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Positron Emission T...
Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis : A Meta-analysis Using Individual Participant Data
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- Plaven-Sigray, Pontus (författare)
- Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden.
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- Matheson, Granville J. (författare)
- Karolinska Institutet
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- Collste, Karin (författare)
- Karolinska Institutet
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- Ashok, Abhishekh H. (författare)
- Imperial Coll London, Fac Med, Inst Psychiat Psychol & Neurosci, London, England.;Imperial Coll London, Fac Med, Kings Coll London, Med Res Council,London Inst Med Sci, London, England.;Imperial Coll London, Fac Med, Hammersmith Hosp, London, England.;Imperial Coll London, Fac Med, Inst Clin Sci, London, England.
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- Coughlin, Jennifer M. (författare)
- Johns Hopkins Med Inst, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.;Johns Hopkins Med Inst, Russell H Morgan Dept Radiol & Radiol Sci, 600 N Wolfe St, Baltimore, MD 21205 USA.
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- Howes, Oliver D. (författare)
- Imperial Coll London, Fac Med, Inst Psychiat Psychol & Neurosci, London, England.;Imperial Coll London, Fac Med, Kings Coll London, Med Res Council,London Inst Med Sci, London, England.;Imperial Coll London, Fac Med, Hammersmith Hosp, London, England.;Imperial Coll London, Fac Med, Inst Clin Sci, London, England.
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- Mizrahi, Romina (författare)
- Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
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- Pomper, Martin G. (författare)
- Johns Hopkins Med Inst, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.;Johns Hopkins Med Inst, Russell H Morgan Dept Radiol & Radiol Sci, 600 N Wolfe St, Baltimore, MD 21205 USA.
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- Rusjan, Pablo (författare)
- Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
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- Veronese, Mattia (författare)
- Imperial Coll London, Fac Med, Dept Neuroimaging, London, England.
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- Wang, Yuchuan (författare)
- Johns Hopkins Med Inst, Russell H Morgan Dept Radiol & Radiol Sci, 600 N Wolfe St, Baltimore, MD 21205 USA.
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- Cervenka, Simon (författare)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden;Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden. (creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Biological Psychiatry. - : Elsevier BV. - 0006-3223 .- 1873-2402. ; 84:6, s. 433-442
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Accumulating evidence suggests that the immune system may be an important target for new treatment approaches in schizophrenia. Positron emission tomography and radioligands binding to the translocator protein (TSPO), which is expressed in glial cells in the brain including immune cells, represents a potential method for patient stratification and treatment monitoring. This study examined whether patients with first-episode psychosis and schizophrenia had altered TSPO levels compared with healthy control subjects.METHODS: PubMed was searched for studies comparing patients with psychosis with healthy control subjects using second-generation TSPO radioligands. The outcome measure was total distribution volume (V-T), an index of TSPO levels, in frontal cortex, temporal cortex, and hippocampus. Bayes factors (BFs) were applied to examine the relative support for higher, lower, or no difference in patients' TSPO levels compared with healthy control subjects.RESULTS: Five studies, with 75 participants with first-episode psychosis or schizophrenia and 77 healthy control subjects, were included. BFs showed strong support for lower VT in patients relative to no difference (all BFs > 32), or relative to higher V-T (all BFs > 422), in all brain regions. From the posterior distributions, mean patient-control differences in standardized V-T values were -0.48 for frontal cortex (95% credible interval [CredInt] = -0.88 to 0.09), -0.47 for temporal cortex (CredInt = -0.87 to -0.07), and -0.63 for hippocampus (CredInt = -1.00 to -0.25).CONCLUSIONS: The lower levels of TSPO observed in patients may correspond to altered function or lower density of brain immune cells. Future studies should focus on investigating the underlying biological mechanisms and their relevance for treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Immune activation
- Meta-analysis
- Microglia
- Positron emission tomography
- Psychosis
- Schizophrenia
- Translocator protein
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Plaven-Sigray, P ...
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Matheson, Granvi ...
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Collste, Karin
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Ashok, Abhishekh ...
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Coughlin, Jennif ...
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Howes, Oliver D.
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Mizrahi, Romina
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Pomper, Martin G ...
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Rusjan, Pablo
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Veronese, Mattia
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Wang, Yuchuan
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Cervenka, Simon
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