| 1. |
- Pirianov, Grisha, et al.
(författare)
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Deletion of the c-Jun N-terminal kinase 3 gene protects neonatal mice against cerebral hypoxic-ischaemic injury
- 2007
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Ingår i: J Cereb Blood Flow Metab. ; 27:5, s. 1022-32
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Tidskriftsartikel (refereegranskat)abstract
- c-Jun N-terminal kinase 3 (JNK3) is a member of the stress-activated group of mitogen-activated protein kinases. c-Jun N-terminal kinase 3 is a potent mediator of apoptosis and the use of JNK inhibitors or jnk3 gene deletion each protect against brain injury in adults. However, little is known about the role of JNK3 or its mechanism of action in neonatal brain injury. The aim of the present study was to compare the vulnerability of neonatal JNK3 knockout (JNK3 KO) mice and wild-type (WT) mice to cerebral hypoxic-ischaemic injury (HII) using unilateral-carotid occlusion combined with transient hypoxia. The degree of neural tissue loss in JNK3 KO mice was substantially reduced compared with WT mice (JNK3 KO 27.8%+/-2.8% versus WT 48.3%+/-2.0%, P
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| 2. |
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| 3. |
- Giron, MST, et al.
(författare)
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Drug use patterns in a very elderly population : a seven-year review
- 1999
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Ingår i: Clinical drug investigation. - 1173-2563 .- 1179-1918. ; 17:15, s. 389-98
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To determine the extent and rate of drug use and to evaluate the patterns of drug use over time in a very elderly population, we analysed drug use data from phases I (1987-1989) and IV (1994-1996) of the Kungsholmen project, an ongoing longitudinal study on aging in Stockholm, Sweden.Study Participants: Complete drug information was obtained from 1001 subjects in the 1987-1989 study period, and 681 subjects in 1994-1996. The participants were predominantly women and the average age was 85.8 years in 1987-1989 and 86.9 years in 1994-1996.Results: The proportion of users increased from 87.6 to 94.1% and the overall average number of drugs used per subject increased significantly (p < 0.001) from 3.4 to 4.6. Significant differences (p < 0.05) were noted in all age groups and in all types of housing. The frequency of use increased for all classes of drugs. The most frequently used in both study periods were drugs for the nervous system, cardiovascular system, and alimentary tract and metabolism. With regard to therapeutic categories of drugs, the use of vitamins, antithrombotic agents, antianaemic preparations, ACE inhibitors, antibacterials, analgesics, psychoanaleptics, and antiglaucoma preparations increased significantly (p < 0.05). The increased use of these drugs indicated heightened awareness of the most common and preventable medical conditions affecting the elderly and the use of newer classes of drugs. This also study confirmed a high prevalence of drug use and polypharmacy even in the very elderly, and the importance of evaluating the effects and appropriateness of drug use in this population.
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| 4. |
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| 5. |
- Andler, Sten F., et al.
(författare)
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DeeDS : Towards a Distributed and Active Real-Time Database Systems
- 1996
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Ingår i: ACM Sigmod Record. ; 25:1, s. 38-40
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Tidskriftsartikel (refereegranskat)abstract
- DeeDS combines active database functionality with critical timing constraints and integrated system monitoring. Since the reactive database mechanisms, or rule management system, must meet critical deadlines, we must employ methods that make triggering of rules and execution of actions predictable. We will focus on the scheduling issues associated with dynamic scheduling of workloads where the triggered transactions have hard, firm or soft deadlines, and how transient overloads may be resolved by substituting transactions by computationally cheaper ones. The rationale for a loosely coupled general purpose event monitoring facility, that works in tight connection with the scheduler, is presented. For performance and predictability, the scheduler and event monitor are executing on a separate CPU from the rest of the system. Real-time database accesses in DeeDS are made predictable and efficient by employing methods such as main memory resident data, full replication, eventual consistency, and prevention of global deadlocks.
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| 6. |
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| 7. |
- Andler, Sten F., et al.
(författare)
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Information Fusion from Databases, Sensors and Simulations : A Collaborative Research Program
- 2005
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Ingår i: Proceedings. - : IEEE Computer Society. - 0769523064 ; , s. 234-241
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Konferensbidrag (refereegranskat)abstract
- This paper provides an overview of a collaborative research program in information fusion from databases, sensors and simulations. Information fusion entails the combination of data from multiple sources, to generate information that cannot be derived from the individual sources. This area is of strategic importance for industry and defense, as well as public administration areas such as health care, and needs to be pursued as an academic subject. A large number of industrial partners are supporting and participating in the development of the area. The paper describes the program’s general approach and main research areas, with a particular focus on the role of information fusion in systems development
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| 8. |
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| 9. |
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| 10. |
- Bandyopadhyay, Arka, et al.
