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Lower brain fatty a...
Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11]CURB
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- Best, Laura M. (författare)
- Ctr Addict & Mental Hlth, Canada; Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada
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- Williams, Belinda (författare)
- Ctr Addict & Mental Hlth, Canada
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- Le Foll, Bernard (författare)
- Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada; Ctr Addict & Mental Hlth, Canada; Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada; Univ Toronto, Canada; Univ Toronto, Canada
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visa fler...
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- Mansouri, Esmaeil (författare)
- Ctr Addict & Mental Hlth, Canada; Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada
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- Bazinet, Richard P. (författare)
- Univ Toronto, Canada
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- Lin, Lin (författare)
- Univ Toronto, Canada
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- De Luca, Vincenzo (författare)
- Univ Toronto, Canada; Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada; Ctr Addict & Mental Hlth, Canada
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- Lagzdins, Dina (författare)
- Ctr Addict & Mental Hlth, Canada
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- Rusjan, Pablo (författare)
- Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada; Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada
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- Tyndale, Rachel F. (författare)
- Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada; Univ Toronto, Canada
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- Wilson, Alan A. (författare)
- Ctr Addict & Mental Hlth, Canada; Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada
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- Hendershot, Christian S. (författare)
- Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada; Ctr Addict & Mental Hlth, Canada
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- Heilig, Markus, 1959- (författare)
- Linköpings universitet,Medicinska fakulteten,Centrum för social och affektiv neurovetenskap,Region Östergötland, Psykiatriska kliniken i Linköping
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- Houle, Sylvain (författare)
- Ctr Addict & Mental Hlth, Canada; Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada
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- Tong, Junchao (författare)
- Ctr Addict & Mental Hlth, Canada; Ctr Addict & Mental Hlth, Canada; Ctr Addict & Mental Hlth, Canada; Ctr Addict & Mental Hlth, Canada; Ctr Addict & Mental Hlth, Canada
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- Kish, Stephen J. (författare)
- Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada; Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada; Univ Toronto, Canada; Ctr Addict & Mental Hlth, Canada
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- Boileau, Isabelle (författare)
- Ctr Addict & Mental Hlth, Canada; Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada; Ctr Addict & Mental Hlth, Canada; Univ Toronto, Canada; Ctr Addict & Mental Hlth, Canada
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visa färre...
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(creator_code:org_t)
- 2020-01-07
- 2020
- Engelska.
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Ingår i: Neuropsychopharmacology. - : SPRINGERNATURE. - 0893-133X .- 1740-634X. ; 45:8, s. 1289-1296
- Relaterad länk:
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https://www.nature.c...
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visa fler...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The endocannabinoid enzyme, fatty acid amide hydrolase (FAAH), has been proposed as a therapeutic target for alcohol use disorder (AUD) and co-morbid psychiatric illnesses. Investigating this target in the living human brain and its relationship to clinical outcome is a critical step of informed drug development. Our objective was to establish whether brain FAAH levels are low in individuals with AUD and related to drinking behavior. In this pilot study, treatment-seeking patients with AUD completed two PET scans with the FAAH radiotracer [C-11]CURB after 3-7 days (n = 14) and 2-4 weeks (n = 9) of monitored abstinence. Healthy controls (n = 25) completed one scan. FAAH genetic polymorphism (rs324420) and blood concentrations of anandamide and other N-acylethanolamines metabolized by FAAH were determined and AUD symptoms assessed. In AUD, brain FAAH levels were globally lower than controls during early abstinence (F(1,36) = 5.447; p = 0.025)) and FAAH substrates (anandamide, oleoylethanolamide, and N-docosahexaenoylethanolamide) were significantly elevated (30-67%). No significant differences in FAAH or FAAH substrates were noted after 2-4 weeks abstinence. FAAH levels negatively correlated with drinks per week (r = -0.57, p = 0.032) and plasma concentrations of the three FAAH substrates (r > 0.57; p < 0.04)). Our findings suggest that early abstinence from alcohol in AUD is associated with transiently low brain FAAH levels, which are inversely related to heavier alcohol use and elevated plasma levels of FAAH substrates. Whether low FAAH is an adaptive beneficial response to chronic alcohol is unknown. Therapeutic strategies focusing on FAAH inhibition should consider the possibility that low FAAH during early abstinence may be related to drinking.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Beroendelära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Substance Abuse (hsv//eng)
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- Av författaren/redakt...
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Best, Laura M.
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Williams, Belind ...
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Le Foll, Bernard
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Mansouri, Esmaei ...
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Bazinet, Richard ...
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Lin, Lin
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visa fler...
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De Luca, Vincenz ...
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Lagzdins, Dina
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Rusjan, Pablo
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Tyndale, Rachel ...
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Wilson, Alan A.
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Hendershot, Chri ...
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Heilig, Markus, ...
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Houle, Sylvain
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Tong, Junchao
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Kish, Stephen J.
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Boileau, Isabell ...
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Linköpings universitet