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| 2. |
- Appelberg, Jonas, 1964-, et al.
(författare)
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Ventilatory response to CO2 in patients with snoring, obstructive hypopnoea and obstructive apnoea
- 1997
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Ingår i: Clinical Physiology. - : Wiley-Blackwell Publishing Inc.. - 0144-5979 .- 1365-2281. ; 17:5, s. 497-507
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Tidskriftsartikel (refereegranskat)abstract
- Obstructive sleep apnoea (OSA) is caused by an obstruction of the upper airway. Sufficient sensitivity to CO2 in the respiratory centre is known to be a critical factor for adequate tone in the upper airway muscles. The hypothesis of this study is, therefore, that the ventilatory response to CO2 is reduced in patients with OSA. Twenty-six patients who suffered from snoring, 19 snoring patients with obstructive hypopnoea (OH) and 33 snoring patients with obstructive apnoea (OA), were studied. The control group consisted of 25 subjects from a random sample with no history of snoring or daytime sleepiness. Tests of the hyperoxic and hypoxic ventilatory response to CO2 were performed, as well as static and dynamic spirometry. Subjects in the OA group displayed a higher hyperoxic (VE/FetCO2hy = 12.6 l min-1/%) and hypoxic (VE/FetCO2ho = 15.7 l min-1/%) ventilatory response to CO2 than patients with obstructive hypopnoea (VE/FetCO2hy = 8.6 l min-1/%; VE/FetCO2ho = 15.2 l min-1/%), snorers (VE/FetCO2hy = 8.4 l min-1/%; VE/FetCO2ho = 12.7 l min-1/%) and non-snorers (VE/FetCO2hy = 7.6 l min-1/%; VE/FetCOho = 9.6 l min-1/%). Multiple regression analysis reveals that neck circumference, apnoea index, oxygen desaturation index, PCO2 and sex (male gender) are correlated with VE/FetCO2hy (R2 = 0.43). Multiple regression analysis also reveals that ERV (expiratory reserve volume) and sex (male gender) are correlated with VE/FetCO2ho (R2 = 0.21). Arguing against the hypothesis, patients with OSA displayed an increased hyperoxic and hypoxic ventilatory response to CO2. Nocturnal apnoea frequency and the obesity factor in OSA may have contributed to these results.
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| 3. |
- Asplund, Kjell, et al.
(författare)
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Stroke in the elderly
- 1999
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Ingår i: Cerebrovascular Diseases. - 1015-9770 .- 1421-9786. ; 2, s. 152-157
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Tidskriftsartikel (refereegranskat)
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| 8. |
- Granlund, Thomas, et al.
(författare)
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A polythiophene microcavity laser
- 1998
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Ingår i: Chemical Physics Letters. - : Elsevier. - 0009-2614 .- 1873-4448. ; 288:5-6, s. 879-884
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Tidskriftsartikel (refereegranskat)abstract
- We report photopumped lasing in a microcavity device with a polythiophene layer as the emitter. These microcavity devices are built by joining two polymer coated dielectric mirrors at elevated temperature. When photopumping the film, a lasing threshold is observed at 120 nJ/cm(2). Comparative studies with fast pump-probe spectroscopy of thin polythiophene films and the same polymer in photopumped lasing studies, indicate that the gain coefficient is 80 +/- 20 cm(-1), and that the exciton concentration is 2 X 10(17) cm(-3) at the lasing transition, well below the exciton-exciton recombination level. (C) 1998 Elsevier Science B.V. All rights reserved.
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| 9. |
- Granlund, Thomas, et al.
(författare)
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Lasing in substituted polythiophene between dielectric mirrors
- 1999
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Ingår i: Synthetic metals. - : Elsevier. - 0379-6779 .- 1879-3290. ; 102:1-3, s. 1038-1041
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Tidskriftsartikel (refereegranskat)abstract
- We report photopumped lasing in a microcavity device with a polythiophene layer as emitter. The microcavity is made of a polymer film between two dielectric Bragg reflecting mirrors (DBR). The:microcavity devices is built by joining two polymer coated DBR mirrors at elevated temperature. When photopumping the film,a lasing threshold is observed at 120 nJ/cm(2). Comparative studies with fast pump-probe spectroscopy of thin polythiophene films, and the same polymer in photopumped lasing studies, indicate that the gain coefficient is 80 +/- 20 cm(2) and that the exciton concentration is 2X10(17) cm(2) at the lasing transition, well below the exciton-exciton recombination level.
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| 10. |
- Johansson, A, et al.
(författare)
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Epitope specificity of monoclonal anticytokeratin antibody TS1
- 1999
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Ingår i: Cancer Res 1999;59:45-51.
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Tidskriftsartikel (refereegranskat)abstract
- Due to their abundance in epithelial cells and deposition in necrotic regions intratumorally, cytokeratins (CKs) have been established as valuable targets for both radioimmunolocalization and radioimmunotherapy. The target epitope for the monoclonal anti-CK8 antibody, TS1, used for both experimental radioimmunolocalization and radioimmunotherapy, was determined by means of synthesis of 96 overlapping peptides that covered the entire CK8 molecule. A highly conserved peptide sequence, spanning amino acids (aa) 343357 and covering the discontinuous epitope in the helical 2B domain, was identified. The epitope retains its helical structure, as shown with circular dichroism spectroscopy, although the length of the peptide (i.e., >20 aa) is crucial for maintenance of immunoreactivity. To determine which aa residues are crucial for binding to the monoclonal antibody, alanine scanning was performed on a 26-mer covering aa 340365, with the sequence RGELAIKDANAKLSELEAALQRAKQ. The 26 modified peptides were evaluated using ELISA and BIAcore technology. The uniqueness of this epitope has been established by data base sequence comparisons
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| 11. |
- Johansson, A., et al.
