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- Shabani, Mahdi, et al.
(författare)
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Comparative expression profile of orphan receptor tyrosine kinase ROR1 in Iranian patients with lymphoid and myeloid leukemias
- 2011
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Ingår i: Avicenna Journal of Medical Biotechnology. - Stockholm : Karolinska Institutet, Dept of Oncology-Pathology. - 2008-2835.
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Tidskriftsartikel (refereegranskat)abstract
- It has recently been shown that ROR1, a member of the receptor tyrosine kinase family, is overexpressed in leukemic B cells of Chronic Lymphocytic Leukemia (CLL) and a subset of Acute Lymphoblastic Leukemia (ALL). In this comparative study the expression profile of ROR1 mRNA was investigated in Iranian patients with CLL and Acute Myelogenous Leukemia (AML) and the results were compared with those previously reported in our Iranian ALL patients. RT-PCR was performed on bone marrow and/or peripheral blood samples of 84 CLL and 12 AML patients. CLL samples were classified into immunoglobulin heavy chain variable region (IGHV) gene mutated (n = 55) and unmutated (n = 29) and also indolent (n = 42) and progressive (n = 39) subtypes. ROR1 expression was identified in 94% of our CLL patients, but none of the AML patients expressed ROR1. No significant differences were observed between different CLL subtypes for ROR1 expression. Taken together the present data and our previous results on ROR1 expression in ALL, our findings propose ROR1 as a tumor-associated antigen overexpressed in a large proportion of lymphoid (CLL and ALL), but not myeloid (AML) leukemias. Expression of ROR1 seems to be associated to lineage and differentiation stages of leukemic cells with a potential implication for immunotherapy.
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- Shokri, Omid, et al.
(författare)
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Gender and academic stress : a model for moderating effects in cultural context
- 2013
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Ingår i: Journal of Behavioral Science. - : Srinakharinwirot University/Behavioral Science Research Institute. - 1686-1442. ; 7:1, s. 35-42
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Tidskriftsartikel (refereegranskat)abstract
- Introduction:This study examined the moderating effect of cultural contexts in the relationship between gender and academic stress among male and female Iranian and Swedish university students.Method:The Academic Stress Questionnaire (ASQ) was administered to 212 students (112 Iranian (32 male and 78 female) and 100 Swedish (29 male and 71 female)). Linear Regression analysis was used for data analysis.Results:The results of regression analysis indicated that there was a significant positive correlation between gender and academic stress among Iranian and Swedish students. Results also indicated that the relationship between gender and academic stress was not moderated by cultural context. However, gender was found to be a strong predictor for academic stress for Iranian students in comparison with Swedish ones.Conclusion:Although these findings showed that the relationship between gender and academic stress was not oderated by cultural context, obvious differences in predictive values of standardized regression of academic stress by gender among Iranian and Swedish students support theoretical assumptions underlying transactional theory of stress and expectation theory of sexual role.
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