(författare)
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8-16-4 graphyne : Square-lattice two-dimensional nodal line semimetal with a nontrivial topological Zak index
- 2021
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Ingår i: Physical Review B. - : American Physical Society (APS). - 2469-9950 .- 2469-9969. ; 103:7
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Tidskriftsartikel (refereegranskat)abstract
- An unprecedented graphyne allotrope with square symmetry and nodal line semimetallic behavior has been proposed in the two-dimensional (2D) realm. The emergence of the Dirac loop around the high-symmetry points in the presence of both the inversion and time-reversal symmetries is a predominant feature of the electronic band structure of this system. Besides, the structural stability in terms of the dynamic, thermal, and mechanical properties has been critically established for the system. Following the exact analytical model based on the realspace renormalization group scheme and tight-binding approach, we have inferred that the family of 2D nodal line semimetals with square symmetry can be reduced to a universal four-level system in the low-energy limit. This renormalized lattice indeed explains the underlying mechanism responsible for the fascinating emergence of 2D square nodal line semimetals. Besides, the analytical form of the generic dispersion relation of these systems is well supported by our density-functional theory results. Finally, the nontrivial topological properties have been explored for the predicted system without breaking the inversion and time-reversal symmetry of the lattice. We have obtained that the edge states are protected by the nonvanishing topological index, i.e., Zak phase.
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| 11. |
- Bandyopadhyay, Jatisankar, et al.
(författare)
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Identification and characterization the sources of aerosols over Jharkhand state and surrounding areas, India using AHP model
- 2021
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Ingår i: Geomatics, Natural Hazards and Risk. - : Taylor & Francis. - 1947-5705 .- 1947-5713. ; 12:1, s. 2194-2224
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Tidskriftsartikel (refereegranskat)abstract
- The Aerosol Optical Depth (AOD) has measured using remote sensing and GIS methods, with MODIS data collected in Jharkhand from 2011 to 2017. The state’s eastern and northern borders have greater aerosol loadings (AOD: >0.5) while the southern and western parts have lower aerosol loadings (AOD: <0.3). Primary, secondary, tertiary, and quaternary aerosol sources have been identified and categorized using the Analytic Hierarchical Process (AHP). Only 1.29% of the study area, which still emits the most aerosols, is covered by primary sources. Industrial zones, mining regions, thermal power plants, cement industries, high road density, and stone crushers are found in many locations throughout the country. Secondary sources of aerosols account for 5.23% of the study and are located near the main sources. The quaternary (54.08%) and tertiary (39.4%) aerosol sources mainly covered the Southern, Western, and North-Western portions of the state, which is enveloped by a heavily vegetated region. AOD, sources of aerosols, wind direction, and velocity were examined here. There were non-separable connections in this area and also AOD distribution is connected to aerosol sources, wind direction, and wind velocity. Finally, it employs the AOD values to identify different aerosol kinds and source heterogeneity to elucidate their influence.
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| 12. |
- Bandyopadhyay, S., et al.
(författare)
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A statistical approach to determine process parameter impact in Nd : YAG laser drilling of IN718 and Ti-6Al-4V sheets
- 2005
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Ingår i: Optics and lasers in engineering. - 0143-8166 .- 1873-0302. ; 43:2, s. 163-182
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Tidskriftsartikel (refereegranskat)abstract
- The numerous unique advantages afforded by pulsed Nd:YAG laser systems have led to their increasing utility for producing high aspect ratio holes in a wide range of materials. Notwithstanding the growing industrial acceptance of the technique, the increasingly tighter geometrical tolerances and more stringent hole quality requirements of modern industrial components demand that "defects" such as taper, recast, spatter etc., in laser-drilled holes are minimized. Process parameters like pulse energy, pulse repetition rate, pulse duration, focal position, nozzle standoff, type of gas and gas pressure of the assist gas are known to significantly influence hole quality during laser drilling. The present study reports the use of Taguchi design of experiments technique to study the effects of the above process variables on the quality of the drilled holes and ascertain optimum processing conditions. Minimum taper in the drilled hole was considered as the desired target response. The entire study was conducted in three phases:(a) screening experiments, to identify process variables that critically influence taper in laser drilled holes, (b) Optimization experiments, to ascertain the set of parameters that would yield minimum taper and (c) validation trials, to assess the validity of the experimental procedures and results. Results indicate that laser drilling with focal position on the surface of the material being drilled and employing low level values of pulse duration and pulse energy represents the ideal conditions to achieve minimum taper in laser-drilled holes. Thorough assessment of results also reveals that the laser-drilling process, optimized considering taper in the drilled hole as the target response, leads to very significant improvements in respect of other hole quality attributes of interest such as spatter and recast as well. © 2004 Elsevier Ltd. All rights reserved.