(författare)
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Epitope specificity of the monoclonal anticytokeratin antibody TS1
- 1999
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Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 59:1, s. 48-51
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Tidskriftsartikel (refereegranskat)abstract
- Due to their abundance in epithelial cells and deposition in necrotic regions intratumorally, cytokeratins (CKs) have been established as valuable targets for both radioimmunolocalization and radioimmunotherapy. The target epitope for the monoclonal anti-CK8 antibody, TS1, used for both experimental radioimmunolocalization and radioimmunotherapy, was determined by means of synthesis of 96 overlapping peptides that covered the entire CK8 molecule. A highly conserved peptide sequence, spanning amino acids (aa) 343-357 and covering the discontinuous epitope in the helical 2B domain, was identified. The epitope retains its helical structure, as shown with circular dichroism spectroscopy, although the length of the peptide (ie., >20 aa) is crucial for maintenance of immunoreactivity. To determine which aa residues are crucial for binding to the monoclonal antibody, alanine scanning was performed on a 26-mer covering aa 340-365, with the sequence QRGELAIKDANAKLSELEAALQRAKQ. The 26 modified peptides were evaluated using ELISA and BIAcore technology. The uniqueness of this epitope has been established by data base sequence comparisons.
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| 12. |
- Larsson, P G, et al.
(författare)
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Is bacterial vaginosis a sexually transmitted disease?
- 1991
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Ingår i: International journal of STD & AIDS. - : SAGE Publications. - 0956-4624 .- 1758-1052. ; 2:5, s. 362-4
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Tidskriftsartikel (refereegranskat)abstract
- The sexual behaviour of 400 women with and 400 women without bacterial vaginosis from a health screening programme was investigated by a questionnaire to see if women with bacterial vaginosis had similar behaviours to women considered at risk for STDs. These patients were randomly selected from computer records. Eight hundred questionnaires were distributed and 641 women answered. The age of first sexual intercourse was lower among women with bacterial vaginosis (17.8 years) than those without (18.6 years; P less than 0.001). Number of lifetime sexual partners was higher among women with bacterial vaginosis (P less than 0.001). Women with bacterial vaginosis smoked or had smoked more often. These results indicate that women with bacterial vaginosis have similar sexual behaviour to those at risk for STDs.
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| 13. |
- Rosenquist, R, et al.
(författare)
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Clonal evolution as judged by immunoglobulin heavy chain gene rearrangements in relapsing precursor-B acute lymphoblastic leukemia.
- 1999
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Ingår i: European Journal of Haematology. - 0902-4441 .- 1600-0609. ; 63:3, s. 171-9
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Tidskriftsartikel (refereegranskat)abstract
- Oligoclonality and ongoing clonal evolution are common features in patients with precursor-B (pre-B) acute lymphoblastic leukemia (ALL), as judged by immunoglobulin heavy chain (IgH) gene rearrangement analysis. These features are considered to be results of secondary rearrangements after malignant transformation or emergence of new tumor clones. In the present study we analyzed the IgH gene rearrangement status in 18 cases with relapsing pre-B ALL using variable heavy chain (V(H)) gene family specific polymerase chain reaction (PCR) amplification and single stranded conformation polymorphism (SSCP) analysis. Clonal IgH rearrangements were displayed in all leukemias but one, and altered rearrangement patterns occurred in five cases (29%), which were selected for detailed nucleotide sequence analysis. In one case, multiple subclones at diagnosis were suggested to be derived from a progenitor clone through joining of different V(H) germline gene segments to a pre-existing D-J(H) complex (V(H) to D-J(H) joining). Evidence for V(H) gene replacement with identical N-sequences at the V(H)-D junction and a common D-J(H) region was observed in one case. Diversification at the V(H)-D junction consisting of heterogeneous N-sequences were observed in one case. This molecular modification of the V(H)-D region could fit a hypothesized "open-and-shut" mechanism. Nevertheless, despite these ongoing events at least one IgH rearrangement remained unchanged throughout the disease in most patients, indicating that the immunoglobulin heavy chain locus can be a suitable marker for detection of minimal residual disease (MRD).
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| 14. |
- Åström, Gunnar, et al.
(författare)
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Automatic biopsy instruments used through a coaxial bone biopsy system with an eccentric drill tip
- 1995
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Ingår i: Acta Radiologica. - 0284-1851 .- 1600-0455. ; 36:3, s. 237-242
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Tidskriftsartikel (refereegranskat)abstract
- Twenty-eight consecutive CT (n = 23) or ultrasonographically (n = 5) guided biopsy procedures were performed on musculoskeletal lytic lesions covered (n = 13) or not covered (n = 15) with intact bone. Specimens were obtained by means of Biopty techniques (n = 27), i.e. Biopty and Monopty instruments, through different cannulas with normal or shortened needle-throws. Four out of 5 bone penetrations were successful with an Ostycut needle, and all 8 bone penetrations by a coaxial bone biopsy system with an eccentric drill. The eccentric drill makes a hole in the cortical bone larger than the diameter of the outer cannula of this system, making it easy to anchor the cannula and then coaxially insert a Biopty-Gun needle for example. The overall histopathological diagnostic accuracy of the Biopty techniques was 25/27 (92.6%).
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