelids
- cytology
- growth & development
- Genetic Vectors
- Growth Differentiation Factor 5
- Humans
- In Situ Hybridization
- In Situ Nick-End Labeling
- Keratin-5
- Keratinocytes
- cytology
- physiology
- Keratins
- genetics
- Mice
- Mice
- Transgenic
- Morphogenesis
- physiology
- Neoplasm Proteins
- metabolism
- Promoter Regions
- Genetic
- Proteins
- genetics
- metabolism
- Receptors
- Growth Factor
- genetics
- metabolism
- Signal Transduction
- physiology
- Smad Proteins
- Trans-Activators
- metabolism
- Transforming Growth Factor alpha
- metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Sharov, Andrei A
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Weiner, Lorin
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Sharova, Tatyana ...
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Siebenhaar, Fran ...
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Atoyan, Ruzanna
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Reginato, Anthon ...
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visa fler...
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McNamara, Coleen ...
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Funa, Keiko, 194 ...
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Gilchrest, Barba ...
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Brissette, Janic ...
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Botchkarev, Vlad ...
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visa färre...
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Göteborgs universitet