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| 13. |
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| 14. |
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| 15. |
- Borgqvist, Patrick, et al.
(författare)
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Investigation and Comparison of Residual Gas Enhanced HCCI using Trapping (NVO HCCI) or Rebreathing of Residual Gases
- 2011
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Ingår i: SAE Technical Paper Series. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International. - 0148-7191.
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Konferensbidrag (refereegranskat)abstract
- A comparison between throttled and unthrottled spark ignition combustion with residual enhanced HCCI combustion is made. Early intake valve closing and late intake valve closing valve strategies for unthrottled spark ignition combustion are evaluated and compared. Approximately 3-6 percent relative improvement in net indicated efficiency is seen when comparing unthrottled spark ignition combustion with throttled spark ignition combustion depending on valve strategy and engine speed. The relative improvement in efficiency from spark ignition combustion to HCCI combustion is approximately 20 percent for the conditions presented in this study. The rebreathing strategies have the highest efficiency of the cases in this study.
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| 16. |
- Depari, A., et al.
(författare)
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Lightweight Machine Learning-Based Approach for Supervision of Fitness Workout
- 2019
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Ingår i: Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. - 9781538677131
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Konferensbidrag (refereegranskat)abstract
- It is widely known that physical activity helps preventing several diseases. However, unsupervised training often results in low exercise quality, ineffective training, and, in worst cases, injuries. Automatic tracking and quantification of exercises by means of wearable devices could be an effective mean for the monitoring of exercise correctness. As a consequence, such devices could help motivating people, thus improving the quantity of performed physical exercise, with positive effects on users' health conditions. However, despite the availability of several commercial devices, the performance and effectiveness are not well documented. This work proposes a new solution for fitness workout supervision exploiting machine learning techniques, in particular Linear Discriminant Analysis for analyzing data coming from wearable Inertial Measurement Units. Efforts have been done in order to reduce the computational requirements, thus assuring compatibility in perspective of embedded implementation. The experimental tests carried out to assess the proposed approach performance showed an accuracy in exercise detection over 93% and error in exercise counting less than 6%. © 2019 IEEE.
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| 17. |
- Fager, Cecilia, 1990, et al.
(författare)
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Correlating 3D porous structure in polymer films with mass transport properties using FIB-SEM tomography
- 2021
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Ingår i: Chemical Engineering Science: X. - : Elsevier BV. - 2590-1400. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- Porous polymer coatings are used to control drug release from pharmaceutical products. The coating covers a drug core and depending on the porous structure, different drug release rates are obtained. This work presents mass transport simulations performed on porous ethyl cellulose films with different porosities. The simulations were performed on high spatial resolution 3D data obtained using a focused ion beam scanning electron microscope. The effective diffusion coefficient of water was determined using a diffusion chamber. Lattice Boltzmann simulations were used to simulate water diffusion in the 3D data. The simulated coefficient was in good agreement with the measured coefficient. From the results it was concluded that the tortuosity and constrictivity of the porous network increase with decreasing amount of added hydroxypropyl cellulose, resulting in a sharp decrease in effective diffusion. This work shows that high spatial resolution 3D data is necessary, and that 2D data is insufficient, in order to predict diffusion through the porous structure with high accuracy.
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| 18. |
- Hallberg, Peter, 1974-, et al.
(författare)
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Means and Measures for the Benefit of the Persistent Freshman
- 2019
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Konferensbidrag (refereegranskat)abstract
- This paper presents and discusses three novel and interconnected means and measures with the aim to better understand the situation for the freshman student during the first year of study. Ultimately, this contribution seeks answers to what fosters student persistence. Exploration of possible answers is conducted by utilizing faculty registries of curriculum composition and study records, for investigating how different categories of curriculum content impact the performance of the students. Furthermore, the use of questionnaires for measuring coping capabilities among the freshman students is also explored, and finally, techniques of gathering real-time behavioral and environmental data for further analyzing is also discussed.In conclusion, the paper discusses different categories of data sources and presents a set of tools and measures that could be employed by program planners and curriculum designers when evaluating and comparing the content of different engineering curricula and the relation to the performance of the students.
