| 1. |
- Abelev, B., et al.
(författare)
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Technical Design Report for the Upgrade of the ALICE Inner Tracking System
- 2014
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Ingår i: Journal of Physics G: Nuclear and Particle Physics. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 41:8
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Tidskriftsartikel (refereegranskat)abstract
- LICE (A Large Ion Collider Experiment) is studying the physics of strongly interacting matter, and in particular the properties of the Quark–Gluon Plasma (QGP), using proton–proton, proton–nucleus and nucleus–nucleus collisions at the CERN LHC (Large Hadron Collider). The ALICE Collaboration is preparing a major upgrade of the experimental apparatus, planned for installation in the second long LHC shutdown in the years 2018–2019. A key element of the ALICE upgrade is the construction of a new, ultra-light, high-resolution Inner Tracking System (ITS) based on monolithic CMOS pixel detectors. The primary focus of the ITS upgrade is on improving the performance for detection of heavy-flavour hadrons, and of thermal photons and low-mass di-electrons emitted by the QGP. With respect to the current detector, the new Inner Tracking System will significantly enhance the determination of the distance of closest approach to the primary vertex, the tracking efficiency at low transverse momenta, and the read-out rate capabilities. This will be obtained by seven concentric detector layers based on a 50 μm thick CMOS pixel sensor with a pixel pitch of about 30×30 μm2. This document, submitted to the LHCC (LHC experiments Committee) in September 2013, presents the design goals, a summary of the R&D activities, with focus on the technical implementation of the main detector components, and the projected detector and physics performance.
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| 2. |
- Chauvier, D, et al.
(författare)
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Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor.
- 2011
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Ingår i: Cell death & disease. - : Springer Science and Business Media LLC. - 2041-4889. ; 2
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Tidskriftsartikel (refereegranskat)abstract
- Brain protection of the newborn remains a challenging priority and represents a totally unmet medical need. Pharmacological inhibition of caspases appears as a promising strategy for neuroprotection. In a translational perspective, we have developed a pentapeptide-based group II caspase inhibitor, TRP601/ORPHA133563, which reaches the brain, and inhibits caspases activation, mitochondrial release of cytochrome c, and apoptosis in vivo. Single administration of TRP601 protects newborn rodent brain against excitotoxicity, hypoxia-ischemia, and perinatal arterial stroke with a 6-h therapeutic time window, and has no adverse effects on physiological parameters. Safety pharmacology investigations, and toxicology studies in rodent and canine neonates, suggest that TRP601 is a lead compound for further drug development to treat ischemic brain damage in human newborns.
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| 3. |
- Stiller, J., et al.
(författare)
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Phylogeny, biogeography and systematics of hydrothermal vent and methane seep Amphisamytha (Ampharetidae, Annelida), with descriptions of three new species
- 2013
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Ingår i: Systematics and Biodiversity. - : Informa UK Limited. - 1477-2000 .- 1478-0933. ; 11:1, s. 35-65
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Tidskriftsartikel (refereegranskat)abstract
- Amphisamytha has five currently recognized species. One of these, A. galapagensis has been reported from numerous hydrothermal vents and methane seeps across the Pacific Ocean. Here, a collection of Amphisamytha from a range of Pacific habitats, as well as Amathys lutzi from Atlantic hydrothermal vents, were studied using morphology and DNA sequences from mitochondrial (COI and 16S rRNA) and nuclear (18S rRNA) genes. Phylogenetic analyses revealed a deep-sea clade comprised of the previously recognized Amphisamytha species, and three lineages that are treated as new species. The morphologically distinct Amathys lutzi was nested within Amphisamytha and the monotypic Amathys is treated as a junior synonym of Amphisamytha, with a resulting name change to Amphisamytha lutzi comb. nov. A revision of the other Amphisamytha species, the description of three new species, and a key are provided. The geographic range of the ‘cosmopolitan’ A. galapagensis is restricted to hydrothermal vents of the East Pacific Rise and the Galápagos Ridge. Amphisamytha fauchaldi, previously only known from sedimented hydrothermal vents of the Guaymas Basin (Gulf of California, Mexico), is recorded from cold seeps off the coasts of Costa Rica and Oregon. Amphisamytha carldarei sp. nov. is described from hydrothermal vents of the northeast Pacific (Juan de Fuca), while A. jacksoni sp. nov. spans much of the East Pacific Rise and is sympatric with A. galapagensis for part of its range. Amphisamytha julianeae sp. nov. is found at western Pacific vent systems in sympatry with A. vanuatuensis. Relaxed molecular clock analyses were calibrated using the vicariant event involving the Farallon-Pacific Ridge in the northern Pacific Ocean. This provides mean dates for the origin of the deep-sea Amphisamytha clade at 44 or 55 million years ago, and the separation of the Pacific–Atlantic sister-species pair at 13 or 21 million years ago, depending on the tree used.
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