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| 19. |
- Hallberg, Peter, 1984
(författare)
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Mixed Oxide Oxygen Carriers for Chemical-Looping Combustion
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Chemical-Looping Combustion is a promising method for combustion with inherent carbon dioxide capture. Oxygen is provided to the fuel with a solid oxygen carrier. The oxygen carrier is circulated between the reactor for fuel oxidation and another reactor where it is reoxidized with air. A good performing oxygen carrier is vital for this process. An oxygen carrier is typically a metal oxide and this work focus on evaluating oxygen carriers based on mixed metal oxides. A method was developed to determine the reduction reaction enthalpy of oxygen carriers in a fluidized-bed batch reactor. The method was verified using a nickel based oxygen carries with known enthalpy. Different oxygen carriers based of the iron-titanium oxide ilmenite were evaluated to determine the reaction enthalpy in a chemical-looping process. Oxygen carriers manufactured with spray drying technology were developed through a screening process. Starting with 79 different materials those deemed promising were tested in a fluidized-bed batch reactor. The ability to release oxygen, reactivity with fuel and fluidization behavior were the most important parameters and based off the results 10 materials were chosen to be investigated in a small continuous Chemical-Looping reactor system. Based off these results 2 materials were examined in a larger continuous Chemical-Looping reactor system where fuel power up to 6 kW were used. Oxygen carrier particles based on calcium manganite performed best with substantial release off oxygen and high to complete conversion on fuel. The material CaMn0.775Ti0.125Mg0.1O3-δ performed best in all three reactor systems. In addition to the oxygen release and reactivity these particles also proved durable with unaffected reactivity and low attrition after 99 h of continuous chemical-looping operation.
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| 20. |
- Hallberg, Peter
(författare)
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Nyare studier i isländsk sagalitteratur
- 1972
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Ingår i: Samlaren. - Uppsala : Svenska Litteratursällskapet. - 0348-6133 .- 2002-3871. ; 93, s. 211-237
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Forskningsöversikt (övrigt vetenskapligt/konstnärligt)
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| 21. |
- Hallberg, Peter, 1974-, et al.
(författare)
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Redsigning Mature Products for Substainability
- 2006
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This contribution will discuss engineering design projects with various environmental and sustainable objectives. The automotive industry is facing a major vicissitude regarding the system layouts of their products. Given the rapidly increasing demands for environmentally acceptable and sustainable vehicles, developed even faster and under increasing competition, one could expect a future, or a period of transition, where a “market pull”-situation will exact design methods more adapted for new propulsion technologies such as fuel cells, bio-fuels, hybrid configurations and so forth. When looking at two-wheeled vehicles it is also a matter of a dramatic change in the safety requirements that would affect the design process in a similar way.This paper presents studies made regarding development of two-wheeled vehicles with strict safety, environmental and sustainability requirements. It also describes what happens when a very mature product, such as a conventional motorcycle, undergoes dramatic changes in propulsion system and safety features and becomes technically immature, but still has to preserve its traditional values in the eyes of the consumer. Over the last two years, the Department of Mechanical Engineering at Linköping University has conducted various projects dealing with these issues using rapid, low-cost, demonstrator development together with digital models. The demonstrator is used as a vehicle to evaluate the integration of technology, as well as less tangible aspects such as ergonomics, drivability, appeal, visual impression etc. This approach has proven particularly fruitful when dealing with new technologies with a high level of innovation. The rapid nature of these projects also makes them suitable for exploring digital collaboration tools aimed at controlling and speeding up the design process.
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| 22. |
- Johansson Falck, Marlene
(författare)
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Narrow paths, difficult roads, and long ways : Travel through space and metaphorical meaning
- 2013
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Ingår i: The Construal of Spatial Meaning. - Oxford : Oxford University Press. - 9780199641635 ; , s. 214-235
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Bokkapitel (refereegranskat)abstract
- This paper is a corpus linguistic analysis of 1000 random path-, road-, and way-instances from the British National Corpus. The aim is to show that both non-metaphorical and metaphorical instances of these terms (e.g. the bushes had grown across the path and the path of green consumerism) are intimately connected with people’s embodied experiences of travel through space along paths, roads, or ways. This is evident from a) the coherent way in which sentences including these terms are generally structured, b) the differences between path- road-, and way-sentences at a more specific level of abstraction, and c) the similarities between non-metaphorical and metaphorical sentences including the same term (e.g. non-metaphorical path and metaphorical path). The image-schematic structures of these experiences create coherence in word use. Differences between paths, roads, and ways, and hence between journeys along these, lead to variation in spatial metaphorical meaning.
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| 23. |
- Kastberg Weichselberger, Gustaf, 1976, et al.
(författare)
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Accounting in and for hybrids. Observations of the power of disentanglements
- 2022
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Ingår i: Accounting, Auditing & Accountability Journal. - 0951-3574. ; 35:3, s. 706-733
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Tidskriftsartikel (refereegranskat)abstract
- Purpose The authors argue that the mainstream scholarly discourse on hybridity and accounting is thus far primarily interested in the use and effects of accounting “in” hybrid organizations. Consequently, the literature has to a lesser extent explored how accounting mediates hybrid settings (while also being mediated), and the role of disentanglements in such processes. In hybrid settings, objects are difficult to define, and measures and tools difficult to agree upon. However, the literature on hybrid accounting is inconclusive and indicates that accounting can potentially both stabilize and de-stabilize relations in a hybrid setting. The authors address the research question of how accounting emerges and manifests itself in a process of entangling and disentangling in a heterogeneous emerging hybrid setting. Design/methodology/approach The paper is based on a longitudinal qualitative case study of the implementation of social investments, a public sector calculative framework based on the logic of measuring long term and social and economic impact of prevention. Methodologically, the study was guided by actor-network theory. In total, 18 observations and 48 interviews were conducted. Findings The observation the authors make in their case study is that much effort was spent on both keeping things apart and tying elements together. What the authors add to the literature is an illumination of how the interplay between entanglements and disentanglements facilitated the design idea of social investments to be enacted as multiple semi-integrated and purified hybridizations. The authors describe different translation points, each representing a specific hybridization where elements were added, recombined and disentangled. Still, the translation points were not completely compartmentalized, but rather semi-integrated where associations were facilitated through active mediation, likeness and productiveness for each other. Research limitations/implications One limitation is the single case approach. A second limitation arises from the ANT approach to hybridity. Practical implications A practical implication of this paper is that in hybrid settings, the semi-integrated character may be interpreted as a strength because it allows the mobilization of heterogenous actors. However, this may also come at the cost of governability and raises further questions of managerial practices in hybrid settings. Social implications The paper suggests the potentially productive role of disentanglements in allowing multiple hybridizations to evolve in hybrid accounting settings. Originality/value The paper suggests the potentially productive role of disentanglements in allowing multiple stabilized hybridizations to evolve in hybrid accounting settings.
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| 24. |
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| 25. |
- Kobayashi, Tohru, et al.
(författare)
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Intracerebral Infusion of Glial Cell Line-Derived Neurotrophic Factor Promotes Striatal Neurogenesis After Stroke in Adult Rats.
- 2006
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Ingår i: Stroke: a journal of cerebral circulation. - 1524-4628. ; 37:9, s. 2361-2367
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Tidskriftsartikel (refereegranskat)abstract
- Background and Purpose-Stroke triggers increased progenitor proliferation in the subventricular zone (SVZ) and the generation of medium spiny neurons in the damaged striatum of rodents. We explored whether intrastriatal infusion of glial cell line-derived neurotrophic factor (GDNF) promotes neurogenesis after stroke. Methods-Adult rats were subjected to 2-hour middle cerebral artery occlusion (MCAO). GDNF was infused into the ischemic striatum either during the first week after MCAO, with the animals being killed directly thereafter, or during the third and fourth weeks, with the rats being killed 1 week later. New cells were labeled with 5'-bromo-2'deoxyuridine (BrdU) on day 7 or during the second week, respectively. Neurogenesis was assessed immunocytochemically with antibodies against BrdU and neuronal, glial, or progenitor markers. GDNF receptor expression was analyzed in SVZ tissue and neurospheres by reverse transcription-polymerase chain reaction and immunocytochemistry. Results-GDNF infusion increased cell proliferation in the ipsilateral SVZ and the recruitment of new neuroblasts into the striatum after MCAO and improved survival of new mature neurons. The GDNF receptor GFR alpha 1 was upregulated in the SVZ 1 week after MCAO and was coexpressed with markers of dividing progenitor cells. Conclusions-Intrastriatal infusion of GDNF in the postischernic period promotes several steps of striatal neurogenesis after stroke., partly through direct action on SVZ progenitors. Because delivery of GDNF has biological effects in the human brain, our data suggest that administration of this factor may promote neurciregenerative responses in stroke patients.
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